MX2015012629A - Compuestos de imidazo piridina. - Google Patents

Compuestos de imidazo piridina.

Info

Publication number
MX2015012629A
MX2015012629A MX2015012629A MX2015012629A MX2015012629A MX 2015012629 A MX2015012629 A MX 2015012629A MX 2015012629 A MX2015012629 A MX 2015012629A MX 2015012629 A MX2015012629 A MX 2015012629A MX 2015012629 A MX2015012629 A MX 2015012629A
Authority
MX
Mexico
Prior art keywords
pyridine compounds
imidazo pyridine
compounds
imidazo
ch2o
Prior art date
Application number
MX2015012629A
Other languages
English (en)
Inventor
Bryan Hurst Norman
Lance Allen Pfeifer
Spencer Brian Jones
Original Assignee
Lilly Co Eli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lilly Co Eli filed Critical Lilly Co Eli
Publication of MX2015012629A publication Critical patent/MX2015012629A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Rheumatology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pain & Pain Management (AREA)
  • Immunology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Epidemiology (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

La presente invención proporciona compuestos de la fórmula I, en donde X es un enlace o CH2 Q es CH2 u O; L es seleccionado del grupo que consiste de -OCH2- y -CH2O-; o una sal farmacéuticamente aceptable de los mismos. Los compuestos de la invención son inhibidores de autotaxina.
MX2015012629A 2013-03-12 2014-03-04 Compuestos de imidazo piridina. MX2015012629A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201361777216P 2013-03-12 2013-03-12
PCT/US2014/020297 WO2014143583A1 (en) 2013-03-12 2014-03-04 Imidazo pyridine compounds

Publications (1)

Publication Number Publication Date
MX2015012629A true MX2015012629A (es) 2016-07-07

Family

ID=50382634

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2015012629A MX2015012629A (es) 2013-03-12 2014-03-04 Compuestos de imidazo piridina.

Country Status (15)

Country Link
US (1) US9394317B2 (es)
EP (1) EP2970254B1 (es)
JP (1) JP6163248B2 (es)
KR (1) KR20150119081A (es)
CN (1) CN105143218B (es)
AR (1) AR094959A1 (es)
AU (1) AU2014228355B2 (es)
BR (1) BR112015018509A2 (es)
CA (1) CA2900956C (es)
EA (1) EA201591486A1 (es)
ES (1) ES2639125T3 (es)
MX (1) MX2015012629A (es)
TW (1) TW201520219A (es)
WO (1) WO2014143583A1 (es)
ZA (1) ZA201506747B (es)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TWI499591B (zh) * 2013-01-11 2015-09-11 Lilly Co Eli 雙環嘧啶化合物
TW201500356A (zh) * 2013-04-12 2015-01-01 Lilly Co Eli 二氫吡啶并嘧啶化合物
GB201501870D0 (en) 2015-02-04 2015-03-18 Cancer Rec Tech Ltd Autotaxin inhibitors
GB201502020D0 (en) 2015-02-06 2015-03-25 Cancer Rec Tech Ltd Autotaxin inhibitory compounds
WO2016197009A1 (en) 2015-06-05 2016-12-08 Vertex Pharmaceuticals Incorporated Triazoles for the treatment of demyelinating diseases
WO2018106646A1 (en) 2016-12-06 2018-06-14 Vertex Pharmaceuticals Incorporated Aminotriazoles for the treatment of demyelinating diseases
WO2018106643A1 (en) 2016-12-06 2018-06-14 Vertex Pharmaceuticals Incorporated Heterocyclic azoles for the treatment of demyelinating diseases
WO2018106641A1 (en) 2016-12-06 2018-06-14 Vertex Pharmaceuticals Incorporated Pyrazoles for the treatment of demyelinating diseases
KR101798840B1 (ko) 2017-05-17 2017-11-17 주식회사 레고켐 바이오사이언스 신규 오토탁신 저해 화합물 및 이를 함유하는 약제학적 조성물
US10961242B2 (en) 2017-05-17 2021-03-30 Legochem Biosciences, Inc. Compounds as autotaxin inhibitors and pharmaceutical compositions comprising the same
AU2019272377B2 (en) * 2018-05-24 2022-03-10 Guangzhou Henovcom Bioscience Co., Ltd. Heteroaromatic compounds, pharmaceutical compositions and uses thereof
BR112021014777A2 (pt) * 2019-02-01 2021-09-28 Wuhan Humanwell Innovative Drug Research and Development Center Limited Company Composto, composição farmacêutica, uso do composto ou da composição farmacêutica, combinação de fármacos, e, método para tratar ou prevenir doenças relacionadas à atx
CN112778334B (zh) * 2019-11-07 2022-04-15 广州市恒诺康医药科技有限公司 芳杂环化合物、其药物组合物及其应用
TW202128682A (zh) * 2019-12-11 2021-08-01 大陸商四川海思科製藥有限公司 含氮雜環類自分泌運動因子抑制劑及其組合物和用途
TW202214644A (zh) * 2020-07-28 2022-04-16 大陸商武漢人福創新藥物研發中心有限公司 含氮雜環化合物的固體形式及其藥物組合物和用途

