MX2015011575A - Sistemas y metodos para la deteccion de celulas usando particulas manejadas de transduccion. - Google Patents
Sistemas y metodos para la deteccion de celulas usando particulas manejadas de transduccion.Info
- Publication number
- MX2015011575A MX2015011575A MX2015011575A MX2015011575A MX2015011575A MX 2015011575 A MX2015011575 A MX 2015011575A MX 2015011575 A MX2015011575 A MX 2015011575A MX 2015011575 A MX2015011575 A MX 2015011575A MX 2015011575 A MX2015011575 A MX 2015011575A
- Authority
- MX
- Mexico
- Prior art keywords
- transduction particles
- systems
- methods
- engineered
- cells
- Prior art date
Links
- 239000002245 particle Substances 0.000 title abstract 7
- 230000026683 transduction Effects 0.000 title abstract 7
- 238000010361 transduction Methods 0.000 title abstract 7
- 238000000034 method Methods 0.000 title abstract 3
- 238000001514 detection method Methods 0.000 title 1
- 241000894006 Bacteria Species 0.000 abstract 1
- 150000007523 nucleic acids Chemical class 0.000 abstract 1
- 102000039446 nucleic acids Human genes 0.000 abstract 1
- 108020004707 nucleic acids Proteins 0.000 abstract 1
- 230000003362 replicative effect Effects 0.000 abstract 1
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Abstract
En la presenten se describen sistemas y métodos para detectar y/o identificar células (o bacterias) diana usando partículas manejadas de transducción. En algunas modalidades, un método incluye mezclar una cantidad de partículas de transducción dentro de una muestra. Las partículas de transducción se asocian con una célula diana. Las partículas de transducción no son replicativas, y se manejan para incluir una molécula de ácido nucleico formulada para provocar que la célula diana produzca una serie de moléculas indicadoras. La muestra y las partículas de transducción se mantienen para expresar la serie de moléculas indicadoras cuando la célula diana está presente en la muestra. Se recibe una señal asociada con una cantidad de las moléculas indicadoras. En algunas modalidades, una magnitud de la señal es independiente de una cantidad de la partícula de transducción por arriba de una cantidad predeterminada.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201361779177P | 2013-03-13 | 2013-03-13 | |
US13/802,461 US9481903B2 (en) | 2013-03-13 | 2013-03-13 | Systems and methods for detection of cells using engineered transduction particles |
PCT/US2014/023422 WO2014164768A1 (en) | 2013-03-13 | 2014-03-11 | Systems and methods for detection of cells using engineered transduction particles |
Publications (2)
Publication Number | Publication Date |
---|---|
MX2015011575A true MX2015011575A (es) | 2016-05-16 |
MX365093B MX365093B (es) | 2019-05-22 |
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ID=51455187
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
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MX2015011575A MX365093B (es) | 2013-03-13 | 2014-03-11 | Sistemas y metodos para la deteccion de celulas usando particulas manejadas de transduccion. |
Country Status (15)
Country | Link |
---|---|
US (6) | US9481903B2 (es) |
EP (3) | EP2972354B1 (es) |
JP (3) | JP6524057B2 (es) |
KR (3) | KR102100186B1 (es) |
CN (2) | CN107604040B (es) |
AU (3) | AU2014249022C1 (es) |
BR (1) | BR112015022322A2 (es) |
CA (1) | CA2903771C (es) |
ES (2) | ES2835228T3 (es) |
HK (1) | HK1217539A1 (es) |
MX (1) | MX365093B (es) |
NZ (2) | NZ750646A (es) |
RU (1) | RU2666926C2 (es) |
SG (3) | SG10201804883SA (es) |
WO (1) | WO2014164768A1 (es) |
Families Citing this family (54)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2012018741A2 (en) * | 2010-08-02 | 2012-02-09 | Weight Brent L | Pressurizable cartridge for polymerase chain reactions |
WO2014160418A2 (en) | 2013-03-13 | 2014-10-02 | GeneWeave Biosciences, Inc. | Non-replicative transduction particles and transduction particle-based reporter systems |
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