MX2019002471A - Sonda de recolección y métodos para su uso. - Google Patents

Sonda de recolección y métodos para su uso.

Info

Publication number
MX2019002471A
MX2019002471A MX2019002471A MX2019002471A MX2019002471A MX 2019002471 A MX2019002471 A MX 2019002471A MX 2019002471 A MX2019002471 A MX 2019002471A MX 2019002471 A MX2019002471 A MX 2019002471A MX 2019002471 A MX2019002471 A MX 2019002471A
Authority
MX
Mexico
Prior art keywords
methods
collection probe
devices
samples
collection
Prior art date
Application number
MX2019002471A
Other languages
English (en)
Inventor
Lin John
Schiavinato Eberlin Livia
Milner Thomas
Zhang Jialing
Rector John
Katta Nitesh
Zahedivash Aydin
Original Assignee
Univ Texas
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Texas filed Critical Univ Texas
Priority claimed from PCT/US2017/049689 external-priority patent/WO2018045208A1/en
Publication of MX2019002471A publication Critical patent/MX2019002471A/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B10/00—Other methods or instruments for diagnosis, e.g. instruments for taking a cell sample, for biopsy, for vaccination diagnosis; Sex determination; Ovulation-period determination; Throat striking implements
    • A61B10/0045—Devices for taking samples of body liquids
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
    • G01N27/62—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating the ionisation of gases, e.g. aerosols; by investigating electric discharges, e.g. emission of cathode
    • H—ELECTRICITY
    • H01—ELECTRIC ELEMENTS
    • H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
    • H01J49/00—Particle spectrometers or separator tubes
    • H01J49/02—Details
    • H01J49/04—Arrangements for introducing or extracting samples to be analysed, e.g. vacuum locks; Arrangements for external adjustment of electron- or ion-optical components
    • H01J49/0431—Arrangements for introducing or extracting samples to be analysed, e.g. vacuum locks; Arrangements for external adjustment of electron- or ion-optical components for liquid samples
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N1/00—Sampling; Preparing specimens for investigation
    • G01N1/02—Devices for withdrawing samples
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/62—Detectors specially adapted therefor
    • G01N30/72—Mass spectrometers
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/483—Physical analysis of biological material
    • G01N33/487—Physical analysis of biological material of liquid biological material
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6803—General methods of protein analysis not limited to specific proteins or families of proteins
    • G01N33/6848—Methods of protein analysis involving mass spectrometry
    • H—ELECTRICITY
    • H01—ELECTRIC ELEMENTS
    • H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
    • H01J49/00—Particle spectrometers or separator tubes
    • H01J49/0027—Methods for using particle spectrometers
    • H01J49/0031—Step by step routines describing the use of the apparatus
    • H—ELECTRICITY
    • H01—ELECTRIC ELEMENTS
    • H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
    • H01J49/00—Particle spectrometers or separator tubes
    • H01J49/02—Details
    • H01J49/04—Arrangements for introducing or extracting samples to be analysed, e.g. vacuum locks; Arrangements for external adjustment of electron- or ion-optical components
    • H—ELECTRICITY
    • H01—ELECTRIC ELEMENTS
    • H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
    • H01J49/00—Particle spectrometers or separator tubes
    • H01J49/02—Details
    • H01J49/04—Arrangements for introducing or extracting samples to be analysed, e.g. vacuum locks; Arrangements for external adjustment of electron- or ion-optical components
    • H01J49/0404—Capillaries used for transferring samples or ions
    • H—ELECTRICITY
    • H01—ELECTRIC ELEMENTS
    • H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
    • H01J49/00—Particle spectrometers or separator tubes
    • H01J49/02—Details
    • H01J49/04—Arrangements for introducing or extracting samples to be analysed, e.g. vacuum locks; Arrangements for external adjustment of electron- or ion-optical components
    • H01J49/0459—Arrangements for introducing or extracting samples to be analysed, e.g. vacuum locks; Arrangements for external adjustment of electron- or ion-optical components for solid samples
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/06—Fluid handling related problems
    • B01L2200/0605—Metering of fluids
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/06—Valves, specific forms thereof
    • B01L2400/0633—Valves, specific forms thereof with moving parts
    • B01L2400/0655—Valves, specific forms thereof with moving parts pinch valves
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/02—Burettes; Pipettes
    • B01L3/0289—Apparatus for withdrawing or distributing predetermined quantities of fluid
    • B01L3/0293—Apparatus for withdrawing or distributing predetermined quantities of fluid for liquids
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N1/00—Sampling; Preparing specimens for investigation
    • G01N1/02—Devices for withdrawing samples
    • G01N2001/028—Sampling from a surface, swabbing, vaporising
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N1/00—Sampling; Preparing specimens for investigation
    • G01N1/28—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
    • G01N1/40—Concentrating samples
    • G01N1/4055—Concentrating samples by solubility techniques
    • G01N2001/4061—Solvent extraction
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2560/00—Chemical aspects of mass spectrometric analysis of biological material

