MX2013005389A - Dispositivo de mezclado de alimentacion y su uso. - Google Patents
Dispositivo de mezclado de alimentacion y su uso.Info
- Publication number
- MX2013005389A MX2013005389A MX2013005389A MX2013005389A MX2013005389A MX 2013005389 A MX2013005389 A MX 2013005389A MX 2013005389 A MX2013005389 A MX 2013005389A MX 2013005389 A MX2013005389 A MX 2013005389A MX 2013005389 A MX2013005389 A MX 2013005389A
- Authority
- MX
- Mexico
- Prior art keywords
- value
- feed
- cultivation
- mixing device
- feed mixing
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P21/00—Preparation of peptides or proteins
- C12P21/005—Glycopeptides, glycoproteins
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M1/00—Apparatus for enzymology or microbiology
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
- C07K16/244—Interleukins [IL]
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M1/00—Apparatus for enzymology or microbiology
- C12M1/16—Apparatus for enzymology or microbiology containing, or adapted to contain, solid media
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M29/00—Means for introduction, extraction or recirculation of materials, e.g. pumps
- C12M29/26—Conditioning fluids entering or exiting the reaction vessel
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M3/00—Tissue, human, animal or plant cell, or virus culture apparatus
- C12M3/02—Tissue, human, animal or plant cell, or virus culture apparatus with means providing suspensions
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M41/00—Means for regulation, monitoring, measurement or control, e.g. flow regulation
- C12M41/26—Means for regulation, monitoring, measurement or control, e.g. flow regulation of pH
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
- B01F2215/00—Auxiliary or complementary information in relation with mixing
- B01F2215/04—Technical information in relation with mixing
- B01F2215/0413—Numerical information
- B01F2215/0436—Operational information
- B01F2215/044—Numerical composition values of components or mixtures, e.g. percentage of components
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
- B01F35/00—Accessories for mixers; Auxiliary operations or auxiliary devices; Parts or details of general application
- B01F35/80—Forming a predetermined ratio of the substances to be mixed
- B01F35/88—Forming a predetermined ratio of the substances to be mixed by feeding the materials batchwise
- B01F35/883—Forming a predetermined ratio of the substances to be mixed by feeding the materials batchwise using flow rate controls for feeding the substances
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/10—Immunoglobulins specific features characterized by their source of isolation or production
- C07K2317/14—Specific host cells or culture conditions, e.g. components, pH or temperature
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2500/00—Specific components of cell culture medium
- C12N2500/60—Buffer, e.g. pH regulation, osmotic pressure
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Genetics & Genomics (AREA)
- Biotechnology (AREA)
- Biomedical Technology (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- Microbiology (AREA)
- Sustainable Development (AREA)
- Medicinal Chemistry (AREA)
- Cell Biology (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Immunology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Analytical Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Virology (AREA)
