MX2017002858A - Sales novedosas de 3-[(dimetilamino)metil]-n-{2-[4-(hidroxicarbamo il)fenoxi]etil}-1-benzofuran-2-carboxamida, formas cristalinas relacionadas, metodo para preparar las mismas y las composiciones farmaceuticas que contiene las mismas. - Google Patents
Sales novedosas de 3-[(dimetilamino)metil]-n-{2-[4-(hidroxicarbamo il)fenoxi]etil}-1-benzofuran-2-carboxamida, formas cristalinas relacionadas, metodo para preparar las mismas y las composiciones farmaceuticas que contiene las mismas.Info
- Publication number
- MX2017002858A MX2017002858A MX2017002858A MX2017002858A MX2017002858A MX 2017002858 A MX2017002858 A MX 2017002858A MX 2017002858 A MX2017002858 A MX 2017002858A MX 2017002858 A MX2017002858 A MX 2017002858A MX 2017002858 A MX2017002858 A MX 2017002858A
- Authority
- MX
- Mexico
- Prior art keywords
- same
- benzofuran
- carboxamide
- dimethylamino
- ethyl
- Prior art date
Links
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
- A61K31/343—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide condensed with a carbocyclic ring, e.g. coumaran, bufuralol, befunolol, clobenfurol, amiodarone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
- A61K31/166—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the carbon of a carboxamide group directly attached to the aromatic ring, e.g. procainamide, procarbazine, metoclopramide, labetalol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
- C07D307/82—Benzo [b] furans; Hydrogenated benzo [b] furans with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring
- C07D307/84—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
- C07D307/85—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 2
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N23/00—Investigating or analysing materials by the use of wave or particle radiation, e.g. X-rays or neutrons, not covered by groups G01N3/00 – G01N17/00, G01N21/00 or G01N22/00
- G01N23/20—Investigating or analysing materials by the use of wave or particle radiation, e.g. X-rays or neutrons, not covered by groups G01N3/00 – G01N17/00, G01N21/00 or G01N22/00 by using diffraction of the radiation by the materials, e.g. for investigating crystal structure; by using scattering of the radiation by the materials, e.g. for investigating non-crystalline materials; by using reflection of the radiation by the materials
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01V—GEOPHYSICS; GRAVITATIONAL MEASUREMENTS; DETECTING MASSES OR OBJECTS; TAGS
- G01V3/00—Electric or magnetic prospecting or detecting; Measuring magnetic field characteristics of the earth, e.g. declination, deviation
- G01V3/14—Electric or magnetic prospecting or detecting; Measuring magnetic field characteristics of the earth, e.g. declination, deviation operating with electron or nuclear magnetic resonance
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/13—Crystalline forms, e.g. polymorphs
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Physics & Mathematics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Physics & Mathematics (AREA)
- Neurology (AREA)
- Immunology (AREA)
- High Energy & Nuclear Physics (AREA)
- Geophysics (AREA)
- General Life Sciences & Earth Sciences (AREA)
- Crystallography & Structural Chemistry (AREA)
- Remote Sensing (AREA)
- Analytical Chemistry (AREA)
- Pathology (AREA)
- Geology (AREA)
- Environmental & Geological Engineering (AREA)
- Biochemistry (AREA)
