MX2015011507A - Thioesterases and cells for production of tailored oils. - Google Patents

Thioesterases and cells for production of tailored oils.

Info

Publication number
MX2015011507A
MX2015011507A MX2015011507A MX2015011507A MX2015011507A MX 2015011507 A MX2015011507 A MX 2015011507A MX 2015011507 A MX2015011507 A MX 2015011507A MX 2015011507 A MX2015011507 A MX 2015011507A MX 2015011507 A MX2015011507 A MX 2015011507A
Authority
MX
Mexico
Prior art keywords
genes
cells
thioesterases
production
fatty acid
Prior art date
Application number
MX2015011507A
Other languages
Spanish (es)
Inventor
Scott Franklin
George N Rudenko
Jason Casolari
Original Assignee
Solazyme Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US13/837,996 external-priority patent/US9290749B2/en
Application filed by Solazyme Inc filed Critical Solazyme Inc
Publication of MX2015011507A publication Critical patent/MX2015011507A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/16—Hydrolases (3) acting on ester bonds (3.1)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/82—Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
    • C12N15/8241—Phenotypically and genetically modified plants via recombinant DNA technology
    • C12N15/8242—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits
    • C12N15/8243—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits involving biosynthetic or metabolic pathways, i.e. metabolic engineering, e.g. nicotine, caffeine
    • C12N15/8247—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits involving biosynthetic or metabolic pathways, i.e. metabolic engineering, e.g. nicotine, caffeine involving modified lipid metabolism, e.g. seed oil composition
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/64—Fats; Fatty oils; Ester-type waxes; Higher fatty acids, i.e. having at least seven carbon atoms in an unbroken chain bound to a carboxyl group; Oxidised oils or fats
    • C12P7/6409—Fatty acids
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y301/00—Hydrolases acting on ester bonds (3.1)
    • C12Y301/02—Thioester hydrolases (3.1.2)
    • C12Y301/02014—Oleoyl-[acyl-carrier-protein] hydrolase (3.1.2.14), i.e. ACP-thioesterase
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02E—REDUCTION OF GREENHOUSE GAS [GHG] EMISSIONS, RELATED TO ENERGY GENERATION, TRANSMISSION OR DISTRIBUTION
    • Y02E50/00—Technologies for the production of fuel of non-fossil origin
    • Y02E50/10—Biofuels, e.g. bio-diesel

Abstract

The invention features plant acyl-ACP thioesterase genes of the FatB class and proteins encoded by these genes. The genes are useful for constructing recombinant host cells having altered fatty acid profiles. Oleaginous microalga host cells with the new genes or previously identified FatB genes are disclosed. The microalgae cells produce triglycerides with useful fatty acid profiles.
MX2015011507A 2013-03-15 2014-03-13 Thioesterases and cells for production of tailored oils. MX2015011507A (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US201361791861P 2013-03-15 2013-03-15
US13/837,996 US9290749B2 (en) 2013-03-15 2013-03-15 Thioesterases and cells for production of tailored oils
US201361917217P 2013-12-17 2013-12-17
PCT/US2014/026644 WO2014151904A1 (en) 2013-03-15 2014-03-13 Thioesterases and cells for production of tailored oils

Publications (1)

Publication Number Publication Date
MX2015011507A true MX2015011507A (en) 2016-04-07

Family

ID=51581068

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2015011507A MX2015011507A (en) 2013-03-15 2014-03-13 Thioesterases and cells for production of tailored oils.

Country Status (9)

Country Link
EP (1) EP2971024A4 (en)
JP (1) JP2016518112A (en)
KR (1) KR20150128770A (en)
CN (1) CN105143458A (en)
AU (2) AU2014236763B2 (en)
BR (1) BR112015023192A8 (en)
CA (1) CA2904395A1 (en)
MX (1) MX2015011507A (en)
WO (1) WO2014151904A1 (en)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9816079B2 (en) 2013-01-29 2017-11-14 Terravia Holdings, Inc. Variant thioesterases and methods of use
US9567615B2 (en) 2013-01-29 2017-02-14 Terravia Holdings, Inc. Variant thioesterases and methods of use
US9290749B2 (en) 2013-03-15 2016-03-22 Solazyme, Inc. Thioesterases and cells for production of tailored oils
US9783836B2 (en) 2013-03-15 2017-10-10 Terravia Holdings, Inc. Thioesterases and cells for production of tailored oils
WO2016014968A1 (en) * 2014-07-24 2016-01-28 Solazyme, Inc. Variant thioesterases and methods of use
WO2016044779A2 (en) * 2014-09-18 2016-03-24 Solazyme, Inc. Acyl-acp thioesterases and mutants thereof
US20180142218A1 (en) 2016-10-05 2018-05-24 Terravia Holdings, Inc. Novel acyltransferases, variant thioesterases, and uses thereof
WO2021146520A1 (en) 2020-01-16 2021-07-22 Corbion Biotech, Inc. β-KETOACYL-ACP SYNTHASE IV VARIANTS

