MX2017006083A - Composicones y metodos de tratamiento con profarmacos de tizoxanida, un analogo o sal de la misma. - Google Patents
Composicones y metodos de tratamiento con profarmacos de tizoxanida, un analogo o sal de la misma.Info
- Publication number
- MX2017006083A MX2017006083A MX2017006083A MX2017006083A MX2017006083A MX 2017006083 A MX2017006083 A MX 2017006083A MX 2017006083 A MX2017006083 A MX 2017006083A MX 2017006083 A MX2017006083 A MX 2017006083A MX 2017006083 A MX2017006083 A MX 2017006083A
- Authority
- MX
- Mexico
- Prior art keywords
- tizoxanide
- prodrugs
- analogue
- salt
- compositions
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D277/58—Nitro radicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
- A61K31/138—Aryloxyalkylamines, e.g. propranolol, tamoxifen, phenoxybenzamine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/425—Thiazoles
- A61K31/426—1,3-Thiazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/555—Heterocyclic compounds containing heavy metals, e.g. hemin, hematin, melarsoprol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7028—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
- A61K31/7034—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin
- A61K31/704—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin attached to a condensed carbocyclic ring system, e.g. sennosides, thiocolchicosides, escin, daunorubicin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
- A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
- A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
- A61K31/7068—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D277/38—Nitrogen atoms
- C07D277/44—Acylated amino or imino radicals
- C07D277/46—Acylated amino or imino radicals by carboxylic acids, or sulfur or nitrogen analogues thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Organic Chemistry (AREA)
- Epidemiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Molecular Biology (AREA)
- Virology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Thiazole And Isothizaole Compounds (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
Se describen profármacos de tizoxanida, un análogo o sal de la misma. Los profármacos tienen una porción éster que comprende una porción de aminoácido, e incrementan la biodisponibilidad de la tizoxanida, un análogo o sal de la misma. También se describen composiciones y métodos para el tratamiento de una infección intracelular por protozoarios, una infección vírica o un cáncer.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201462078384P | 2014-11-11 | 2014-11-11 | |
PCT/US2015/060084 WO2016077420A1 (en) | 2014-11-11 | 2015-11-11 | Compositions and methods of treatment with prodrugs of tizoxanide, an analogue or salt thereof |
Publications (1)
Publication Number | Publication Date |
---|---|
MX2017006083A true MX2017006083A (es) | 2017-11-08 |
Family
ID=55954973
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2017006083A MX2017006083A (es) | 2014-11-11 | 2015-11-11 | Composicones y metodos de tratamiento con profarmacos de tizoxanida, un analogo o sal de la misma. |
Country Status (15)
Country | Link |
---|---|
US (3) | US10100023B2 (es) |
EP (1) | EP3217795A4 (es) |
JP (1) | JP6633092B2 (es) |
KR (1) | KR20170081228A (es) |
CN (1) | CN107105660A (es) |
AU (1) | AU2015346413B2 (es) |
BR (1) | BR112017009651A2 (es) |
CA (1) | CA2967333A1 (es) |
CO (1) | CO2017005038A2 (es) |
EA (1) | EA201790847A1 (es) |
IL (1) | IL252153A0 (es) |
MX (1) | MX2017006083A (es) |
TW (1) | TW201619142A (es) |
WO (1) | WO2016077420A1 (es) |
ZA (1) | ZA201703507B (es) |
Families Citing this family (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
