MX2019005933A - Polipeptidos biespecificos para gitr y ctla-4. - Google Patents
Polipeptidos biespecificos para gitr y ctla-4.Info
- Publication number
- MX2019005933A MX2019005933A MX2019005933A MX2019005933A MX2019005933A MX 2019005933 A MX2019005933 A MX 2019005933A MX 2019005933 A MX2019005933 A MX 2019005933A MX 2019005933 A MX2019005933 A MX 2019005933A MX 2019005933 A MX2019005933 A MX 2019005933A
- Authority
- MX
- Mexico
- Prior art keywords
- gitr
- ctla
- bispecific polypeptides
- polypeptides
- bispecific
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2878—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the NGF-receptor/TNF-receptor superfamily, e.g. CD27, CD30, CD40, CD95
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
- A61K39/39541—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against normal tissues, cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
- A61K39/39558—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against tumor tissues, cells, antigens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/70503—Immunoglobulin superfamily
- C07K14/70532—B7 molecules, e.g. CD80, CD86
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
- C07K16/2818—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against CD28 or CD152
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/40—Immunoglobulins specific features characterized by post-translational modification
- C07K2317/41—Glycosylation, sialylation, or fucosylation
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/52—Constant or Fc region; Isotype
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/565—Complementarity determining region [CDR]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/72—Increased effector function due to an Fc-modification
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
- C07K2317/732—Antibody-dependent cellular cytotoxicity [ADCC]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
- C07K2317/734—Complement-dependent cytotoxicity [CDC]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/75—Agonist effect on antigen
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto
Abstract
La presente invención proporciona polipéptidos multiespecíficos, tales como anticuerpos biespecíficos, que comprenden un primer dominio de fijación capaz de fijarse específicamente a GITR, y un segundo dominio de fijación, capaz de fijarse específicamente a CTLA-4. La invención proporciona además composiciones de dichos polipéptidos biespecíficos, así como métodos y usos de estos.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GBGB1619652.9A GB201619652D0 (en) | 2016-11-21 | 2016-11-21 | Novel polypeptides |
PCT/EP2017/079925 WO2018091739A1 (en) | 2016-11-21 | 2017-11-21 | Bispecific polypeptides to gitr and ctla-4 |
Publications (1)
Publication Number | Publication Date |
---|---|
MX2019005933A true MX2019005933A (es) | 2019-07-08 |
Family
ID=57993718
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2019005933A MX2019005933A (es) | 2016-11-21 | 2017-11-21 | Polipeptidos biespecificos para gitr y ctla-4. |
Country Status (13)
Country | Link |
---|---|
US (1) | US20190309084A1 (es) |
EP (1) | EP3541475A1 (es) |
JP (1) | JP2019535282A (es) |
KR (1) | KR20190082235A (es) |
CN (1) | CN109963621A (es) |
AU (1) | AU2017360093A1 (es) |
BR (1) | BR112019010139A2 (es) |
CA (1) | CA3044345A1 (es) |
GB (1) | GB201619652D0 (es) |
IL (1) | IL266765A (es) |
MX (1) | MX2019005933A (es) |
RU (1) | RU2019116638A (es) |
WO (1) | WO2018091739A1 (es) |
Families Citing this family (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US11421029B2 (en) * | 2017-09-01 | 2022-08-23 | Sichuan Kelun-Biotech Biopharmaceutical Co., Ltd. | Recombinant bispecific antibodies to PD-L1 and CTLA-4 |
EP3830129A4 (en) * | 2018-07-30 | 2022-05-04 | Invenra, Inc. | MULTISPECIFIC TREG-BINDING MOLECULES |
EP3831849A1 (en) * | 2019-12-02 | 2021-06-09 | LamKap Bio beta AG | Bispecific antibodies against ceacam5 and cd47 |
CN111592580A (zh) * | 2020-05-08 | 2020-08-28 | 中国药科大学 | 一种具有免疫检查点ctla-4抑制活性的多肽及其应用 |
Family Cites Families (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6682736B1 (en) | 1998-12-23 | 2004-01-27 | Abgenix, Inc. | Human monoclonal antibodies to CTLA-4 |
US7960512B2 (en) | 2003-01-09 | 2011-06-14 | Macrogenics, Inc. | Identification and engineering of antibodies with variant Fc regions and methods of using same |
CA2779559A1 (en) | 2004-08-04 | 2006-02-23 | Applied Molecular Evolution Inc. | Variant fc regions |
