MX2013002055A - Variantes anti-enlace de albumina de suero mejodas. - Google Patents

Variantes anti-enlace de albumina de suero mejodas.

Info

Publication number
MX2013002055A
MX2013002055A MX2013002055A MX2013002055A MX2013002055A MX 2013002055 A MX2013002055 A MX 2013002055A MX 2013002055 A MX2013002055 A MX 2013002055A MX 2013002055 A MX2013002055 A MX 2013002055A MX 2013002055 A MX2013002055 A MX 2013002055A
Authority
MX
Mexico
Prior art keywords
serum albumin
albumin binding
improved anti
binding variants
variants
Prior art date
Application number
MX2013002055A
Other languages
English (en)
Inventor
Carolyn Enever
Haiqun Liu
Elena De Angelis
Oliver Schon
Malgorzata Pupecka-Swider
Original Assignee
Glaxosmithkline Ip Dev Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Glaxosmithkline Ip Dev Ltd filed Critical Glaxosmithkline Ip Dev Ltd
Publication of MX2013002055A publication Critical patent/MX2013002055A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
    • A61K47/6835—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site
    • A61K47/6843—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site the antibody targeting a material from animals or humans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/33—Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/569—Single domain, e.g. dAb, sdAb, VHH, VNAR or nanobody®
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Immunology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Zoology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biomedical Technology (AREA)
  • Epidemiology (AREA)
  • Wood Science & Technology (AREA)
  • Microbiology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Plant Pathology (AREA)
  • Mycology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Toxicology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Endocrinology (AREA)

Abstract

La invención se refiere a variantes mejoradas del único dominio variable de inmunoglobulina anti-albúmina de suero DOM7h-14-10, así como a ligandos y conjugados de fármacos que comprenden estas variantes, composiciones, ácidos nucleicos, vectores y huéspedes.
MX2013002055A 2010-08-20 2011-08-12 Variantes anti-enlace de albumina de suero mejodas. MX2013002055A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US37532810P 2010-08-20 2010-08-20
PCT/EP2011/064000 WO2012022703A2 (en) 2010-08-20 2011-08-12 Improved anti-serum albumin binding variants

Publications (1)

Publication Number Publication Date
MX2013002055A true MX2013002055A (es) 2013-07-22

Family

ID=44582955

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2013002055A MX2013002055A (es) 2010-08-20 2011-08-12 Variantes anti-enlace de albumina de suero mejodas.

Country Status (12)

Country Link
US (1) US20130230519A1 (es)
EP (1) EP2606065A2 (es)
JP (2) JP2013537421A (es)
KR (1) KR20130055663A (es)
CN (1) CN103282381A (es)
AU (1) AU2011290797A1 (es)
BR (1) BR112013003899A2 (es)
CA (1) CA2808683A1 (es)
EA (1) EA201390116A1 (es)
MX (1) MX2013002055A (es)
SG (1) SG188204A1 (es)
WO (1) WO2012022703A2 (es)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2022101604A (ru) * 2016-12-07 2022-03-29 Аблинкс Нв Улучшенные отдельные вариабельные домены иммуноглобулина, связывающиеся с сывороточным альбумином
IL312292A (en) 2017-01-17 2024-06-01 Ablynx Nv Improved serum albumin binding agents
BR112019014600A2 (pt) 2017-01-17 2020-02-18 Ablynx N.V. Ligantes de albumina sérica melhorados
GB201818460D0 (en) * 2018-11-13 2018-12-26 Crescendo Biologics Ltd Single domain antibodies that bind human serum albumin
TW202045545A (zh) * 2019-02-22 2020-12-16 美商安維塔生物科學股份有限公司 白蛋白結合抗體及其用途