- Apparatus Associated With Microorganisms And Enzymes (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Abstract
Se describe aquí un dispositivo de mezclado de alimentación para agregar las soluciones de la alimentación con un valor del pH no fisiológico al recipiente de cultivo de las células, que comprende una cámara para el mezclado de las soluciones de la alimentación previo a su adición al recipiente de cultivo de las células, así como a su uso. Con el dispositivo del mezclado de alimentación como se describe aquí, los componentes de la alimentación pueden ser provistos en solución a un valor del pH en el cual los mismos tienen buena solubilidad y/o una buena estabilidad por lo cual el valor de pH puede ser claramente diferente del valor del pH del medio de cultivo, es decir diferente del valor de pH fisiológico. Esto permite efectuar el cultivo con mayor flexibilidad comparado con un cultivo en el cual el valor del pH de la solución de alimentación está limitado a un intervalo pequeño alrededor del valor del pH del cultivo.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP10194025 | 2010-12-07 | ||
PCT/EP2011/071696 WO2012076441A1 (en) | 2010-12-07 | 2011-12-05 | Feed mixing device and its use |
Publications (2)
Publication Number | Publication Date |
---|---|
MX2013005389A true MX2013005389A (es) | 2013-07-29 |
MX345885B MX345885B (es) | 2017-02-22 |
Family
ID=44026647
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2013005389A MX345885B (es) | 2010-12-07 | 2011-12-05 | Dispositivo de mezclado de alimentacion y su uso. |
Country Status (11)
Country | Link |
---|---|
US (3) | US20140051121A1 (es) |
EP (1) | EP2649176B1 (es) |
JP (2) | JP5824527B2 (es) |
KR (1) | KR101507254B1 (es) |
CN (1) | CN103221534B (es) |
BR (1) | BR112013009934A2 (es) |
CA (1) | CA2817874A1 (es) |
HK (1) | HK1187647A1 (es) |
MX (1) | MX345885B (es) |
RU (1) | RU2595407C2 (es) |
WO (1) | WO2012076441A1 (es) |
Families Citing this family (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2018113907A (ja) * | 2017-01-18 | 2018-07-26 | 株式会社Regene Pharm | 動物細胞の培養方法 |
Family Cites Families (24)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5081036A (en) | 1987-01-23 | 1992-01-14 | Hoffmann-La Roche Inc. | Method and apparatus for cell culture |
JP2509630B2 (ja) | 1987-07-29 | 1996-06-26 | 三井石油化学工業株式会社 | 培養方法及び培養装置 |
ES2053410T1 (es) | 1991-06-17 | 1994-08-01 | Life Technologies Inc | Metodo para la preparacion de un medio de cultivo de celulas. |
US5856179A (en) * | 1994-03-10 | 1999-01-05 | Genentech, Inc. | Polypeptide production in animal cell culture |
RU2102472C1 (ru) * | 1994-07-19 | 1998-01-20 | Научно-исследовательский институт микробиологии МО РФ | Способ получения биомассы чумного микроба |
JPH10201467A (ja) * | 1997-01-20 | 1998-08-04 | Ishikawajima Harima Heavy Ind Co Ltd | 被培養体の生長判定方法および培養装置 |
US20060003448A1 (en) | 2003-12-30 | 2006-01-05 | Richard Fike | Dry powder cells and cell culture reagents and methods of production thereof |
US20030092652A1 (en) | 1998-08-14 | 2003-05-15 | Maria Bruno | Protected one-vial formulation for nucleic acid molecules, methods of making the same by in-line mixing, and related products and methods |
CA2340416C (en) * | 1998-08-14 | 2009-06-02 | Valentis, Inc. | Co-lyophilized complex of a nucleic acid vector and a formulating agent |
KR100283499B1 (ko) * | 1998-12-23 | 2001-03-02 | 이금용 | 폐기물 매립지의 매립가스 발생량 조절방법 및 그 장치 |
EP2295533A3 (en) * | 2000-11-06 | 2011-07-13 | Life Technologies Corporation | Dry powder cells and cell culture reagents and methods of production thereof |
