MX2017007648A - Composicion farmaceutica que comprende compuesto biciclico de amida heterociclica aromatica que contiene nitrogeno como ingrediente activo. - Google Patents
Composicion farmaceutica que comprende compuesto biciclico de amida heterociclica aromatica que contiene nitrogeno como ingrediente activo.Info
- Publication number
- MX2017007648A MX2017007648A MX2017007648A MX2017007648A MX2017007648A MX 2017007648 A MX2017007648 A MX 2017007648A MX 2017007648 A MX2017007648 A MX 2017007648A MX 2017007648 A MX2017007648 A MX 2017007648A MX 2017007648 A MX2017007648 A MX 2017007648A
- Authority
- MX
- Mexico
- Prior art keywords
- pharmaceutical composition
- containing aromatic
- amide compounds
- bicyclic nitrogen
- active ingredient
- Prior art date
Links
- 239000008194 pharmaceutical composition Substances 0.000 title abstract 4
- 239000004480 active ingredient Substances 0.000 title abstract 2
- -1 amide compounds Chemical class 0.000 title abstract 2
- 206010028980 Neoplasm Diseases 0.000 abstract 3
- 230000002438 mitochondrial effect Effects 0.000 abstract 3
- 206010009944 Colon cancer Diseases 0.000 abstract 2
- 206010025323 Lymphomas Diseases 0.000 abstract 2
- 208000029742 colonic neoplasm Diseases 0.000 abstract 2
- 230000000694 effects Effects 0.000 abstract 2
- 208000032839 leukemia Diseases 0.000 abstract 2
- 102100036009 5'-AMP-activated protein kinase catalytic subunit alpha-2 Human genes 0.000 abstract 1
- 101000783681 Homo sapiens 5'-AMP-activated protein kinase catalytic subunit alpha-2 Proteins 0.000 abstract 1
- 230000004913 activation Effects 0.000 abstract 1
- 230000005764 inhibitory process Effects 0.000 abstract 1
- 238000011835 investigation Methods 0.000 abstract 1
- 230000001225 therapeutic effect Effects 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/4965—Non-condensed pyrazines
- A61K31/497—Non-condensed pyrazines containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
- A61K31/4184—1,3-Diazoles condensed with carbocyclic rings, e.g. benzimidazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
Landscapes
- Health & Medical Sciences (AREA)
- Public Health (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Hematology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Diabetes (AREA)
- Oncology (AREA)
Abstract
[Problema] Se proporciona una composición farmacéutica para el tratamiento de diversos tipos de cáncer en los cuales está involucrado el Complejo I de la mitocondria, particularmente cáncer colorrectal, leucemia y/o linfoma maligno. [Medios para Solución] Como resultado de un examen intenso para crear una composición farmacéutica para el tratamiento de diversos tipos de cáncer, los inventores de la presente invención confirmaron que un compuesto específico de amida heterocíclica aromática que contiene nitrógeno bicíclico tiene el efecto de inhibir el Complejo I de la mitocondria y activar la AMPK, y que una composición farmacéutica que omprende el compuesto como un ingrediente activo tiene un efecto de tratamiento sobre diversos tipos de cáncer en los cuales está involucrado el Complejo I de la mitocondria, particularmente cáncer colorrectal, leucemia y/o linfoma maligno, y por lo tanto finalizaron la presente invención.
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2014249347 | 2014-12-09 | ||
| JP2014249349 | 2014-12-09 | ||
| JP2014249346 | 2014-12-09 | ||
| PCT/JP2015/084456 WO2016093255A1 (ja) | 2014-12-09 | 2015-12-08 | 二環式含窒素芳香族ヘテロ環アミド化合物を有効成分とする医薬組成物 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MX2017007648A true MX2017007648A (es) | 2017-10-11 |
Family
ID=56107432
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2017007648A MX2017007648A (es) | 2014-12-09 | 2015-12-08 | Composicion farmaceutica que comprende compuesto biciclico de amida heterociclica aromatica que contiene nitrogeno como ingrediente activo. |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US20170360781A1 (es) |
| EP (1) | EP3231426A1 (es) |
| JP (1) | JPWO2016093255A1 (es) |
| KR (1) | KR20170088880A (es) |
| CN (1) | CN106999489A (es) |
| BR (1) | BR112017012355A2 (es) |
| CA (1) | CA2972230A1 (es) |
| MX (1) | MX2017007648A (es) |
| RU (1) | RU2017120180A (es) |
| WO (1) | WO2016093255A1 (es) |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7410998B2 (en) * | 2000-09-06 | 2008-08-12 | The Scripps Research Institute | Inhibitors of NADH:ubiquinone oxidoreductase |
| EP3009424B1 (en) * | 2013-06-10 | 2017-12-20 | Astellas Pharma Inc. | Bicyclic nitrogen-containing aromatic heterocyclic amide compound |
-
2015
- 2015-12-08 JP JP2016563700A patent/JPWO2016093255A1/ja active Pending
- 2015-12-08 RU RU2017120180A patent/RU2017120180A/ru not_active Application Discontinuation
- 2015-12-08 CA CA2972230A patent/CA2972230A1/en not_active Abandoned
- 2015-12-08 EP EP15867977.9A patent/EP3231426A1/en not_active Withdrawn
- 2015-12-08 US US15/534,360 patent/US20170360781A1/en not_active Abandoned
- 2015-12-08 KR KR1020177015802A patent/KR20170088880A/ko unknown
- 2015-12-08 WO PCT/JP2015/084456 patent/WO2016093255A1/ja active Application Filing
- 2015-12-08 CN CN201580067347.0A patent/CN106999489A/zh active Pending
- 2015-12-08 MX MX2017007648A patent/MX2017007648A/es unknown
- 2015-12-08 BR BR112017012355-0A patent/BR112017012355A2/pt not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| KR20170088880A (ko) | 2017-08-02 |
| EP3231426A1 (en) | 2017-10-18 |
| BR112017012355A2 (pt) | 2018-02-27 |
| US20170360781A1 (en) | 2017-12-21 |
| CN106999489A (zh) | 2017-08-01 |
| JPWO2016093255A1 (ja) | 2017-09-21 |
| CA2972230A1 (en) | 2016-06-16 |
| RU2017120180A (ru) | 2019-01-11 |
| WO2016093255A1 (ja) | 2016-06-16 |
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