MX2019011574A - Método mejorado para producir aplicaciones relacionadas con la colagenasa. - Google Patents

Método mejorado para producir aplicaciones relacionadas con la colagenasa.

Info

Publication number
MX2019011574A
MX2019011574A MX2019011574A MX2019011574A MX2019011574A MX 2019011574 A MX2019011574 A MX 2019011574A MX 2019011574 A MX2019011574 A MX 2019011574A MX 2019011574 A MX2019011574 A MX 2019011574A MX 2019011574 A MX2019011574 A MX 2019011574A
Authority
MX
Mexico
Prior art keywords
collagenase
improved method
compositions
producing collagenase
producing
Prior art date
Application number
MX2019011574A
Other languages
English (en)
Inventor
A Sheaffer Christine
Berbaum Michael
Hanna John
Dziadosz Jason
Shanafelt Daniel
Original Assignee
Endo Ventures Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Endo Ventures Ltd filed Critical Endo Ventures Ltd
Publication of MX2019011574A publication Critical patent/MX2019011574A/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/46—Hydrolases (3)
    • A61K38/48—Hydrolases (3) acting on peptide bonds (3.4)
    • A61K38/4886—Metalloendopeptidases (3.4.24), e.g. collagenase
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/52—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from bacteria or Archaea
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
    • C12Y304/24—Metalloendopeptidases (3.4.24)
    • C12Y304/24003—Microbial collagenase (3.4.24.3)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/569—Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses
    • G01N33/56911—Bacteria

Abstract

La presente invencion se refiere a los campos de produccion de colagenasa y de los productos de colagenasa, y en particular al mejoramiento de la reproductibilidad, la pureza y la estabilidad de las composiciones de colagenasa I y colagenasa II, en donde las composiciones son al menos 95% puras por area, medido por cromatografia liquida a alta presion de fase inversa (RP-HPLC) y están esencialmente libres de proteasa neutra.
MX2019011574A 2017-03-28 2018-03-28 Método mejorado para producir aplicaciones relacionadas con la colagenasa. MX2019011574A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201762477846P 2017-03-28 2017-03-28
PCT/US2018/024973 WO2018183582A2 (en) 2017-03-28 2018-03-28 Improved method of producing collagenase

Publications (1)

Publication Number Publication Date
MX2019011574A true MX2019011574A (es) 2019-12-19

Family

ID=62017610

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2019011574A MX2019011574A (es) 2017-03-28 2018-03-28 Método mejorado para producir aplicaciones relacionadas con la colagenasa.

Country Status (12)

Country Link
US (3) US11473074B2 (es)
EP (1) EP3601556A2 (es)
JP (2) JP7227918B2 (es)
KR (2) KR20240001279A (es)
CN (1) CN110741085A (es)
AR (2) AR111843A1 (es)
AU (1) AU2018244426A1 (es)
BR (1) BR112019020394A2 (es)
CA (1) CA3057982A1 (es)
IL (1) IL269651A (es)
MX (1) MX2019011574A (es)
WO (1) WO2018183582A2 (es)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HUE057423T2 (hu) 2012-01-12 2022-05-28 Endo Global Ventures Clostridium histolyticum enzim
CN115969318A (zh) 2017-03-01 2023-04-18 恩多风投有限公司 用于评估和治疗橘皮组织的装置和方法
AU2018244426A1 (en) 2017-03-28 2019-10-17 Endo Ventures Limited Improved method of producing collagenase
WO2020021330A2 (en) 2018-07-12 2020-01-30 Endo Global Aesthetics Limited Injection techniques for the treatment of cellulite
WO2020021332A2 (en) 2018-07-12 2020-01-30 Endo Global Aesthetics Limited Injection techniques for the treatment of cellulite
EP3924363A1 (de) * 2019-02-14 2021-12-22 Nordmark Pharma GmbH Chromatographische aufreinigung von wenigstens einem enzym, ausgesucht aus der gruppe bestehend aus kollagenase typ i, kollagenase typ ii, neutrale protease und clostripain
WO2023172070A1 (ko) * 2022-03-08 2023-09-14 주식회사 코넥스트 콜라게네이즈, 칼슘, 히스티딘 및 글리신을 포함하는 조성물 및 콜라게네이즈의 안정화 방법

