MX2014015345A - Inhibidores piranopiridona de tanquirasa. - Google Patents
Inhibidores piranopiridona de tanquirasa.Info
- Publication number
- MX2014015345A MX2014015345A MX2014015345A MX2014015345A MX2014015345A MX 2014015345 A MX2014015345 A MX 2014015345A MX 2014015345 A MX2014015345 A MX 2014015345A MX 2014015345 A MX2014015345 A MX 2014015345A MX 2014015345 A MX2014015345 A MX 2014015345A
- Authority
- MX
- Mexico
- Prior art keywords
- pyranopyridone
- tankyrase
- inhibitors
- compounds
- activity
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
- C07D491/044—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
- C07D491/052—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring the oxygen-containing ring being six-membered
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/10—Spiro-condensed systems
- C07D491/107—Spiro-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/12—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains three hetero rings
- C07D491/14—Ortho-condensed systems
- C07D491/147—Ortho-condensed systems the condensed system containing one ring with oxygen as ring hetero atom and two rings with nitrogen as ring hetero atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/12—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains three hetero rings
- C07D491/14—Ortho-condensed systems
- C07D491/153—Ortho-condensed systems the condensed system containing two rings with oxygen as ring hetero atom and one ring with nitrogen as ring hetero atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
- C07D495/14—Ortho-condensed systems
Abstract
Se proporcionan compuestos de fórmula: (ver Fórmulas) o una sal farmacéuticamente aceptable de los mismos, en los que X, M, Y, R1 y R2 son tal como se define en la presente memoria. Los compuestos presentan actividad como agentes anticáncer.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201261661915P | 2012-06-20 | 2012-06-20 | |
PCT/EP2013/062563 WO2013189904A1 (en) | 2012-06-20 | 2013-06-18 | Pyranopyridone inhibitors of tankyrase |
Publications (1)
Publication Number | Publication Date |
---|---|
MX2014015345A true MX2014015345A (es) | 2015-03-05 |
Family
ID=48628700
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2014015345A MX2014015345A (es) | 2012-06-20 | 2013-06-18 | Inhibidores piranopiridona de tanquirasa. |
Country Status (12)
Country | Link |
---|---|
US (1) | US20140121231A1 (es) |
EP (1) | EP2864335A1 (es) |
JP (1) | JP2015520204A (es) |
KR (1) | KR20150009599A (es) |
CN (1) | CN104284898A (es) |
AR (1) | AR091520A1 (es) |
BR (1) | BR112014031785A2 (es) |
CA (1) | CA2869239A1 (es) |
HK (1) | HK1201066A1 (es) |
MX (1) | MX2014015345A (es) |
RU (1) | RU2014152792A (es) |
WO (1) | WO2013189904A1 (es) |
Families Citing this family (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2013132253A1 (en) | 2012-03-07 | 2013-09-12 | Institute Of Cancer Research: Royal Cancer Hospital (The) | 3-aryl-5-substituted-isoquinolin-1-one compounds and their therapeutic use |
RU2014152790A (ru) * | 2012-06-20 | 2016-08-10 | Ф. Хоффманн-Ля Рош Аг | Пирролопиразоновые ингибиторы танкиразы |
WO2014087165A1 (en) * | 2012-12-06 | 2014-06-12 | University Of Bath | Tankyrase inhibitors |
JP6456392B2 (ja) | 2013-09-11 | 2019-01-23 | インスティチュート オブ キャンサー リサーチ:ロイヤル キャンサー ホスピタル | 3−アリール−5−置換イソキノリン−1−オン化合物及びその治療的使用 |
CN106536478A (zh) * | 2014-05-22 | 2017-03-22 | 悉尼大学 | ω‑3类似物 |
US10722484B2 (en) | 2016-03-09 | 2020-07-28 | K-Gen, Inc. | Methods of cancer treatment |
Family Cites Families (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2003014121A1 (en) * | 2001-08-07 | 2003-02-20 | Guilford Pharmaceuticals Inc. | Compounds, derivatives, compositions, preparation and uses |
WO2005082368A1 (en) * | 2004-02-26 | 2005-09-09 | Inotek Pharmaceuticals Corporation | Isoquinoline derivatives and methods of use thereof |
US20060079510A1 (en) * | 2004-09-30 | 2006-04-13 | Kristoffer Hellstrand | Use of PARP-1 inhibitors for protecting tumorcidal lymphocytes from apoptosis |
US7576080B2 (en) | 2004-12-23 | 2009-08-18 | Memory Pharmaceuticals Corporation | Certain thienopyrimidine derivatives as phosphodiesterase 10 inhibitors |
AU2006232660B2 (en) | 2005-04-05 | 2010-03-25 | F. Hoffmann-La Roche Ag | 1H-Pyrazole 4-Carboxylamides, their preparation and their use as 11Beta-hydroxysteroid dehydrogenase |
US20080242861A1 (en) | 2007-04-02 | 2008-10-02 | Chi-Feng Yen | Synthesis of amino-protected cyclohexane-1,4-diyldimethanamine and its derivatives |
AU2009274454A1 (en) | 2008-04-21 | 2010-01-28 | Merck Sharp & Dohme Corp. | Inhibitors of janus kinases |
-
2013
- 2013-06-18 BR BR112014031785A patent/BR112014031785A2/pt not_active IP Right Cessation
- 2013-06-18 CA CA2869239A patent/CA2869239A1/en not_active Abandoned
- 2013-06-18 KR KR20147035760A patent/KR20150009599A/ko not_active Application Discontinuation
- 2013-06-18 JP JP2015517716A patent/JP2015520204A/ja active Pending
- 2013-06-18 WO PCT/EP2013/062563 patent/WO2013189904A1/en active Application Filing
- 2013-06-18 MX MX2014015345A patent/MX2014015345A/es unknown
- 2013-06-18 CN CN201380024545.XA patent/CN104284898A/zh active Pending
- 2013-06-18 RU RU2014152792A patent/RU2014152792A/ru unknown
- 2013-06-18 EP EP13729366.8A patent/EP2864335A1/en not_active Withdrawn
- 2013-06-19 US US13/921,937 patent/US20140121231A1/en not_active Abandoned
- 2013-06-19 AR ARP130102188 patent/AR091520A1/es unknown
-
2015
- 2015-02-12 HK HK15101545.1A patent/HK1201066A1/xx unknown
Also Published As
Publication number | Publication date |
---|---|
AR091520A1 (es) | 2015-02-11 |
CA2869239A1 (en) | 2013-12-27 |
US20140121231A1 (en) | 2014-05-01 |
KR20150009599A (ko) | 2015-01-26 |
RU2014152792A (ru) | 2016-08-10 |
CN104284898A (zh) | 2015-01-14 |
HK1201066A1 (en) | 2015-08-21 |
JP2015520204A (ja) | 2015-07-16 |
BR112014031785A2 (pt) | 2017-06-27 |
EP2864335A1 (en) | 2015-04-29 |
WO2013189904A1 (en) | 2013-12-27 |
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