MX2019011117A - Anticuerpo b7-h3, fragmento de union a antigeno de los mismos y uso medico de los mismos. - Google Patents

Anticuerpo b7-h3, fragmento de union a antigeno de los mismos y uso medico de los mismos.

Info

Publication number
MX2019011117A
MX2019011117A MX2019011117A MX2019011117A MX2019011117A MX 2019011117 A MX2019011117 A MX 2019011117A MX 2019011117 A MX2019011117 A MX 2019011117A MX 2019011117 A MX2019011117 A MX 2019011117A MX 2019011117 A MX2019011117 A MX 2019011117A
Authority
MX
Mexico
Prior art keywords
antigen
antibody
binding fragment
medical use
medicament
Prior art date
Application number
MX2019011117A
Other languages
English (en)
Inventor
Zhang Ting
Ye Xin
Tao Weikang
Zhang Lianshan
Gu Jinming
Wang Xiaohua
Yang Liuqing
Original Assignee
Jiangsu Hengrui Medicine Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Jiangsu Hengrui Medicine Co filed Critical Jiangsu Hengrui Medicine Co
Publication of MX2019011117A publication Critical patent/MX2019011117A/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2827—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against B7 molecules, e.g. CD80, CD86
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/577—Immunoassay; Biospecific binding assay; Materials therefor involving monoclonal antibodies binding reaction mechanisms characterised by the use of monoclonal antibodies; monoclonal antibodies per se are classified with their corresponding antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/567—Framework region [FR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/705—Assays involving receptors, cell surface antigens or cell surface determinants
    • G01N2333/70503—Immunoglobulin superfamily, e.g. VCAMs, PECAM, LFA-3
    • G01N2333/70532—B7 molecules, e.g. CD80, CD86

Abstract

La invención proporciona un anticuerpo B7-H3, un fragmento de unión a antígeno del mismo y un uso médico del mismo. Además, la presente invención describe una composición farmacéutica que comprende el anticuerpo B7-H3 o fragmento de unión a antígeno del mismo, y el uso del mismo como medicamento. En particular, la invención describe un uso de un anticuerpo B7-H3 humano o un fragmento de unión a antígeno del mismo para 10 la fabricación de un medicamento para el tratamiento de una enfermedad o afección asociada a B7-H3.
MX2019011117A 2017-03-31 2018-03-30 Anticuerpo b7-h3, fragmento de union a antigeno de los mismos y uso medico de los mismos. MX2019011117A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CN201710206261 2017-03-31
PCT/CN2018/081249 WO2018177393A1 (zh) 2017-03-31 2018-03-30 B7-h3抗体、其抗原结合片段及其医药用途

Publications (1)

Publication Number Publication Date
MX2019011117A true MX2019011117A (es) 2019-11-05

Family

ID=63674249

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2019011117A MX2019011117A (es) 2017-03-31 2018-03-30 Anticuerpo b7-h3, fragmento de union a antigeno de los mismos y uso medico de los mismos.

Country Status (12)

Country Link
US (2) US10899837B2 (es)
EP (1) EP3604337A4 (es)
JP (1) JP7158403B2 (es)
CN (1) CN109937212B (es)
AU (1) AU2018243123A1 (es)
BR (1) BR112019019111A2 (es)
CA (1) CA3056474A1 (es)
MX (1) MX2019011117A (es)
RU (1) RU2765306C2 (es)
TW (1) TWI796328B (es)
UA (1) UA125593C2 (es)
WO (1) WO2018177393A1 (es)

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JP7158403B2 (ja) 2017-03-31 2022-10-21 ジエンス ヘンルイ メデイシンカンパニー リミテッド Ｂ７－ｈ３抗体、その抗原結合フラグメント、及びそれらの医学的使用
CN109963591B (zh) * 2017-08-04 2023-04-04 江苏恒瑞医药股份有限公司 B7h3抗体-药物偶联物及其医药用途
US11403813B2 (en) 2019-11-26 2022-08-02 Sdc U.S. Smilepay Spv Systems and methods for constructing a three-dimensional model from two-dimensional images
US10916053B1 (en) 2019-11-26 2021-02-09 Sdc U.S. Smilepay Spv Systems and methods for constructing a three-dimensional model from two-dimensional images
US11270523B2 (en) 2017-11-29 2022-03-08 Sdc U.S. Smilepay Spv Systems and methods for constructing a three-dimensional model from two-dimensional images
WO2020018964A1 (en) 2018-07-20 2020-01-23 Fred Hutchinson Cancer Research Center Compositions and methods for controlled expression of antigen-specific receptors
WO2020114479A1 (zh) * 2018-12-07 2020-06-11 江苏恒瑞医药股份有限公司 多特异性蛋白分子
US11030801B2 (en) 2019-05-17 2021-06-08 Standard Cyborg, Inc. Three-dimensional modeling toolkit
KR20210006637A (ko) * 2019-07-09 2021-01-19 주식회사 와이바이오로직스 B7-h3(cd276)에 특이적으로 결합하는 항체 및 그의 용도
US20220332829A1 (en) * 2019-09-16 2022-10-20 Nanjing Sanhome Pharmaceutical Co., Ltd. Anti-b7-h3 antibody and application thereof
BR112022026401A2 (pt) * 2020-06-26 2023-03-14 Intocell Inc Conjugados anticorpo-fármaco compreendendo anticorpos anti-b7-h3
KR20230145038A (ko) * 2021-02-09 2023-10-17 메디링크 테라퓨틱스 (쑤저우) 컴퍼니, 리미티드 생물활성 물질 접합체, 이의 제조방법 및 이의 용도
WO2022203414A1 (ko) * 2021-03-26 2022-09-29 세라노틱스(주) B7-h3 항체 또는 이의 항원 결합 단편 및 이의 용도
CN116178553B (zh) * 2022-02-25 2023-11-17 南京蓬勃生物科技有限公司 针对人b7-h3的抗体及其变体
TW202402808A (zh) * 2022-05-18 2024-01-16 中國大陸商上海藥明生物技術有限公司 抗-b7h3抗體及其用途
WO2023221975A1 (zh) * 2022-05-18 2023-11-23 苏州宜联生物医药有限公司 包含蛋白降解剂类生物活性化合物的抗体药物偶联物及其制备方法和用途

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Also Published As

Publication number Publication date
RU2019132843A (ru) 2021-04-30
CN109937212B (zh) 2022-06-21
RU2765306C2 (ru) 2022-01-28
US20210101984A1 (en) 2021-04-08
EP3604337A4 (en) 2021-03-10
JP7158403B2 (ja) 2022-10-21
US10899837B2 (en) 2021-01-26
RU2019132843A3 (es) 2021-08-16
TWI796328B (zh) 2023-03-21
TW201837056A (zh) 2018-10-16
JP2020515251A (ja) 2020-05-28
KR20190134614A (ko) 2019-12-04
CN109937212A (zh) 2019-06-25
WO2018177393A1 (zh) 2018-10-04
EP3604337A1 (en) 2020-02-05
UA125593C2 (uk) 2022-04-27
BR112019019111A2 (pt) 2020-05-05
US20200031934A1 (en) 2020-01-30
US11680100B2 (en) 2023-06-20
AU2018243123A1 (en) 2019-09-26
CA3056474A1 (en) 2018-10-04

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