MX2019012508A - Metodo para preparar una composicion con un bajo contenido de oxigeno disuelto, que comprende paracetamol, y opcionalmente uno o mas aine, y una composicion obtenida de la misma. - Google Patents
Metodo para preparar una composicion con un bajo contenido de oxigeno disuelto, que comprende paracetamol, y opcionalmente uno o mas aine, y una composicion obtenida de la misma.Info
- Publication number
- MX2019012508A MX2019012508A MX2019012508A MX2019012508A MX2019012508A MX 2019012508 A MX2019012508 A MX 2019012508A MX 2019012508 A MX2019012508 A MX 2019012508A MX 2019012508 A MX2019012508 A MX 2019012508A MX 2019012508 A MX2019012508 A MX 2019012508A
- Authority
- MX
- Mexico
- Prior art keywords
- acetaminophen
- composition
- nsaids
- optionally
- preparing
- Prior art date
Links
- RZVAJINKPMORJF-UHFFFAOYSA-N Acetaminophen Chemical compound CC(=O)NC1=CC=C(O)C=C1 RZVAJINKPMORJF-UHFFFAOYSA-N 0.000 title abstract 8
- 239000000203 mixture Substances 0.000 title abstract 4
- 229940021182 non-steroidal anti-inflammatory drug Drugs 0.000 title abstract 4
- 229960005489 paracetamol Drugs 0.000 title abstract 4
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 title abstract 3
- 238000000034 method Methods 0.000 title abstract 3
- 229910052760 oxygen Inorganic materials 0.000 title abstract 3
- 239000001301 oxygen Substances 0.000 title abstract 3
- 239000000041 non-steroidal anti-inflammatory agent Substances 0.000 title 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 3
- 239000008215 water for injection Substances 0.000 abstract 2
- 238000013329 compounding Methods 0.000 abstract 1
- 238000010438 heat treatment Methods 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
- A61K31/167—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the nitrogen of a carboxamide group directly attached to the aromatic ring, e.g. lidocaine, paracetamol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/192—Carboxylic acids, e.g. valproic acid having aromatic groups, e.g. sulindac, 2-aryl-propionic acids, ethacrynic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/02—Inorganic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/20—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing sulfur, e.g. dimethyl sulfoxide [DMSO], docusate, sodium lauryl sulfate or aminosulfonic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/08—Solutions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Engineering & Computer Science (AREA)
- Pain & Pain Management (AREA)
- Dermatology (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Inorganic Chemistry (AREA)
- Rheumatology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
La presente invención proporciona un método para preparar una composición acuosa para administración intravenosa que comprende paracetamol, y opcionalmente uno o más fármacos antiinflamatorios no esteroides (AINE), por lo cual el oxígeno disuelto de la composición en un recipiente cerrado es de 1,0 ppm como máximo, caracterizado dicho método porque comprende enjuagar por lo menos una vez un recipiente para la producción del compuesto con agua de una temperatura de por lo menos 80°C, calentando de este modo el recipiente y creando un entorno de bajo contenido de oxígeno en dicho recipiente; y en dicho recipiente enjuagado disolver paracetamol en agua par inyectables, donde dicha agua para inyectables está a una temperatura de por lo menos 80°C, por medio de lo cual opcionalmente uno o más AINE se agregan antes de o después de disolver el paracetamol.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PCT/EP2017/059440 WO2018192664A1 (en) | 2017-04-20 | 2017-04-20 | METHOD FOR PREPARING A COMPOSITION WITH A LOW DISSOLVED OXYGEN CONTENT, COMPRISING ACETAMINOPHEN, AND OPTIONALLY ONE OR MORE NSAIDs, AND A COMPOSITION OBTAINED THEREOF |
| PCT/EP2018/060205 WO2018193099A1 (en) | 2017-04-20 | 2018-04-20 | METHOD FOR PREPARING A COMPOSITION WITH A LOW DISSOLVED OXYGEN CONTENT, COMPRISING ACETAMINOPHEN, AND OPTIONALLY ONE OR MORE NSAIDs, AND A COMPOSITION OBTAINED THEREOF |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MX2019012508A true MX2019012508A (es) | 2020-02-05 |