- Oncology (AREA)
- Dermatology (AREA)
- Biomedical Technology (AREA)
- Physical Education & Sports Medicine (AREA)
- Neurosurgery (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Hematology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Furan Compounds (AREA)
Abstract
Sales novedosas de 3-[(dimetilamino)metil]-n-(2 [4- (hidroxicarbamoil)fenoxi]etil]-l-benzofuran-2-carboxamida, formas cristalinas relacionadas, método para preparar las mismas y las composiciones farmacéuticas que contienen las mismas a Se describen en el presente documento sales de 3- [(dimetilamino)metil]-/V-{2-E4-(hidroxicarbamoil)fenoxiietill-1 benzofuran 2-carboxamida, en particular de formula (I): (ver formula I) en la que HA es ácido naftaleno-1,5 disulfónico, Acido naftaleno-2-sulf6nico, Acido oxálico, Acido bencenosulfónico o ácido sulfúrico, o hidratos de los mismos, y formas cristalinas de los mismos caracterizadas por el diagrama de difracción de rayos X en polvo y el espectro de RMN CP/MAS 13C en estado sólido. También se describen composiciones, métodos de use o preparación de los mismos.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR1458224A FR3025197B1 (fr) | 2014-09-03 | 2014-09-03 | Nouveau sel de 3-[(dimethylamino)methyl]-n-{2-[4-(hydroxycarbamoyl)phenoxy]ethyl}-1-benzofurane-2-carboxamide, formes cristallines associees, leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
FR1458215A FR3025196B1 (fr) | 2014-09-03 | 2014-09-03 | Nouveaux sels de 3-[(dimethylamino)methyl]-n-{2-[4-(hydroxycarbamoyl)phenoxy]ethyl}-1-benzofurane-2-carboxamide, formes cristallines associees, leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
PCT/US2015/048243 WO2016036910A1 (en) | 2014-09-03 | 2015-09-03 | Novel salts of 3-[(dimethylamino)methyl]-n-{2-[4-(hydroxycarbamoyl) phenoxy]ethyl}-1-benzofuran-2-carboxamide, related crystalline forms, method for preparing the same and pharmaceutical compositions containing the same |
Publications (1)
Publication Number | Publication Date |
---|---|
MX2017002858A true MX2017002858A (es) | 2017-10-24 |
Family
ID=54186276
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2017002858A MX2017002858A (es) | 2014-09-03 | 2015-09-03 | Sales novedosas de 3-[(dimetilamino)metil]-n-{2-[4-(hidroxicarbamo il)fenoxi]etil}-1-benzofuran-2-carboxamida, formas cristalinas relacionadas, metodo para preparar las mismas y las composiciones farmaceuticas que contiene las mismas. |
Country Status (10)
Country | Link |
---|---|
US (2) | US20170266151A1 (es) |
EP (1) | EP3189040B1 (es) |
JP (1) | JP2017530106A (es) |
KR (1) | KR20170043648A (es) |
CN (1) | CN107001307A (es) |
AU (1) | AU2015311905B2 (es) |
CA (1) | CA2960044A1 (es) |
MX (1) | MX2017002858A (es) |
SG (2) | SG11201701674RA (es) |
WO (1) | WO2016036910A1 (es) |
Families Citing this family (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA2960044A1 (en) | 2014-09-03 | 2016-03-10 | Pharmacyclics Llc | Novel salts of 3-[(dimethylamino)methyl]-n-{2-[4-(hydroxycarbamoyl)phenoxy]ethyl}-1-benzofuran-2-carboxamide, related crystalline forms, method for preparing the same and pharmaceutical compositions containing the same |
EP4351734A1 (en) * | 2021-06-10 | 2024-04-17 | Teva Pharmaceuticals International GmbH | Solid state forms of abexinostat and process for preparation thereof |
Family Cites Families (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3038004A (en) | 1958-04-18 | 1962-06-05 | Burroughs Wellcome Co | Quaternary ammonium compounds |
