MX2017015149A - Inmunoterapia personalizada basada en vectores de suministro y usos de esta. - Google Patents
Inmunoterapia personalizada basada en vectores de suministro y usos de esta.Info
- Publication number
- MX2017015149A MX2017015149A MX2017015149A MX2017015149A MX2017015149A MX 2017015149 A MX2017015149 A MX 2017015149A MX 2017015149 A MX2017015149 A MX 2017015149A MX 2017015149 A MX2017015149 A MX 2017015149A MX 2017015149 A MX2017015149 A MX 2017015149A
- Authority
- MX
- Mexico
- Prior art keywords
- vectors
- subject
- disease
- immunotherapy
- peptides
- Prior art date
Links
- 239000013598 vector Substances 0.000 title abstract 7
- 238000009169 immunotherapy Methods 0.000 title abstract 4
- 108090000765 processed proteins & peptides Proteins 0.000 abstract 4
- 206010028980 Neoplasm Diseases 0.000 abstract 3
- 201000010099 disease Diseases 0.000 abstract 3
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 3
- 102000004196 processed proteins & peptides Human genes 0.000 abstract 3
- 230000001580 bacterial effect Effects 0.000 abstract 2
- 201000011510 cancer Diseases 0.000 abstract 2
- 238000000034 method Methods 0.000 abstract 2
- 208000023275 Autoimmune disease Diseases 0.000 abstract 1
- 241000186781 Listeria Species 0.000 abstract 1
- 206010052779 Transplant rejections Diseases 0.000 abstract 1
- 239000012472 biological sample Substances 0.000 abstract 1
- 102000037865 fusion proteins Human genes 0.000 abstract 1
- 108020001507 fusion proteins Proteins 0.000 abstract 1
- 230000014509 gene expression Effects 0.000 abstract 1
- 230000028993 immune response Effects 0.000 abstract 1
- 230000001024 immunotherapeutic effect Effects 0.000 abstract 1
- 230000001939 inductive effect Effects 0.000 abstract 1
- 208000015181 infectious disease Diseases 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 230000035772 mutation Effects 0.000 abstract 1
- 210000000056 organ Anatomy 0.000 abstract 1
- 230000001225 therapeutic effect Effects 0.000 abstract 1
- 239000013603 viral vector Substances 0.000 abstract 1
Classifications
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- A61K48/0008—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy characterised by an aspect of the 'non-active' part of the composition delivered, e.g. wherein such 'non-active' part is not delivered simultaneously with the 'active' part of the composition
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
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- C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
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Abstract
Esta invención proporciona un sistema para proporcionar y crear composiciones inmunoterapéuticas personalizadas para un sujeto que tiene una enfermedad o afección, que incluye vectores de suministro de una inmunoterapia terapéutica y métodos para producir los mismos que comprenden constructos de expresión génica que expresan péptidos asociados con uno o más neoepítopos o péptidos que contienen mutaciones que son específicas para el cáncer o tejido no saludable del sujeto. Un vector de suministro de esta invención incluye vectores bacterianos que incluyen vectores bacterianos de Listeria; o vectores virales, vectores para inmunoterapia de péptidos; o vectores para inmunoterapia de ADN, que comprenden una o más proteínas de fusión que comprenden uno o más péptidos que comprenden uno o más neoepítopos presentes en muestras biológicas que portan la enfermedad obtenidas del sujeto. Esta invención proporciona, además, métodos para usar los mismos para inducir una respuesta inmunitaria contra una enfermedad o afección, que incluye un tumor o cáncer, o una infección, o una enfermedad autoinmunitaria o un rechazo de un trasplante de órganos en el sujeto.
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201562166591P | 2015-05-26 | 2015-05-26 | |
US201562174692P | 2015-06-12 | 2015-06-12 | |
US201562218936P | 2015-09-15 | 2015-09-15 | |
PCT/US2016/034301 WO2016191545A1 (en) | 2015-05-26 | 2016-05-26 | Personalized delivery vector-based immunotherapy and uses thereof |
Publications (1)
Publication Number | Publication Date |
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MX2017015149A MX2017015149A (es) | 2015-05-26 | 2016-05-26 | Inmunoterapia personalizada basada en vectores de suministro y usos de esta. |
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EP (1) | EP3302574A4 (es) |
JP (1) | JP2018515588A (es) |
KR (1) | KR20180026670A (es) |
CN (1) | CN107847611A (es) |
AU (1) | AU2016267155A1 (es) |
CA (1) | CA2987239A1 (es) |
HK (1) | HK1253334A1 (es) |
IL (1) | IL255851A (es) |
MA (1) | MA43362A (es) |
MX (1) | MX2017015149A (es) |