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL127127A0 (en) 1998-11-18 1999-09-22 Peptor Ltd Small functional units of antibody heavy chain variable regions
US9321832B2 (en) 2002-06-28 2016-04-26 Domantis Limited Ligand
EP1517921B1 (en) 2002-06-28 2006-06-07 Domantis Limited Dual specific ligands with increased serum half-life
US20060002935A1 (en) 2002-06-28 2006-01-05 Domantis Limited Tumor Necrosis Factor Receptor 1 antagonists and methods of use therefor
PT1737962E (pt) 2004-03-24 2010-12-03 Domantis Ltd Sequência líder universal gas1
BRPI0511755A (pt) 2004-06-01 2008-01-02 Domantis Ltd composições, fusões e conjugados de drogas e métodos de produção, tratamento e utilização
BRPI0518761A2 (pt) 2004-12-02 2008-12-09 Domantis Ltd fusço de droga, conjugado de droga, Ácido nucleico recombinante, construÇço de Ácido nucleico, cÉlula hospedeira, mÉtodo para produzir uma fusço de droga, composiÇço farmacÊutica, droga, mÉtodo de tratamento e/ou prevenÇço de uma condiÇço em um paciente, mÉtodo de retardo ou prevenÇço de progressço de doenÇa, e, mÉtodo para diminuir a absorÇço de alimentos por um paciente
GB0521621D0 (en) 2005-10-24 2005-11-30 Domantis Ltd Tumor necrosis factor receptor 1 antagonists for treating respiratory diseases
TW200804425A (en) * 2005-12-06 2008-01-16 Domantis Ltd Ligands that have binding specificity for EGFR and/or VEGF and methods of use therefor
EP1976991A1 (en) 2006-01-24 2008-10-08 Domantis Limited Fusion proteins that contain natural junctions
EA200901494A1 (ru) * 2007-06-06 2010-06-30 Домантис Лимитед Способы селекции протеазоустойчивых полипептидов
GB0724331D0 (en) 2007-12-13 2008-01-23 Domantis Ltd Compositions for pulmonary delivery
AU2008328726B2 (en) 2007-11-30 2014-06-12 Glaxo Group Limited Antigen-binding constructs
MX2010010776A (es) * 2008-03-31 2010-10-26 Glaxo Group Ltd Fusiones y conjugados de farmaco.
EP2364326B1 (en) * 2008-12-05 2018-07-04 Glaxo Group Limited Methods for selecting protease resistant polypeptides
WO2010081787A1 (en) 2009-01-14 2010-07-22 Domantis Limited IMPROVED TNFα ANTAGONISM, PROPHYLAXIS & THERAPY WITH REDUCED ORGAN NECROSIS

Also Published As

Publication number Publication date
CA2808683A1 (en) 2012-02-23
AU2011290797A1 (en) 2013-04-11
JP2013537421A (ja) 2013-10-03
BR112013003899A2 (pt) 2016-06-07
EP2606065A2 (en) 2013-06-26
SG188204A1 (en) 2013-04-30
JP2016027801A (ja) 2016-02-25
US20130230519A1 (en) 2013-09-05
WO2012022703A2 (en) 2012-02-23
EA201390116A1 (ru) 2013-09-30
CN103282381A (zh) 2013-09-04
WO2012022703A3 (en) 2012-04-26
KR20130055663A (ko) 2013-05-28

Similar Documents

Publication Publication Date Title
MX2011008752A (es) Variantes de union a anti-albumina de suero mejoradas.
MX2012000765A (es) Dominios variables sencillos de union de albumina anti-suero mejorados.
MX2012013406A (es) Variantes de union mejoradas anti-albumina serica.
MX2011008749A (es) Variantes de union a anti-albumina de suero mejoradas.
CY1119567T1 (el) Θεραπευτικα πεπτιδια
WO2014083208A9 (en) Binding proteins comprising at least two repeat domains against her2
EA201401254A1 (ru) Самостабилизирующиеся линкерные конъюгаты
EA201390785A1 (ru) Антитела, обладающие низкой аффинностью к рецепторам гематоэнцефалического барьера, и их применения
AU2015370918A8 (en) Binding protein drug conjugates comprising anthracycline derivatives
UA106900C2 (uk) Агоністичний dr5-зв'язувальний поліпептид
NZ700891A (en) 4-1bb binding molecules
WO2012019024A3 (en) Her3-binding molecules and immunoconjugates thereof
WO2011086143A3 (en) Liver targeting domain antibodies
EA201290642A1 (ru) Соединения и способы
WO2012072731A3 (en) Improved anti-serum albumin binding single variable domains
WO2011112566A3 (en) Basigin binding proteins
MX2013002055A (es) Variantes anti-enlace de albumina de suero mejodas.
NZ700274A (en) Anti-pdgf-c antibodies
MX2015014198A (es) Anticuerpos cuyo objetivo es m-csf.
CA3036643C (en) Cmet monoclonal binding agents, drug conjugates thereof and uses thereof
WO2014044793A3 (en) Cd22-binding peptides
MX2016008478A (es) Nuevo anticuerpo anti adam17 y su uso en el tratamiento del cancer.
WO2012136792A3 (en) Cck compositions
CR20110473A (es) Variantes de union a anti-albúmina de suero mejoradas.
NZ626296A (en) Compositions and methods for antibodies targeting factor p

Legal Events

Date Code Title Description
FA Abandonment or withdrawal