MX2016008448A - Var2csa-drug conjugates. - Google Patents
Var2csa-drug conjugates.Info
- Publication number
- MX2016008448A MX2016008448A MX2016008448A MX2016008448A MX2016008448A MX 2016008448 A MX2016008448 A MX 2016008448A MX 2016008448 A MX2016008448 A MX 2016008448A MX 2016008448 A MX2016008448 A MX 2016008448A MX 2016008448 A MX2016008448 A MX 2016008448A
- Authority
- MX
- Mexico
- Prior art keywords
- var2csa
- drug conjugates
- conjugates
- disclosed
- drug
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/337—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having four-membered rings, e.g. taxol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
- A61K31/404—Indoles, e.g. pindolol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7028—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
- A61K31/7034—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin
- A61K31/704—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin attached to a condensed carbocyclic ring system, e.g. sennosides, thiocolchicosides, escin, daunorubicin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/05—Dipeptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
- A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
- A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
- A61K47/6415—Toxins or lectins, e.g. clostridial toxins or Pseudomonas exotoxins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/04—Drugs for skeletal disorders for non-specific disorders of the connective tissue
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/44—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from protozoa
- C07K14/445—Plasmodium
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Abstract
VAR2CSA-drug conjugates having biological activity are disclosed. Methods associated with preparation and use of such conjugates, as well as pharmaceutical compositions comprising such conjugates, are also disclosed.
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201361921242P | 2013-12-27 | 2013-12-27 | |
US201462051899P | 2014-09-17 | 2014-09-17 | |
US201462051886P | 2014-09-17 | 2014-09-17 | |
PCT/CA2014/000919 WO2015095952A1 (en) | 2013-12-27 | 2014-12-29 | Var2csa-drug conjugates |
Publications (1)
Publication Number | Publication Date |
---|---|
MX2016008448A true MX2016008448A (en) | 2017-01-09 |
Family
ID=53477241
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2016008448A MX2016008448A (en) | 2013-12-27 | 2014-12-29 | Var2csa-drug conjugates. |
Country Status (12)
Country | Link |
---|---|
US (1) | US10675355B2 (en) |
EP (1) | EP3087091B1 (en) |
JP (1) | JP6615115B2 (en) |
KR (1) | KR20160125361A (en) |
CN (1) | CN106459162A (en) |
AU (1) | AU2014373640B2 (en) |
BR (1) | BR112016015105A8 (en) |
CA (1) | CA2935064C (en) |
MX (1) | MX2016008448A (en) |
RU (1) | RU2714933C2 (en) |
SG (1) | SG11201605260VA (en) |
WO (1) | WO2015095952A1 (en) |
Families Citing this family (19)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
PT2968440T (en) * | 2013-03-15 | 2019-07-31 | Zymeworks Inc | Cytotoxic and anti-mitotic compounds, and methods of using the same |
ES2916722T3 (en) | 2013-12-27 | 2022-07-05 | Zymeworks Inc | Sulfonamide-containing linkage systems for drug conjugates |
MX2016008448A (en) | 2013-12-27 | 2017-01-09 | Zymeworks Inc | Var2csa-drug conjugates. |
IL287645B2 (en) | 2014-09-17 | 2024-04-01 | Zymeworks Bc Inc | Cytotoxic and anti-mitotic compounds, and methods of using the same |
PL3250237T3 (en) | 2015-01-30 | 2021-12-13 | Sutro Biopharma, Inc. | Hemiasterlin derivatives for conjugation and therapy |
EP3413920A1 (en) * | 2016-02-08 | 2018-12-19 | Synaffix B.V. | Bioconjugates containing sulfamide linkers for use in treatment |
