MX2014000113A - Compuestos para tratar neuropatias perifericas y otros desordenes neurodegenerativos. - Google Patents
Compuestos para tratar neuropatias perifericas y otros desordenes neurodegenerativos.Info
- Publication number
- MX2014000113A MX2014000113A MX2014000113A MX2014000113A MX2014000113A MX 2014000113 A MX2014000113 A MX 2014000113A MX 2014000113 A MX2014000113 A MX 2014000113A MX 2014000113 A MX2014000113 A MX 2014000113A MX 2014000113 A MX2014000113 A MX 2014000113A
- Authority
- MX
- Mexico
- Prior art keywords
- compounds
- neurodegenerative disorders
- peripheral neuropathies
- treating peripheral
- disease
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/20—Oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/34—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
- G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicinal Chemistry (AREA)
- Immunology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Molecular Biology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Zoology (AREA)
- Biochemistry (AREA)
- Hematology (AREA)
- Physics & Mathematics (AREA)
- Analytical Chemistry (AREA)
- Wood Science & Technology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biotechnology (AREA)
- Urology & Nephrology (AREA)
- Microbiology (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Cell Biology (AREA)
- Genetics & Genomics (AREA)
- General Engineering & Computer Science (AREA)
- Toxicology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Biophysics (AREA)
- Food Science & Technology (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
Abstract
Se proporciona compuesto y métodos para el tratamiento o la prevención de una enfermedad, trastorno o afección neurodegenerativa asociada con la actividad general de hsp90 pero no con la actividad de ATPasa de hsp90, incluyendo neuropatía, tal como neuropatía periférica causada por quimioterapia o diabetes, trastornos del sistema nervioso central, tal como enfermedad de Alzheimer y enfermedad de parkinson, y enfermedades neuromotoras tales como esclerosis lateral amiotrófica (ALS), en un sujeto.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201161499242P | 2011-06-21 | 2011-06-21 | |
US201161499921P | 2011-06-22 | 2011-06-22 | |
PCT/US2012/043475 WO2012177831A2 (en) | 2011-06-21 | 2012-06-21 | Compounds for treating peripheral neuropathies and other neurodegenerative disorders |
Publications (1)
Publication Number | Publication Date |
---|---|
MX2014000113A true MX2014000113A (es) | 2015-04-13 |
Family
ID=47423197
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2014000113A MX2014000113A (es) | 2011-06-21 | 2012-06-21 | Compuestos para tratar neuropatias perifericas y otros desordenes neurodegenerativos. |
Country Status (7)
Country | Link |
---|---|
US (1) | US9527817B2 (es) |
EP (1) | EP2723339A4 (es) |
CN (1) | CN103702669A (es) |
AU (1) | AU2012272924A1 (es) |
CA (1) | CA2840003A1 (es) |
MX (1) | MX2014000113A (es) |
WO (1) | WO2012177831A2 (es) |
Families Citing this family (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN104569398B (zh) * | 2013-10-22 | 2016-06-22 | 北京勤邦生物技术有限公司 | 检测乙氧基喹啉的酶联免疫试剂盒及其应用 |
PT3377476T (pt) * | 2015-11-16 | 2022-12-29 | Ptc Therapeutics Inc | Análogos enriquecidos com isótopo de hidrogénio de compostos de ácido 1,2,4-oxadiazole benzoico, composições e suas utilizações |
CN107779436A (zh) * | 2017-10-27 | 2018-03-09 | 南京中医药大学 | 化疗所致周围神经病变细胞模型构建及其检测方法 |
US11234947B2 (en) * | 2020-06-30 | 2022-02-01 | Imperial College Innovations Limited | Treatment of peripheral neuropathy induced by cancer chemotherapy |
WO2022265960A1 (en) * | 2021-06-13 | 2022-12-22 | Daya Drug Discoveries, Inc. | Prevention and treatment of neuronal damage with pyridoindolobenz[b, d] azepine compositions |
Family Cites Families (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3952023A (en) * | 1972-12-16 | 1976-04-20 | Nippon Oil Company Ltd. | Method for preparing adduct of butadiene polymer or copolymer and α, β-ethylenically unsaturated dicarboxylic acid compound |
US4196113A (en) | 1973-11-01 | 1980-04-01 | Nippon Oil Co., Ltd. | Water-soluble coating composition |