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Analytical Chemistry (AREA)
  • Hematology (AREA)
  • General Health & Medical Sciences (AREA)
  • Pathology (AREA)
  • Urology & Nephrology (AREA)
  • General Physics & Mathematics (AREA)
  • Biochemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Food Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Biophysics (AREA)
  • Microbiology (AREA)
  • Cell Biology (AREA)
  • Biotechnology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Surgery (AREA)
  • Animal Behavior & Ethology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Veterinary Medicine (AREA)
  • Medical Informatics (AREA)
  • Oncology (AREA)
  • Hospice & Palliative Care (AREA)
  • Clinical Laboratory Science (AREA)
  • Electrochemistry (AREA)
  • Other Investigation Or Analysis Of Materials By Electrical Means (AREA)
  • Sampling And Sample Adjustment (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)

Abstract

Se proporcionan métodos y dispositivos para evaluar muestras de tejido a partir de una pluralidad de sitios de tejido en un sujeto usando análisis molecular; en ciertos aspectos, los dispositivos de las modalidades permiten la recolección de muestras de tejido líquidas y el suministro de las muestras para análisis de espectrometría de masas.
MX2019002471A 2016-09-02 2017-08-31 Sonda de recolección y métodos para su uso. MX2019002471A (es)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US201662383234P 2016-09-02 2016-09-02
US201662411321P 2016-10-21 2016-10-21
US201762462524P 2017-02-23 2017-02-23
PCT/US2017/049689 WO2018045208A1 (en) 2016-09-02 2017-08-31 Collection probe and methods for the use thereof

Publications (1)

Publication Number Publication Date
MX2019002471A true MX2019002471A (es) 2019-09-18

Family

ID=62243007

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2019002471A MX2019002471A (es) 2016-09-02 2017-08-31 Sonda de recolección y métodos para su uso.

Country Status (11)