CN109069658B (en) | 2016-02-08 | 2022-10-14 | 西纳福克斯股份有限公司 | Antibody-conjugates with improved therapeutic index for targeting HER2 tumors and methods for improving the therapeutic index of antibody-conjugates |
EP3413922A1 (en) * | 2016-02-08 | 2018-12-19 | SynAffix B.V. | Improved sulfamide linkers for use in bioconjugates |
US9840481B2 (en) | 2016-03-22 | 2017-12-12 | Merck Sharp & Dohme Corp. | Allosteric modulators of nicotinic acetylcholine receptors |
US10517958B2 (en) | 2016-10-04 | 2019-12-31 | Zymeworks Inc. | Compositions and methods for the treatment of platinum-drug resistant cancer |
CN106512022B (en) * | 2016-10-12 | 2019-09-27 | 广东艾时代生物科技有限责任公司 | Hydroxyl radical carthamin yellow carthamus A-red blood cell sticks chondroitin sulfate A (CSA) receptor protein polypeptide compound in the application for preparing anti-tumor drug |
DK3666787T3 (en) | 2017-08-10 | 2024-03-11 | Sumitomo Pharma Co Ltd | ANTIBODIAL DRUG CONJUGATES INCLUDING HEMIASTERN DERIVATIVES |
EP4321523A3 (en) | 2017-08-10 | 2024-04-24 | Sumitomo Pharma Co., Ltd. | Hemiasterlin derivatives and antibody-drug conjugates including same |
CN108570118B (en) * | 2017-10-17 | 2020-07-03 | 中国科学院深圳先进技术研究院 | Affinity chromatography purification method of placenta-like chondroitin sulfate A or derivative thereof |
GB2585607B (en) * | 2017-11-29 | 2022-09-07 | Cas Lamvac Guangzhou Biomedical Tech Co Ltd | Chimeric antigen receptor and application thereof |
CN113412271A (en) | 2019-02-13 | 2021-09-17 | 大日本住友制药株式会社 | Hamiltrin derivatives having cysteine residue |
CN110124045A (en) * | 2019-04-30 | 2019-08-16 | 云南大学 | Application of the plasmodium VAR2CSA albumen in anti-tumor drug |
CN113952467A (en) * | 2020-07-21 | 2022-01-21 | 深圳先进技术研究院 | Endometriosis molecular diagnosis and treatment preparation and preparation method and application thereof |
WO2023118150A1 (en) | 2021-12-22 | 2023-06-29 | Royal College Of Surgeons In Ireland | A conjugate for use in localising a molecule to the vascular endothelium. |
Family Cites Families (69)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5137877B1 (en) | 1990-05-14 | 1996-01-30 | Bristol Myers Squibb Co | Bifunctional linking compounds conjugates and methods for their production |
US5635483A (en) | 1992-12-03 | 1997-06-03 | Arizona Board Of Regents Acting On Behalf Of Arizona State University | Tumor inhibiting tetrapeptide bearing modified phenethyl amides |
US6569834B1 (en) | 1992-12-03 | 2003-05-27 | George R. Pettit | Elucidation and synthesis of antineoplastic tetrapeptide w-aminoalkyl-amides |
AU679479B2 (en) | 1992-12-16 | 1997-07-03 | Basf Aktiengesellschaft | Dolostatin analog |
US5780588A (en) | 1993-01-26 | 1998-07-14 | Arizona Board Of Regents | Elucidation and synthesis of selected pentapeptides |
EP0731106B1 (en) | 1993-10-01 | 2004-11-17 | Teikoku Hormone Mfg. Co., Ltd. | Dolastatin derivatives |
US5599902A (en) | 1994-11-10 | 1997-02-04 | Arizona Board Of Regents Acting On Behalf Of Arizona State University | Cancer inhibitory peptides |
US5663149A (en) | 1994-12-13 | 1997-09-02 | Arizona Board Of Regents Acting On Behalf Of Arizona State University | Human cancer inhibitory pentapeptide heterocyclic and halophenyl amides |
GB9508195D0 (en) | 1995-04-20 | 1995-06-07 | Univ British Columbia | Novel biologically active compounds and compositions,their use and derivation |
CA2225325A1 (en) | 1997-12-19 | 1999-06-19 | The University Of British Columbia | Hemiasterlin analogs |
US8097648B2 (en) | 1998-06-17 | 2012-01-17 | Eisai R&D Management Co., Ltd. | Methods and compositions for use in treating cancer |
US6323315B1 (en) | 1999-09-10 | 2001-11-27 | Basf Aktiengesellschaft | Dolastatin peptides |