US6746678B1 (en) * | 1991-02-22 | 2004-06-08 | Howard K. Shapiro | Method of treating neurological diseases and etiologically related symptomology using carbonyl trapping agents in combination with medicaments |
US6335157B1 (en) | 1999-05-07 | 2002-01-01 | The European Molecular Biology Laboratory | Method based on localization of Hsp90 to the centrosome |
US20070078144A1 (en) * | 2003-01-29 | 2007-04-05 | Stockwell Brent R | Agents for treating neurodegenerative diseases |
CN1897972A (zh) * | 2003-12-22 | 2007-01-17 | 爱尔康公司 | 用于治疗青光眼性视网膜病和视神经病的活性剂 |
US20090179638A1 (en) | 2006-02-01 | 2009-07-16 | Aegera Therapeutics Inc. | Assay for identifying inhibitors of neuronal apoptotic pathways |
US7960353B2 (en) | 2007-05-10 | 2011-06-14 | University Of Kansas | Novobiocin analogues as neuroprotective agents and in the treatment of autoimmune disorders |
EP2226632B1 (en) | 2007-12-28 | 2014-02-12 | Takeda Pharmaceutical Company Limited | Method for screening of cell-protecting agent |
-
2012
- 2012-06-21 AU AU2012272924A patent/AU2012272924A1/en not_active Abandoned
- 2012-06-21 CN CN201280036503.3A patent/CN103702669A/zh active Pending
- 2012-06-21 EP EP12802536.8A patent/EP2723339A4/en not_active Withdrawn
- 2012-06-21 WO PCT/US2012/043475 patent/WO2012177831A2/en active Application Filing
- 2012-06-21 MX MX2014000113A patent/MX2014000113A/es unknown
- 2012-06-21 CA CA2840003A patent/CA2840003A1/en not_active Abandoned
- 2012-06-21 US US14/127,326 patent/US9527817B2/en active Active
Also Published As
Publication number | Publication date |
---|---|
US9527817B2 (en) | 2016-12-27 |
CA2840003A1 (en) | 2012-12-27 |
CN103702669A (zh) | 2014-04-02 |
WO2012177831A3 (en) | 2013-04-11 |
EP2723339A2 (en) | 2014-04-30 |
WO2012177831A2 (en) | 2012-12-27 |
US20140303203A1 (en) | 2014-10-09 |
AU2012272924A1 (en) | 2014-01-16 |
EP2723339A4 (en) | 2015-02-25 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
MX2014000113A (es) | Compuestos para tratar neuropatias perifericas y otros desordenes neurodegenerativos. | |
MX2017014443A (es) | Adeno-asociado para administracion terapeutica al sistema nervioso central. | |
MX2013006056A (es) | Metodos para diagnosticar y tratar trastornos relacionados con la longitud del ojo. | |
MX354662B (es) | Anticuerpos fosfoespecificos que reconocen la tau. | |
WO2014150817A3 (en) | Method and system to predict response to treatments for mental disorders | |
MX2008009947A (es) | Composiciones farmaceuticas que comprenden dextrometorfano y quinidina para el tratamiento de depresion, ansiedad y trastornos neurodegenerativos. | |
EP3498729A3 (en) | Therapeutic targets for alzheimer's disease | |
AU2012205878A8 (en) | miRNA for treating diseases and conditions associated with neo-angiogenesis | |
WO2014037416A3 (en) | Compositions for treating parkinson's disease | |
MX2013008067A (es) | Metodos y productos de farmaco para tratar enfermedad de alzheimer. | |
EA033420B1 (ru) | Производные индолин-2-она или пирролопиридин-2-она, обладающие антипсихотической активностью | |
WO2014186599A3 (en) | Anti-complement factor c1s antibodies and uses thereof | |
WO2013033037A3 (en) | Novel antiprion compounds | |
EA201991375A1 (ru) | Бицикло[1.1.1]пентановые ингибиторы киназы, содержащей домен с двумя лейциновыми "застежками-молниями" (dlk), для лечения заболевания | |
CA2851761C (en) | Method of diagnosis, prognostic or treatment of neurodegenerative diseases | |
EP2542085A4 (en) | COMPOUNDS FOR THE TREATMENT OF NEURODEEGENERATIVE DISORDER | |
MX2019013524A (es) | Composiciones para tratar enfermedades neurodegenerativas. | |
ATE382101T1 (de) | Einen transkriptionsfaktor kodierendes humanes prädispositionsgen für autismus sowie dessen verwendungen | |
WO2006087634A3 (en) | Uses of human autism susceptibility gene encoding a kinase | |
WO2008057609A8 (en) | Methods of treating neuronal disorders using mntf peptides and analogs thereof | |
WO2012103282A3 (en) | Methods and compositions for treating alzheimer's disease | |
RU2014153894A (ru) | Способ предупреждения неврологических заболеваний | |
SA515360200B1 (ar) | محاكيات عامل نمو خلية كبدية كعوامل علاجية | |
WO2012068553A3 (en) | Methods of diagnosing and treating neurodegenerative diseases | |
WO2011163607A3 (en) | Olfactory receptor copy number association with age at onset of alzheimer's disease |