Family Cites Families (104)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3821364A (en) 1966-07-08 1974-06-28 Advance Biofactures Corp Process of producing collagenase
JPS5662229A (en) 1979-10-25 1981-05-28 Asahi Glass Co Ltd Electro-optical dimming panel
US4338300A (en) 1981-02-05 1982-07-06 The Regents Of The University Of California Use of purified clostridial collangenase in the treatment of Peyronie's disease
DE3473827D1 (en) 1983-01-05 1988-10-13 Pasteur Institut Highly active collagenolytic preparation and pharmaceutical compositions containing it
US4524065A (en) 1983-08-04 1985-06-18 Bio-Specifics N.V. Method for the prevention and treatment of scars with enzymes
US4645668A (en) * 1983-08-04 1987-02-24 Biospecifics, Nv Method for the prevention and treatment of scars with enzymes
US5252461A (en) 1990-05-01 1993-10-12 The Regents Of The Univ. Of California Mixed immunoglobulins for detection of rheumatoid factors
CA2047306A1 (en) 1990-07-23 1992-01-24 Milan Holjevac Mutant bacterium clostridium histolyticum, a process for the obtaining thereof, and its use in the production of clostripain-free collagenase
US5393792A (en) 1991-11-20 1995-02-28 Advance Biofactures Of Curacao, N.V. High dosage topical forms of collagenase
US5462739A (en) 1991-11-21 1995-10-31 Yeda Research And Development Co., Ltd. Microdelivery device and method for enhanced drug administration to the eye
US5256140A (en) 1992-03-27 1993-10-26 Fallien Cosmeceuticals, Ltd. Composition for levelling skin
AU4644793A (en) 1992-06-22 1994-01-24 Trigen, Inc. Molecular cloning of the genes reponsible for collagenase production from clostridium histolyticum
JP3186881B2 (ja) 1993-02-18 2001-07-11 倉敷紡績株式会社 肝細胞の分離方法
US5332503A (en) 1993-04-16 1994-07-26 Baxter International Inc. Process for purifying collagenase
US5514340A (en) 1994-01-24 1996-05-07 Magnetix Biotechnology, Inc. Device for separating magnetically labelled cells
WO1996000283A1 (en) 1994-06-24 1996-01-04 Boehringer Mannheim Corporation A purified mixture of collagenases and two other proteases obtained from clostridium histolyticum
US5589171A (en) 1994-08-22 1996-12-31 Advance Biofactures Of Curacao Treatment of Dupuytren's disease with collagenase
CA2158822C (en) 1994-09-27 2008-12-23 Kusuki Nishioka Therapeutic agent for rheumatic disease
US6958150B2 (en) 1994-12-15 2005-10-25 Advance Biofactures Of Curacao, N.V. Reduction of adipose tissue
BR9607143A (pt) 1995-03-16 1997-11-25 Knoll Ag Enzima ibtenível de clostridium histolyticum mistura de enzimas uso da mistura uso de enzimas colagenase hp na forma pura colagenase az na forma pura e elastase na forma pura
US5705170A (en) 1995-10-24 1998-01-06 Plantech International, Inc. Herbal cellulite treatments
US5989888A (en) 1996-01-24 1999-11-23 Roche Diagnostics Corporation Purified mixture of collagenase I, collagenase II and two other proteases
BR9713108A (pt) * 1996-11-19 2004-06-22 Roche Diagnostics Gmbh Colagenase recombinante do tipo i de clostridium histolytucum e o uso da mesma para o isolamento de células e de grupos de células
US5830741A (en) 1996-12-06 1998-11-03 Boehringer Mannheim Corporation Composition for tissue dissociation containing collagenase I and II from clostridium histolyticum and a neutral protease
US5753785A (en) 1996-12-16 1998-05-19 Fina Technology, Inc. Production of E-B copolymers with a single metallocene catalyst and a single monomer
