MX2013007502A - Solucion oftalmica que comprende diquafosol, metodo para producir la misma, y metodo para inhibir la formacion de precipitado insoluble. - Google Patents
Solucion oftalmica que comprende diquafosol, metodo para producir la misma, y metodo para inhibir la formacion de precipitado insoluble.Info
- Publication number
- MX2013007502A MX2013007502A MX2013007502A MX2013007502A MX2013007502A MX 2013007502 A MX2013007502 A MX 2013007502A MX 2013007502 A MX2013007502 A MX 2013007502A MX 2013007502 A MX2013007502 A MX 2013007502A MX 2013007502 A MX2013007502 A MX 2013007502A
- Authority
- MX
- Mexico
- Prior art keywords
- ophthalmic solution
- solution containing
- containing diquafosol
- insoluble precipitate
- formation
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7084—Compounds having two nucleosides or nucleotides, e.g. nicotinamide-adenine dinucleotide, flavine-adenine dinucleotide
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/02—Inorganic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/12—Carboxylic acids; Salts or anhydrides thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
- A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
- A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
- A61K47/183—Amino acids, e.g. glycine, EDTA or aspartame
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/24—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing atoms other than carbon, hydrogen, oxygen, halogen, nitrogen or sulfur, e.g. cyclomethicone or phospholipids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0048—Eye, e.g. artificial tears
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/08—Solutions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/04—Artificial tears; Irrigation solutions
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Molecular Biology (AREA)
- Ophthalmology & Optometry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biophysics (AREA)
- Inorganic Chemistry (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
Con respecto a solución oftálmica de Diquafosol que comprende un agente quelante, se ha inhibido la formación de precipitados insolubles encontrada en solución oftálmica de Diquafosol durante su almacenamiento, así como el deterioro del desempeño en filtración en el curso de producción (esterilización por filtración). Además, en la solución oftálmica de Diquafosol que comprende un agente quelante, se ha confirmado la mejora de la eficacia conservadora. En consecuencia, la presente invención proporciona UNA solución oftálmica de Diquafosol que tiene propiedades fisioquímicas que son estables durante los cursos de producción y distribución así como el curso de almacenamiento por un paciente. Particularmente en el curso de producción, la solución se puede someter a esterilización por filtración eficiente. Por otra parte, la solución tiene excelente eficacia conservadora. La presente invención también proporciona un método para inhibir la formación de precipitados insoluble de una solución oftálmica acuosa que comprende diquafosol o una sal de los mismos, al agregar un agente quelante a la solución.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2010291463 | 2010-12-28 | ||
PCT/JP2011/080179 WO2012090994A1 (ja) | 2010-12-28 | 2011-12-27 | ジクアホソル含有点眼液およびその製造方法、不溶性析出物発生の抑制方法 |
Publications (1)
Publication Number | Publication Date |
---|---|
MX2013007502A true MX2013007502A (es) | 2013-08-01 |
Family
ID=46383087
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2013007502A MX2013007502A (es) | 2010-12-28 | 2011-12-27 | Solucion oftalmica que comprende diquafosol, metodo para producir la misma, y metodo para inhibir la formacion de precipitado insoluble. |
Country Status (16)
Country | Link |
---|---|
US (1) | US20140221306A1 (es) |
EP (1) | EP2659894A4 (es) |
JP (1) | JP2012149057A (es) |
KR (1) | KR20140003493A (es) |
CN (1) | CN103282039A (es) |
AU (1) | AU2011350762B2 (es) |
BR (1) | BR112013016008B1 (es) |
CA (1) | CA2823148A1 (es) |
EA (1) | EA027736B1 (es) |
GE (1) | GEP20166448B (es) |
MX (1) | MX2013007502A (es) |
MY (1) | MY161032A (es) |
SG (2) | SG10201508591UA (es) |
TW (1) | TW201306844A (es) |
UA (1) | UA113839C2 (es) |
