MX2018015236A - Lipido cationico. - Google Patents
Lipido cationico.Info
- Publication number
- MX2018015236A MX2018015236A MX2018015236A MX2018015236A MX2018015236A MX 2018015236 A MX2018015236 A MX 2018015236A MX 2018015236 A MX2018015236 A MX 2018015236A MX 2018015236 A MX2018015236 A MX 2018015236A MX 2018015236 A MX2018015236 A MX 2018015236A
- Authority
- MX
- Mexico
- Prior art keywords
- carbon atoms
- cationic lipid
- formulae
- formula
- alkyl group
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/60—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D211/62—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals attached in position 4
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7088—Compounds having three or more nucleosides or nucleotides
- A61K31/7105—Natural ribonucleic acids, i.e. containing only riboses attached to adenine, guanine, cytosine or uracil and having 3'-5' phosphodiester links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7088—Compounds having three or more nucleosides or nucleotides
- A61K31/713—Double-stranded nucleic acids or oligonucleotides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/14—Esters of carboxylic acids, e.g. fatty acid monoglycerides, medium-chain triglycerides, parabens or PEG fatty acid esters
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
- A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/22—Heterocyclic compounds, e.g. ascorbic acid, tocopherol or pyrrolidones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/28—Steroids, e.g. cholesterol, bile acids or glycyrrhetinic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/44—Oils, fats or waxes according to two or more groups of A61K47/02-A61K47/42; Natural or modified natural oils, fats or waxes, e.g. castor oil, polyethoxylated castor oil, montan wax, lignite, shellac, rosin, beeswax or lanolin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
- A61K9/1075—Microemulsions or submicron emulsions; Preconcentrates or solids thereof; Micelles, e.g. made of phospholipids or block copolymers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/127—Liposomes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1617—Organic compounds, e.g. phospholipids, fats
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/52—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring condensed with a ring other than six-membered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
- C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
- C07D241/04—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Molecular Biology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biochemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Dispersion Chemistry (AREA)
- Biophysics (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Saccharide Compounds (AREA)
- Hydrogenated Pyridines (AREA)
- Indole Compounds (AREA)
Abstract
La presente invención proporciona un lípido catiónico que es apto para usarse en el suministro de ácidos nucleicos al citoplasma. Un lípido catiónico de acuerdo con la presente invención es, por ejemplo, un compuesto representado por la fórmula (1a) o una sal farmacéuticamente aceptable de este. (En la fórmula (1a), cada uno de L1 y L2 representa independientemente un grupo alquileno que tiene 3-10 átomos de carbono; cada uno de R1 y R2 representa independientemente un grupo alquilo que tiene 4-22 átomos de carbono o un grupo alquenilo que tiene 4-22 átomos de carbono; X1 representa un enlace sencillo o -CO-O-; y el anillo P representa una de las fórmulas (P-1) a (P-5)). (En las fórmulas (P-1) a (P-5), R3 representa un grupo alquilo que tiene 1-3 átomos de carbono). (ver Fórmulas).