Country Link
US (5) US10643832B2 (es)
EP (2) EP4357784A3 (es)
JP (2) JP7195002B2 (es)
KR (1) KR102543773B1 (es)
CN (2) CN113834869A (es)
AU (1) AU2017318661B2 (es)
CA (1) CA3035743A1 (es)
ES (1) ES2971214T3 (es)
IL (1) IL265129B2 (es)
MX (1) MX2019002471A (es)
SG (1) SG11201901866TA (es)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN113834869A (zh) 2016-09-02 2021-12-24 得克萨斯大学体系董事会 收集探针及其使用方法
JP7128810B2 (ja) * 2016-10-14 2022-08-31 ディーエイチ テクノロジーズ デベロップメント プライベート リミテッド 化学的分析のためのシステムおよび方法
US20210343515A1 (en) * 2017-06-08 2021-11-04 Board Of Regents, The University Of Texas System Systems and methods for microarray droplet ionization analysis
WO2019102350A1 (en) * 2017-11-21 2019-05-31 Dh Technologies Development Pte. Ltd. Methods and systems utilizing ultrasound-assisted sampling interfaces for mass spectrometric analysis
SG11202004568UA (en) 2017-11-27 2020-06-29 Univ Texas Minimally invasive collection probe and methods for the use thereof
US10147052B1 (en) * 2018-01-29 2018-12-04 C-SATS, Inc. Automated assessment of operator performance
EP3522201B1 (en) * 2018-02-02 2020-10-07 Tofwerk AG Autosampler
US11219393B2 (en) 2018-07-12 2022-01-11 Trace Matters Scientific Llc Mass spectrometry system and method for analyzing biological samples
EP3803946A4 (en) * 2018-06-07 2022-03-09 DH Technologies Development Pte. Ltd. SAMPLING INTERFACE FOR MASS SPECTROMETER
EP3647763B1 (en) * 2018-10-29 2021-07-14 FEI Company A method of preparing a biological sample for study in an analysis device
EP3914891A4 (en) * 2019-01-25 2022-09-28 Board of Regents, The University of Texas System DEVICE AND METHOD FOR CLEANING AND/OR REPLACING MEDICAL DEVICES
WO2020242911A1 (en) * 2019-05-31 2020-12-03 Purdue Research Foundation Integrated microfluidic probe (imfp) and methods of use thereof
JP2022535404A (ja) 2019-06-06 2022-08-08 ボード オブ リージェンツ ザ ユニヴァーシティ オブ テキサス システム 質量分析を使用した子宮内膜症組織の特定
CN114981919A (zh) * 2020-01-14 2022-08-30 Dh科技发展私人贸易有限公司 质量分析方法-控制opp操作溶剂的粘度
CN111351831A (zh) * 2020-02-26 2020-06-30 西安交通大学医学院第二附属医院 基于质谱分析组织术中检测、标记设备及其检测方法
CA3176865A1 (en) * 2020-04-27 2021-11-04 Livia SCHIAVINATO EBERLIN Identifying and classifying microorganisms
EP4143563A4 (en) * 2020-04-27 2024-05-15 Board of Regents, The University of Texas System DETECTION OF CHEMICAL COMPOUNDS FOR FORENSIC ANALYSIS
CN112017942B (zh) * 2020-09-04 2021-03-02 中国地质科学院地质研究所 一种提高二次离子探针质谱仪质谱成像空间分辨率的方法
EP4288991A1 (en) * 2021-02-02 2023-12-13 DH Technologies Development Pte. Ltd. Methods and apparatus for washing sampling probe for use in mass spectrometry systems
CN113764257B (zh) * 2021-08-25 2024-01-12 清华大学深圳国际研究生院 一种基于3d打印的解吸电喷雾离子化装置
US11848094B2 (en) 2022-04-08 2023-12-19 Ohio State Innovation Foundation Multidimensional optical tissue classification and display
WO2023200850A1 (en) * 2022-04-14 2023-10-19 Board Of Regents, The University Of Texas System Collection probe and methods of use thereof
CN116169005B (zh) * 2023-02-28 2023-07-28 厦门金诺花科学仪器有限公司 一次性疏水纳升点样针头及点样测试方法

