MX2015011575A - Sistemas y metodos para la deteccion de celulas usando particulas manejadas de transduccion. - Google Patents

Sistemas y metodos para la deteccion de celulas usando particulas manejadas de transduccion.

Info

Publication number
MX2015011575A
MX2015011575A MX2015011575A MX2015011575A MX2015011575A MX 2015011575 A MX2015011575 A MX 2015011575A MX 2015011575 A MX2015011575 A MX 2015011575A MX 2015011575 A MX2015011575 A MX 2015011575A MX 2015011575 A MX2015011575 A MX 2015011575A
Authority
MX
Mexico
Prior art keywords
transduction particles
systems
methods
engineered
cells
Prior art date
Application number
MX2015011575A
Other languages
English (en)
Other versions
MX365093B (es
Inventor
Shaunak Roy
Diego Ariel Rey
Leonardo M Teixeira
Ryan C Griswold
Damian S Matthews
Kenneth G Olson
Rick V Stellmacher
Victor H Yee
Bruce J Richardson
Original Assignee
Geneweave Biosciences Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Geneweave Biosciences Inc filed Critical Geneweave Biosciences Inc
Publication of MX2015011575A publication Critical patent/MX2015011575A/es
Publication of MX365093B publication Critical patent/MX365093B/es

Links

Classifications

    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/508Containers for the purpose of retaining a material to be analysed, e.g. test tubes rigid containers not provided for above
    • B01L3/5082Test tubes per se
    • B01L3/50825Closing or opening means, corks, bungs
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/52Containers specially adapted for storing or dispensing a reagent
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/52Containers specially adapted for storing or dispensing a reagent
    • B01L3/523Containers specially adapted for storing or dispensing a reagent with means for closing or opening
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/54Labware with identification means
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/54Labware with identification means
    • B01L3/545Labware with identification means for laboratory containers
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L7/00Heating or cooling apparatus; Heat insulating devices
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/63Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/70Vectors or expression systems specially adapted for E. coli
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/02Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving viable microorganisms
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/02Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving viable microorganisms
    • C12Q1/04Determining presence or kind of microorganism; Use of selective media for testing antibiotics or bacteriocides; Compositions containing a chemical indicator therefor
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/02Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving viable microorganisms
    • C12Q1/04Determining presence or kind of microorganism; Use of selective media for testing antibiotics or bacteriocides; Compositions containing a chemical indicator therefor
    • C12Q1/06Quantitative determination
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/02Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving viable microorganisms
    • C12Q1/04Determining presence or kind of microorganism; Use of selective media for testing antibiotics or bacteriocides; Compositions containing a chemical indicator therefor
    • C12Q1/10Enterobacteria
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/02Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving viable microorganisms
    • C12Q1/04Determining presence or kind of microorganism; Use of selective media for testing antibiotics or bacteriocides; Compositions containing a chemical indicator therefor
    • C12Q1/14Streptococcus; Staphylococcus
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/66Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving luciferase
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6897Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids involving reporter genes operably linked to promoters
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01JMEASUREMENT OF INTENSITY, VELOCITY, SPECTRAL CONTENT, POLARISATION, PHASE OR PULSE CHARACTERISTICS OF INFRARED, VISIBLE OR ULTRAVIOLET LIGHT; COLORIMETRY; RADIATION PYROMETRY
    • G01J1/00Photometry, e.g. photographic exposure meter
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/01Arrangements or apparatus for facilitating the optical investigation
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/01Arrangements or apparatus for facilitating the optical investigation
    • G01N21/03Cuvette constructions
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/01Arrangements or apparatus for facilitating the optical investigation
    • G01N21/13Moving of cuvettes or solid samples to or from the investigating station
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/75Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated
    • G01N21/76Chemiluminescence; Bioluminescence
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/75Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated
    • G01N21/76Chemiluminescence; Bioluminescence
    • G01N21/763Bioluminescence
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/00584Control arrangements for automatic analysers
    • G01N35/00722Communications; Identification
    • G01N35/00732Identification of carriers, materials or components in automatic analysers
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/10Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/02Adapting objects or devices to another
    • B01L2200/028Modular arrangements
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/16Reagents, handling or storing thereof
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00Additional constructional details
    • B01L2300/02Identification, exchange or storage of information
    • B01L2300/021Identification, e.g. bar codes
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00Additional constructional details
    • B01L2300/04Closures and closing means
    • B01L2300/041Connecting closures to device or container
    • B01L2300/042Caps; Plugs
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00Additional constructional details
    • B01L2300/04Closures and closing means
    • B01L2300/046Function or devices integrated in the closure
    • B01L2300/047Additional chamber, reservoir
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00Additional constructional details
    • B01L2300/04Closures and closing means
    • B01L2300/046Function or devices integrated in the closure
    • B01L2300/049Valves integrated in closure
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00Additional constructional details
    • B01L2300/06Auxiliary integrated devices, integrated components
    • B01L2300/0672Integrated piercing tool
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00Moving or stopping fluids
    • B01L2400/04Moving fluids with specific forces or mechanical means
    • B01L2400/0475Moving fluids with specific forces or mechanical means specific mechanical means and fluid pressure
    • B01L2400/0478Moving fluids with specific forces or mechanical means specific mechanical means and fluid pressure pistons
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00Moving or stopping fluids
    • B01L2400/06Valves, specific forms thereof
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00Moving or stopping fluids
    • B01L2400/06Valves, specific forms thereof
    • B01L2400/0677Valves, specific forms thereof phase change valves; Meltable, freezing, dissolvable plugs; Destructible barriers
    • B01L2400/0683Valves, specific forms thereof phase change valves; Meltable, freezing, dissolvable plugs; Destructible barriers mechanically breaking a wall or membrane within a channel or chamber
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N2035/00346Heating or cooling arrangements
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N2035/00346Heating or cooling arrangements
    • G01N2035/00356Holding samples at elevated temperature (incubation)
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/02Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations
    • G01N35/04Details of the conveyor system
    • G01N2035/0401Sample carriers, cuvettes or reaction vessels
    • G01N2035/0403Sample carriers with closing or sealing means
    • G01N2035/0405Sample carriers with closing or sealing means manipulating closing or opening means, e.g. stoppers, screw caps, lids or covers
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/005Assays involving biological materials from specific organisms or of a specific nature from viruses
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/195Assays involving biological materials from specific organisms or of a specific nature from bacteria