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1230225A2 (en) * 1999-11-01 2002-08-14 Eli Lilly And Company Pharmaceutically active 4-substituted pyrimidine derivatives
AU2003242252A1 (en) 2002-06-07 2003-12-22 Kyowa Hakko Kogyo Co., Ltd. Bicyclic pyrimidine derivatives
US7465739B2 (en) * 2003-06-10 2008-12-16 Solvay Pharmaceuticals B.V. Compounds and their use in therapy
DE102004020908A1 (de) * 2004-04-28 2005-11-17 Grünenthal GmbH Substituierte 5,6,7,8,-Tetrahydro-pyrido[4,3-d]pyrimidin-2-yl- und 5,6,7,8,-Tetrahydro-chinazolin-2-yl-Verbindungen
PL1828197T3 (pl) * 2004-12-13 2009-11-30 Solvay Pharm Gmbh Nowe podstawione pochodne tiofenopirymidynonu jako inhibitory dehydrogenazy 17ß-hydroksysteroidowej
BRPI0922154A2 (pt) * 2008-12-01 2016-01-05 Merck Patent Gmbh pirido[4,3-d]pirimidinas 2,5-diamino-substituídas como inibidores de autotaxina contra o cãncer
ITRE20090102A1 (it) 2009-10-22 2011-04-23 Cgm Spa Stampo, attrezzatura e metodo per la formatura dietro compressione di oggetti di materiale termoplastico
JP2013536200A (ja) * 2010-08-20 2013-09-19 アミラ ファーマシューティカルス，インコーポレーテッド オートタキシン阻害剤およびその使用
EP2714680B1 (en) * 2011-05-27 2015-11-25 Amira Pharmaceuticals, Inc. Heterocyclic autotaxin inhibitors and uses thereof

Also Published As

Publication number Publication date
EP2970254A1 (en) 2016-01-20
CA2900956C (en) 2017-11-28
BR112015018509A2 (pt) 2017-07-18
CN105143218A (zh) 2015-12-09
AU2014228355A1 (en) 2015-10-01
WO2014143583A1 (en) 2014-09-18
EP2970254B1 (en) 2017-06-21
EA201591486A1 (ru) 2016-01-29
AU2014228355B2 (en) 2016-02-25
CA2900956A1 (en) 2014-09-18
TW201520219A (zh) 2015-06-01
JP6163248B2 (ja) 2017-07-12
CN105143218B (zh) 2016-12-14
JP2016512254A (ja) 2016-04-25
ZA201506747B (en) 2017-09-27
KR20150119081A (ko) 2015-10-23
US20150368273A1 (en) 2015-12-24
ES2639125T3 (es) 2017-10-25
AR094959A1 (es) 2015-09-09
US9394317B2 (en) 2016-07-19

Similar Documents

Publication Publication Date Title
MX2015012629A (es) Compuestos de imidazo piridina.
PH12015502031B1 (en) Tetrahydropyrrolothiazine compounds
PH12015500263A1 (en) New bicyclic derivatives
PH12016501007A1 (en) Substituted benzamides and methods of use thereof
MX2017006266A (es) Compuestos de heteroarilo como inhibidores de cinasas asociadas al receptor de interleucina 1(irak) y sus usos.
PH12017501523A1 (en) Selective bace1 inhibitors
EA201591634A1 (ru) Дигидропиридопиримидиновые соединения
RS54730B1 (sr) Inhibitori beta sekretaze
IN2015DN00598A (es)
JO3318B1 (ar) مثبطات bace
IN2014DN07996A (es)
MX2015015841A (es) Compuestos de fenoxietil dihidro-1h-isoquinolina.
MX364207B (es) Inhibidores de agrecanasa.
PH12017501404A1 (en) Diaza-benzofluoranthrene compounds
EA201690924A1 (ru) Фторфенилпиразольные соединения
TN2019000038A1 (en) Triazolopyrazinone derivative useful as a human pde1 inhibitor
TN2017000065A1 (en) A tetrahydropyrrolo[3,4-d][1,3]thiazine-derivative as bace inhibitor
EA201690593A1 (ru) Новые соединения мочевины
EA201690908A1 (ru) Пиразолопиримидиновые соединения
EA201791596A1 (ru) Пиразоловые соединения
IN2014MU00070A (es)
IN2014MU00069A (es)
IN2013CH05394A (es)
IN2013CH05395A (es)
IN2013MU01524A (es)