MX2013005389A - Dispositivo de mezclado de alimentacion y su uso. - Google Patents

Dispositivo de mezclado de alimentacion y su uso.

Info

Publication number
MX2013005389A
MX2013005389A MX2013005389A MX2013005389A MX2013005389A MX 2013005389 A MX2013005389 A MX 2013005389A MX 2013005389 A MX2013005389 A MX 2013005389A MX 2013005389 A MX2013005389 A MX 2013005389A MX 2013005389 A MX2013005389 A MX 2013005389A
Authority
MX
Mexico
Prior art keywords
value
feed
cultivation
mixing device
feed mixing
Prior art date
Application number
MX2013005389A
Other languages
English (en)
Other versions
MX345885B (es
Inventor
Jens Hoffmann
Sylvia Baumann
Alexander Jockwer
Christian Klinger
Thomas Troebs
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of MX2013005389A publication Critical patent/MX2013005389A/es
Publication of MX345885B publication Critical patent/MX345885B/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P21/00—Preparation of peptides or proteins
    • C12P21/005—Glycopeptides, glycoproteins
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M1/00—Apparatus for enzymology or microbiology
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
    • C07K16/244—Interleukins [IL]
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M1/00—Apparatus for enzymology or microbiology
    • C12M1/16—Apparatus for enzymology or microbiology containing, or adapted to contain, solid media
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M29/00—Means for introduction, extraction or recirculation of materials, e.g. pumps
    • C12M29/26—Conditioning fluids entering or exiting the reaction vessel
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M3/00—Tissue, human, animal or plant cell, or virus culture apparatus
    • C12M3/02—Tissue, human, animal or plant cell, or virus culture apparatus with means providing suspensions
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M41/00—Means for regulation, monitoring, measurement or control, e.g. flow regulation
    • C12M41/26—Means for regulation, monitoring, measurement or control, e.g. flow regulation of pH
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F2215/00—Auxiliary or complementary information in relation with mixing
    • B01F2215/04—Technical information in relation with mixing
    • B01F2215/0413—Numerical information
    • B01F2215/0436—Operational information
    • B01F2215/044—Numerical composition values of components or mixtures, e.g. percentage of components
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F35/00—Accessories for mixers; Auxiliary operations or auxiliary devices; Parts or details of general application
    • B01F35/80—Forming a predetermined ratio of the substances to be mixed
    • B01F35/88—Forming a predetermined ratio of the substances to be mixed by feeding the materials batchwise
    • B01F35/883—Forming a predetermined ratio of the substances to be mixed by feeding the materials batchwise using flow rate controls for feeding the substances
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/10—Immunoglobulins specific features characterized by their source of isolation or production
    • C07K2317/14—Specific host cells or culture conditions, e.g. components, pH or temperature
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2500/00—Specific components of cell culture medium
    • C12N2500/60—Buffer, e.g. pH regulation, osmotic pressure

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Sustainable Development (AREA)
  • Medicinal Chemistry (AREA)
  • Cell Biology (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Analytical Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Virology (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

Se describe aquí un dispositivo de mezclado de alimentación para agregar las soluciones de la alimentación con un valor del pH no fisiológico al recipiente de cultivo de las células, que comprende una cámara para el mezclado de las soluciones de la alimentación previo a su adición al recipiente de cultivo de las células, así como a su uso. Con el dispositivo del mezclado de alimentación como se describe aquí, los componentes de la alimentación pueden ser provistos en solución a un valor del pH en el cual los mismos tienen buena solubilidad y/o una buena estabilidad por lo cual el valor de pH puede ser claramente diferente del valor del pH del medio de cultivo, es decir diferente del valor de pH fisiológico. Esto permite efectuar el cultivo con mayor flexibilidad comparado con un cultivo en el cual el valor del pH de la solución de alimentación está limitado a un intervalo pequeño alrededor del valor del pH del cultivo.
MX2013005389A 2010-12-07 2011-12-05 Dispositivo de mezclado de alimentacion y su uso. MX345885B (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP10194025 2010-12-07
PCT/EP2011/071696 WO2012076441A1 (en) 2010-12-07 2011-12-05 Feed mixing device and its use

Publications (2)

Publication Number Publication Date
MX2013005389A true MX2013005389A (es) 2013-07-29
MX345885B MX345885B (es) 2017-02-22

Family

ID=44026647

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2013005389A MX345885B (es) 2010-12-07 2011-12-05 Dispositivo de mezclado de alimentacion y su uso.