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Molecular Biology (AREA)
  • Microbiology (AREA)
  • Biophysics (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Clinical Laboratory Science (AREA)
  • Toxicology (AREA)
  • Plasma & Fusion (AREA)
  • Hematology (AREA)
  • Medicinal Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Plant Pathology (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
  • Investigating Or Analysing Biological Materials (AREA)

Abstract

En la presenten se describen sistemas y métodos para detectar y/o identificar células (o bacterias) diana usando partículas manejadas de transducción. En algunas modalidades, un método incluye mezclar una cantidad de partículas de transducción dentro de una muestra. Las partículas de transducción se asocian con una célula diana. Las partículas de transducción no son replicativas, y se manejan para incluir una molécula de ácido nucleico formulada para provocar que la célula diana produzca una serie de moléculas indicadoras. La muestra y las partículas de transducción se mantienen para expresar la serie de moléculas indicadoras cuando la célula diana está presente en la muestra. Se recibe una señal asociada con una cantidad de las moléculas indicadoras. En algunas modalidades, una magnitud de la señal es independiente de una cantidad de la partícula de transducción por arriba de una cantidad predeterminada.
MX2015011575A 2013-03-13 2014-03-11 Sistemas y metodos para la deteccion de celulas usando particulas manejadas de transduccion. MX365093B (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201361779177P 2013-03-13 2013-03-13
US13/802,461 US9481903B2 (en) 2013-03-13 2013-03-13 Systems and methods for detection of cells using engineered transduction particles
PCT/US2014/023422 WO2014164768A1 (en) 2013-03-13 2014-03-11 Systems and methods for detection of cells using engineered transduction particles

Publications (2)

Publication Number Publication Date
MX2015011575A true MX2015011575A (es) 2016-05-16
MX365093B MX365093B (es) 2019-05-22

Family

ID=51455187

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2015011575A MX365093B (es) 2013-03-13 2014-03-11 Sistemas y metodos para la deteccion de celulas usando particulas manejadas de transduccion.

Country Status (15)

Country Link
US (6) US9481903B2 (es)
EP (3) EP2972354B1 (es)
JP (3) JP6524057B2 (es)
KR (3) KR102100186B1 (es)
CN (2) CN107604040B (es)
AU (3) AU2014249022C1 (es)
BR (1) BR112015022322A2 (es)
CA (1) CA2903771C (es)
ES (2) ES2835228T3 (es)
HK (1) HK1217539A1 (es)
MX (1) MX365093B (es)
NZ (2) NZ750646A (es)
RU (1) RU2666926C2 (es)
SG (3) SG10201804883SA (es)
WO (1) WO2014164768A1 (es)