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2016125925 | 2016-06-24 | ||
PCT/JP2017/023051 WO2017222016A1 (ja) | 2016-06-24 | 2017-06-22 | カチオン性脂質 |
Publications (1)
Publication Number | Publication Date |
---|---|
MX2018015236A true MX2018015236A (es) | 2019-04-11 |
Family
ID=60784078
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2018015236A MX2018015236A (es) | 2016-06-24 | 2017-06-22 | Lipido cationico. |
Country Status (15)
Country | Link |
---|---|
US (1) | US10501416B2 (es) |
EP (1) | EP3476832B1 (es) |
JP (1) | JP6883034B2 (es) |
KR (1) | KR102358341B1 (es) |
CN (1) | CN109311809B (es) |
AU (1) | AU2017282459B2 (es) |
BR (1) | BR112018075123A2 (es) |
CA (1) | CA3020271A1 (es) |
ES (1) | ES2948971T3 (es) |
IL (1) | IL262574B (es) |
MX (1) | MX2018015236A (es) |
RU (1) | RU2740921C2 (es) |
SG (1) | SG11201808928YA (es) |
TW (1) | TWI745386B (es) |
WO (1) | WO2017222016A1 (es) |
Families Citing this family (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
TWI801477B (zh) * | 2017-12-27 | 2023-05-11 | 日商衛材R&D企管股份有限公司 | 陽離子性脂質 |
CN110283223B (zh) * | 2018-03-19 | 2022-01-04 | 广州市锐博生物科技有限公司 | 一种阳离子脂质分子及其在核酸递送中的应用 |
JP6997862B2 (ja) | 2018-08-21 | 2022-02-10 | 株式会社東芝 | 生分解性化合物、脂質粒子、脂質粒子を含む組成物、およびキット |
US10526603B1 (en) | 2018-10-26 | 2020-01-07 | Eisai R&D Management Co., Ltd. | Double-stranded ribonucleic acid capable of suppressing expression of complement C5 |
JP6918197B2 (ja) * | 2019-12-26 | 2021-08-11 | エーザイ・アール・アンド・ディー・マネジメント株式会社 | 脂質複合体を含む医薬組成物及び脂質ナノ粒子を含む医薬組成物 |
CA3163264A1 (en) | 2019-12-26 | 2021-07-01 | Eisai R&D Management Co., Ltd. | Pharmaceutical composition containing double-stranded ribonucleic acid inhibiting expression of complement c5 |
WO2022168884A1 (ja) | 2021-02-04 | 2022-08-11 | 塩野義製薬株式会社 | カチオン性脂質 |
WO2023053016A1 (en) * | 2021-09-28 | 2023-04-06 | Seqirus Inc. | Ionizable cationic compound |
CN114213346B (zh) * | 2022-02-22 | 2022-05-20 | 中国科学院基础医学与肿瘤研究所(筹) | 一种双价可电离脂质化合物、组合物及其应用 |
Family Cites Families (17)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN104119242B (zh) | 2008-10-09 | 2017-07-07 | 泰米拉制药公司 | 改善的氨基脂质和递送核酸的方法 |
LT2440183T (lt) | 2009-06-10 | 2018-08-10 | Arbutus Biopharma Corporation | Patobulinta lipido kompozicija |
CN103096875B (zh) | 2010-06-03 | 2016-08-17 | 阿尔尼拉姆医药品有限公司 | 用于递送活性剂的生物可降解脂质 |
KR101878361B1 (ko) | 2010-09-20 | 2018-08-20 | 시르나 쎄러퓨틱스 인코퍼레이티드 | 올리고뉴클레오티드 전달을 위한 신규 저분자량 양이온성 지질 |
DK2635265T3 (en) | 2010-11-05 | 2018-07-16 | Sirna Therapeutics Inc | New low molecular weight cyclic amine-containing cationic lipids for oligonucleotide delivery |
WO2013059496A1 (en) | 2011-10-18 | 2013-04-25 | Dicerna Pharmaceuticals, Inc. | Amine cationic lipids and uses thereof |
JP6305344B2 (ja) | 2011-12-07 | 2018-04-04 | アルニラム・ファーマシューティカルズ・インコーポレーテッド | 活性作用物質の送達のための生分解性脂質 |
SI2825157T1 (sl) * | 2012-03-16 | 2019-01-31 | Merck Patent Gmbh | Aminokislinski lipidi |