Family Cites Families (117)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0369012A4 (en) 1987-07-23 1990-12-27 Terumo Kabushiki Kaisha Catheter tube
US5711816A (en) 1990-07-06 1998-01-27 Advanced Technolgy Materials, Inc. Source reagent liquid delivery apparatus, and chemical vapor deposition system comprising same
US5119827A (en) 1990-09-05 1992-06-09 Board Of Regents, The University Of Texas System Mechanisms of antiestrogen resistance in breast cancer
US5100402A (en) * 1990-10-05 1992-03-31 Megadyne Medical Products, Inc. Electrosurgical laparoscopic cauterization electrode
US5241990A (en) 1992-07-10 1993-09-07 Inlet Medical, Inc. Irrigation/aspiration valve and probe for laparoscopy
US5470308A (en) 1992-08-12 1995-11-28 Vidamed, Inc. Medical probe with biopsy stylet
US5746720A (en) 1995-10-18 1998-05-05 Stouder, Jr.; Albert E. Method and apparatus for insertion of a cannula and trocar
US5742050A (en) * 1996-09-30 1998-04-21 Aviv Amirav Method and apparatus for sample introduction into a mass spectrometer for improving a sample analysis
US6297499B1 (en) 1997-07-17 2001-10-02 John B Fenn Method and apparatus for electrospray ionization
AU772052B2 (en) 1999-10-29 2004-04-08 Mds Inc., Through Its Mds Sciex Division Atmospheric pressure photoionization (APPI): a new ionization method for liquid chromatography-mass spectrometry
US6786884B1 (en) 1999-10-29 2004-09-07 Bard Access Systems, Inc. Bolus tip design for a multi-lumen catheter
AU2002245043B2 (en) 2000-11-16 2006-10-26 Bio-Rad Laboratories, Inc. Method for analyzing mass spectra
US6784439B2 (en) 2001-07-19 2004-08-31 Ut Battelle, Llc Thin-channel electrospray emitter
US6756586B2 (en) * 2001-10-15 2004-06-29 Vanderbilt University Methods and apparatus for analyzing biological samples by mass spectrometry
US20040014227A1 (en) 2002-01-04 2004-01-22 Frederick Erik D. Apparatus, method and computer program product for automated high-throughput sampling and data acquisition
US6803566B2 (en) * 2002-04-16 2004-10-12 Ut-Battelle, Llc Sampling probe for microarray read out using electrospray mass spectrometry
JP4095349B2 (ja) 2002-06-03 2008-06-04 ペンタックス株式会社 蛍光測定装置
US6677593B1 (en) 2002-08-28 2004-01-13 Ut-Battelle, Llc Planar flow-by electrode capacitive electrospray ion source
CA2433205A1 (en) 2003-03-18 2004-09-18 James Alexander Keenan Drug delivery, bodily fluid drainage, and biopsy device with enhanced ultrasonic visibility
US7684934B2 (en) 2003-06-06 2010-03-23 The United States Of America As Represented By The Department Of Health And Human Services Pattern recognition of whole cell mass spectra
US7335897B2 (en) 2004-03-30 2008-02-26 Purdue Research Foundation Method and system for desorption electrospray ionization
WO2005116256A2 (en) * 2004-04-16 2005-12-08 Wei-Sing Chu Device for extracting biological molecules from tissue specimens
US7445603B2 (en) 2004-05-12 2008-11-04 Zkz Science Corp. Apparatus for removable distal internal cassette for in situ fixation and specimen processing with serial collection and storage of biopsy specimens
TW200626892A (en) 2004-09-14 2006-08-01 Metara Inc In-process mass spectrometry with sample multiplexing
US20090286305A1 (en) * 2005-04-15 2009-11-19 Wei-Sing Chu Method for non-destructive macromolecule extraction from biological samples on slide
US7295026B2 (en) 2005-06-03 2007-11-13 Ut-Battelle, Llc Automated position control of a surface array relative to a liquid microjunction surface sampler
CA2611591A1 (en) 2005-06-08 2006-12-14 Vanderbilt University Analysis of tissue samples surrounding malignancies
DE102005044307B4 (de) * 2005-09-16 2008-04-17 Bruker Daltonik Gmbh Ionisierung desorbierter Moleküle