BR112017009651A2 (pt) * | 2014-11-11 | 2017-12-19 | Romark Laboratories Lc | composto, composição farmacêutica, e, método para tratamento de uma infecção por protozoário intracelular, uma infecção viral ou um câncer. |
ES2810303T3 (es) | 2016-03-31 | 2021-03-08 | Romark Laboratories Lc | Compuestos de tiazolida para tratar infecciones virales |
SG10202004425XA (en) | 2016-04-11 | 2020-06-29 | Genfit | Methods of treatment for cholestatic and fibrotic diseases |
WO2017178174A1 (en) * | 2016-04-11 | 2017-10-19 | Genfit | Methods of treatment of cholestasis and fibrosis |
WO2017223491A1 (en) * | 2016-06-23 | 2017-12-28 | Health Research, Inc. | Pharmaceutical compositions with antiflaviviral activity |
CN114599365A (zh) * | 2019-08-22 | 2022-06-07 | 内布拉斯加大学董事会 | 前药及其制剂 |
US20230140290A1 (en) * | 2020-01-26 | 2023-05-04 | The Board Of Regents Of The University Of Texas Sy | Salicylamide derivatives and related methods of making |
EP4182304A1 (en) | 2020-07-20 | 2023-05-24 | Romark Laboratories, L.C. | Crystalline salts of tizoxanide and 2-hydroxy-n-(5-chloro-1,3-thiazol-2-yl)benzamide (rm-4848) with ethanolamine, morpholine, propanolamine, piperazine and n-methylpiperazine |
EP4199923A1 (en) | 2020-08-24 | 2023-06-28 | Romark Laboratories, L.C. | Use of thiazolides against coronaviruses |
GB202017724D0 (en) | 2020-11-10 | 2020-12-23 | Univ Liverpool | Pharmaceutically active compound formulations |
CN114044761B (zh) * | 2021-02-24 | 2022-05-17 | 成都贝诺科成生物科技有限公司 | 一种新的硝基噻唑衍生物及其应用 |
WO2023040990A1 (zh) * | 2021-09-15 | 2023-03-23 | 南京强新生物医药有限公司 | 治疗冠状病毒感染的新联用药物、药物组合物及其用途 |
WO2023077711A1 (zh) * | 2021-11-03 | 2023-05-11 | 南方科技大学 | 预防***癌的药剂的筛选方法及硝唑尼特在制药中的应用 |
CN114134195B (zh) * | 2021-11-03 | 2024-06-11 | 南方科技大学 | 预防***癌的药剂的筛选方法、硝唑尼特在制药中的应用 |
Family Cites Families (24)
Publication number | Priority date | Publication date | Assignee | Title |
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GB1437800A (en) | 1973-08-08 | 1976-06-03 | Phavic Sprl | Derivatives of 2-benzamido-5-nitro-thiazoles |
US5387598A (en) | 1994-04-13 | 1995-02-07 | Rossignol; Jean-Francois | Composition and galenic formulation suitable for combatting affections of the lower abdomen |
MX9604483A (es) | 1994-09-08 | 1998-02-28 | Jean-Francois Rossignol | Derivados de benzamida, composiciones que contienen dicho derivado y uso de las mismas. |
US5968961A (en) | 1997-05-07 | 1999-10-19 | Romark Laboratories, L.C. | Pharmaceutical compositions of tizoxanide and nitazoxanide |
US5859038A (en) | 1994-09-08 | 1999-01-12 | Romark Laboratories, L.C. | Method for treatment of helicobacter pylori infections |
US5965590A (en) | 1994-09-08 | 1999-10-12 | Romark Lab Lc | Method for treatment of opportunistic infections with pharmaceutical compositions of tizoxanide and nitazoxanide |
US5856348A (en) | 1994-09-08 | 1999-01-05 | Romark Laboratories, L.C. | Method for treatment of trematodes with pharmaceutical compositions of tizoxanide and nitazoxanide |
IL155799A (en) * | 1997-05-07 | 2004-08-31 | Romark Lab Lc | Pharmaceutical preparations of thizoxanide and nitazoxanide |
US5935591A (en) | 1998-01-15 | 1999-08-10 | Romark Laboratories, L.C. | Method for treatment of equine protozoal myeloencephalitis with thiazolides |
US20050171169A1 (en) | 2004-02-02 | 2005-08-04 | Rossignol Jean F. | Combination chemotherapy for helminth infections |
UA90864C2 (en) | 2004-09-09 | 2010-06-10 | Ромарк Лебораториз, Л.К. | Halogenated benzamide derivatives |
US20060194853A1 (en) | 2004-10-08 | 2006-08-31 | Rossignol Jean F | Alkyl benzamides |
JP2008538362A (ja) | 2005-04-12 | 2008-10-23 | ロマーク ラボラトリーズ エル.シー. | タンパク質の成熟の遮断を介して疾患を処置するための方法、タンパク質ジスルフィドイソメラーゼなどの分子シャペロンの機能を阻害する、またはグリコシル化を妨害する化合物、それらを含む薬学的組成物、および治療剤を同定するためのスクリーニング方法 |