FR2836910B1 (fr) * | 2002-03-08 | 2005-02-11 | Amenagement Urbain & Rural | Procede de degradation de la matiere organique par voie mycelienne |
US6924124B1 (en) | 2002-08-23 | 2005-08-02 | Immunex Corporation | Feeding strategies for cell culture |
AU2003295584A1 (en) | 2002-11-18 | 2004-06-15 | Taurus Hsa Llc | Method for continuous, automated blending of solutions from acids and bases |
EA012617B1 (ru) | 2005-03-24 | 2009-10-30 | ДСМ АйПи АССЕТС Б.В. | Способ микробиального производства ценного соединения |
WO2008013809A1 (en) | 2006-07-24 | 2008-01-31 | Amgen Inc. | Cell culture methods |
PT2115126E (pt) | 2007-03-02 | 2015-08-24 | Wyeth Llc | Utilização de cobre e glutamato na cultura de células para a produção de polipeptídeos |
PT2195035T (pt) * | 2007-09-28 | 2018-03-07 | Engene Inc | Composições de poliplexos de ácido nucleico de quitosano de alta concentração |
DE102008021483A1 (de) | 2008-04-29 | 2009-12-03 | Forschungszentrum Jülich GmbH | Zuleitungssystem |
CN102617735B (zh) | 2008-09-29 | 2015-09-09 | 罗氏格黎卡特股份公司 | 针对人il17的抗体及其应用 |
US8349591B2 (en) * | 2008-10-16 | 2013-01-08 | Scientek Llc | Method and apparatus for producing alcohol or sugar using a commercial-scale bioreactor |
RU2577972C2 (ru) * | 2010-04-26 | 2016-03-20 | Новартис Аг | Способ получения рекомбинантного полипептида |
SG185038A1 (en) * | 2010-04-26 | 2012-11-29 | Novartis Ag | Improved cell culture medium |
WO2012030838A1 (en) * | 2010-08-30 | 2012-03-08 | Honda Motor Co., Ltd. | Belief tracking and action selection in spoken dialog systems |
-
2011
- 2011-12-05 CN CN201180055657.2A patent/CN103221534B/zh not_active Expired - Fee Related
- 2011-12-05 JP JP2013542484A patent/JP5824527B2/ja not_active Expired - Fee Related
- 2011-12-05 WO PCT/EP2011/071696 patent/WO2012076441A1/en active Application Filing
- 2011-12-05 RU RU2013129008/10A patent/RU2595407C2/ru not_active IP Right Cessation
- 2011-12-05 BR BR112013009934A patent/BR112013009934A2/pt not_active IP Right Cessation
- 2011-12-05 KR KR1020137014738A patent/KR101507254B1/ko not_active IP Right Cessation
- 2011-12-05 EP EP11790633.9A patent/EP2649176B1/en not_active Not-in-force
- 2011-12-05 CA CA2817874A patent/CA2817874A1/en not_active Abandoned
- 2011-12-05 MX MX2013005389A patent/MX345885B/es active IP Right Grant
-
2013
- 2013-06-04 US US13/909,591 patent/US20140051121A1/en not_active Abandoned
-
2014
- 2014-01-22 HK HK14100683.6A patent/HK1187647A1/zh not_active IP Right Cessation
-
2015
- 2015-10-09 JP JP2015200871A patent/JP6117885B2/ja not_active Expired - Fee Related
-
2017
- 2017-09-22 US US15/713,268 patent/US10837042B2/en active Active
-
2020
- 2020-10-28 US US17/083,048 patent/US20210040528A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
US10837042B2 (en) | 2020-11-17 |
WO2012076441A1 (en) | 2012-06-14 |
CN103221534A (zh) | 2013-07-24 |
HK1187647A1 (zh) | 2014-04-11 |
JP2014500025A (ja) | 2014-01-09 |
KR101507254B1 (ko) | 2015-03-30 |
US20140051121A1 (en) | 2014-02-20 |
CN103221534B (zh) | 2016-05-18 |
CA2817874A1 (en) | 2012-06-14 |
BR112013009934A2 (pt) | 2016-07-05 |
US20210040528A1 (en) | 2021-02-11 |
JP6117885B2 (ja) | 2017-04-19 |
JP2016028596A (ja) | 2016-03-03 |
EP2649176A1 (en) | 2013-10-16 |
MX345885B (es) | 2017-02-22 |
RU2595407C2 (ru) | 2016-08-27 |
EP2649176B1 (en) | 2018-01-17 |
RU2013129008A (ru) | 2015-01-20 |
JP5824527B2 (ja) | 2015-11-25 |
US20180010162A1 (en) | 2018-01-11 |
KR20130095789A (ko) | 2013-08-28 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FG | Grant or registration |