Families Citing this family (54)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2012018741A2 (en) * 2010-08-02 2012-02-09 Weight Brent L Pressurizable cartridge for polymerase chain reactions
WO2014160418A2 (en) 2013-03-13 2014-10-02 GeneWeave Biosciences, Inc. Non-replicative transduction particles and transduction particle-based reporter systems
US9481903B2 (en) 2013-03-13 2016-11-01 Roche Molecular Systems, Inc. Systems and methods for detection of cells using engineered transduction particles
US9540675B2 (en) * 2013-10-29 2017-01-10 GeneWeave Biosciences, Inc. Reagent cartridge and methods for detection of cells
FR3019895B1 (fr) * 2014-04-10 2016-05-27 Gilson Sas Systeme de pipetage multicanaux comprenant deux chambres d'aspiration imbriquees l'une dans l'autre
EP3594360B1 (en) 2014-04-24 2021-06-23 Lucira Health, Inc. Colorimetric detection of nucleic acid amplification
EP3155133B1 (en) 2014-06-13 2021-04-07 Geneweave Biosciences, Inc. Growth-independent detection of cells
CA2957938A1 (en) 2014-08-25 2016-03-03 GeneWeave Biosciences, Inc. Non-replicative transduction particles and transduction particle-based reporter systems
EP3207472A4 (en) * 2014-10-16 2018-06-20 Cepheid Biosecurity screening system and method
US10227661B2 (en) 2014-11-21 2019-03-12 GeneWeave Biosciences, Inc. Sequence-specific detection and phenotype determination
US9879328B2 (en) 2014-11-21 2018-01-30 GeneWeave Biosciences, Inc. Mechanisms of antimicrobial susceptibility
WO2016130964A1 (en) 2015-02-13 2016-08-18 Abbott Laboratories Decapping and capping apparatus, systems and methods for use in diagnostic analyzers
WO2016131859A1 (en) * 2015-02-20 2016-08-25 Ventana Medical Systems, Inc. Assembly for storing and transporting tissue samples immersed in a fluid
US10351893B2 (en) 2015-10-05 2019-07-16 GeneWeave Biosciences, Inc. Reagent cartridge for detection of cells
IL242807A0 (en) * 2015-11-26 2016-04-21 Novamed Ltd Test facility
EP3178557B1 (en) * 2015-12-11 2018-11-28 Biotage AB Device for flow control
US10718003B2 (en) * 2015-12-31 2020-07-21 Roche Molecular Systems, Inc. Detecting an analyte in a flash and glow reaction
EP3430372A4 (en) 2016-03-14 2019-10-16 Lucira Health, Inc. DEVICES AND METHODS FOR PREPARING AND DELIVERING BIOLOGICAL TEST SAMPLE
JP6937774B2 (ja) 2016-03-14 2021-09-22 ルシラ ヘルス インコーポレイテッド 生物学的アッセイを実行するためのシステムおよび方法
US11291995B2 (en) 2016-03-14 2022-04-05 Lucira Health, Inc. Selectively vented biological assay devices and associated methods
WO2017172644A2 (en) * 2016-03-28 2017-10-05 The Charles Stark Draper Laboratory, Inc. Bacteria identification and antibiotic susceptibility profiling device
US20170336397A1 (en) 2016-05-19 2017-11-23 Roche Molecular Systems, Inc. RFID Detection Systems And Methods
US20170336428A1 (en) 2016-05-19 2017-11-23 Roche Molecular Systems, Inc. RFID Tracking Systems And Methods
US11149319B2 (en) 2016-12-20 2021-10-19 Roche Molecular Systems, Inc. Systems and methods for detecting cells using engineered transduction particles
US20190099758A1 (en) * 2016-12-28 2019-04-04 Kabushiki Kaisha Dnaform Analysis device
EP3562953A1 (en) 2016-12-30 2019-11-06 Quidel Corporation Phage-mediated immunoassay and methods for determining susceptibility of bacteria to antibiotic or probiotic agents
CN116965434A (zh) 2017-02-27 2023-10-31 意优科迪有限公司 用于制作面包的设备和方法
GB201703383D0 (en) 2017-03-02 2017-04-19 Gargle Tech Ltd Testing for particulates
WO2020049569A2 (en) 2018-09-05 2020-03-12 Hero Scientific Ltd. Testing for particulates
US10520498B2 (en) 2017-03-14 2019-12-31 Becton, Dickinson And Company Devices and techniques for oral fluid collection and seroprotection testing
US11080848B2 (en) 2017-04-06 2021-08-03 Lucira Health, Inc. Image-based disease diagnostics using a mobile device
US11077444B2 (en) 2017-05-23 2021-08-03 Roche Molecular Systems, Inc. Packaging for a molecular diagnostic cartridge
US10549275B2 (en) 2017-09-14 2020-02-04 Lucira Health, Inc. Multiplexed biological assay device with electronic readout
CN111133113B (zh) 2017-09-21 2024-03-29 贝克顿·迪金森公司 有害污染物测试中的高动态范围测定物
EP3684945A4 (en) 2017-09-21 2021-09-22 Becton, Dickinson and Company SAMPLING SYSTEMS AND METHODS FOR SAMPLING HAZARDOUS CONTAMINANTS WITH HIGH EFFICIENCY
CN209624606U (zh) 2017-09-21 2019-11-12 贝克顿·迪金森公司 危险污染检测***
JP7344198B2 (ja) 2017-09-21 2023-09-13 ベクトン・ディキンソン・アンド・カンパニー 有害汚染物質の検査のための境界決め用テンプレート
JP7303799B2 (ja) 2017-09-21 2023-07-05 ベクトン・ディキンソン・アンド・カンパニー 有害汚染物質検査のための反応性分画テンプレート
CA3075766A1 (en) 2017-09-21 2019-03-28 Becton, Dickinson And Company Hazardous contaminant collection kit and rapid testing
EP3684512A4 (en) 2017-09-21 2021-06-09 Becton, Dickinson and Company EXTENDED REALITY DEVICES FOR DETECTING HAZARDOUS POLLUTION
US11008602B2 (en) 2017-12-20 2021-05-18 Roche Molecular Systems, Inc. Non-replicative transduction particles and transduction particle-based reporter systems
BR112020020949A2 (pt) * 2018-04-10 2021-03-02 Mgi Tech Co., Ltd. método de registro de imagem de fluorescência, instrumento e sistema de sequenciamento genético e meio de armazenagem
US10968491B2 (en) 2018-12-05 2021-04-06 GeneWeave Biosciences, Inc. Growth-independent detection of cells
USD910200S1 (en) 2018-12-21 2021-02-09 Lucira Health, Inc. Test tube
JP2022515833A (ja) * 2018-12-29 2022-02-22 エフ.ホフマン-ラ ロシュ アーゲー 抗生物質感受性アッセイにおける交差反応性の制限および細菌同定の改善のためのシデロマイシンの使用
WO2020159790A1 (en) 2019-01-28 2020-08-06 Becton, Dickinson And Company Hazardous contaminant collection device with integrated swab and test device
JP2023515001A (ja) 2020-02-14 2023-04-12 デノビクス・インコーポレイテッド 動的広体積範囲ピペット
WO2021226145A1 (en) * 2020-05-04 2021-11-11 Biotex, Inc. Methods and devices for pathogen detection
USD953561S1 (en) 2020-05-05 2022-05-31 Lucira Health, Inc. Diagnostic device with LED display
USD962470S1 (en) 2020-06-03 2022-08-30 Lucira Health, Inc. Assay device with LCD display
US10991185B1 (en) 2020-07-20 2021-04-27 Abbott Laboratories Digital pass verification systems and methods
WO2022149135A2 (en) 2021-01-06 2022-07-14 Hero Scientific Ltd. Filtration sampling devices
KR20220107586A (ko) 2021-01-25 2022-08-02 금오공과대학교 산학협력단 전기신호를 이용한 세포수 검출장치 및 이를 이용한 검출방법
KR20240035596A (ko) * 2021-08-31 2024-03-15 주식회사 씨젠 검체 수집 장치 및 검체 수집 방법