Family
ID=58645031
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2019012508A MX2019012508A (es) | 2017-04-20 | 2018-04-20 | Metodo para preparar una composicion con un bajo contenido de oxigeno disuelto, que comprende paracetamol, y opcionalmente uno o mas aine, y una composicion obtenida de la misma. |
Country Status (20)
| Country | Link |
|---|---|
| US (1) | US11413241B2 (es) |
| EP (1) | EP3612157A1 (es) |
| JP (1) | JP6944590B2 (es) |
| KR (2) | KR102625301B1 (es) |
| CN (1) | CN110719773A (es) |
| AR (1) | AR111484A1 (es) |
| AU (1) | AU2018255376B2 (es) |
| CA (1) | CA3060325A1 (es) |
| CL (1) | CL2019002985A1 (es) |
| CO (1) | CO2019011569A2 (es) |
| EC (1) | ECSP19075614A (es) |
| IL (1) | IL270035B2 (es) |
| MX (1) | MX2019012508A (es) |
| PE (1) | PE20191793A1 (es) |
| PH (1) | PH12019502385A1 (es) |
| RU (1) | RU2019137019A (es) |
| SA (1) | SA519410340B1 (es) |
| SG (1) | SG11201909726YA (es) |
| TW (1) | TW201841632A (es) |
| WO (2) | WO2018192664A1 (es) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN115040475A (zh) * | 2022-06-23 | 2022-09-13 | 杭州浙中医药科技有限公司 | 一种n-乙酰半胱氨酸口服溶液 |
Family Cites Families (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2751875B1 (fr) | 1996-08-05 | 1998-12-24 | Scr Newpharm | Nouvelles formulations liquides stables a base de paracetamol et leur mode de preparation |
| FR2809619B1 (fr) * | 2000-06-06 | 2004-09-24 | Pharmatop | Nouvelles formulations aqueuses de principes actifs sensibles a l'oxydation et leur procede d'obtention |
| US20060100578A1 (en) | 2004-09-13 | 2006-05-11 | Tandem Medical, Inc. | Medication delivery apparatus and methods for intravenous infusions |
| CN102006867A (zh) | 2008-01-03 | 2011-04-06 | 沃根哈德研究中心 | 含有扑热息痛和布洛芬的口服药物混悬剂 |
| WO2010044681A1 (en) | 2008-10-14 | 2010-04-22 | Aft Pharmaceuticals Limited | A medicinal product and treatment |
| EP2243477A1 (de) | 2009-04-22 | 2010-10-27 | Fresenius Kabi Deutschland GmbH | Paracetamol zur parenteralen Verabreichung |
| US8404748B2 (en) | 2009-08-13 | 2013-03-26 | Neogen N.V. | Storage-stable formulation of paracetamol in aqueous solution |
| DK2389923T3 (da) | 2010-05-19 | 2013-03-18 | Uni Pharma Kleon Tsetis Pharmaceutical Lab S A | Stabil klar til brug injicerbar paracetamol-formulering |
| NZ609727A (en) | 2010-11-04 | 2015-07-31 | Aft Pharmaceuticals Ltd | A combination composition comprising ibuprofen and paracetamol |
| US9205037B2 (en) | 2011-07-20 | 2015-12-08 | Church & Dwight Co., Inc. | Single phase depilatory composition |
| ES2414557B1 (es) * | 2012-01-16 | 2014-06-10 | Novocat Farma, S.A. | Composición acuosa de paracetamol para inyección |
| BE1020614A5 (nl) | 2012-01-27 | 2014-01-07 | Hubert De Backer Nv | Injectiespuit. |
| US9072661B2 (en) | 2012-03-16 | 2015-07-07 | Cumberland Pharmaceuticals Inc. | Injectable ibuprofen formulation |
| AU2013232038B2 (en) | 2012-03-16 | 2016-07-07 | Cumberland Pharmaceuticals, Inc. | Injectable ibuprofen formulation |
| WO2016008546A1 (en) | 2014-07-18 | 2016-01-21 | Everbright Pharmaceuticals S.A.R.L. | Aqueous formulation comprising paracetamol and ibuprofen |
-
2017
- 2017-04-20 WO PCT/EP2017/059440 patent/WO2018192664A1/en active Application Filing
-
2018
- 2018-04-18 TW TW107113225A patent/TW201841632A/zh unknown
- 2018-04-20 EP EP18718164.9A patent/EP3612157A1/en active Pending
- 2018-04-20 AR ARP180101010A patent/AR111484A1/es unknown
- 2018-04-20 SG SG11201909726Y patent/SG11201909726YA/en unknown
- 2018-04-20 PE PE2019002070A patent/PE20191793A1/es unknown
- 2018-04-20 KR KR1020197032849A patent/KR102625301B1/ko active IP Right Grant
- 2018-04-20 CA CA3060325A patent/CA3060325A1/en active Pending
- 2018-04-20 JP JP2020508076A patent/JP6944590B2/ja active Active
- 2018-04-20 RU RU2019137019A patent/RU2019137019A/ru unknown
- 2018-04-20 CN CN201880035790.3A patent/CN110719773A/zh active Pending
- 2018-04-20 WO PCT/EP2018/060205 patent/WO2018193099A1/en active Search and Examination
- 2018-04-20 US US16/605,711 patent/US11413241B2/en active Active
- 2018-04-20 MX MX2019012508A patent/MX2019012508A/es unknown
- 2018-04-20 AU AU2018255376A patent/AU2018255376B2/en active Active