WO (1) | WO2012090994A1 (es) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US10071113B2 (en) | 2012-03-26 | 2018-09-11 | Santen Pharmaceutical Co., Ltd. | Ophthalmic solution comprising diquafosol |
Families Citing this family (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
BR112017013841A2 (pt) * | 2014-12-25 | 2018-06-19 | Santen Pharmaceutical Co., Ltd. | solução oftálmica aquosa |
TW201707710A (zh) | 2015-06-05 | 2017-03-01 | 參天製藥股份有限公司 | 特徵爲用於滴入戴著軟性隱形眼鏡的乾眼症患者的眼睛之乾眼症治療劑 |
EA202092030A1 (ru) * | 2018-02-28 | 2020-11-16 | Сантен Фармасьютикал Ко., Лтд. | Офтальмологическая композиция, включающая диквафозол и катионный полимер |
CN108853016A (zh) * | 2018-09-26 | 2018-11-23 | 广州大光制药有限公司 | 一种地夸磷索钠滴眼液及其制备方法 |
CN113518646B (zh) * | 2019-02-27 | 2023-12-12 | 参天制药株式会社 | 含有地夸磷索或其盐,乙烯基系高分子及纤维素系高分子的眼科用组合物 |
CN117771172A (zh) * | 2019-08-27 | 2024-03-29 | 参天制药株式会社 | 含有地夸磷索或其盐、及聚乙烯吡咯烷酮的水性眼科用组合物 |
JP7230169B2 (ja) * | 2020-12-25 | 2023-02-28 | 参天製薬株式会社 | ジクアホソルまたはその塩、銀塩およびイオン性等張化剤を含有する水性点眼液 |
CN113712910A (zh) * | 2021-08-05 | 2021-11-30 | 广州市桐晖药业有限公司 | 一种滴眼液及其制备方法 |
Family Cites Families (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5900407A (en) * | 1997-02-06 | 1999-05-04 | Inspire Pharmaceuticals, Inc. | Method of treating dry eye disease with uridine triphosphates and related compounds |
CA2295515C (en) | 1997-07-25 | 2006-03-14 | Inspire Pharmaceuticals, Inc. | Method for large-scale production of di(uridine 5'-tetraphosphate) and salts thereof |
JP4003008B2 (ja) * | 2000-05-30 | 2007-11-07 | 参天製薬株式会社 | 角膜上皮伸展促進剤 |
AU2001260643B9 (en) * | 2000-05-30 | 2006-10-19 | Merck Sharp & Dohme Corp. | Ectocornea extension promoters |
JP2003160491A (ja) * | 2001-09-11 | 2003-06-03 | Santen Pharmaceut Co Ltd | ジウリジンリン酸含有点眼液 |
JP4168071B2 (ja) | 2005-12-08 | 2008-10-22 | 興和株式会社 | 点眼用組成物 |
CN103096929A (zh) * | 2010-09-10 | 2013-05-08 | 参天制药株式会社 | 以组合p2y2受体激动剂和透明质酸或其盐为特征的干眼症治疗剂、干眼症的治疗方法、及干眼症治疗剂的应用 |
-
2011
- 2011-12-27 TW TW100148759A patent/TW201306844A/zh unknown
- 2011-12-27 MY MYPI2013002461A patent/MY161032A/en unknown
- 2011-12-27 MX MX2013007502A patent/MX2013007502A/es unknown
- 2011-12-27 UA UAA201309390A patent/UA113839C2/uk unknown
- 2011-12-27 AU AU2011350762A patent/AU2011350762B2/en not_active Ceased
- 2011-12-27 US US13/976,408 patent/US20140221306A1/en not_active Abandoned
- 2011-12-27 BR BR112013016008-0A patent/BR112013016008B1/pt not_active IP Right Cessation
- 2011-12-27 SG SG10201508591UA patent/SG10201508591UA/en unknown
- 2011-12-27 EA EA201390985A patent/EA027736B1/ru unknown
- 2011-12-27 CA CA2823148A patent/CA2823148A1/en not_active Abandoned
- 2011-12-27 WO PCT/JP2011/080179 patent/WO2012090994A1/ja active Application Filing
- 2011-12-27 CN CN2011800632699A patent/CN103282039A/zh active Pending
- 2011-12-27 EP EP11852288.7A patent/EP2659894A4/en not_active Withdrawn
- 2011-12-27 KR KR1020137019146A patent/KR20140003493A/ko not_active Application Discontinuation
- 2011-12-27 SG SG2013050000A patent/SG191389A1/en unknown
- 2011-12-27 JP JP2011285977A patent/JP2012149057A/ja not_active Withdrawn
- 2011-12-27 GE GEAP201113176A patent/GEP20166448B/en unknown
Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US10071113B2 (en) | 2012-03-26 | 2018-09-11 | Santen Pharmaceutical Co., Ltd. | Ophthalmic solution comprising diquafosol |
US10632139B2 (en) | 2012-03-26 | 2020-04-28 | Santen Pharmaceutical Co., Ltd. | Ophthalmic solution comprising diquafosol |
US11166974B2 (en) | 2012-03-26 | 2021-11-09 | Santen Pharmaceutical Co., Ltd. | Ophthalmic solution comprising Diquafosol |
Also Published As
Publication number | Publication date |
---|---|
SG191389A1 (en) | 2013-07-31 |
MY161032A (en) | 2017-04-03 |
KR20140003493A (ko) | 2014-01-09 |
BR112013016008A2 (pt) | 2018-07-10 |
SG10201508591UA (en) | 2015-11-27 |
CN103282039A (zh) | 2013-09-04 |
EP2659894A1 (en) | 2013-11-06 |
CA2823148A1 (en) | 2012-07-05 |
GEP20166448B (en) | 2016-03-25 |
UA113839C2 (xx) | 2017-03-27 |
WO2012090994A1 (ja) | 2012-07-05 |
AU2011350762B2 (en) | 2017-04-06 |
BR112013016008B1 (pt) | 2021-06-29 |
JP2012149057A (ja) | 2012-08-09 |
EP2659894A4 (en) | 2014-12-10 |
EA027736B1 (ru) | 2017-08-31 |
EA201390985A1 (ru) | 2013-11-29 |
AU2011350762A1 (en) | 2013-07-25 |
US20140221306A1 (en) | 2014-08-07 |
TW201306844A (zh) | 2013-02-16 |
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