Family Cites Families (139)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE628679A (es) 1962-02-28
US3826574A (en) 1973-02-12 1974-07-30 Continental Distributors Nephelometer
US4057148A (en) 1974-06-25 1977-11-08 G. D. Searle & Co. Multiple sample support assembly and apparatus for facilitating radioimmunoassays and the like
GB1571466A (en) 1976-12-14 1980-07-16 Univ California Assay mehtod
CA1277931C (en) 1984-06-05 1990-12-18 Shimon Ulitzur Detection and/or identification of microorganisms in a test sample usingbioluminescence or other exogenous genetically-introduced marker
US4861709A (en) 1985-05-31 1989-08-29 Technicon Research A.G. Detection and/or identification of microorganisms in a test sample using bioluminescence or other exogenous genetically-introduced marker
US5139941A (en) 1985-10-31 1992-08-18 University Of Florida Research Foundation, Inc. AAV transduction vectors
DE3540823C1 (de) 1985-11-16 1986-10-02 Laboratorium Prof. Dr. Rudolf Berthold, 7547 Wildbad Fotometrische Messstation
EP0658564B1 (en) 1986-04-30 2002-01-16 Igen International, Inc. Electroluminescent compounds and intermediates in their synthesis
US5221623A (en) 1986-07-22 1993-06-22 Boyce Thompson Institute For Plant Research, Inc. Use of bacterial luciferase structural genes for cloning and monitoring gene expression in microorganisms and for tagging and identification of genetically engineered organisms
AU7751687A (en) 1986-07-22 1988-02-10 Boyce Thompson Institute For Plant Research Inc. Use of bacterial luciferase structural genes for cloning and monitoring gene expression in microorganisms and for tagging and identification of genetically engineered organisms
US5128104A (en) 1987-04-27 1992-07-07 Murphy Harold R Cuvette for automated testing machine
ATE149208T1 (de) * 1988-10-04 1997-03-15 Dna Plant Techn Corp Bakterieller nachweis durch phagentransduktion von nachweisbaren phenotypen
FR2641793B1 (fr) 1988-12-26 1993-10-01 Setratech Procede de recombinaison in vivo de sequences d'adn presentant des mesappariements de bases
US5139745A (en) 1990-03-30 1992-08-18 Block Medical, Inc. Luminometer
GB9017443D0 (en) 1990-08-09 1990-09-26 Amersham Int Plc Reporter bacteria for rapid microbial detection
US5188455A (en) 1990-11-13 1993-02-23 The Pennsylvania Research Corporation Apparatus for remote mixing of fluids
US5086233A (en) 1991-01-22 1992-02-04 Dynatech Corporation Luminometers with sample container displacement controlled by ramped abutment
US5252479A (en) 1991-11-08 1993-10-12 Research Corporation Technologies, Inc. Safe vector for gene therapy
US6300061B1 (en) 1992-02-07 2001-10-09 Albert Einstein College Of Medicine Of Yeshiva University Mycobacterial species-specific reporter mycobacteriophages
US5242660A (en) 1992-02-28 1993-09-07 Paul Hsei Sample preparation device
US5364591A (en) 1992-06-01 1994-11-15 Eastman Kodak Company Device for moving a target-bearing solid through a liquid for detection while being contained
JPH0634546A (ja) 1992-07-17 1994-02-08 Tosoh Corp 蛍光検出器
JP2936973B2 (ja) * 1993-09-17 1999-08-23 東洋紡績株式会社 発光測定装置
AU687363B2 (en) 1993-03-19 1998-02-26 Ciba Corning Diagnostics Corp. Luminometer
US5494646A (en) 1993-04-14 1996-02-27 Seymour; Eugene H. Sampling device and sample adequacy system
AU6905294A (en) 1993-04-29 1994-11-21 Albert Einstein College Of Medicine Of Yeshiva University Mycobacterial species-specific reporter mycobacteriophages
GB2281966B (en) 1993-09-07 1997-06-04 Biotrace Ltd Bio-luminescence monitoring method
US5645801A (en) 1993-10-21 1997-07-08 Abbott Laboratories Device and method for amplifying and detecting target nucleic acids
DE4423935C2 (de) 1994-07-07 1998-02-05 Deutsche Forsch Luft Raumfahrt Küvette zur mikroskopischen oder makroskopischen Beobachtung einer biologischen Probe
JP2675532B2 (ja) 1994-12-20 1997-11-12 株式会社バイオセンサー研究所 化学発光測定装置
US5656424A (en) 1995-02-15 1997-08-12 Albert Einstein College Of Medicine, A Division Of Yeshiva University Identification of mycobacterium tuberculosis complex species
US5476768A (en) 1995-03-10 1995-12-19 Becton, Dickinson And Company Mycobacteriophage DSGA specific for the mycobacterium tuberculosis complex
DE19517940A1 (de) 1995-05-18 1996-11-21 Merck Patent Gmbh Nachweis von Listerien mittels rekombinanter Bakteriophagen