- 2018-04-20 KR KR1020237039452A patent/KR20230160413A/ko not_active Application Discontinuation
-
2019
- 2019-10-17 IL IL270035A patent/IL270035B2/en unknown
- 2019-10-18 CL CL2019002985A patent/CL2019002985A1/es unknown
- 2019-10-18 CO CONC2019/0011569A patent/CO2019011569A2/es unknown
- 2019-10-20 SA SA519410340A patent/SA519410340B1/ar unknown
- 2019-10-21 PH PH12019502385A patent/PH12019502385A1/en unknown
- 2019-10-21 EC ECSENADI201975614A patent/ECSP19075614A/es unknown
Also Published As
| Publication number | Publication date |
|---|---|
| CA3060325A1 (en) | 2018-10-25 |
| AR111484A1 (es) | 2019-07-17 |
| US11413241B2 (en) | 2022-08-16 |
| JP6944590B2 (ja) | 2021-10-06 |
| IL270035B2 (en) | 2023-05-01 |
| WO2018193099A1 (en) | 2018-10-25 |
| RU2019137019A3 (es) | 2021-07-05 |
| AU2018255376B2 (en) | 2023-07-06 |
| JP2020522564A (ja) | 2020-07-30 |
| CL2019002985A1 (es) | 2020-01-31 |
| SG11201909726YA (en) | 2019-11-28 |
| SA519410340B1 (ar) | 2022-03-13 |
| PH12019502385A1 (en) | 2020-09-14 |
| PE20191793A1 (es) | 2019-12-24 |
| RU2019137019A (ru) | 2021-05-20 |
| IL270035B1 (en) | 2023-01-01 |
| US20210338578A1 (en) | 2021-11-04 |
| AU2018255376A1 (en) | 2019-11-07 |
| EP3612157A1 (en) | 2020-02-26 |
| ECSP19075614A (es) | 2019-11-30 |
| WO2018192664A1 (en) | 2018-10-25 |
| KR20230160413A (ko) | 2023-11-23 |
| IL270035A (es) | 2019-12-31 |
| CN110719773A (zh) | 2020-01-21 |
| CO2019011569A2 (es) | 2021-03-08 |
| KR102625301B1 (ko) | 2024-01-15 |
| TW201841632A (zh) | 2018-12-01 |
| KR20190137859A (ko) | 2019-12-11 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CL2017001488A1 (es) | Benzamidas sustituidas con 1,3–tiazol–2–ilo | |
| AR098107A1 (es) | Proceso para la preparación de 3-(3-cloro-1h-pirazol-1-il)piridina | |
| BR112017012888A2 (pt) | composição baseada em chlorella mixotrófica e processo para sua preparação e aplicação em plantas | |
| BR112017009028A2 (pt) | métodos e sistema para suprimir corrosão em superfícies de metal. | |
| NAYELLI | Hallyu y su impacto en la sociedad mexicana | |
| PH12019502385A1 (en) | METHOD FOR PREPARING A COMPOSITION WITH A LOW DISSOLVED OXYGEN CONTENT, COMPRISING ACETAMINOPHEN, AND OPTIONALLY ONE OR MORE NASIDs, AND A COMPOSITION OBTAINED THEREOF | |
| BR112016026042A8 (pt) | preparação de rocurônio em forma líquida e método | |
| BR112018074486A2 (pt) | composição oral de celecoxib para tratamento da dor | |
| Kim et al. | Kinetic Study on Aminolysis of 4-Chloro-2-Nitrophenyl X-Substituted-Benzoates in Acetonitrile and in 80 mol% H2O/20 mol% DMSO: Effect of Medium on Reactivity and Reaction Mechanism | |
| Karlsson | “Must we really cut people's toes off to uphold the law?”: Confucian Statecraft, Punishment and the Body in Chosŏn Korea | |
| Sharma et al. | Prostatic adenocarcinoma with aberrant diffuse expression of high molecular weight cytokeratin | |
| Beulig et al. | Corrigendum: Altered carbon turnover processes and microbiomes in soils under long-term extremely high CO2 exposure | |
| 陈袁琪 | Hottest Rising Star: Elizobeth Olsen | |
| 임정욱 | On almost factoriality of integral domains | |
| 신민혜 | Hierarchy of Competencies for Modern Dancers' Performance based on AHP: For the Performance on Stag | |
| Jae-Young | The Achievements and Tasks of the Eastern Economic Forum and Korea-Russia Summit | |
| 김칠성 | A Study on Paul’s Missiological Thoughts in Romans | |
| Kim | Crack repair effects of injection method using organic/inorganic composite materials | |
| Lim et al. | Long-term Object Tracking using Optical Flow and Template Matching | |
| 하지혜 et al. | Fabrication and antibacterial properties of hydroxyapatite-based housings of vibration humidifiers | |
| Michael | Doubting the Folk: A Critique of Experimental Philosophy as it pertains to the Problem of Free Will: A Critique of Experimental Philosophy as it pertains to the Problem of Free Will | |
| UA118032U (uk) | Фармацевтична композиція | |
| 최윤경 | La féminité et le postcolonialisme chez Mohammed Dib et Han Yong-Un | |
| Keremidchieva | LIFE OF A WORD FROM THE GLOSSARY OF SOPHRONIUS. | |
| 김종석 | Polish Aid for North Korea during the Korean War |