US7714276B2 (en) * 2005-09-30 2010-05-11 New York University Methods for direct biomolecule identification by matrix-assisted laser desorption ionization (MALDI) mass spectrometry
CN102512716B (zh) 2005-12-14 2016-01-13 史赛克公司 医疗/手术废物收集和处理***
US7544933B2 (en) 2006-01-17 2009-06-09 Purdue Research Foundation Method and system for desorption atmospheric pressure chemical ionization
EP2035121A4 (en) 2006-05-26 2010-04-28 Ionsense Inc APPARATUS FOR SUPPORTING SOLIDS FOR USE WITH SURFACE IONIZATION TECHNOLOGY
HU226837B1 (hu) 2006-05-31 2009-12-28 Semmelweis Egyetem Folyadéksugárral mûködõ deszorpciós ionizációs eljárás és eszköz
US7800056B2 (en) * 2006-10-26 2010-09-21 Smiths Detection Montreal Inc. Document sampler and method of sampling a document
US20100176287A1 (en) * 2006-11-23 2010-07-15 Koninklijke Philips Electronics N.V. Device for separation and maldi analysis of an analyte in a sample
US7847244B2 (en) * 2006-12-28 2010-12-07 Purdue Research Foundation Enclosed desorption electrospray ionization
WO2008097831A1 (en) * 2007-02-02 2008-08-14 Waters Investments Limited Device and method for analyzing a sample
US20080243141A1 (en) 2007-04-02 2008-10-02 Salvatore Privitera Surgical instrument with separate tool head and method of use
JP5704917B2 (ja) * 2007-06-02 2015-04-22 セルノ・バイオサイエンス・エルエルシー 質量分析のための自己較正アプローチ
CN101932727A (zh) * 2008-01-03 2010-12-29 得克萨斯大学体系董事会 通过极光激酶a的荧光原位杂交非侵入性检测膀胱癌
US20090324617A1 (en) * 2008-01-24 2009-12-31 Glykos Finland Ltd. Cancer specific glycans and use thereof
US9213030B2 (en) 2008-01-28 2015-12-15 National University Of Singapore Lipid tumour profile
WO2009109879A2 (en) 2008-03-03 2009-09-11 Koninklijke Philips Electronics N.V. Biopsy guidance by electromagnetic tracking and photonic needle
CN102037142A (zh) * 2008-04-10 2011-04-27 不列颠哥伦比亚大学 诊断慢性心脏同种异体移植物排斥的方法
US8207494B2 (en) 2008-05-01 2012-06-26 Indiana University Research And Technology Corporation Laser ablation flowing atmospheric-pressure afterglow for ambient mass spectrometry
CA2726072A1 (en) * 2008-05-29 2009-12-23 Universitaetsklinikum Muenster Ion source means for desorption / ionisation of analyte substances an d method of desorbing / ionising of analyte substances
US8084735B2 (en) 2008-09-25 2011-12-27 Ut-Battelle, Llc Pulsed voltage electrospray ion source and method for preventing analyte electrolysis
US8203117B2 (en) 2008-09-30 2012-06-19 Prosolia, Inc. Method and apparatus for embedded heater for desorption and ionization of analytes
AU2009328507A1 (en) 2008-12-19 2011-07-14 Medirista Biotechnologies Ab Oxidized cardiolipin as a novel pro-inflammatory factor
US20100224013A1 (en) * 2009-03-05 2010-09-09 Van Berkel Gary J Method and system for formation and withdrawal of a sample from a surface to be analyzed
EP2415067B1 (en) 2009-04-01 2017-12-20 Prosolia, Inc. Method and system for surface sampling
NZ595809A (en) 2009-04-30 2013-02-22 Purdue Research Foundation Ion generation using wetted porous material
US9500572B2 (en) 2009-04-30 2016-11-22 Purdue Research Foundation Sample dispenser including an internal standard and methods of use thereof
US8704167B2 (en) 2009-04-30 2014-04-22 Purdue Research Foundation Mass spectrometry analysis of microorganisms in samples
AU2010252652B2 (en) 2009-05-27 2015-05-07 Micromass Uk Limited System and method for identification of biological tissues
EP2438605A4 (en) 2009-06-03 2016-09-28 Univ Wayne State MASS SPECTROMETRY USING LASER SPRAY IONIZATION TECHNIQUE
EP2467868A1 (en) 2009-08-17 2012-06-27 Temple University Of The Commonwealth System Of Higher Education Vaporization device and method for imaging mass spectrometry
US8546752B2 (en) 2009-12-07 2013-10-01 Advion Inc. Solid-phase extraction (SPE) tips and methods of use
