MX2018000462A - Metodos de sintesis quimica de compuestos de 10h-fenotiazina-3,7-d iamina sustituidos. - Google Patents
Metodos de sintesis quimica de compuestos de 10h-fenotiazina-3,7-d iamina sustituidos.Info
- Publication number
- MX2018000462A MX2018000462A MX2018000462A MX2018000462A MX2018000462A MX 2018000462 A MX2018000462 A MX 2018000462A MX 2018000462 A MX2018000462 A MX 2018000462A MX 2018000462 A MX2018000462 A MX 2018000462A MX 2018000462 A MX2018000462 A MX 2018000462A
- Authority
- MX
- Mexico
- Prior art keywords
- formula
- compounds
- methods
- chemical synthesis
- phenothiazine
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D279/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one sulfur atom as the only ring hetero atoms
- C07D279/10—1,4-Thiazines; Hydrogenated 1,4-thiazines
- C07D279/14—1,4-Thiazines; Hydrogenated 1,4-thiazines condensed with carbocyclic rings or ring systems
- C07D279/18—[b, e]-condensed with two six-membered rings
- C07D279/20—[b, e]-condensed with two six-membered rings with hydrogen atoms directly attached to the ring nitrogen atom
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Catalysts (AREA)
Abstract
La presente invención se refiere, en términos generales, al campo de la síntesis química y, más particularmente, a métodos de síntesis química que incluyen la etapa para preparar un compuesto de 10H-fenotiazina-3,7-diamina sustituido de la Fórmula (1) mediante una etapa, de alquilación selectiva mediante aminación reductora, en la que la diamina no sustituida correspondiente de la Fórmula (4) se hace reaccionar con aldehído/cetona, en condiciones de aminación reductora. La presente invención se refiere también a los métodos que incorporan las etapas precedentes y/o posteriores adicionales, por ejemplo, para preparar compuestos de las Fórmulas (2) y (3) a partir de compuestos de la Fórmula (1) y para preparar compuestos de la Fórmula (4) a partir, por ejemplo, de compuestos de las Fórmulas (5), (6), (7), (8) y (9) . Los compuestos de la Fórmula (1), Fórmula (2) y Fórmula (3) son útiles, por ejemplo, en el tratamiento de enfermedades de agregación de proteínas, tal como la enfermedad de Alzheimer.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB1512678.2A GB201512678D0 (en) | 2015-07-20 | 2015-07-20 | Methods of chemical synthesis |
| PCT/EP2016/067302 WO2017013174A1 (en) | 2015-07-20 | 2016-07-20 | Methods of chemical synthesis of substituted 10h-phenothiazine-3,7-diamine compounds |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MX2018000462A true MX2018000462A (es) | 2018-04-30 |
Family
ID=54013271
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2018000462A MX2018000462A (es) | 2015-07-20 | 2016-07-20 | Metodos de sintesis quimica de compuestos de 10h-fenotiazina-3,7-d iamina sustituidos. |
Country Status (17)
| Country | Link |
|---|---|
| US (1) | US10323010B2 (es) |
| EP (1) | EP3325453B1 (es) |
| JP (1) | JP6735810B2 (es) |
| CN (1) | CN107848992B (es) |
| AU (1) | AU2016296221B2 (es) |
| BR (1) | BR112018000498B1 (es) |
| CA (1) | CA2993123A1 (es) |
| DK (1) | DK3325453T3 (es) |
| ES (1) | ES2836492T3 (es) |
| GB (1) | GB201512678D0 (es) |
| HR (1) | HRP20202039T8 (es) |
| MX (1) | MX2018000462A (es) |
| MY (1) | MY189631A (es) |
| PL (1) | PL3325453T3 (es) |
| PT (1) | PT3325453T (es) |
| SI (1) | SI3325453T1 (es) |
| WO (1) | WO2017013174A1 (es) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3375777A1 (en) | 2017-03-15 | 2018-09-19 | MIKROCHEM spol. s.r.o. | Method for preparation of 3,7-bis-(dimethylamino)-phenothiazin-5-ium chloride or bromide |
| CN116687936A (zh) * | 2019-08-26 | 2023-09-05 | 广州威溶特医药科技有限公司 | 吩噻嗪类或其类似结构的化合物在制药中的新应用 |
| US20220049102A1 (en) * | 2019-09-21 | 2022-02-17 | RK Pharma Solutions LLC | Process for the Purification of Methylene Blue |
| CN114989113A (zh) * | 2022-06-01 | 2022-09-02 | 山东科源制药股份有限公司 | 一种药用亚甲基蓝的精制方法 |
