MX2015012808A - Inmunotoxinas de union a cd20 para inducir internalizacion celular y metodos que usan las mismas. - Google Patents

Inmunotoxinas de union a cd20 para inducir internalizacion celular y metodos que usan las mismas.

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Publication number
MX2015012808A
MX2015012808A MX2015012808A MX2015012808A MX2015012808A MX 2015012808 A MX2015012808 A MX 2015012808A MX 2015012808 A MX2015012808 A MX 2015012808A MX 2015012808 A MX2015012808 A MX 2015012808A MX 2015012808 A MX2015012808 A MX 2015012808A
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Mexico
Prior art keywords
binding proteins
expressing cells
methods
binding
same
Prior art date
Application number
MX2015012808A
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English (en)
Inventor
Eric Poma
Erin Willert
Jason Kim
Jack Higgins
Sangeetha Rajagopalan
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Molecular Templates Inc
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Publication date
Application filed by Molecular Templates Inc filed Critical Molecular Templates Inc
Publication of MX2015012808A publication Critical patent/MX2015012808A/es

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    • C07K16/2887—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against CD20
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Abstract

La presente invención proporciona proteínas de unión de CD20 que se unen a e internalizan rápidamente antígenos de CD20 a partir de una ubicación de superficie celular al interior de una célula. Las proteínas de unión de CD20 de la invención comprenden una región de unión de CD20 y una región efectora de toxina Shiga. Ciertas de las proteínas de unión de CD20 descritas matan células que expresan CD20 sobre su superficie. Además, las proteínas de unión de CD20 actualmente descritas pueden comprender materiales exógenos adicionales y son capaces de entrega dirigida de estos materiales exógenos adicionales al interior de células que expresan CD20. Tales materiales adicionales pueden incluir péptidos, antígenos, enzimas y polinucleótidos. Estas proteínas de unión de CD20 tienen usos en métodos para internalizarse ellas mismas, matar de manera dirigida células que expresan CD20, entregar materiales exógenos en células que expresan CD20, y tratar una variedad de enfermedades que involucran células que expresan CD20, tales como cáncer y desórdenes inmunes.
MX2015012808A 2013-03-12 2014-03-11 Inmunotoxinas de union a cd20 para inducir internalizacion celular y metodos que usan las mismas. MX2015012808A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201361777130P 2013-03-12 2013-03-12
PCT/US2014/023198 WO2014164680A1 (en) 2013-03-12 2014-03-11 Cd20-binding immunotoxins for inducing cellular internalization and methods using same

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MX2015012808A true MX2015012808A (es) 2016-05-31

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US (4) US10450354B2 (es)
EP (4) EP2970478B1 (es)
JP (6) JP6548630B2 (es)
KR (2) KR101990341B1 (es)
CN (2) CN111363047A (es)
AU (1) AU2014249107C1 (es)
CA (2) CA2902324A1 (es)
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IL (3) IL240433B (es)
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MX (1) MX2015012808A (es)
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PT (1) PT2970487T (es)
RS (1) RS60280B1 (es)
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WO (2) WO2014164680A1 (es)

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