AU2011214344A1 (en) 2010-02-11 2012-08-16 KATHOLIEKE UNIVERSITEIT LEUVEN, KULeuven R&D Phospholipid profiling and cancer
WO2011127091A1 (en) 2010-04-05 2011-10-13 Indiana University Research And Technology Corporation Method for enhancement of mass resolution over a limited mass range for time-of-flight spectrometry
JP5596402B2 (ja) * 2010-04-19 2014-09-24 株式会社日立ハイテクノロジーズ 分析装置、イオン化装置及び分析方法
US9063047B2 (en) * 2010-05-07 2015-06-23 Ut-Battelle, Llc System and method for extracting a sample from a surface
CN201811941U (zh) * 2010-05-26 2011-04-27 中国石油化工股份有限公司 液体样品解析电喷雾质谱desi-ms电离装置
ES2812457T3 (es) 2010-06-23 2021-03-17 Univ Louisville Res Found Inc Uso de ácidos grasos en procedimientos para detectar cáncer
US20130131470A1 (en) 2010-07-14 2013-05-23 The Regents of the University of Colorado, a body coporate Methods and systems for in vivo clinical data measurement of analytes
US9153425B2 (en) * 2010-09-01 2015-10-06 Ut-Battelle, Llc Device for high spatial resolution chemical analysis of a sample and method of high spatial resolution chemical analysis
EP2612345B1 (en) 2010-09-02 2020-04-08 University of the Sciences in Philadelphia System and method for ionization of molecules for mass spectrometry and ion mobility spectrometry
US8486703B2 (en) * 2010-09-30 2013-07-16 Ut-Battelle, Llc Surface sampling concentration and reaction probe
EP3185016B1 (en) * 2010-10-29 2021-06-23 Thermo Fisher Scientific OY System layout for an automated system for sample preparation and analysis
CA2816472A1 (en) * 2010-11-08 2012-05-18 Dako Denmark A/S Quantification of single target molecules in histological samples
CN102115741B (zh) * 2010-12-10 2013-07-17 许汉鹏 一种原位分类提取生物大分子的方法及其***
CN102221614B (zh) * 2011-03-28 2013-07-17 山东大学 一种利用金纳米探针来鉴别小分子化合物作用靶点的分析方法
US9546979B2 (en) 2011-05-18 2017-01-17 Purdue Research Foundation Analyzing a metabolite level in a tissue sample using DESI
US9157921B2 (en) * 2011-05-18 2015-10-13 Purdue Research Foundation Method for diagnosing abnormality in tissue samples by combination of mass spectral and optical imaging
US9024254B2 (en) 2011-06-03 2015-05-05 Purdue Research Foundation Enclosed desorption electrospray ionization probes and method of use thereof
WO2013098645A2 (en) 2011-12-28 2013-07-04 Medimass, Ltd. System and method for rapid evaporative ionization of liquid phase samples
WO2013112836A2 (en) 2012-01-26 2013-08-01 The Cleveland Clinic Foundation Diagnostic and prognostic biomarkers for cancer
WO2013112680A1 (en) 2012-01-26 2013-08-01 University Of The Sciences In Philadelphia Ionization at intermediate pressure for atmospheric pressure ionization mass spectrometers
JP5955032B2 (ja) * 2012-03-01 2016-07-20 キヤノン株式会社 イオン化方法、質量分析方法、抽出方法及び精製方法
US9105458B2 (en) 2012-05-21 2015-08-11 Sarah Trimpin System and methods for ionizing compounds using matrix-assistance for mass spectrometry and ion mobility spectrometry
WO2013188846A1 (en) 2012-06-15 2013-12-19 Harry Stylli Methods of detecting diseases or conditions
WO2014045087A1 (en) 2012-09-20 2014-03-27 Oslo Universitetssykehus Hf Prostate cancer markers and uses thereof
BR112015012239B1 (pt) 2012-11-27 2022-07-19 Pontificia Universidad Católica De Chile Método in vitro de diagnóstico de câncer de tireoide
US9568477B2 (en) 2012-12-30 2017-02-14 Brigham And Women's Hospital, Inc. System and method for analysis of bio-metabolites for-use in image-guided surgery
WO2014204638A2 (en) 2013-05-31 2014-12-24 Brigham And Women's Hospital, Inc. System and method for analyzing tissue for the presence of cancer using bio-marker profiles
WO2014209905A2 (en) 2013-06-26 2014-12-31 Stealth Peptides International, Inc. Methods and compositions for detecting and diagnosing diseases and conditions