EP0773830A1 (en) 1995-06-07 1997-05-21 Becton, Dickinson and Company Device and method for phage-based antibiotic susceptibility testing
US5730938A (en) 1995-08-09 1998-03-24 Bio-Chem Laboratory Systems, Inc. Chemistry analyzer
US5814022A (en) 1996-02-06 1998-09-29 Plasmaseal Llc Method and apparatus for applying tissue sealant
US5677124A (en) 1996-07-03 1997-10-14 Ambion, Inc. Ribonuclease resistant viral RNA standards
US5939262A (en) 1996-07-03 1999-08-17 Ambion, Inc. Ribonuclease resistant RNA preparation and utilization
US5905029A (en) 1997-02-19 1999-05-18 Fritz Berthold Method for rapid hygiene testing
US5917592A (en) * 1997-02-28 1999-06-29 Charm Sciences, Inc. Photometer, and test sample holder for use therein, method and system
US6410275B1 (en) 1997-05-02 2002-06-25 Biomerieux, Inc. Disposable test devices for performing nucleic acid amplification reactions
US5989499A (en) 1997-05-02 1999-11-23 Biomerieux, Inc. Dual chamber disposable reaction vessel for amplification reactions
SE9702005D0 (sv) 1997-05-28 1997-05-28 Alphahelix Ab New reaction vessel and method for its use
US6326208B1 (en) 1997-07-17 2001-12-04 Synermed International Inc. Assay for total and direct bilirubin
US6003566A (en) 1998-02-26 1999-12-21 Becton Dickinson And Company Vial transferset and method
AU2638199A (en) * 1998-03-02 1999-09-20 Biosensing Technologies Ltd. Luminescent microbe assay
DE60014987T2 (de) 1999-02-22 2005-11-10 Matsushita Electric Industrial Co., Ltd., Kadoma Verfahren zum Nachweis von Bakterien
US6818185B1 (en) 1999-05-28 2004-11-16 Cepheid Cartridge for conducting a chemical reaction
US6271034B1 (en) 1999-07-08 2001-08-07 Albert Einstein College Of Medicine Of Yeshiva University One step allelic exchange in mycobacteria using in vitro generated conditional transducing phages
US6737266B1 (en) 1999-10-01 2004-05-18 3M Innovative Properties Company Devices and methods for microorganism detection
US7160511B2 (en) 2000-02-18 2007-01-09 Olympus Corporation Liquid pipetting apparatus and micro array manufacturing apparatus
US6548018B2 (en) * 2000-03-31 2003-04-15 Neogen Corporation Apparatus for chemiluminescent assays
JP2001337039A (ja) * 2000-05-26 2001-12-07 Dkk Toa Corp 発光検出装置
US8216797B2 (en) 2001-02-07 2012-07-10 Massachusetts Institute Of Technology Pathogen detection biosensor
GB0108830D0 (en) 2001-04-09 2001-05-30 Univ Nottingham Controlling DNA packaging
RS50219B (sr) * 2001-05-09 2009-07-15 Axis-Shield Asa, Sistem analize
US6544729B2 (en) 2001-07-20 2003-04-08 University Of Tennessee Bioluminescent biosensor device
ES2559668T3 (es) 2001-09-27 2016-02-15 Gangagen, Inc. Bacteriófagos deficientes en lisina, que tienen inmunogenicidad reducida
US20030148335A1 (en) 2001-10-10 2003-08-07 Li Shen Detecting targets by unique identifier nucleotide tags
US20030097824A1 (en) 2001-10-19 2003-05-29 Monogen, Inc. Specimen vial sealing apparatus and method
AU2002365188A1 (en) 2001-11-07 2003-07-30 Musc Foundation For Research Development Nucleic acid delivery and expression
EP1451560B1 (en) 2001-12-06 2017-11-29 BioControl Systems, Inc. Sample collection and testing system
US20030148536A1 (en) 2002-02-04 2003-08-07 Chi-Wang Liang Chemiluminescence analyzer
US6902704B2 (en) * 2002-02-28 2005-06-07 Equistar Chemicals, L.P Injection pump assembly for a combinatorial reactor and related method
US8216780B2 (en) 2002-04-12 2012-07-10 Microphage (Tm) Incorporated Method for enhanced sensitivity in bacteriophage-based diagnostic assays
US20050003346A1 (en) 2002-04-12 2005-01-06 Colorado School Of Mines Apparatus and method for detecting microscopic living organisms using bacteriophage
US7166425B2 (en) 2002-04-12 2007-01-23 Colorado School Of Mines Method for detecting low concentrations of a target bacterium that uses phages to infect target bacterial cells
WO2004005553A1 (en) 2002-07-10 2004-01-15 Massachusetts Institute Of Technology Apparatus and method for isolating a nucleic acid from a sample
SE0203366L (sv) 2002-11-14 2003-11-04 Magnetic Biosolutions Sweden A Pipetteringsapparat
US7238520B2 (en) * 2002-12-04 2007-07-03 Smiths Detection Inc. PCR sample preparation holder and method
US7125727B2 (en) 2003-01-29 2006-10-24 Protedyne Corporation Sample handling tool with piezoelectric actuator