Family Cites Families (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE4302013C1 (de) * | 1993-01-26 | 1994-06-01 | Uwe Dr Fiedeldei | Verfahren zur Herstellung reiner Phenothiazinfarbstoffe |
| GB9506197D0 (en) | 1995-03-27 | 1995-05-17 | Hoffmann La Roche | Inhibition of tau-tau association. |
| JP2000198766A (ja) * | 1999-01-07 | 2000-07-18 | Chemiprokasei Kaisha Ltd | Ｎ，ｎ―ジ分岐アルキルアニリン類の製造方法 |
| EP1248777A2 (en) | 2000-01-07 | 2002-10-16 | Warner-Lambert Company | Tricyclic compounds with antiviral activity |
| GB0101049D0 (en) | 2001-01-15 | 2001-02-28 | Univ Aberdeen | Materials and methods relating to protein aggregation in neurodegenerative disease |
| US7777051B2 (en) * | 2003-05-13 | 2010-08-17 | Icagen, Inc. | Asymmetric benzimidazoles and related compounds as potassium channel modulators |
| GB0322756D0 (en) | 2003-09-29 | 2003-10-29 | Univ Aberdeen | Methods of chemical synthesis |
| AU2013200732B2 (en) | 2006-03-29 | 2015-04-09 | Wista Laboratories Ltd. | 3,7-diamino-10H-phenothiazine salts and their use |
| PL2853293T3 (pl) | 2006-03-29 | 2018-05-30 | Wista Laboratories Ltd. | Związki tioniny i ich zastosowanie |
| CN104606199B (zh) * | 2006-03-29 | 2022-09-13 | 维斯塔实验室有限公司 | 3,7-二氨基-10h-吩噻嗪化合物盐及其用途 |
| LT2457905T (lt) * | 2006-07-11 | 2016-11-10 | Wista Laboratories Ltd. | Diaminofenotiazino junginių sintezės ir (arba) gryninimo metodai |
| FR2920775B1 (fr) | 2007-09-07 | 2009-11-06 | Pharma Hydro Dev P H D Soc Par | Nouveaux composes diaminophenothiazine, leur procede de preparation et leurs utilisations. |
| EP2370407B1 (en) * | 2008-12-19 | 2014-06-18 | Bristol-Myers Squibb Company | Carbazole and carboline kinase inhibitors |
| US8809317B2 (en) * | 2011-03-29 | 2014-08-19 | Prosetta Antiviral Inc. | Antiviral compounds |
| WO2012107706A1 (en) | 2011-02-11 | 2012-08-16 | Wista Laboratories Ltd. | Phenothiazine diaminium salts and their use |
-
2015
- 2015-07-20 GB GBGB1512678.2A patent/GB201512678D0/en not_active Ceased
-
2016
- 2016-07-20 ES ES16745078T patent/ES2836492T3/es active Active
- 2016-07-20 SI SI201631037T patent/SI3325453T1/sl unknown
- 2016-07-20 US US15/746,338 patent/US10323010B2/en active Active
- 2016-07-20 AU AU2016296221A patent/AU2016296221B2/en active Active
- 2016-07-20 CN CN201680041666.9A patent/CN107848992B/zh active Active
- 2016-07-20 PT PT167450782T patent/PT3325453T/pt unknown
- 2016-07-20 BR BR112018000498-7A patent/BR112018000498B1/pt active IP Right Grant
- 2016-07-20 DK DK16745078.2T patent/DK3325453T3/da active
- 2016-07-20 WO PCT/EP2016/067302 patent/WO2017013174A1/en active Application Filing
- 2016-07-20 JP JP2018502417A patent/JP6735810B2/ja active Active
- 2016-07-20 CA CA2993123A patent/CA2993123A1/en active Pending
- 2016-07-20 PL PL16745078T patent/PL3325453T3/pl unknown
- 2016-07-20 MY MYPI2018700217A patent/MY189631A/en unknown
- 2016-07-20 EP EP16745078.2A patent/EP3325453B1/en active Active
- 2016-07-20 MX MX2018000462A patent/MX2018000462A/es active IP Right Grant
-
2020
- 2020-12-21 HR HRP20202039TT patent/HRP20202039T8/hr unknown
Also Published As
| Publication number | Publication date |
|---|---|
| AU2016296221A1 (en) | 2018-02-22 |
| US10323010B2 (en) | 2019-06-18 |
| US20180208565A1 (en) | 2018-07-26 |
| CA2993123A1 (en) | 2017-01-26 |
| GB201512678D0 (en) | 2015-08-26 |
| CN107848992A (zh) | 2018-03-27 |
| BR112018000498A2 (pt) | 2018-09-11 |
| ES2836492T3 (es) | 2021-06-25 |
| MY189631A (en) | 2022-02-22 |
| JP2018528170A (ja) | 2018-09-27 |
| WO2017013174A1 (en) | 2017-01-26 |
| PT3325453T (pt) | 2020-12-15 |
| SI3325453T1 (sl) | 2021-04-30 |
| EP3325453A1 (en) | 2018-05-30 |
| DK3325453T3 (da) | 2020-11-02 |
| EP3325453B1 (en) | 2020-10-21 |
| PL3325453T3 (pl) | 2021-04-19 |
| BR112018000498B1 (pt) | 2023-02-07 |
| HRP20202039T1 (hr) | 2021-02-19 |
| JP6735810B2 (ja) | 2020-08-05 |
| CN107848992B (zh) | 2022-05-31 |
| AU2016296221B2 (en) | 2020-05-07 |
| HRP20202039T8 (hr) | 2021-07-23 |
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| FG | Grant or registration |