MX2019000188A - Composiciones y metodos basados en crispr/cas9 para el tratamiento del cancer. - Google Patents

Composiciones y metodos basados en crispr/cas9 para el tratamiento del cancer.

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Publication number
MX2019000188A
MX2019000188A MX2019000188A MX2019000188A MX2019000188A MX 2019000188 A MX2019000188 A MX 2019000188A MX 2019000188 A MX2019000188 A MX 2019000188A MX 2019000188 A MX2019000188 A MX 2019000188A MX 2019000188 A MX2019000188 A MX 2019000188A
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Mexico
Prior art keywords
crispr
methods
cas9
treating cancer
raav
Prior art date
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MX2019000188A
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English (en)
Inventor
Zack Donald
Jaskula-Ranga Vinod
Bunz Fred
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Univ Johns Hopkins
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Application filed by Univ Johns Hopkins filed Critical Univ Johns Hopkins
Publication of MX2019000188A publication Critical patent/MX2019000188A/es

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    • A61K48/0066—Manipulation of the nucleic acid to modify its expression pattern, e.g. enhance its duration of expression, achieved by the presence of particular introns in the delivered nucleic acid
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Abstract

En este documento se describen métodos para prevenir, inhibir, o tratar el cáncer en un sujeto. En el presente documento también se proporcionan métodos para alterar la expresión de uno o más productos génicos en una célula, como una célula cancerosa. Dichos métodos pueden comprender utilizar un sistema de nucleasa modificada, como las Repeticiones Palindrómicas Cortas Agrupadas y Regularmente Interespaciadas (CRISPR)/CRISPR asociadas (Cas) 9 (CRISPR-Cas9) que comprenden un promotor H1 bidireccional y los ARNg dirigidos a oncogenes (rAAV-Onco-CRISPR) o genes supresores de tumores (rAAV-TSG) empaquetados en una partícula compacta de virus adeno-asociado (AAV). Dichos métodos pueden comprender la co-administración o proporcionar concurrentemente un adenovirus empaquetador de virus adeno-asociado recombinante (Ad-rAAVpack) con el sistema de nucleasa.
MX2019000188A 2016-07-05 2017-07-05 Composiciones y metodos basados en crispr/cas9 para el tratamiento del cancer. MX2019000188A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201662358339P 2016-07-05 2016-07-05
PCT/US2017/040696 WO2018009525A1 (en) 2016-07-05 2017-07-05 Crispr/cas9-based compositions and methods for treating cancer

Publications (1)

Publication Number Publication Date
MX2019000188A true MX2019000188A (es) 2019-06-20

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MX2019000188A MX2019000188A (es) 2016-07-05 2017-07-05 Composiciones y metodos basados en crispr/cas9 para el tratamiento del cancer.

Country Status (14)

Country Link
US (1) US20200069818A1 (es)
EP (1) EP3481431A4 (es)
JP (1) JP2019520394A (es)
KR (1) KR20190039115A (es)
CN (1) CN109963598A (es)
AU (1) AU2017292772A1 (es)
BR (1) BR112019000107A2 (es)
CA (1) CA3029908A1 (es)
CL (1) CL2019000023A1 (es)
EA (1) EA201990214A1 (es)
IL (1) IL264034A (es)
MX (1) MX2019000188A (es)
SG (1) SG11201900028VA (es)
WO (1) WO2018009525A1 (es)

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