AU2007204963B2 (en) | 2006-01-09 | 2012-09-27 | Romark Laboratories, L.C. | Viral hepatitis treatment |
CA2695517C (en) * | 2007-08-03 | 2016-09-20 | J. Edward Semple | Alkylsulfonyl-substituted thiazolide compounds |
HUE049501T2 (hu) | 2009-02-13 | 2020-09-28 | Romark Laboratories Lc | Nitazoxanidot tartalmazó szabályozott felszabadulású gyógyszerkészítmény |
KR101760956B1 (ko) | 2009-05-12 | 2017-07-24 | 로마크 레버러토리즈, 엘.씨. | 할로알킬 헤테로아릴 벤즈아미드 화합물 |
JP5932640B2 (ja) | 2009-06-26 | 2016-06-08 | ロマーク ラボラトリーズ エル.シー. | インフルエンザを治療するための化合物および方法 |
US9333193B2 (en) | 2010-09-20 | 2016-05-10 | University Of Virginia Patent Foundation | Compositions and methods for treating tuberculosis |
WO2012058378A1 (en) | 2010-10-29 | 2012-05-03 | Romark Laboratories L.C. | Pharmaceutical compositions and methods of use of salicylanilides for treatment of hepatitis viruses |
WO2012061190A1 (en) * | 2010-11-01 | 2012-05-10 | Romark Laboratories L.C. | Alkylsulfinyl-substituted thiazolide compounds |
DK2709453T3 (da) | 2011-05-16 | 2020-01-20 | Romark Laboratories Lc | Anvendelse af thiazolid-forbindelser til forebyggelse og behandling af virussygdomme, cancer og sygdomme forårsaget af intracellulære infektioner |
EP3006431B1 (en) | 2013-07-04 | 2019-01-30 | Institute of Pharmacology and Toxicology Academy of Military Medical Sciences P.L.A. China | Tizoxanide carbamate and pharmaceutical use thereof |
BR112017009651A2 (pt) * | 2014-11-11 | 2017-12-19 | Romark Laboratories Lc | composto, composição farmacêutica, e, método para tratamento de uma infecção por protozoário intracelular, uma infecção viral ou um câncer. |
-
2015
- 2015-11-11 BR BR112017009651A patent/BR112017009651A2/pt not_active Application Discontinuation
- 2015-11-11 CA CA2967333A patent/CA2967333A1/en not_active Abandoned
- 2015-11-11 WO PCT/US2015/060084 patent/WO2016077420A1/en active Application Filing
- 2015-11-11 MX MX2017006083A patent/MX2017006083A/es unknown
- 2015-11-11 AU AU2015346413A patent/AU2015346413B2/en not_active Ceased
- 2015-11-11 TW TW104137196A patent/TW201619142A/zh unknown
- 2015-11-11 EA EA201790847A patent/EA201790847A1/ru unknown
- 2015-11-11 US US15/525,658 patent/US10100023B2/en active Active
- 2015-11-11 CN CN201580072877.4A patent/CN107105660A/zh active Pending
- 2015-11-11 EP EP15858727.9A patent/EP3217795A4/en not_active Withdrawn
- 2015-11-11 JP JP2017544567A patent/JP6633092B2/ja not_active Expired - Fee Related
- 2015-11-11 KR KR1020177015256A patent/KR20170081228A/ko unknown
-
2017
- 2017-05-07 IL IL252153A patent/IL252153A0/en unknown
- 2017-05-22 CO CONC2017/0005038A patent/CO2017005038A2/es unknown
- 2017-05-22 ZA ZA2017/03507A patent/ZA201703507B/en unknown
-
2018
- 2018-10-05 US US16/153,070 patent/US10358428B2/en active Active
-
2019
- 2019-05-23 US US16/420,669 patent/US10577337B2/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
AU2015346413A1 (en) | 2017-05-25 |
ZA201703507B (en) | 2019-07-31 |
EA201790847A1 (ru) | 2017-11-30 |
CO2017005038A2 (es) | 2017-09-20 |
BR112017009651A2 (pt) | 2017-12-19 |
TW201619142A (zh) | 2016-06-01 |
JP6633092B2 (ja) | 2020-01-22 |
CA2967333A1 (en) | 2016-05-19 |
EP3217795A1 (en) | 2017-09-20 |
AU2015346413B2 (en) | 2019-08-29 |
KR20170081228A (ko) | 2017-07-11 |
US10358428B2 (en) | 2019-07-23 |
WO2016077420A1 (en) | 2016-05-19 |
US10100023B2 (en) | 2018-10-16 |
EP3217795A4 (en) | 2018-08-22 |
JP2017537977A (ja) | 2017-12-21 |
CN107105660A (zh) | 2017-08-29 |
US20170334868A1 (en) | 2017-11-23 |
US10577337B2 (en) | 2020-03-03 |
IL252153A0 (en) | 2017-07-31 |
US20190276417A1 (en) | 2019-09-12 |
US20190040026A1 (en) | 2019-02-07 |
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