DE10319045A1 (de) 2003-04-25 2004-12-09 november Aktiengesellschaft Gesellschaft für Molekulare Medizin Vorrichtung und Verfahren zur Aufbereitung Biopolymerhaltiger Flüssigkeiten
FI20030867A (fi) 2003-06-10 2004-12-11 Wallac Oy Optinen mittausmenetelmä ja laboratoriomittauslaite
EP3718635A1 (en) 2003-07-31 2020-10-07 Handylab, Inc. Processing particle-containing samples
US7517495B2 (en) 2003-08-25 2009-04-14 Inverness Medical Switzerland Gmbh Biological specimen collection and analysis system
US20070020240A1 (en) 2003-10-06 2007-01-25 Gangagen, Inc. Defined dose therapeutic phage
FR2860731B1 (fr) 2003-10-14 2006-01-21 Maxmat S A Appareil de mixage d'un analyseur chimique ou biochimique avec entrainement pendulaire d'une pipette
US20050119589A1 (en) 2003-11-14 2005-06-02 Tung Hsiaoho E. Rapid sample collection and analysis device and methods of use
DE102004003434B4 (de) 2004-01-21 2006-06-08 Eppendorf Ag Pipettiervorrichtung mit einer Verdrängungseinrichtung und einer damit lösbar verbundenen Antriebseinrichtung
US8101431B2 (en) 2004-02-27 2012-01-24 Board Of Regents, The University Of Texas System Integration of fluids and reagents into self-contained cartridges containing sensor elements and reagent delivery systems
US20060257991A1 (en) 2004-02-27 2006-11-16 Mcdevitt John T Integration of fluids and reagents into self-contained cartridges containing particle-based sensor elements and membrane-based sensor elements
AU2005324479A1 (en) * 2004-04-07 2006-07-20 The Government Of The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Reporter plasmid phage packaging system for detection of bacteria
RU2006139643A (ru) 2004-04-09 2008-05-20 Ресерч Тинк Тэнк, Инк. (Us) Способ сбора, хранения и транспортировки биологических образцов и устройство для его осуществления
US7674621B2 (en) 2004-05-21 2010-03-09 The United States Of America As Represented By The Department Of Health And Human Services Plasmids and phages for homologous recombination and methods of use
AU2005259411A1 (en) 2004-07-06 2006-01-12 Mixis France S.A. Generation of recombinant genes in bacteriophages
WO2006137847A2 (en) 2004-09-13 2006-12-28 Trustees Of Boston University Engineered enzymatically active bacteriophages and methods of uses thereof
US20060068398A1 (en) 2004-09-24 2006-03-30 Cepheid Universal and target specific reagent beads for nucleic acid amplification
US7244612B2 (en) 2004-10-07 2007-07-17 University Of Wyoming Template reporter bacteriophage platform and multiple bacterial detection assays based thereon
KR100668310B1 (ko) 2004-11-01 2007-01-12 삼성전자주식회사 표적 세포 특이적 바이러스를 이용하여 표적 세포의존재를 검출하는 방법
CN101080349A (zh) 2004-11-04 2007-11-28 Viz企业有限责任公司 多室容器及其盖
WO2006053588A1 (en) * 2004-11-17 2006-05-26 Agilent Technologies, Inc. Supply arrangement with supply reservoir element and fluidic device
EP1849012A2 (en) 2005-01-28 2007-10-31 Parker-Hannifin Corporation Sampling probe, gripper and interface for laboratory sample management systems
JP5123660B2 (ja) 2005-03-30 2013-01-23 オリンパス株式会社 測定装置
US8092990B2 (en) 2005-03-31 2012-01-10 Colorado School Of Mines Apparatus and method for detecting microscopic organisms using bacteriophage
US20110097702A1 (en) 2005-03-31 2011-04-28 Voorhees Kent J Methods and compositions for in situ detection of microorganisms on a surface
CA2610793A1 (en) 2005-05-31 2007-05-10 Labnow, Inc. Methods and compositions related to determination and use of white blood cell counts
JP2009508490A (ja) 2005-09-15 2009-03-05 マイクロファージ・インコーポレーテッド バクテリオファージを用いた、微生物同定のための方法および装置
US20070072174A1 (en) 2005-09-28 2007-03-29 Sayler Gary S Bioreporter for detection of microbes
US7727473B2 (en) 2005-10-19 2010-06-01 Progentech Limited Cassette for sample preparation
US20070178450A1 (en) 2006-01-27 2007-08-02 Microphage (Tm) Incorporation Method and apparatus for determining level of microorganisms using bacteriophage
US20080003564A1 (en) 2006-02-14 2008-01-03 Iquum, Inc. Sample processing
WO2007115378A1 (en) 2006-04-11 2007-10-18 Minifab (Australia) Pty Ltd Microfluidic package housing
AU2007256364A1 (en) 2006-06-09 2007-12-13 Bio Pur Ag A method for the detection of enzymatic reactions
US20070292397A1 (en) 2006-06-19 2007-12-20 Mcnulty Amy K Method for the detection and neutralization of bacteria
WO2008049036A2 (en) 2006-10-17 2008-04-24 Zymera, Inc. Enzyme detection system with caged substrates
