MX2016000195A - Oligosacaridos sinteticos para vacuna de p. aeruginosa. - Google Patents

Oligosacaridos sinteticos para vacuna de p. aeruginosa.

Info

Publication number
MX2016000195A
MX2016000195A MX2016000195A MX2016000195A MX2016000195A MX 2016000195 A MX2016000195 A MX 2016000195A MX 2016000195 A MX2016000195 A MX 2016000195A MX 2016000195 A MX2016000195 A MX 2016000195A MX 2016000195 A MX2016000195 A MX 2016000195A
Authority
MX
Mexico
Prior art keywords
aeruginosa
los
synthetic oligosaccharides
aeruginosa vaccine
oligosaccharides
Prior art date
Application number
MX2016000195A
Other languages
English (en)
Inventor
A Campbell Stewart
J Plante Obadiah
Original Assignee
Synglyco Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Synglyco Pharmaceuticals Inc filed Critical Synglyco Pharmaceuticals Inc
Publication of MX2016000195A publication Critical patent/MX2016000195A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H13/00—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids
    • C07H13/02—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by carboxylic acids
    • C07H13/04—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by carboxylic acids having the esterifying carboxyl radicals attached to acyclic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/02—Bacterial antigens
    • A61K39/104—Pseudomonadales, e.g. Pseudomonas
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/02—Acyclic radicals, not substituted by cyclic structures
    • C07H15/04—Acyclic radicals, not substituted by cyclic structures attached to an oxygen atom of the saccharide radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/12—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria
    • C07K16/1203—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria from Gram-negative bacteria
    • C07K16/1214—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria from Gram-negative bacteria from Pseudomonadaceae (F)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/44—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material not provided for elsewhere, e.g. haptens, metals, DNA, RNA, amino acids
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/569—Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses
    • G01N33/56911—Bacteria
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
    • C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
    • C07K2317/622—Single chain antibody (scFv)
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/195—Assays involving biological materials from specific organisms or of a specific nature from bacteria
    • G01N2333/21—Assays involving biological materials from specific organisms or of a specific nature from bacteria from Pseudomonadaceae (F)
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2469/00—Immunoassays for the detection of microorganisms
    • G01N2469/10—Detection of antigens from microorganism in sample from host

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Microbiology (AREA)
  • Biomedical Technology (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • General Physics & Mathematics (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Cell Biology (AREA)
  • Epidemiology (AREA)
  • Mycology (AREA)
  • Virology (AREA)
  • Food Science & Technology (AREA)
  • Pathology (AREA)
  • Analytical Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

Abstract

La presente invención proporciona oligosacáridos con base en lipooligosacáridos (LOS) de Pseudomonas aeruginosa sintéticos y conjugados que contienen diversos antígenos de oligosacáridos específicos del serotipo P. aeruginosa o diversos motivos o estructuras de oligosacáridos P. aeruginosa núcleo. La invención proporciona adicionalmente composiciones inmunoprotectoras e inrnunogénicas con base en LOS de P. aeruginosa y anticuerpos derivados de estos para diagnosticar, tratar, y evitar infecciones provocadas por P. aeruginosa.
MX2016000195A 2013-07-03 2014-07-01 Oligosacaridos sinteticos para vacuna de p. aeruginosa. MX2016000195A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201361842474P 2013-07-03 2013-07-03
PCT/US2014/045057 WO2015002954A1 (en) 2013-07-03 2014-07-01 Synthetic oligosaccharides for p. aeruginosa vaccine

Publications (1)

Publication Number Publication Date
MX2016000195A true MX2016000195A (es) 2016-08-18

Family

ID=52144159

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2016000195A MX2016000195A (es) 2013-07-03 2014-07-01 Oligosacaridos sinteticos para vacuna de p. aeruginosa.

Country Status (13)

Country Link
US (1) US20160144016A1 (es)
EP (1) EP3016685B1 (es)
JP (1) JP2016525507A (es)
KR (1) KR20160098161A (es)
CN (1) CN105517573A (es)
AU (1) AU2014284457A1 (es)
CA (1) CA2917192A1 (es)
CL (1) CL2015003792A1 (es)
HK (1) HK1217642A1 (es)
IL (1) IL243432A0 (es)
MX (1) MX2016000195A (es)
SG (1) SG11201510792XA (es)
WO (1) WO2015002954A1 (es)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN107249629A (zh) * 2015-02-26 2017-10-13 生控基因疫苗股份有限公司 包含免疫原性蛋白质及组合佐剂并用以诱发抗原特异性t细胞反应的疫苗组合物
CN110423274B (zh) * 2017-11-01 2022-03-11 深圳市国创纳米抗体技术有限公司 抗绿脓杆菌外毒素a纳米抗体及其应用
WO2021113495A1 (en) * 2019-12-04 2021-06-10 University Of Montana Antibacterial carbohydrate vaccine

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4693891A (en) * 1985-09-09 1987-09-15 Miles Laboratories, Inc. Vaccine for Pseudomonas aeruginosa
DE60331292D1 (de) * 2003-05-14 2010-04-01 Kenta Biotech Ag Humaner monoklonaler Antikörper spezifisch für Lipopolysacchariden (LPS) des Serotyps IATS O6 von Pseudomonas aeruginosa
CN101912609B (zh) * 2009-08-20 2012-02-01 成都蓉生药业有限责任公司 防治绿脓杆菌感染的组合物及其制备方法
CA2797052A1 (en) * 2010-04-23 2011-10-27 Ancora Pharmaceuticals Inc. Synthetic oligosaccharides for staphyloccocus vaccine
CN101947323B (zh) * 2010-07-26 2013-02-27 北京绿竹生物制药有限公司 一种革兰氏阴性细菌疫苗及其制备方法
WO2012082635A1 (en) * 2010-12-13 2012-06-21 Ancora Pharmaceuticals, Inc. Synthetic oligosaccharide group a streptococcus
EP2554549A1 (en) * 2011-08-02 2013-02-06 Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. Oligosaccharides and oligosaccharides-protein conjugates derived from clostridium difficile polysaccharide PS-I, methods of synthesis and uses thereof, in particular as vaccines and diagnostic tools
JP2015525771A (ja) * 2012-07-16 2015-09-07 シングリコ、インコーポレイテッド 緑膿菌ワクチンのための合成オリゴ糖

Also Published As

Publication number Publication date
SG11201510792XA (en) 2016-01-28
US20160144016A1 (en) 2016-05-26
CL2015003792A1 (es) 2017-01-20
KR20160098161A (ko) 2016-08-18
EP3016685A4 (en) 2016-11-23
WO2015002954A1 (en) 2015-01-08
AU2014284457A1 (en) 2016-01-28
IL243432A0 (en) 2016-03-31
CN105517573A (zh) 2016-04-20
CA2917192A1 (en) 2015-01-08
EP3016685A1 (en) 2016-05-11
JP2016525507A (ja) 2016-08-25
HK1217642A1 (zh) 2017-01-20
EP3016685B1 (en) 2018-01-31

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