WO2013158579A1 (en) | 2012-04-19 | 2013-10-24 | Merck Sharp & Dohme Corp. | Novel diester and triester based low molecular weight, biodegradable cationic lipids for oligonucleotide delivery |
TW201726600A (zh) * | 2012-07-06 | 2017-08-01 | 協和醱酵麒麟有限公司 | 陽離子性脂質 |
WO2014089239A1 (en) | 2012-12-07 | 2014-06-12 | Alnylam Pharmaceuticals, Inc. | Improved nucleic acid lipid particle formulations |
TW201534578A (zh) * | 2013-07-08 | 2015-09-16 | Daiichi Sankyo Co Ltd | 新穎脂質 |
US10426737B2 (en) * | 2013-12-19 | 2019-10-01 | Novartis Ag | Lipids and lipid compositions for the delivery of active agents |
WO2015095351A1 (en) | 2013-12-19 | 2015-06-25 | Novartis Ag | LEPTIN mRNA COMPOSITIONS AND FORMULATIONS |
CN105916839B (zh) | 2014-01-09 | 2018-09-18 | 卫材R&D管理有限公司 | 阳离子性脂质 |
AU2015285279A1 (en) * | 2014-06-30 | 2017-02-16 | Kyowa Hakko Kirin Co., Ltd. | Cationic lipid |
CA2969664C (en) | 2014-12-26 | 2022-06-21 | Eisai R&D Management Co., Ltd. | Cationic lipid |
-
2017
- 2017-06-22 CN CN201780035314.7A patent/CN109311809B/zh active Active
- 2017-06-22 MX MX2018015236A patent/MX2018015236A/es unknown
- 2017-06-22 CA CA3020271A patent/CA3020271A1/en active Pending
- 2017-06-22 WO PCT/JP2017/023051 patent/WO2017222016A1/ja active Application Filing
- 2017-06-22 AU AU2017282459A patent/AU2017282459B2/en active Active
- 2017-06-22 BR BR112018075123A patent/BR112018075123A2/pt not_active Application Discontinuation
- 2017-06-22 TW TW106120878A patent/TWI745386B/zh active
- 2017-06-22 US US16/307,202 patent/US10501416B2/en active Active
- 2017-06-22 JP JP2018524158A patent/JP6883034B2/ja active Active
- 2017-06-22 RU RU2018143237A patent/RU2740921C2/ru active
- 2017-06-22 SG SG11201808928YA patent/SG11201808928YA/en unknown
- 2017-06-22 EP EP17815482.9A patent/EP3476832B1/en active Active
- 2017-06-22 KR KR1020187034307A patent/KR102358341B1/ko active IP Right Grant
- 2017-06-22 ES ES17815482T patent/ES2948971T3/es active Active
-
2018
- 2018-10-24 IL IL262574A patent/IL262574B/en unknown
Also Published As
Publication number | Publication date |
---|---|
EP3476832B1 (en) | 2023-04-19 |
US20190218180A1 (en) | 2019-07-18 |
JP6883034B2 (ja) | 2021-06-02 |
RU2018143237A3 (es) | 2020-07-24 |
TWI745386B (zh) | 2021-11-11 |
TW201803849A (zh) | 2018-02-01 |
KR20190021218A (ko) | 2019-03-05 |
ES2948971T3 (es) | 2023-09-22 |
RU2018143237A (ru) | 2020-07-24 |
CN109311809B (zh) | 2022-04-08 |
EP3476832A1 (en) | 2019-05-01 |
BR112018075123A2 (pt) | 2019-06-18 |
RU2740921C2 (ru) | 2021-01-21 |
IL262574B (en) | 2021-10-31 |
IL262574A (en) | 2018-12-31 |
CA3020271A1 (en) | 2017-12-28 |
EP3476832A4 (en) | 2020-02-19 |
SG11201808928YA (en) | 2018-11-29 |
JPWO2017222016A1 (ja) | 2019-04-18 |
WO2017222016A1 (ja) | 2017-12-28 |
AU2017282459B2 (en) | 2021-05-06 |
US10501416B2 (en) | 2019-12-10 |
CN109311809A (zh) | 2019-02-05 |
KR102358341B1 (ko) | 2022-02-07 |
AU2017282459A1 (en) | 2018-11-01 |
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