US6086872A (en) * 1997-03-27 2000-07-11 Advance Biofactures Of Curacao, Nv Amelioration of dupuytren's disease
JPH10262658A (ja) 1997-03-28 1998-10-06 Kikkoman Corp ザルコシン・オキシダーゼの結晶、その製造方法及び三次元構造
AU738512B2 (en) 1997-10-03 2001-09-20 Lavipharm Laboratories, Inc. A prolamine-plant polar lipid composition, its method of preparation and applications thereof
GB9724802D0 (en) 1997-11-24 1998-01-21 Unilever Plc Antiperspirant or deodorant compoistions
US20020036328A1 (en) 1998-11-16 2002-03-28 William R. Richards, Jr. Offset drain fermi-threshold field effect transistors
FR2788682B1 (fr) 1999-01-26 2001-04-06 Seb Sa Dispositif de thermographie
US6022539A (en) 1999-06-03 2000-02-08 Advance Biofactures Of Curacao Amelioration of peyronie's disease
RU2180002C2 (ru) 1999-08-16 2002-02-27 Пермское научно-производственное объединение "Биомед" Способ получения коллагеназы
WO2001013865A1 (en) 1999-08-20 2001-03-01 Howard Murad Pharmaceutical compositions and methods for reducing the appearance of cellulite
US6280993B1 (en) 1999-08-24 2001-08-28 Ichiro Yamato Gene encoding class I collagenase
ITMI991894A1 (it) 1999-09-09 2001-03-09 Carlo Ghisalberti Acido linoleico coniugato e trigliceride nuovi metodi di sintesi e d'uso
CA2385488C (en) 1999-09-24 2015-07-07 Nicholas F. Franano Systems and methods for opening obstructed biological conduits
EP1187602A4 (en) 2000-04-18 2004-09-15 Peptron Inc SUSTAINABLE RELEASE INJECTABLE PHARMACEUTICAL COMPOSITION AND METHODS OF PREPARING THE SAME
WO2002049501A2 (en) 2000-12-18 2002-06-27 Board Of Regents, University Of Texas System Local regional chemotherapy and radiotherapy using in situ hydrogel
AU2002251831A1 (en) 2001-01-30 2002-08-12 The Regents Of The University Of Michigan Methods for sustained release local delivery of drugs for ablation of unwanted tissue
ATE302844T1 (de) 2001-07-02 2005-09-15 Nordmark Arzneimittel Gmbh & C Verfahren zur aufreinigung eines enzyms und hiernach hergestelltes, aufgereinigtes enzym sowie verwendung des enzyms
GB0124124D0 (en) 2001-10-08 2001-11-28 Medical Res Council Methods of treatment
JP2003284553A (ja) 2002-03-28 2003-10-07 Seikagaku Kogyo Co Ltd 生理活性タンパク質
CA2490725A1 (en) 2002-06-25 2003-12-31 Ultrashape Inc. Devices and methodologies useful in body aesthetics
EP1433845A1 (en) 2002-12-23 2004-06-30 Georg-August-Universität Clostridium tetani collagenase and uses thereof
EP1462519A1 (en) 2003-03-24 2004-09-29 Boehringer Ingelheim Austria GmbH Method and devices for producing biomolecules
JP4205496B2 (ja) 2003-06-19 2009-01-07 三菱化学株式会社 新規カルボニル還元酵素及びこれをコードするｄｎａ、ならびにこれらを利用した光学活性アルコールの製造方法
JP2007514445A (ja) 2003-12-17 2007-06-07 ザ・トラスティーズ・オブ・コロンビア・ユニバーシティ・イン・ザ・シティ・オブ・ニューヨーク 宿主細胞から標的細胞へのギャップジャンクションを介したＤＮＡまたはＲＮＡの送達、及びアンチセンスまたはｓｉＲＮＡのための細胞ベースの送達システム
NZ576986A (en) 2004-01-30 2010-12-24 Shire Pharmaceuticals Ireland Ltd Production and purification of recombinant arylsulfatase A
ES2660172T3 (es) 2004-05-19 2018-03-21 Los Angeles Biomedical Research Institute At Harbor-Ucla Medical Center Composición inyectable que comprende desoxicolato de sodio
US7754230B2 (en) 2004-05-19 2010-07-13 The Regents Of The University Of California Methods and related compositions for reduction of fat
US7355027B2 (en) 2004-06-16 2008-04-08 Dynport Vaccine Company Llc Bacillus anthracis protective antigen
PT1781697E (pt) 2004-07-07 2009-06-25 Lundbeck & Co As H Nova epo carbamilada e método para a sua produção