FR3007634B1 (fr) 2013-06-28 2016-09-02 Commissariat Energie Atomique Dispositif de prelevement in vivo d'especes biologiques et procede automatise d'analyse d'especes biologiques capturees au moyen d'un tel dispositif
CN105493227B (zh) 2013-07-19 2018-05-01 史密斯探测公司 具有降低平均流速的质谱仪入口
JP6323922B2 (ja) 2013-08-07 2018-05-16 ディーエイチ テクノロジーズ デベロップメント プライベート リミテッド 質量分析計供給源中への液体流れからの気泡除去
US9245722B2 (en) * 2013-09-16 2016-01-26 Georgia Tech Research Corporation SMS probe and SEM imaging system and methods of use
US20160341712A1 (en) 2013-10-23 2016-11-24 Brigham And Women's Hospital, Inc. System and method for analyzing tissue intra-operatively using mass spectrometry
US10395913B2 (en) * 2013-12-30 2019-08-27 Purdue Research Foundation Mass spectrometry probes and systems for ionizing a sample transport
US20150202005A1 (en) 2014-01-20 2015-07-23 Omniguide, Inc. System and Method To Control Surgical Energy Devices
JP2015171467A (ja) 2014-03-12 2015-10-01 セイコーエプソン株式会社 液体噴射装置および手術機器
US9297828B2 (en) 2014-03-27 2016-03-29 Ut-Battelle, Llc High heating rate thermal desorption for molecular surface sampling
US9595428B2 (en) 2014-06-17 2017-03-14 The Board Of Regents Of The University Oklahoma Cellular probe device, system and analysis method
US10000789B2 (en) 2014-06-17 2018-06-19 The Board Of Regents Of The University Of Oklahoma Cellular probe device, system and analysis method
US20160041138A1 (en) 2014-08-11 2016-02-11 Arizona Board Of Regents On Behalf Of Arizona State University Methods for Monitoring Airborne Contaminants and Agents using Atmospheric Condensate
US11239066B2 (en) * 2015-03-06 2022-02-01 Micromass Uk Limited Cell population analysis
EP3265821B1 (en) * 2015-03-06 2021-06-16 Micromass UK Limited Liquid trap or separator for electrosurgical applications
CA2977900A1 (en) * 2015-03-06 2016-09-15 Micromass Uk Limited Collision surface for improved ionisation
GB2554181B (en) 2015-03-06 2021-09-08 Micromass Ltd Inlet instrumentation for ion analyser coupled to rapid evaporative ionisation mass spectrometry ("REIMS") device
CN107580675B (zh) 2015-03-06 2020-12-08 英国质谱公司 拭子和活检样品的快速蒸发电离质谱（“reims”）和解吸电喷雾电离质谱（“desi-ms”）分析
EP3265822B1 (en) 2015-03-06 2021-04-28 Micromass UK Limited Tissue analysis by mass spectrometry or ion mobility spectrometry
US10060838B2 (en) 2015-04-09 2018-08-28 Ut-Battelle, Llc Capture probe
US9632066B2 (en) 2015-04-09 2017-04-25 Ut-Battelle, Llc Open port sampling interface
WO2016196312A1 (en) 2015-05-29 2016-12-08 Purdue Research Foundation Methods for analyzing a tissue sample
GB201509402D0 (en) 2015-06-01 2015-07-15 Micromass Ltd Lock mass library for internal correction
WO2017049403A1 (en) 2015-09-22 2017-03-30 University Health Network System and method for optimized mass spectrometry analysis
US20170097355A1 (en) 2015-10-06 2017-04-06 University Of Washington Biomarkers and methods to distinguish ovarian cancer from benign tumors
GB2548596A (en) 2016-03-22 2017-09-27 Micromass Ltd An interface probe
WO2018013678A2 (en) 2016-07-13 2018-01-18 Board Of Regents, The University Of Texas System Molecular markers and methods for sample analysis via mass spectrometry
CN113834869A (zh) 2016-09-02 2021-12-24 得克萨斯大学体系董事会 收集探针及其使用方法
WO2018045208A1 (en) 2016-09-02 2018-03-08 Board Of Regents, The University Of Texas System Collection probe and methods for the use thereof
US10492801B2 (en) 2016-09-20 2019-12-03 Osteomed Llc Power driven surgical tool
SG11202004568UA (en) 2017-11-27 2020-06-29 Univ Texas Minimally invasive collection probe and methods for the use thereof
US20210033623A1 (en) 2018-02-23 2021-02-04 Board Of Regents, The University Of Texas System Tissue analysis by mass spectrometry

