MX2017015149A - Inmunoterapia personalizada basada en vectores de suministro y usos de esta. - Google Patents

Inmunoterapia personalizada basada en vectores de suministro y usos de esta.

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Publication number
MX2017015149A
MX2017015149A MX2017015149A MX2017015149A MX2017015149A MX 2017015149 A MX2017015149 A MX 2017015149A MX 2017015149 A MX2017015149 A MX 2017015149A MX 2017015149 A MX2017015149 A MX 2017015149A MX 2017015149 A MX2017015149 A MX 2017015149A
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MX
Mexico
Prior art keywords
vectors
subject
disease
immunotherapy
peptides
Prior art date
Application number
MX2017015149A
Other languages
English (en)
Inventor
Petit Robert
F Princiotta Michael
PERRY Kyle
J O ' Connor Daniel
Original Assignee
Advaxis Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Advaxis Inc filed Critical Advaxis Inc
Publication of MX2017015149A publication Critical patent/MX2017015149A/es

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    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • A61K48/0008—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy characterised by an aspect of the 'non-active' part of the composition delivered, e.g. wherein such 'non-active' part is not delivered simultaneously with the 'active' part of the composition
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
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    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
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Abstract

Esta invención proporciona un sistema para proporcionar y crear composiciones inmunoterapéuticas personalizadas para un sujeto que tiene una enfermedad o afección, que incluye vectores de suministro de una inmunoterapia terapéutica y métodos para producir los mismos que comprenden constructos de expresión génica que expresan péptidos asociados con uno o más neoepítopos o péptidos que contienen mutaciones que son específicas para el cáncer o tejido no saludable del sujeto. Un vector de suministro de esta invención incluye vectores bacterianos que incluyen vectores bacterianos de Listeria; o vectores virales, vectores para inmunoterapia de péptidos; o vectores para inmunoterapia de ADN, que comprenden una o más proteínas de fusión que comprenden uno o más péptidos que comprenden uno o más neoepítopos presentes en muestras biológicas que portan la enfermedad obtenidas del sujeto. Esta invención proporciona, además, métodos para usar los mismos para inducir una respuesta inmunitaria contra una enfermedad o afección, que incluye un tumor o cáncer, o una infección, o una enfermedad autoinmunitaria o un rechazo de un trasplante de órganos en el sujeto.
MX2017015149A 2015-05-26 2016-05-26 Inmunoterapia personalizada basada en vectores de suministro y usos de esta. MX2017015149A (es)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US201562166591P 2015-05-26 2015-05-26
US201562174692P 2015-06-12 2015-06-12
US201562218936P 2015-09-15 2015-09-15
PCT/US2016/034301 WO2016191545A1 (en) 2015-05-26 2016-05-26 Personalized delivery vector-based immunotherapy and uses thereof

Publications (1)

Publication Number Publication Date
MX2017015149A true MX2017015149A (es) 2018-03-28

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