US6884869B2 (en) | 2001-04-30 | 2005-04-26 | Seattle Genetics, Inc. | Pentapeptide compounds and uses related thereto |
US7256257B2 (en) | 2001-04-30 | 2007-08-14 | Seattle Genetics, Inc. | Pentapeptide compounds and uses related thereto |
EP1531846A4 (en) | 2002-02-27 | 2006-04-19 | Us Gov Health & Human Serv | Conjugates of ligand, linker and cytotoxic agent and related compositions and methods of use |
NZ535139A (en) * | 2002-03-22 | 2007-07-27 | Eisai Co Ltd | Hemiasterlin derivatives and uses thereof in the treatment of cancer |
US7064211B2 (en) | 2002-03-22 | 2006-06-20 | Eisai Co., Ltd. | Hemiasterlin derivatives and uses thereof |
CA2483725A1 (en) | 2002-04-23 | 2003-11-06 | Ohio State University | Antileishmanial dinitroaniline sulfonamides with activity against parasite tubulin |
ITMI20021391A1 (en) | 2002-06-25 | 2003-12-29 | Nicox Sa | NITRO-DERIVATIVES OF CYCLOOXYGENASE-2 INHIBITORS |
EP2357006B1 (en) | 2002-07-31 | 2015-09-16 | Seattle Genetics, Inc. | Drug conjugates and their use for treating cancer, an autoimmune disease or an infectious disease |
EP1539682A2 (en) | 2002-09-20 | 2005-06-15 | Wyeth Holdings Corporation | Process for the synthesis of intermediates useful for the synthesis of tubulin inhibitors |
US20040121965A1 (en) | 2002-09-20 | 2004-06-24 | Wyeth Holdings Corporation | Method of treating resistant tumors |
AU2003295808A1 (en) | 2002-11-21 | 2004-06-18 | Wyeth | Hemiasterlin affinity probes and their uses |
US7390910B2 (en) | 2003-08-08 | 2008-06-24 | Wyeth | Compounds for treating tumors |
US7576206B2 (en) | 2003-08-14 | 2009-08-18 | Cephalon, Inc. | Proteasome inhibitors and methods of using the same |
CA2538829A1 (en) | 2003-09-15 | 2005-03-24 | The University Of British Columbia | Ceratamines a and b, and analogues, syntheses and pharmaceutical compositions thereof |
ATE459364T1 (en) | 2003-10-22 | 2010-03-15 | Univ Johns Hopkins | IMPROVED BACTERIOLYSIS COMBINATION THERAPY FOR THE TREATMENT OF TUMORS |
BR122018071968B8 (en) | 2003-11-06 | 2021-07-27 | Seattle Genetics Inc | antibody-drug conjugate, pharmaceutical composition, article of manufacture and use of an antibody-drug conjugate |
US7078562B2 (en) | 2004-01-19 | 2006-07-18 | Mitsubishi Gas Chemical Company, Inc. | Adamantane derivatives and resin compositions using the same as raw material |
AU2005281359A1 (en) * | 2004-08-26 | 2006-03-16 | Apparao Satyam | Prodrugs and codrugs containing novel bio-cleavable disulfide linkers |
WO2006039652A2 (en) * | 2004-09-30 | 2006-04-13 | The Government Of The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Chondroitin sulfate a binding domains |
EP3505191A1 (en) | 2004-11-12 | 2019-07-03 | Seattle Genetics, Inc. | Auristatins having an aminobenzoic acid unit at the n terminus |
EP1817341A2 (en) | 2004-11-29 | 2007-08-15 | Seattle Genetics, Inc. | Engineered antibodies and immunoconjugates |
EP2722051B1 (en) | 2005-07-07 | 2018-11-07 | Seattle Genetics, Inc. | Monomethylvaline compounds having phenylalanine side-chain modifications at the C-terminus |
WO2007008848A2 (en) | 2005-07-07 | 2007-01-18 | Seattle Genetics, Inc. | Monomethylvaline compounds having phenylalanine carboxy modifications at the c-terminus |
CN104016970A (en) | 2007-10-10 | 2014-09-03 | 诺华股份有限公司 | Spiropyrrolidines and their use against HCV and HIV infection |
US20090155289A1 (en) | 2007-11-01 | 2009-06-18 | Steve Roberts | Furin-cleavable peptide linkers for drug-ligand conjugates |
EP2245054B1 (en) | 2008-01-30 | 2018-11-28 | Pieris Pharmaceuticals GmbH | Muteins of tear lipocalin having affinity to human c-met receptor tyrosine kinase and methods for obtaining the same |
EP2842575B1 (en) | 2008-03-18 | 2017-09-27 | Seattle Genetics, Inc. | Auristatin drug linker conjugates |