Family Cites Families (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5512482A (en) 1990-04-26 1996-04-30 Calgene, Inc. Plant thioesterases
US5344771A (en) 1990-04-26 1994-09-06 Calgene, Inc. Plant thiosterases
US5298421A (en) 1990-04-26 1994-03-29 Calgene, Inc. Plant medium-chain-preferring acyl-ACP thioesterases and related methods
US5455167A (en) 1991-05-21 1995-10-03 Calgene Inc. Medium-chain thioesterases in plants
US5639790A (en) 1991-05-21 1997-06-17 Calgene, Inc. Plant medium-chain thioesterases
US5654495A (en) 1992-10-30 1997-08-05 Calgene, Inc. Production of myristate in plant cells
US5850022A (en) 1992-10-30 1998-12-15 Calgene, Inc. Production of myristate in plant cells
US5910631A (en) * 1993-09-03 1999-06-08 Max-Planck-Gesellschaft Zur Forderung Der Wissenschaften E.V. Middle chain-specific thioesterase genes from Cuphea lanceolata
CA2176137A1 (en) 1993-11-10 1995-05-18 Alois Toni Voelker Plant acyl acp thioesterase sequences
US5807893A (en) 1993-11-18 1998-09-15 Voelker; Toni Alois Plant thioesterases and use for modification of fatty acid composition in plant seed oils
US20090061493A1 (en) 2007-06-01 2009-03-05 Solazyme, Inc. Lipid Pathway Modification in Oil-Bearing Microorganisms
DK2167667T3 (en) * 2007-07-09 2015-07-27 Bayer Cropscience Nv Brassica plant comprising the mutant fatty acyl-ACP thioesterase alleles
US7982035B2 (en) 2007-08-27 2011-07-19 Duquesne University Of The Holy Spirit Tricyclic compounds having antimitotic and/or antitumor activity and methods of use thereof
US20110099669A1 (en) * 2008-06-20 2011-04-28 Basf Plant Science Gmbh Plants having enhanced yield-related traits and a method for making the same
BRPI0921539A2 (en) 2008-11-28 2020-08-04 Solazyme, Inc. cell, triglyceride oil composition, oil blend, method of preparing a fuel by processing the oil, and fuel
WO2010118409A1 (en) * 2009-04-10 2010-10-14 Ls9, Inc. Production of commercial biodiesel from genetically modified microorganisms
SG185780A1 (en) 2010-05-28 2013-01-30 Solazyme Inc Tailored oils produced from recombinant heterotrophic microorganisms
EP3643774A1 (en) 2011-02-02 2020-04-29 Corbion Biotech, Inc. Tailored oils produced from recombinant oleaginous microorganisms
US8951762B2 (en) * 2011-07-27 2015-02-10 Iowa State University Research Foundation, Inc. Materials and methods for using an acyl—acyl carrier protein thioesterase and mutants and chimeras thereof in fatty acid synthesis
CN102586350A (en) 2012-01-09 2012-07-18 北京化工大学 Production method for C8:0/C10:0/C12:0/C14:0 medium-chain fatty acid and ethyl ester thereof
AU2013249172C1 (en) 2012-04-18 2017-08-10 Corbion Biotech, Inc. Tailored oils

Also Published As

Publication number Publication date
JP2016518112A (en) 2016-06-23
BR112015023192A8 (en) 2018-01-02
CN105143458A (en) 2015-12-09
KR20150128770A (en) 2015-11-18
EP2971024A4 (en) 2016-11-16
WO2014151904A1 (en) 2014-09-25
AU2018267601A1 (en) 2018-12-06
AU2014236763B2 (en) 2018-08-23
BR112015023192A2 (en) 2017-11-21
EP2971024A1 (en) 2016-01-20
CA2904395A1 (en) 2014-09-25
AU2014236763A1 (en) 2015-10-01

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