WO2008063838A2 (en) 2006-10-31 2008-05-29 Microphage Incorporated Method and apparatus for enhanced bacteriophage-based diagnostic assays by selective inhibition of potential cross-reactive organisms
CN101568636A (zh) 2006-11-02 2009-10-28 威腾技术公司 用于诊断性检测的模块
ITPD20060419A1 (it) 2006-11-13 2008-05-14 Federico Nalesso Dispositivo per il trattamento manutentivo di cateteri venosi centrali
US8355132B2 (en) 2007-04-06 2013-01-15 Qiagen Gaithersburg, Inc. Sample adequacy measurement system having a plurality of sample tubes and using turbidity light scattering techniques
WO2008131230A1 (en) 2007-04-18 2008-10-30 Cornell University Microorganism detection method and apparatus
JP5026849B2 (ja) * 2007-04-20 2012-09-19 株式会社日立製作所 化学発光計測装置
US8454895B2 (en) 2007-05-03 2013-06-04 Nanyang Technological University Online contaminant detection and removal system
CA2690809A1 (en) 2007-06-15 2008-12-24 Microphage Incorporated Method of detection of microorganisms with enhanced bacteriophage amplification
JP2011505011A (ja) 2007-11-28 2011-02-17 スマート チューブ,インコーポレイテッド 生体試料の採取、刺激、安定化及び分析のためのデバイス、システム及び方法
US8619257B2 (en) 2007-12-13 2013-12-31 Kimberley-Clark Worldwide, Inc. Recombinant bacteriophage for detection of nosocomial infection
US8153119B2 (en) 2007-12-18 2012-04-10 Trustees Of Boston University Engineered enzymatically active bacteriophage and methods for dispersing biofilms
WO2009137136A2 (en) 2008-02-15 2009-11-12 Trustees Of Boston University In vivo gene sensors
US8865399B2 (en) 2008-05-14 2014-10-21 Guild Associates, Inc. Phage-mediated bioluminescent detection of Yersinia pestis
EP3501384A3 (en) 2008-05-20 2019-10-16 University Health Network Method for fluorescence-based imaging and monitoring
US20120134975A1 (en) 2008-08-13 2012-05-31 Searete Llc, A Limited Liability Corporation Of The State Of Delaware Biological targeting compositions and methods of using the same
JP2010107418A (ja) * 2008-10-31 2010-05-13 Optex Co Ltd 光測定方法および装置
US8748122B2 (en) 2008-12-16 2014-06-10 BIO MéRIEUX, INC. Methods for the characterization of microorganisms on solid or semi-solid media
WO2010075441A1 (en) 2008-12-22 2010-07-01 Trustees Of Boston University Modular nucleic acid-based circuits for counters, binary operations, memory, and logic
JP2010151510A (ja) 2008-12-24 2010-07-08 Tdk Corp 液性測定装置
US10316000B2 (en) 2009-02-18 2019-06-11 Cornell University Coupled recognition/detection system for in vivo and in vitro use
EP2302029A1 (en) * 2009-09-29 2011-03-30 Fundacion Gaiker Portable enrichment, aliquoting, and testing device of microorganisms and toxins
US20110183314A1 (en) 2010-01-26 2011-07-28 Microphage Incorporated Bacteriophage-based microorganism diagnostic assay using speed or acceleration of bacteriophage reproduction
CA2977845C (en) * 2010-02-23 2020-08-04 Luminex Corporation Apparatus and methods for integrated sample preparation, reaction and detection
TW201217783A (en) 2010-09-15 2012-05-01 Mbio Diagnostics Inc System and method for detecting multiple molecules in one assay
EP2705130B1 (en) 2011-05-04 2016-07-06 Luminex Corporation Apparatus and methods for integrated sample preparation, reaction and detection
WO2012155097A2 (en) 2011-05-11 2012-11-15 Luminex Corporation Systems and methods for producing an evaporation barrier in a reaction chamber
WO2012175637A1 (en) 2011-06-22 2012-12-27 INSERM (Institut National de la Santé et de la Recherche Médicale) Method for detecting the presence of carbapenemase-producing bacteria in a sample
WO2013049121A2 (en) 2011-09-26 2013-04-04 Sample6 Technologies, Inc. Recombinant phage and methods
US9075042B2 (en) 2012-05-15 2015-07-07 Wellstat Diagnostics, Llc Diagnostic systems and cartridges
EP2863733B1 (en) 2012-06-20 2019-05-08 Advanced Animal Diagnostics, Inc. Sample collection and transfer assembly and related methods
WO2014160418A2 (en) 2013-03-13 2014-10-02 GeneWeave Biosciences, Inc. Non-replicative transduction particles and transduction particle-based reporter systems
US9481903B2 (en) 2013-03-13 2016-11-01 Roche Molecular Systems, Inc. Systems and methods for detection of cells using engineered transduction particles
US9540675B2 (en) 2013-10-29 2017-01-10 GeneWeave Biosciences, Inc. Reagent cartridge and methods for detection of cells