Also Published As

Publication number Publication date
US20220310378A1 (en) 2022-09-29
EP4357784A2 (en) 2024-04-24
JP2022159359A (ja) 2022-10-17
EP3496859A1 (en) 2019-06-19
IL265129A (es) 2019-04-30
EP4357784A3 (en) 2024-07-31
KR20190043598A (ko) 2019-04-26
US11756778B2 (en) 2023-09-12
US11239065B2 (en) 2022-02-01
BR112019004261A2 (pt) 2019-06-04
CN109789420B (zh) 2021-09-24
EP3496859A4 (en) 2020-04-01
CN113834869A (zh) 2021-12-24
US20230386815A1 (en) 2023-11-30
JP7195002B2 (ja) 2022-12-23
IL265129B2 (en) 2024-02-01
ES2971214T3 (es) 2024-06-04
US20210257202A1 (en) 2021-08-19
EP3496859C0 (en) 2024-01-10
US20200279728A1 (en) 2020-09-03
SG11201901866TA (en) 2019-03-28
AU2017318661A1 (en) 2019-03-21
IL265129B1 (en) 2023-10-01
CN109789420A (zh) 2019-05-21
US10643832B2 (en) 2020-05-05
US20180158661A1 (en) 2018-06-07
AU2017318661B2 (en) 2022-01-27
EP3496859B1 (en) 2024-01-10
US10943775B2 (en) 2021-03-09
JP2019534724A (ja) 2019-12-05
KR102543773B1 (ko) 2023-06-16
CA3035743A1 (en) 2018-03-08

Similar Documents

Publication Publication Date Title
MX2019002471A (es) Sonda de recolección y métodos para su uso.
MX2020005448A (es) Sonda de recoleccion minimamente invasiva y metodos para el uso de esta.
IL258101A (en) Device and system for testing samples, especially blood, and methods for using them
MA47466A (fr) Procédé, appareil et serveur de sélection d'échantillons
EP3242130A4 (en) Sample collection, thermal analysis, and sample injection apparatus and method, and trace detection device
IL253860A0 (en) Devices for the collection and analysis of biological samples and methods for their use
MX362545B (es) Analisis de imagen y medicion de muestras biologicas.
DK3145634T3 (da) Prøveudtagnings- og analysekit, prøveholder og fremgangsmåde
EP3353354A4 (en) MEANS FOR COLLECTING, SAMPLING, AND DIAGNOSING SEASON SAMPLES AND ASSOCIATED METHODS
GB2541150A (en) Improvements in and relating to sample collection
PL3350342T3 (pl) Zestaw sond do analizowania próbki DNA i sposób jego zastosowania
WO2018045208A8 (en) Collection probe and methods for the use thereof
EP3256849A4 (en) Devices, solutions and methods for sample collection related applications, analysis and diagnosis
CA185466S (en) Sample collection container for drug testing
IL263024A (en) Blood sample analysis method and system, for determining diabetes
EP3654021A4 (en) BIOLOGICAL SAMPLE ANALYSIS DEVICE
SG11201913243RA (en) Data statistical analysis method, apparatus, and device
GB201510765D0 (en) Method, apparatus and electrochemical test device
SG11202008891RA (en) Biological tissue analyzing device, biological tissue analyzing program, and biological tissue analyzing method
GB2545850A (en) System and method using a combined modality optical probe
EP3555311A4 (en) DETERMINATION OF A PHYSIOLOGICAL STATE IN A PERSON BY ANALYSIS OF CELL-FREE DNA FRAGMENT END POINTS IN A BIOLOGICAL SAMPLE
BR112016028838A2 (pt) anticorpos, ácido nucleico, célula hospedeira, método de produção de um anticorpo, imunoconjugado, formulação farmacêutica, métodos de detecção de lgr5 humano em uma amostra biológica, de detecção de um câncer, de identificação de um paciente com câncer, de seleção de um paciente com câncer para tratamento com um imunoconjugado e de tratamento de um paciente com câncer
FR3023650B1 (fr) Interrupteur isole par du vide autorisant un test du vide, ensemble d'interrupteur et procede de test
EP3649470A4 (en) METHOD AND DEVICE FOR SAMPLE ANALYSIS USING LATERAL FLOW
EP3374774B8 (fr) Dispositif d'agitation et de prélèvement d'échantillons de liquides biologiques adapté pour trier