PL2865387T3 (en) * | 2008-11-21 | 2019-12-31 | Københavns Universitet (University Of Copenhagen) | Priming of an immune response |
US20110182850A1 (en) | 2009-04-10 | 2011-07-28 | Trixi Brandl | Organic compounds and their uses |
US8394922B2 (en) | 2009-08-03 | 2013-03-12 | Medarex, Inc. | Antiproliferative compounds, conjugates thereof, methods therefor, and uses thereof |
TW201117809A (en) | 2009-09-25 | 2011-06-01 | Astellas Pharma Inc | Substituted amide compounds |
EP2579887B1 (en) | 2010-06-10 | 2014-11-12 | Seattle Genetics, Inc. | Novel auristatin derivatives and use thereof |
FR2963241B1 (en) * | 2010-07-30 | 2014-10-24 | Inst Rech Developpement Ird | VACCINE AGAINST GESTATIONAL MALARIA |
ES2537726T3 (en) | 2010-09-24 | 2015-06-11 | Astellas Pharma Inc. | Substituted amide compound |
PL2678037T3 (en) | 2011-02-25 | 2015-05-29 | Lonza Ag | Branched linker for protein drug conjugates |
WO2012123957A1 (en) | 2011-03-16 | 2012-09-20 | Council Of Scientific & Industrial Research | Oligopeptides and process for preparation thereof |
WO2012135440A1 (en) | 2011-03-30 | 2012-10-04 | Arizona Board Of Regents, For And On Behalf Of, Arizona State University | Auristatin tyramine phosphate salts and auristatin aminoquinoline derivatives and prodrugs thereof |
CN103826661B (en) | 2011-04-21 | 2019-03-05 | 西雅图基因公司 | New bonding agent-drug conjugate (ADC) and application thereof |
US20130190248A1 (en) | 2011-07-26 | 2013-07-25 | Agensys, Inc. | Substituted peptide analogs |
WO2013068874A1 (en) | 2011-11-11 | 2013-05-16 | Pfizer Inc. | Antibody-drug conjugates |
KR101733853B1 (en) | 2011-11-17 | 2017-05-08 | 화이자 인코포레이티드 | Cytotoxic peptides and antibody drug conjugates thereof |
US11787844B2 (en) * | 2012-02-09 | 2023-10-17 | Var2 Pharmaceuticals Aps | Targeting of chondroitin sulfate glycans |
EP3925627A1 (en) | 2012-05-15 | 2021-12-22 | Concortis Biosystems, Corp | Drug-conjugates and uses thereof |
AU2013270686B2 (en) | 2012-06-07 | 2016-11-10 | Ambrx, Inc. | Prostate-specific membrane antigen antibody drug conjugates |
EP2861262B1 (en) | 2012-06-19 | 2018-11-28 | Ambrx, Inc. | Anti-cd70 antibody drug conjugates |
AU2013280644B2 (en) | 2012-06-26 | 2018-08-02 | Jeffrey A. BACHA | Methods for treating tyrosine-kinase-inhibitor-resistant malignancies in patients with genetic polymorphisms or AHI1 dysregulations or mutations employing dianhydrogalactitol, diacetyldianhydrogalactitol, dibromodulcitol, or analogs or derivatives thereof |
JP6133431B2 (en) | 2012-11-24 | 2017-05-24 | ハンジョウ ディーエーシー バイオテック シーオー.,エルティディ.Hangzhou Dac Biotech Co.,Ltd. | Use of hydrophilic conjugates and conjugation reactions between drug molecules and cell binding molecules |
SG11201504887TA (en) | 2012-12-21 | 2015-07-30 | Bioalliance Cv | Hydrophilic self-immolative linkers and conjugates thereof |
WO2014126836A1 (en) | 2013-02-14 | 2014-08-21 | Bristol-Myers Squibb Company | Tubulysin compounds, methods of making and use |
PT2968440T (en) | 2013-03-15 | 2019-07-31 | Zymeworks Inc | Cytotoxic and anti-mitotic compounds, and methods of using the same |
CA2934030A1 (en) | 2013-10-15 | 2015-04-23 | Sorrento Therapeutics Inc. | Drug-conjugates with a targeting molecule and two different drugs |
CA2930614A1 (en) | 2013-12-17 | 2015-06-25 | Novartis Ag | Cytotoxic peptides and conjugates thereof |
MX2016008448A (en) | 2013-12-27 | 2017-01-09 | Zymeworks Inc | Var2csa-drug conjugates. |
ES2916722T3 (en) | 2013-12-27 | 2022-07-05 | Zymeworks Inc | Sulfonamide-containing linkage systems for drug conjugates |
IL287645B2 (en) | 2014-09-17 | 2024-04-01 | Zymeworks Bc Inc | Cytotoxic and anti-mitotic compounds, and methods of using the same |
US10077287B2 (en) | 2014-11-10 | 2018-09-18 | Bristol-Myers Squibb Company | Tubulysin analogs and methods of making and use |