Country Status (11)

Country Link
US (3) US20140051121A1 (es)
EP (1) EP2649176B1 (es)
JP (2) JP5824527B2 (es)
KR (1) KR101507254B1 (es)
CN (1) CN103221534B (es)
BR (1) BR112013009934A2 (es)
CA (1) CA2817874A1 (es)
HK (1) HK1187647A1 (es)
MX (1) MX345885B (es)
RU (1) RU2595407C2 (es)
WO (1) WO2012076441A1 (es)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2018113907A (ja) * 2017-01-18 2018-07-26 株式会社Ｒｅｇｅｎｅ Ｐｈａｒｍ 動物細胞の培養方法

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US5081036A (en) 1987-01-23 1992-01-14 Hoffmann-La Roche Inc. Method and apparatus for cell culture
JP2509630B2 (ja) 1987-07-29 1996-06-26 三井石油化学工業株式会社 培養方法及び培養装置
ES2053410T1 (es) 1991-06-17 1994-08-01 Life Technologies Inc Metodo para la preparacion de un medio de cultivo de celulas.
US5856179A (en) * 1994-03-10 1999-01-05 Genentech, Inc. Polypeptide production in animal cell culture
RU2102472C1 (ru) * 1994-07-19 1998-01-20 Научно-исследовательский институт микробиологии МО РФ Способ получения биомассы чумного микроба
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EP2295533A3 (en) * 2000-11-06 2011-07-13 Life Technologies Corporation Dry powder cells and cell culture reagents and methods of production thereof
FR2836910B1 (fr) * 2002-03-08 2005-02-11 Amenagement Urbain & Rural Procede de degradation de la matiere organique par voie mycelienne
US6924124B1 (en) 2002-08-23 2005-08-02 Immunex Corporation Feeding strategies for cell culture
AU2003295584A1 (en) 2002-11-18 2004-06-15 Taurus Hsa Llc Method for continuous, automated blending of solutions from acids and bases
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PT2115126E (pt) 2007-03-02 2015-08-24 Wyeth Llc Utilização de cobre e glutamato na cultura de células para a produção de polipeptídeos
PT2195035T (pt) * 2007-09-28 2018-03-07 Engene Inc Composições de poliplexos de ácido nucleico de quitosano de alta concentração
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WO2012030838A1 (en) * 2010-08-30 2012-03-08 Honda Motor Co., Ltd. Belief tracking and action selection in spoken dialog systems

Also Published As

Publication number Publication date
US10837042B2 (en) 2020-11-17
WO2012076441A1 (en) 2012-06-14
CN103221534A (zh) 2013-07-24
HK1187647A1 (zh) 2014-04-11
JP2014500025A (ja) 2014-01-09
KR101507254B1 (ko) 2015-03-30
US20140051121A1 (en) 2014-02-20
CN103221534B (zh) 2016-05-18
CA2817874A1 (en) 2012-06-14
BR112013009934A2 (pt) 2016-07-05
US20210040528A1 (en) 2021-02-11
JP6117885B2 (ja) 2017-04-19
JP2016028596A (ja) 2016-03-03
EP2649176A1 (en) 2013-10-16
MX345885B (es) 2017-02-22
RU2595407C2 (ru) 2016-08-27
EP2649176B1 (en) 2018-01-17
RU2013129008A (ru) 2015-01-20
JP5824527B2 (ja) 2015-11-25
US20180010162A1 (en) 2018-01-11
KR20130095789A (ko) 2013-08-28

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