MX2019003021A - Combinacion de agonistas de fxr. - Google Patents

Combinacion de agonistas de fxr.

Info

Publication number
MX2019003021A
MX2019003021A MX2019003021A MX2019003021A MX2019003021A MX 2019003021 A MX2019003021 A MX 2019003021A MX 2019003021 A MX2019003021 A MX 2019003021A MX 2019003021 A MX2019003021 A MX 2019003021A MX 2019003021 A MX2019003021 A MX 2019003021A
Authority
MX
Mexico
Prior art keywords
combination
fxr agonists
fxr
farnesoid
agonist
Prior art date
Application number
MX2019003021A
Other languages
English (en)
Inventor
Bauer Andreas
Laffitte Bryan
Mueller Patrick
Original Assignee
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novartis Ag filed Critical Novartis Ag
Publication of MX2019003021A publication Critical patent/MX2019003021A/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
    • A61K31/4162—1,2-Diazoles condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A61K31/4178—1,3-Diazoles not condensed 1,3-diazoles and containing further heterocyclic rings, e.g. pilocarpine, nitrofurantoin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/46—8-Azabicyclo [3.2.1] octane; Derivatives thereof, e.g. atropine, ***e
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Emergency Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

La invención proporciona composiciones farmacéuticas que comprenden un agonista del receptor farnesoide X (FXR) y otro agente terapéutico, en particular para el tratamiento o la prevención de enfermedades o trastornos hepáticos.
MX2019003021A 2016-09-14 2017-09-12 Combinacion de agonistas de fxr. MX2019003021A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201662394446P 2016-09-14 2016-09-14
PCT/IB2017/055503 WO2018051230A1 (en) 2016-09-14 2017-09-12 Combination of fxr agonists

Publications (1)

Publication Number Publication Date
MX2019003021A true MX2019003021A (es) 2019-09-26

Family

ID=60043251

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2019003021A MX2019003021A (es) 2016-09-14 2017-09-12 Combinacion de agonistas de fxr.

Country Status (23)

Country Link
US (1) US20210290610A1 (es)
EP (1) EP3512558A1 (es)
JP (1) JP6878596B2 (es)
KR (1) KR102218498B1 (es)
CN (1) CN109689105A (es)
AR (1) AR109652A1 (es)
AU (2) AU2017328999B2 (es)
BR (1) BR112019004684A2 (es)
CA (1) CA3036760A1 (es)
CL (1) CL2019000625A1 (es)
CO (1) CO2019002245A2 (es)
CR (1) CR20190125A (es)
EC (1) ECSP19016844A (es)
IL (1) IL264628A (es)
JO (1) JOP20190040A1 (es)
MX (1) MX2019003021A (es)
PE (1) PE20190972A1 (es)
PH (1) PH12019500326A1 (es)
RU (1) RU2019110780A (es)
SG (1) SG11201900651PA (es)
TW (1) TW201811372A (es)
WO (1) WO2018051230A1 (es)
ZA (1) ZA201900528B (es)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN110418641A (zh) * 2017-02-24 2019-11-05 基恩菲特公司 用于组合疗法的药物组合物
JP2021525750A (ja) 2018-05-31 2021-09-27 ノバルティス アーゲー トロピフェクサーとセニクリビロックとを含む組合せ
MX2022000743A (es) * 2019-07-18 2022-02-14 Enyo Pharma Tratamiento mejorado utilizando eyp001.
IL293895A (en) * 2019-12-20 2022-08-01 Novartis Ag Combined treatment of liver diseases using integrin inhibitors
CN112402430A (zh) * 2020-12-11 2021-02-26 大连医科大学 泽泻醇b-23-醋酸酯在预防和治疗急性肾损伤中的应用

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6987121B2 (en) * 2002-04-25 2006-01-17 Smithkline Beecham Corporation Compositions and methods for hepatoprotection and treatment of cholestasis
PE20110831A1 (es) * 2008-11-26 2011-11-20 Pfizer 3-aminociclopentanocarboxamidas como moduladores del receptor de quimiocina
US8383812B2 (en) 2009-10-13 2013-02-26 Bristol-Myers Squibb Company N-((1R,2S,5R)-5-(tert-butylamino)-2-((S)-3-(7-tert-butylpyrazolo[1,5-A][1,3,5]triazin-4-ylamino)-2-oxopyrrolidin-1-yl)cyclohexyl)acetamide, a dual modulator of chemokine receptor activity, crystalline forms and processes
CU24152B1 (es) * 2010-12-20 2016-02-29 Irm Llc 1,2 oxazol-8-azabiciclo[3,2,1]octano 8 il como moduladores de fxr
UY35818A (es) * 2013-11-05 2015-05-29 Irm Llc Composiciones y métodos para modular los receptores x farnesoides
EP3116878A4 (en) * 2014-03-13 2018-02-14 Salk Institute for Biological Studies Fxr agonists and methods for making and using
US20170319548A1 (en) * 2014-09-12 2017-11-09 Tobira Therapeutics, Inc. Cenicriviroc combination therapy for the treatment of fibrosis
AU2015365481B2 (en) * 2014-12-18 2018-08-09 Novartis Ag Azabicyclooctane derivatives as FXR agonists for use in the treatment of liver and gastrointestinal diseases
ES2862194T3 (es) * 2016-02-22 2021-10-07 Novartis Ag Métodos para usar agonistas del FXR

Also Published As

Publication number Publication date
PE20190972A1 (es) 2019-07-09
KR20190044666A (ko) 2019-04-30
CN109689105A (zh) 2019-04-26
AU2017328999A1 (en) 2019-02-21
ECSP19016844A (es) 2019-03-29
JOP20190040A1 (ar) 2019-03-10
BR112019004684A2 (pt) 2019-05-28
AR109652A1 (es) 2019-01-09
CO2019002245A2 (es) 2019-05-31
CA3036760A1 (en) 2018-03-22
PH12019500326A1 (en) 2019-11-11
KR102218498B1 (ko) 2021-02-22
TW201811372A (zh) 2018-04-01
JP6878596B2 (ja) 2021-05-26
RU2019110780A (ru) 2020-10-15
AU2017328999B2 (en) 2019-12-19
WO2018051230A1 (en) 2018-03-22
RU2019110780A3 (es) 2020-11-30
CL2019000625A1 (es) 2019-05-17
JP2019526644A (ja) 2019-09-19
EP3512558A1 (en) 2019-07-24
SG11201900651PA (en) 2019-04-29
AU2020201980A1 (en) 2020-04-09
ZA201900528B (en) 2021-06-30
CR20190125A (es) 2019-06-04
US20210290610A1 (en) 2021-09-23
IL264628A (en) 2019-02-28

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