US10975112B2 (en) | 2015-06-16 | 2021-04-13 | Hangzhou Dac Biotech Co., Ltd. | Linkers for conjugation of cell-binding molecules |
-
2014
- 2014-12-29 MX MX2016008448A patent/MX2016008448A/en unknown
- 2014-12-29 BR BR112016015105A patent/BR112016015105A8/en not_active Application Discontinuation
- 2014-12-29 SG SG11201605260VA patent/SG11201605260VA/en unknown
- 2014-12-29 RU RU2016130348A patent/RU2714933C2/en active
- 2014-12-29 WO PCT/CA2014/000919 patent/WO2015095952A1/en active Application Filing
- 2014-12-29 EP EP14874710.8A patent/EP3087091B1/en active Active
- 2014-12-29 KR KR1020167020681A patent/KR20160125361A/en not_active Application Discontinuation
- 2014-12-29 AU AU2014373640A patent/AU2014373640B2/en active Active
- 2014-12-29 JP JP2016561041A patent/JP6615115B2/en active Active
- 2014-12-29 US US15/108,258 patent/US10675355B2/en active Active
- 2014-12-29 CA CA2935064A patent/CA2935064C/en active Active
- 2014-12-29 CN CN201480076448.XA patent/CN106459162A/en active Pending
Also Published As
Publication number | Publication date |
---|---|
CA2935064A1 (en) | 2015-07-02 |
WO2015095952A1 (en) | 2015-07-02 |
CA2935064C (en) | 2023-06-27 |
SG11201605260VA (en) | 2016-07-28 |
US20170246310A1 (en) | 2017-08-31 |
CN106459162A (en) | 2017-02-22 |
EP3087091A4 (en) | 2017-06-14 |
BR112016015105A2 (en) | 2017-09-19 |
US10675355B2 (en) | 2020-06-09 |
KR20160125361A (en) | 2016-10-31 |
BR112016015105A8 (en) | 2018-04-24 |
US20180117163A9 (en) | 2018-05-03 |
RU2016130348A (en) | 2018-01-31 |
RU2714933C2 (en) | 2020-02-21 |
JP2017505335A (en) | 2017-02-16 |
AU2014373640A1 (en) | 2016-07-07 |
JP6615115B2 (en) | 2019-12-04 |
RU2016130348A3 (en) | 2018-08-06 |
AU2014373640B2 (en) | 2018-08-30 |
EP3087091B1 (en) | 2021-10-20 |
EP3087091A1 (en) | 2016-11-02 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
MX2016008448A (en) | Var2csa-drug conjugates. | |
PH12019500176A1 (en) | Heterocyclic compounds and ther uses | |
TN2017000246A1 (en) | Anti-c10orf54 antibodies and uses thereof | |
MX2016016666A (en) | Boronic acid derivatives and therapeutic uses thereof. | |
MX2016015093A (en) | Boronic acid derivatives and therapeutic uses thereof. | |
WO2014197849A3 (en) | Anti-c10orf54 antibodies and uses thereof | |
MX2015008627A (en) | Boronic acid derivatives and therapeutic uses thereof. | |
PH12014502601A1 (en) | ANTI-Ly6E ANTIBODIES AND IMMUNOCONJUGATES AND METHODS OF USE | |
MX2015009106A (en) | Solid solution compositions and use in severe pain. | |
MX2017004838A (en) | Interleukin-15 compositions and uses thereof. | |
NZ711982A (en) | Cytotoxic and anti-mitotic compounds, and methods of using the same | |
GB201106750D0 (en) | Novel compounds | |
TN2015000411A1 (en) | Ceftolozane antibiotic compositions | |
MX359769B (en) | Methods of decellularizing bone. | |
EP3878445A3 (en) | Acamprosate formulations, methods of using the same, and combinations comprising the same | |
TR201910866T4 (en) | Combined preparations for cancer treatment. | |
PH12016500863A1 (en) | Tetracyclic autotaxin inhibitors | |
MX367393B (en) | ANTIFUNGAL COMPOSITIONS FOR THE TREATMENT OF SKIN and NAILS. | |
MX2017012596A (en) | A pharmaceutical composition and the use thereof. | |
MX2019015527A (en) | Texaphyrin-pt(iv) conjugates and compositions for use in overcoming platinum resistance. | |
EP3071214A4 (en) | Salacia compositions, methods of treatment by their administration, and methods of their preparation | |
MX2015016603A (en) | Corticosteroid compositions. | |
MX367773B (en) | Solid salt form of alpha-6-mpeg6-o-hydroxycodone as opioid agonists and uses thereof. | |
MX345263B (en) | Stable pexiganan formulation. | |
PH12017501979A1 (en) | Pharmaceutical compound |