GB0020721D0 (en) | 2000-08-22 | 2000-10-11 | Merck Sharp & Dohme | Therapeutic agents |
EP1611088B1 (en) * | 2003-04-07 | 2009-06-17 | Pharmacyclics, Inc. | Hydroxamates as therapeutic agents |
WO2005063713A1 (ja) | 2003-12-25 | 2005-07-14 | Eisai Co., Ltd. | 4−(3−クロロ−4−(シクロプロピルアミノカルボニル)アミノフェノキシ)−7−メトキシ−6−キノリンカルボキサミドの塩またはその溶媒和物の結晶およびそれらの製造方法 |
US8702670B2 (en) | 2004-06-30 | 2014-04-22 | Mcneil-Ppc, Inc. | Intravaginal device with controlled expansion |
US20090270497A1 (en) * | 2008-04-24 | 2009-10-29 | Pharmacyclics, Inc. | Treatment of Non-Localized Inflammation with pan-HDAC Inhibitors |
US8603521B2 (en) | 2009-04-17 | 2013-12-10 | Pharmacyclics, Inc. | Formulations of histone deacetylase inhibitor and uses thereof |
CA2775229C (en) | 2009-09-24 | 2014-07-29 | Ranbaxy Laboratories Limited | Process for the preparation of sorafenib tosylate |
ES2842970T3 (es) * | 2011-03-09 | 2021-07-15 | Cereno Scient Ab | Compuestos y métodos para mejorar la fibrinólisis endógena alterada usando inhibidores de la histona desacetilasa |
FR2977492B1 (fr) | 2011-07-04 | 2013-07-05 | Servier Lab | Nouvelle association entre le n-hydroxy-4-{2-[3-(n,n-dimethylaminomethyl) benzofuran-2-ylcarbonylamino]ethoxy}benzamide et le folfox |
WO2013039956A2 (en) | 2011-09-14 | 2013-03-21 | The Trustees Of Columbia University In The City Of New York | Compositions and methods for treating mood disorders |
CN102531964B (zh) * | 2011-10-10 | 2014-06-11 | 华东理工大学 | 具有抗肿瘤作用的二元羧酸衍生物及制备方法 |
FR3002733B1 (fr) | 2013-03-04 | 2015-08-14 | Servier Lab | Nouveau sel de l'abexinostat, forme cristalline associee,leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
CA2960044A1 (en) | 2014-09-03 | 2016-03-10 | Pharmacyclics Llc | Novel salts of 3-[(dimethylamino)methyl]-n-{2-[4-(hydroxycarbamoyl)phenoxy]ethyl}-1-benzofuran-2-carboxamide, related crystalline forms, method for preparing the same and pharmaceutical compositions containing the same |
-
2015
- 2015-09-03 CA CA2960044A patent/CA2960044A1/en not_active Abandoned
- 2015-09-03 AU AU2015311905A patent/AU2015311905B2/en not_active Ceased
- 2015-09-03 EP EP15767627.1A patent/EP3189040B1/en active Active
- 2015-09-03 WO PCT/US2015/048243 patent/WO2016036910A1/en active Application Filing
- 2015-09-03 CN CN201580053195.9A patent/CN107001307A/zh active Pending
- 2015-09-03 KR KR1020177007906A patent/KR20170043648A/ko unknown
- 2015-09-03 SG SG11201701674RA patent/SG11201701674RA/en unknown
- 2015-09-03 SG SG10201901916WA patent/SG10201901916WA/en unknown
- 2015-09-03 JP JP2017512319A patent/JP2017530106A/ja active Pending
- 2015-09-03 US US15/508,609 patent/US20170266151A1/en not_active Abandoned
- 2015-09-03 MX MX2017002858A patent/MX2017002858A/es unknown
-
2019
- 2019-11-07 US US16/676,911 patent/US10898461B2/en active Active
Also Published As
Publication number | Publication date |
---|---|
JP2017530106A (ja) | 2017-10-12 |
CN107001307A (zh) | 2017-08-01 |
US10898461B2 (en) | 2021-01-26 |
WO2016036910A1 (en) | 2016-03-10 |
US20170266151A1 (en) | 2017-09-21 |
EP3189040B1 (en) | 2020-07-29 |
KR20170043648A (ko) | 2017-04-21 |
SG10201901916WA (en) | 2019-04-29 |
US20200069637A1 (en) | 2020-03-05 |
SG11201701674RA (en) | 2017-04-27 |
AU2015311905A1 (en) | 2017-03-23 |
CA2960044A1 (en) | 2016-03-10 |
EP3189040A1 (en) | 2017-07-12 |
AU2015311905B2 (en) | 2020-03-05 |
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