EP1773400A2 (en) 2004-07-08 2007-04-18 Amgen Inc. Therapeutic peptides
US20060020448A1 (en) 2004-07-21 2006-01-26 Microsoft Corporation Method and apparatus for capitalizing text using maximum entropy
WO2006025226A1 (ja) 2004-08-30 2006-03-09 Daicel Chemical Industries, Ltd. ポリグリセリンモノエーテル及びその製造方法
US20150025420A1 (en) 2004-10-06 2015-01-22 Guided Therapy Systems, Llc Ultrasound treatment device and methods of use
DE102004060075A1 (de) 2004-12-14 2006-07-06 Merck Patent Gmbh Verfahren zur Herstellung von Onium-Salzen mit Dialkylphosphat-, Dialkylphosphinat oder (O-Alkyl)-alkyl- oder Alkyl-phosphonat-Anionen mit geringem Halogenid-Gehalt
US7854929B2 (en) 2005-01-21 2010-12-21 The Research Foundation Of State University Of New York Method for treating lateral epicondylitis using collagenase
US20070224184A1 (en) 2006-02-22 2007-09-27 The Research Foundation Of The State University Of New York Method for treating cellulite
CA2593038C (en) 2005-01-21 2015-03-17 Advance Biofactures Corporation Methods for treating adhesive capsulitis
JP2006254876A (ja) 2005-03-18 2006-09-28 Hokkaido Univ Ｌ−トリプトファン製造法
US20060241673A1 (en) 2005-04-21 2006-10-26 Zadini Filiberto P Subcision device
US20060251581A1 (en) 2005-05-09 2006-11-09 Mcintyre Jon T Method for treatment of uterine fibroid tumors
US20070003541A1 (en) 2005-07-01 2007-01-04 Rodolfo Faudoa Methods and compositions for therapeutics
ITPD20050207A1 (it) 2005-07-07 2007-01-08 Fidia Farmaceutici Nuove composizioni farmaceutiche contenenti acido ialuronico e collagenas nel trattamento topico di ferite, ustioni ed ulcere
US20070031482A1 (en) 2005-08-02 2007-02-08 Ceramoptec Industries, Ind. PDT treatment method for cellulites and cosmetic use
US7811560B2 (en) 2006-01-30 2010-10-12 Auxilium Us Holdings, Llc Compositions and methods for treating collagen-mediated diseases
WO2007100590A2 (en) 2006-02-22 2007-09-07 Auxilium Pharmaceuticals, Inc. Methods for treating cellulite
EA200802090A1 (ru) 2006-03-31 2010-04-30 ДСМ АйПи АССЕТС Б.В. Новое применение соединений и комбинаций соединений для улучшения внешнего вида
WO2008100833A2 (en) 2007-02-13 2008-08-21 Auxilium International Holdings, Inc. Production of recombinant collagenases colg and colh in escherichia coli
US8617543B2 (en) 2007-02-14 2013-12-31 Yolare Pharmaceuticals, LLC Modified mutant collagenase and its use in fat melting and in scar reduction
CN101677912B (zh) 2007-05-11 2013-06-12 希格马托制药工业公司 可用于递送化妆品活性成分的凝胶
US9987221B2 (en) 2007-08-23 2018-06-05 Boston Scientific Scimed, Inc. Injectable hydrogel compositions
WO2009059379A1 (en) 2007-11-07 2009-05-14 Dynamic Microbials Limited Antimicrobial compositions, formulations and uses thereof
US20100159564A1 (en) 2007-11-30 2010-06-24 Dwulet Francis E Protease resistant recombinant bacterial collagenases
EP2130551B1 (en) 2008-06-02 2012-06-06 Roche Diagnostics GmbH Improved purification of collagenases from clostridium histolyticum liquid culture
US8236356B2 (en) 2008-06-11 2012-08-07 Roche Diagnostics Operations, Inc. Growth medium for Clostridium histolyticum
JP5421366B2 (ja) 2008-07-21 2014-02-19 オトノミ―，インク． 制御放出性の耳の構造体調節および生来の免疫システム調節化合物および耳の障害の処置のための方法
US8380531B2 (en) 2008-07-25 2013-02-19 Invivodata, Inc. Clinical trial endpoint development process
WO2010048409A1 (en) 2008-10-22 2010-04-29 Allergan, Inc. Clinical assessment scales and methods
US20110217252A1 (en) 2008-11-11 2011-09-08 Sigma-Tau Industrie Farmaceutiche Riunite S.P.A. Compound useful for treating cellulite