Also Published As

Publication number Publication date
US20170152576A1 (en) 2017-06-01
US9133497B2 (en) 2015-09-15
JP2021087445A (ja) 2021-06-10
CN107604040B (zh) 2021-07-20
RU2666926C2 (ru) 2018-09-13
NZ711573A (en) 2019-09-27
US9546391B2 (en) 2017-01-17
JP7145254B2 (ja) 2022-09-30
AU2014249022B2 (en) 2018-07-05
US20140272928A1 (en) 2014-09-18
JP6843915B2 (ja) 2021-03-17
ES2835228T3 (es) 2021-06-22
WO2014164768A1 (en) 2014-10-09
AU2014249022C1 (en) 2019-02-07
BR112015022322A2 (pt) 2017-07-18
US20190194765A1 (en) 2019-06-27
CN105209915B (zh) 2017-10-24
KR102100186B1 (ko) 2020-04-14
EP3734279A1 (en) 2020-11-04
CN105209915A (zh) 2015-12-30
JP2019162115A (ja) 2019-09-26
US20150132795A1 (en) 2015-05-14
EP2972354A4 (en) 2016-09-14
US9481903B2 (en) 2016-11-01
JP2016519566A (ja) 2016-07-07
SG10201911550TA (en) 2020-02-27
CA2903771C (en) 2021-08-17
AU2014249022A1 (en) 2015-09-17
CA2903771A1 (en) 2014-10-09
NZ750646A (en) 2019-09-27
US20150148261A1 (en) 2015-05-28
AU2018203991A1 (en) 2018-06-28
KR20150126921A (ko) 2015-11-13
EP2972354A1 (en) 2016-01-20
RU2015143532A (ru) 2017-04-19
US10240212B2 (en) 2019-03-26
MX365093B (es) 2019-05-22
SG11201506977SA (en) 2015-10-29
KR102060220B1 (ko) 2020-02-11
AU2018203991B2 (en) 2018-08-09
JP6524057B2 (ja) 2019-06-05
EP3401680A1 (en) 2018-11-14
SG10201804883SA (en) 2018-07-30
ES2703601T3 (es) 2019-03-11
AU2018214156B1 (en) 2018-09-20
KR20200028035A (ko) 2020-03-13
US8829473B1 (en) 2014-09-09
US20140273180A1 (en) 2014-09-18
KR102189517B1 (ko) 2020-12-14
KR20190141788A (ko) 2019-12-24
HK1217539A1 (zh) 2017-01-13
CN107604040A (zh) 2018-01-19
EP2972354B1 (en) 2018-10-03
EP3401680B1 (en) 2020-09-30

Similar Documents

Publication Publication Date Title
MX2015011575A (es) Sistemas y metodos para la deteccion de celulas usando particulas manejadas de transduccion.
GB2516196A8 (en) Methods, compositions, kits, and systems for selective enrichment of target cells
IN2015DN01126A (es)
MX2016016902A (es) Metodos para analizar acidos nucleicos de celulas individuales o poblaciones de celulas.
IN2014DN09784A (es)
SG10201806890VA (en) Massively parallel single cell analysis
MX2015011446A (es) Partículas de transducción no replicativas y sistemas indicadores a base de partículas de transducción.
EP3529357A4 (en) METHODS AND SYSTEMS FOR ENCODING NUCLEIC ACID MOLECULES FROM INDIVIDUAL CELLS OR CELL POPULATIONS
GB2519906A (en) Methods and systems for detecting biological components
NZ615154A (en) Micro-organism threat detection
EP4303314A3 (en) Polypeptide tagged nucleotides and use thereof in nucleic acid sequencing by nanopore detection
NZ711033A (en) Nanofluidic devices for the rapid mapping of whole genomes and related systems and methods of analysis
TW201614073A (en) Non-replicative transduction particles and transduction particle-based reporter systems
WO2014152048A3 (en) Assemblies and methods for reducing optical crosstalk in particle processing systems
WO2012042374A3 (en) Method of determining number or concentration of molecules
WO2013050881A3 (en) Direct nucleic acid analysis
PH12014502581A1 (en) Aptamer-based mulitiplexed assays
WO2011088014A3 (en) Systems and methods for counting cells and biomolecules
WO2011094572A3 (en) Hanging drop devices, systems and/or methods
SG10201903822XA (en) Method for the enrichment of circulating tumor dna
WO2013166338A3 (en) Cell capture system and use thereof
MX2015001961A (es) Metodos y sistemas para ensayos.
PH12016500300A1 (en) Methods for measuring enzyme activity useful in determining cell viability in non-purified samples
EP3543362A3 (en) Pcr primer set for bacterial dna amplification, kit for detecting and/or identifying bacterial species, and method for detecting and/or identifying bacterial species
WO2012040603A3 (en) Use of diazolidinyl urea for anti-clumping of biological samples

Legal Events

Date Code Title Description
FG Grant or registration