MX2013006877A - Composiciones farmaceuticas para inhibidores selectivos del factor xa para administracion oral. - Google Patents

Composiciones farmaceuticas para inhibidores selectivos del factor xa para administracion oral.

Info

Publication number
MX2013006877A
MX2013006877A MX2013006877A MX2013006877A MX2013006877A MX 2013006877 A MX2013006877 A MX 2013006877A MX 2013006877 A MX2013006877 A MX 2013006877A MX 2013006877 A MX2013006877 A MX 2013006877A MX 2013006877 A MX2013006877 A MX 2013006877A
Authority
MX
Mexico
Prior art keywords
oral administration
selective factor
pharmaceutical compositions
inhibitors
enhancer
Prior art date
Application number
MX2013006877A
Other languages
English (en)
Inventor
Thomas W Leonard
David C Coughlan
Alan Cullen
Original Assignee
Merrion Res Iii Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merrion Res Iii Ltd filed Critical Merrion Res Iii Ltd
Publication of MX2013006877A publication Critical patent/MX2013006877A/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/702—Oligosaccharides, i.e. having three to five saccharide radicals attached to each other by glycosidic linkages
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7028—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/12—Carboxylic acids; Salts or anhydrides thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
    • A61K9/2806—Coating materials
    • A61K9/2833—Organic macromolecular compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

La presente invención provee composiciones farmacéuticas para administración oral que comprenden una cantidad terapéuticamente eficaz de un inhibidor selectivo del factor Xa, o una sal farmacéuticamente aceptable del mismo, y un mejorador; en donde el mejorador es un ácido graso de cadena media, o una sal, éster, éter o derivado de un ácido graso de cadena media, y tiene una longitud de cadena de carbono de 4 a 20 átomos de carbono; la presente invención también provee un método para obtener una biodisponibilidad reproducible de un inhibidor selectivo del factor Xa en un sujeto después de su administración oral, que comprende administrar por vía oral una composición farmacéutica como la que se menciona arriba.
MX2013006877A 2010-12-15 2011-09-23 Composiciones farmaceuticas para inhibidores selectivos del factor xa para administracion oral. MX2013006877A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US42326110P 2010-12-15 2010-12-15
PCT/US2011/052963 WO2012082209A1 (en) 2010-12-15 2011-09-23 Pharmaceutical compositions of selective factor xa inhibitors for oral administration

Publications (1)

Publication Number Publication Date
MX2013006877A true MX2013006877A (es) 2013-07-05

Family

ID=46234738

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2013006877A MX2013006877A (es) 2010-12-15 2011-09-23 Composiciones farmaceuticas para inhibidores selectivos del factor xa para administracion oral.

Country Status (10)

Country Link
US (1) US20120156294A1 (es)
EP (1) EP2651395A4 (es)
JP (1) JP2013545802A (es)
KR (1) KR20140046395A (es)
CN (1) CN103370051A (es)
AU (1) AU2011341637A1 (es)
BR (1) BR112013014940A2 (es)
CA (1) CA2819108A1 (es)
MX (1) MX2013006877A (es)
WO (1) WO2012082209A1 (es)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7658938B2 (en) 1999-02-22 2010-02-09 Merrion Reasearch III Limited Solid oral dosage form containing an enhancer
US20110182985A1 (en) * 2010-01-28 2011-07-28 Coughlan David C Solid Pharmaceutical Composition with Enhancers and Methods of Preparing thereof
WO2012094598A2 (en) 2011-01-07 2012-07-12 Merrion Research Iii Limited Pharmaceutical compositions of iron for oral administration
US10265384B2 (en) 2015-01-29 2019-04-23 Novo Nordisk A/S Tablets comprising GLP-1 agonist and enteric coating
CN108148102A (zh) * 2016-12-03 2018-06-12 烟台东诚药业集团股份有限公司 喷雾干燥法制备低水分磺达肝癸钠原料药
KR20190130411A (ko) 2018-05-14 2019-11-22 신일제약주식회사 아픽사반 약제학적 제제 및 그의 제조방법

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2363123C (en) * 1999-02-22 2011-09-06 Kenneth Iain Cumming Solid oral dosage form containing an enhancer
WO2002064148A2 (en) * 2001-02-16 2002-08-22 Shimizu Pharmaceutical Co., Ltd. Oral formulations containing mucopolysaccharide for small intestine delivery and their use in the treatment circulatory disorders
US20070219131A1 (en) * 2004-04-15 2007-09-20 Ben-Sasson Shmuel A Compositions capable of facilitating penetration across a biological barrier
US20070212395A1 (en) * 2006-03-08 2007-09-13 Allergan, Inc. Ocular therapy using sirtuin-activating agents
ES2426445T3 (es) * 2006-04-07 2013-10-23 Merrion Research Iii Limited Forma de dosificación oral sólida que contiene un potenciador
US8999383B2 (en) * 2008-05-07 2015-04-07 Merrion Research Iii Limited Compositions of GnRH related compounds and processes of preparation
EP2343982B1 (en) * 2008-09-17 2017-03-22 Chiasma Inc. Pharmaceutical compositions and related methods of delivery
US9089484B2 (en) * 2010-03-26 2015-07-28 Merrion Research Iii Limited Pharmaceutical compositions of selective factor Xa inhibitors for oral administration

Also Published As

Publication number Publication date
US20120156294A1 (en) 2012-06-21
JP2013545802A (ja) 2013-12-26
KR20140046395A (ko) 2014-04-18
AU2011341637A1 (en) 2013-06-20
EP2651395A1 (en) 2013-10-23
CN103370051A (zh) 2013-10-23
EP2651395A4 (en) 2014-05-07
WO2012082209A1 (en) 2012-06-21
CA2819108A1 (en) 2012-06-21
BR112013014940A2 (pt) 2016-09-13

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