ES2531402T3 (es) 2008-11-19 2015-03-13 Meiji Seika Pharma Co Ltd Colagenasa de fusión a la que se une una marca de afinidad, y método para producir la misma
IT1397646B1 (it) 2009-12-15 2013-01-18 Seidita Collagenasi ricombinanti di c. histolyticum e metodo per la loro produzione.
WO2011109732A2 (en) 2010-03-05 2011-09-09 University Of Pittsburgh-Of The Commonwealth System Of Higher Education Reverse thermal gels and uses therefor
WO2011130537A2 (en) 2010-04-14 2011-10-20 Northwestern University Pharmaceutical compositions and methods for digesting atherosclerotic plaques
US20130217789A1 (en) 2010-09-03 2013-08-22 North Carolina Central University Biodegradable liquogel and ph sensitive nanocarriers
ES2385239B1 (es) 2010-09-30 2013-06-19 Proteos Biotech S.L.U. Uso de colagenasa g recombinante, colagenasa h recombinante y pz-peptidasa recombinante para el tratamiento de enfermedades que cursan con alteraciones del colágeno.
EP2675460A4 (en) 2011-02-18 2014-07-09 Kythera Biopharmaceuticals Inc TREATMENT OF FAT TISSUE UNDER CHIN
US10119131B2 (en) * 2011-03-16 2018-11-06 Biospecifics Technologies Corp. Compositions and methods for producing clostridial collagenases
TWI461214B (zh) 2011-06-13 2014-11-21 Univ Chang Gung Biodegradable water-sensitive glue, a drug delivery system as a carrier thereof, and a pharmaceutical composition for the treatment and / or prevention of eye diseases
CN104114115B (zh) 2011-10-17 2017-02-22 声外科技术有限公司 用于处理脂肪团的超声波探头
FI3581199T3 (fi) 2011-10-21 2023-08-18 Endo Global Ventures Menetelmiä turvottavan fibroskleroottisen pannikulopatian hoitamiseksi tai vähentämiseksi
HUE057423T2 (hu) 2012-01-12 2022-05-28 Endo Global Ventures Clostridium histolyticum enzim
CN104603616B (zh) 2012-09-07 2017-03-08 株式会社资生堂 使用纤蛋白‑3和/或肌聚糖γ作为指标评价脂肪团的方法和评价脂肪团有效药物的方法
CN105050580B (zh) 2013-03-15 2017-11-28 玫琳凯有限公司 化妆品组合物及其用途
DK2968484T3 (da) 2013-03-15 2021-02-22 Biospecifics Tech Corporation Behandlingsfremgangsmåde og produkt til uterus fibromer, som anvender oprenset kollagenase
US20160000890A1 (en) 2013-03-15 2016-01-07 Biospecifics Technologies Corp. Thermosensitive hydrogel collagenase formulations
CN103751102A (zh) 2014-01-15 2014-04-30 上海交通大学 一种胶原酶温敏水凝胶及其制备方法和应用
CN114272251A (zh) 2014-06-27 2022-04-05 玫帝托克斯股份有限公司 用于减少脂肪的胆酸类与盐类的制剂及用途
WO2017139383A1 (en) 2016-02-08 2017-08-17 OutcomeMD, Inc. Determining a wellness, improvement, or effectiveness score
ES2886651T3 (es) 2016-10-28 2021-12-20 Merz Pharma Gmbh & Co Kgaa Tratamiento cosmético de la celulitis
CN115969318A (zh) 2017-03-01 2023-04-18 恩多风投有限公司 用于评估和治疗橘皮组织的装置和方法
AU2018244426A1 (en) 2017-03-28 2019-10-17 Endo Ventures Limited Improved method of producing collagenase

Also Published As

Publication number Publication date
WO2018183582A3 (en) 2019-01-03
CN110741085A (zh) 2020-01-31
US20220119791A1 (en) 2022-04-21
KR20240001279A (ko) 2024-01-03
WO2018183582A2 (en) 2018-10-04
KR20190136030A (ko) 2019-12-09
US20180327731A1 (en) 2018-11-15
US20240110171A1 (en) 2024-04-04
JP7227918B2 (ja) 2023-02-22
JP2020524128A (ja) 2020-08-13
EP3601556A2 (en) 2020-02-05
AR126168A2 (es) 2023-09-27
BR112019020394A2 (pt) 2020-04-22
JP2023016911A (ja) 2023-02-02
US11473074B2 (en) 2022-10-18
CA3057982A1 (en) 2018-10-04
AU2018244426A1 (en) 2019-10-17
AR111843A1 (es) 2019-08-28
KR102642381B1 (ko) 2024-02-28
IL269651A (en) 2019-11-28

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