US9212230B2 (en) | 2007-03-29 | 2015-12-15 | Genmab A/S | Bispecific antibodies and methods for production thereof |
CN110066339A (zh) | 2010-04-20 | 2019-07-30 | 根马布股份公司 | 含异二聚体抗体fc的蛋白及其制备方法 |
GB201115280D0 (en) | 2011-09-05 | 2011-10-19 | Alligator Bioscience Ab | Antibodies, uses and methods |
GB201311475D0 (en) | 2013-06-27 | 2013-08-14 | Alligator Bioscience Ab | Polypeptides |
GB201322583D0 (en) | 2013-12-19 | 2014-02-05 | Alligator Bioscience Ab | Antibodies |
WO2015104406A2 (en) * | 2014-01-13 | 2015-07-16 | Pieris Ag | Multi-specific polypeptide useful for localized tumor immunomodulation |
DK3151921T3 (da) * | 2014-06-06 | 2019-12-02 | Bristol Myers Squibb Co | Antistoffer mod glucocorticoid-induceret tumornekrosefaktor- receptorer (gitr) og anvendelser deraf |
MA41044A (fr) * | 2014-10-08 | 2017-08-15 | Novartis Ag | Compositions et procédés d'utilisation pour une réponse immunitaire accrue et traitement contre le cancer |
LT3221346T (lt) * | 2014-11-21 | 2020-11-10 | Bristol-Myers Squibb Company | Antikūnai, apimantys modifikuotas sunkiosios grandinės pastoviąsias sritis |
CN105669867A (zh) * | 2014-11-21 | 2016-06-15 | 上海中信国健药业股份有限公司 | 抗gitr/ctla-4双特异性抗体及其制备方法和用途 |
BR112017024770A2 (pt) | 2015-05-21 | 2018-07-31 | Alligator Bioscience Ab | polipeptídeos inovadores |
-
2016
- 2016-11-21 GB GBGB1619652.9A patent/GB201619652D0/en not_active Ceased
-
2017
- 2017-11-21 EP EP17809226.8A patent/EP3541475A1/en not_active Withdrawn
- 2017-11-21 CN CN201780071259.7A patent/CN109963621A/zh active Pending
- 2017-11-21 CA CA3044345A patent/CA3044345A1/en not_active Abandoned
- 2017-11-21 BR BR112019010139A patent/BR112019010139A2/pt not_active Application Discontinuation
- 2017-11-21 MX MX2019005933A patent/MX2019005933A/es unknown
- 2017-11-21 JP JP2019527250A patent/JP2019535282A/ja active Pending
- 2017-11-21 KR KR1020197014493A patent/KR20190082235A/ko unknown
- 2017-11-21 AU AU2017360093A patent/AU2017360093A1/en not_active Abandoned
- 2017-11-21 WO PCT/EP2017/079925 patent/WO2018091739A1/en active Application Filing
- 2017-11-21 RU RU2019116638A patent/RU2019116638A/ru not_active Application Discontinuation
- 2017-11-21 US US16/461,525 patent/US20190309084A1/en not_active Abandoned
-
2019
- 2019-05-21 IL IL266765A patent/IL266765A/en unknown
Also Published As
Publication number | Publication date |
---|---|
AU2017360093A1 (en) | 2019-06-20 |
GB201619652D0 (en) | 2017-01-04 |
EP3541475A1 (en) | 2019-09-25 |
CA3044345A1 (en) | 2018-05-24 |
KR20190082235A (ko) | 2019-07-09 |
US20190309084A1 (en) | 2019-10-10 |
JP2019535282A (ja) | 2019-12-12 |
WO2018091739A1 (en) | 2018-05-24 |
RU2019116638A (ru) | 2020-12-21 |
BR112019010139A2 (pt) | 2019-10-08 |
IL266765A (en) | 2019-07-31 |
CN109963621A (zh) | 2019-07-02 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
MX2019012953A (es) | Anticuerpo biespecifico contra ox40 y ctla-4. | |
PH12018502225A1 (en) | Anti-il-33 antibodies, compositions, methods and uses thereof | |
PH12019500540A1 (en) | Anti-pd-1 antibodies and their uses | |
PH12018500711A1 (en) | Anti-pd1 antibodies and methods of use | |
PH12019502283A1 (en) | Anti-lag3 antibodies | |
EP4257613A3 (en) | Bispecific checkpoint inhibitor antibodies | |
PH12019501357A1 (en) | Anti-ox40 antibodies and their uses | |
MX2018016364A (es) | Anticuerpos anti-pd-l1. | |
MX2017003478A (es) | Anticuerpos anti-fgfr2/3 y metodos para su uso. | |
MX2017014699A (es) | Polipeptidos novedosos. | |
MY191581A (en) | Anti-pd-1 antibodies | |
PH12018502456A1 (en) | Anti-cd04 antibodies and their uses | |
MX2017006094A (es) | Anticuerpos anti-interleucina-33 y sus usos. | |
MX2018016038A (es) | Compuestos y metodos para modular la funcion del acido ribonucleico (arn). | |
WO2016061389A3 (en) | Anti-alpha-synuclein antibodies and methods of use | |
EP4299595A3 (en) | Compositions and methods related to engineered fc constructs | |
NZ725568A (en) | Modified j-chain | |
MX2015013901A (es) | Anticuerpos anti-il-4 y anticuerpos biespecificos y sus usos. | |
MX2022000053A (es) | Moduladores de interaccion de sestrina-gator2 y sus usos. | |
PH12015501059A1 (en) | Anti-hemagglutinin antibodies and methods of use | |
SG10201902326XA (en) | Mk2 inhibitors and uses thereof | |
MX2018003183A (es) | Proteinas de enlace de antigeno biespecifico y tetraespecifico tetravalentes y usos de las mismas. | |
MX2022015258A (es) | Anticuerpos anti-cxcr5 y composiciones y usos de los mismos. | |
MX2019005933A (es) | Polipeptidos biespecificos para gitr y ctla-4. | |
PH12017502277A1 (en) | Multi-specific binding proteins |