TW (1) | TW201708536A (es) |
WO (1) | WO2016191545A1 (es) |
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MA41644A (fr) * | 2015-03-03 | 2018-01-09 | Advaxis Inc | Compositions à base de listeria comprenant un système d'expression de minigènes codant pour des peptides, et leurs procédés d'utilisation |
CN108138099A (zh) * | 2015-06-24 | 2018-06-08 | 阿德瓦希斯公司 | 用于个性化的基于递送载体的免疫疗法的制造装置和方法 |
EP3362929B1 (en) * | 2015-10-12 | 2020-08-12 | Nantomics, LLC | Viral neoepitopes and uses thereof |
IL259931B2 (en) | 2015-12-16 | 2024-02-01 | Gritstone Bio Inc | Identification of neo-antigens, preparation, and use |
SG11201807770RA (en) | 2016-03-24 | 2018-10-30 | Nantcell Inc | Sequence arrangements and sequences for neoepitope presentation |
KR20240023684A (ko) | 2016-09-13 | 2024-02-22 | 알레간 인코포레이티드 | 안정화된 비단백질 클로스트리듐 독소 조성물 |
SG10202105561PA (en) | 2016-11-30 | 2021-07-29 | Advaxis Inc | Immunogenic compositions targeting recurrent cancer mutations and methods of use thereof |
US11180535B1 (en) | 2016-12-07 | 2021-11-23 | David Gordon Bermudes | Saccharide binding, tumor penetration, and cytotoxic antitumor chimeric peptides from therapeutic bacteria |
US20210113672A1 (en) * | 2016-12-08 | 2021-04-22 | Nantbio, Inc. | Method of validating the triggering of an immune response to a neoepitope of a tumor with t-cells |
JP6827113B2 (ja) | 2017-01-21 | 2021-02-10 | 広州白雲山漢方現代薬業有限公司Guangzhou Hanfang Pharmaceutical Co.,Ltd. | シェーグレン症候群の治療におけるペオニフロリン−6’−o−ベンゼンスルホン酸の使用 |
AU2018258119B2 (en) * | 2017-04-24 | 2021-04-01 | Nantcell, Inc. | Targeted neoepitope vectors and methods therefor |
SG11201912429RA (en) | 2017-06-21 | 2020-01-30 | Transgene Sa | Personalized vaccine |
WO2019006401A2 (en) * | 2017-06-30 | 2019-01-03 | Advaxis, Inc. | LISTERIA-BASED IMMUNOGENIC COMPOSITIONS COMPRISING HETERICCLIENT WILMS TUMOR PROTEIN ANTIGENS AND METHODS OF USE THEREOF |
MX2020003100A (es) | 2017-09-19 | 2020-08-20 | Advaxis Inc | Composiciones y metodos para la liofilizacion de bacterias o cepas de listeria. |
EP3688165A4 (en) * | 2017-09-25 | 2021-09-29 | Nant Holdings IP, LLC | NEO-EPITOPE PRESENTATION VALIDATION |
CN111465989B (zh) | 2017-10-10 | 2024-06-25 | 磨石生物公司 | 使用热点进行的新抗原鉴别 |
CN111630602A (zh) | 2017-11-22 | 2020-09-04 | 磨石肿瘤生物技术公司 | 减少新抗原的接合表位呈递 |
CN108564661B (zh) * | 2018-01-08 | 2022-06-28 | 佛山市超体软件科技有限公司 | 一种基于增强现实场景的记录方法 |
CN110408634B (zh) * | 2018-04-27 | 2021-08-03 | 苏州若泰医药科技有限公司 | 一种非整合李斯特菌疫苗及抗肿瘤免疫应答方法 |
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CN111334521B (zh) * | 2018-12-18 | 2022-02-18 | 上海若泰医药科技有限公司 | 一种提高非整合减毒李斯特菌外源抗原蛋白表达的方法 |
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KR102278586B1 (ko) * | 2020-01-07 | 2021-07-16 | 한국과학기술원 | 신생항원을 스크리닝하는 방법, 시스템 및 그의 용도 |
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CN114134165B (zh) | 2022-01-27 | 2022-04-29 | 北京循生生物医学研究有限公司 | 一种新型hpv治疗性核酸疫苗 |
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US6099848A (en) * | 1997-11-18 | 2000-08-08 | The Trustees Of The University Of Pennsylvania | Immunogenic compositions comprising DAL/DAT double-mutant, auxotrophic, attenuated strains of Listeria and their methods of use |
CN1548537B (zh) * | 2002-12-27 | 2010-05-05 | 深圳市源兴生物医药科技有限公司 | 疫苗制备方法和抗肿瘤疫苗 |
CN101528254A (zh) * | 2006-07-14 | 2009-09-09 | 赛诺菲巴斯德生物制剂公司 | 通过向载体病毒蛋白中直接转座子介导***外源免疫决定簇构建重组病毒疫苗 |
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WO2012068360A1 (en) * | 2010-11-17 | 2012-05-24 | Aduro Biotech | Methods and compositions for inducing an immune response to egfrviii |
EP2901341B1 (en) * | 2012-09-28 | 2019-04-10 | The University of Connecticut | Identification of tumor-protective epitopes for the treatment of cancers |
CA2892391C (en) * | 2012-11-28 | 2023-10-17 | Biontech Rna Pharmaceuticals Gmbh | Individualized vaccines for cancer |
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- 2016-05-26 MA MA043362A patent/MA43362A/fr unknown
- 2016-05-26 CA CA2987239A patent/CA2987239A1/en not_active Abandoned
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- 2016-05-26 KR KR1020177036535A patent/KR20180026670A/ko unknown
- 2016-05-26 TW TW105116450A patent/TW201708536A/zh unknown
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EP3302574A4 (en) | 2018-10-17 |
US20190381160A1 (en) | 2019-12-19 |
WO2016191545A4 (en) | 2017-02-09 |
EP3302574A1 (en) | 2018-04-11 |
TW201708536A (zh) | 2017-03-01 |
AU2016267155A1 (en) | 2017-12-21 |
CA2987239A1 (en) | 2016-12-01 |
JP2018515588A (ja) | 2018-06-14 |
CN107847611A (zh) | 2018-03-27 |
IL255851A (en) | 2018-01-31 |
HK1253334A1 (zh) | 2019-06-14 |
KR20180026670A (ko) | 2018-03-13 |
MA43362A (fr) | 2018-10-10 |
WO2016191545A1 (en) | 2016-12-01 |
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