MX2012012959A - Procedimiento para preparar 1, 3-dihidro-2h-indol-2-onas sustituidas. - Google Patents
Procedimiento para preparar 1, 3-dihidro-2h-indol-2-onas sustituidas.Info
- Publication number
- MX2012012959A MX2012012959A MX2012012959A MX2012012959A MX2012012959A MX 2012012959 A MX2012012959 A MX 2012012959A MX 2012012959 A MX2012012959 A MX 2012012959A MX 2012012959 A MX2012012959 A MX 2012012959A MX 2012012959 A MX2012012959 A MX 2012012959A
- Authority
- MX
- Mexico
- Prior art keywords
- indol
- dihydro
- ones
- thiocycloalkyl
- thioalkyl
- Prior art date
Links
- JYGFTBXVXVMTGB-UHFFFAOYSA-N indolin-2-one Chemical class C1=CC=C2NC(=O)CC2=C1 JYGFTBXVXVMTGB-UHFFFAOYSA-N 0.000 title abstract 3
- 238000004519 manufacturing process Methods 0.000 title abstract 2
- 150000005625 indol-2-ones Chemical class 0.000 abstract 2
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical compound [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 abstract 1
- 239000005864 Sulphur Substances 0.000 abstract 1
- 239000004480 active ingredient Substances 0.000 abstract 1
- 230000015572 biosynthetic process Effects 0.000 abstract 1
- 238000009835 boiling Methods 0.000 abstract 1
- 239000012847 fine chemical Substances 0.000 abstract 1
- 238000010438 heat treatment Methods 0.000 abstract 1
- 239000000543 intermediate Substances 0.000 abstract 1
- 239000002798 polar solvent Substances 0.000 abstract 1
- 239000011541 reaction mixture Substances 0.000 abstract 1
- 238000010992 reflux Methods 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 239000002904 solvent Substances 0.000 abstract 1
- 239000000725 suspension Substances 0.000 abstract 1
- 238000003786 synthesis reaction Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
- C07D209/32—Oxygen atoms
- C07D209/34—Oxygen atoms in position 2
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
- A01N43/34—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one nitrogen atom as the only ring hetero atom
- A01N43/36—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one nitrogen atom as the only ring hetero atom five-membered rings
- A01N43/38—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one nitrogen atom as the only ring hetero atom five-membered rings condensed with carbocyclic rings
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Environmental Sciences (AREA)
- Engineering & Computer Science (AREA)
- Dentistry (AREA)
- General Health & Medical Sciences (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Plant Pathology (AREA)
- Pest Control & Pesticides (AREA)
- Agronomy & Crop Science (AREA)
- Indole Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Plural Heterocyclic Compounds (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
Abstract
Procedimiento para preparar 1,3-dihid ro-2H-indol-2-onas, partiendo de compuestos de indol-2-ona sustituidos con tioalquilo o tiocicloalquilo, que implica a) disolver o suspender los compuestos de indol-2-ona sustituidos con tioalquilo o tiocicloalquilo en un disolvente polar, b) añadir una sal que contiene azufre a la solución o la suspensión, y c) calentar la mezcla de reacción a reflujo a una temperatura que corresponde como máximo a la temperatura de ebullición del disolvente. Uso de la 1,3-dihidro-2H-indol-2-ona preparada según la invención como intermedios para la síntesis de productos químicos finos y principios activos para farmacia y/o agricultura.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US33294910P | 2010-05-10 | 2010-05-10 | |
| EP10162381 | 2010-05-10 | ||
| PCT/EP2011/057276 WO2011141364A1 (de) | 2010-05-10 | 2011-05-06 | Verfahren zur herstellung von substituierten 1,3-dihydro-2h-indol-2-onen |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MX2012012959A true MX2012012959A (es) | 2012-12-17 |
Family
ID=42537445
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2012012959A MX2012012959A (es) | 2010-05-10 | 2011-05-06 | Procedimiento para preparar 1, 3-dihidro-2h-indol-2-onas sustituidas. |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US8563749B2 (es) |
| EP (1) | EP2569283B1 (es) |
| JP (1) | JP5815679B2 (es) |
| KR (1) | KR101783471B1 (es) |
| CN (1) | CN102985406B (es) |
| BR (1) | BR112012028767B1 (es) |
| DK (1) | DK2569283T3 (es) |
| ES (1) | ES2523226T3 (es) |
| IL (1) | IL222929A (es) |
| MX (1) | MX2012012959A (es) |
| TW (1) | TWI499583B (es) |
| WO (1) | WO2011141364A1 (es) |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4160032A (en) * | 1973-11-21 | 1979-07-03 | Sandoz, Inc. | Oxindoles as sleep-inducers |
| US4503073A (en) * | 1981-01-07 | 1985-03-05 | A. H. Robins Company, Incorporated | 2-Amino-3-(alkylthiobenzoyl)-phenylacetic acids |
| FI80270C (fi) * | 1984-09-19 | 1990-05-10 | Pfizer | Foerfarande foer framstaellning av analgetiska och anti-inflammatoriska 1,3-diacyl-2-oxoindol-foereningar och mellanprodukter. |
| US5076835A (en) * | 1990-05-31 | 1991-12-31 | America Cyanamid Company | Aryloxyspiroalkylindolinone herbicides |
| US5124347A (en) * | 1991-07-31 | 1992-06-23 | Warner-Lambert Co. | 3-5-ditertiarybutylphenyl-4-hydroxymethylidene derivatives of 1,3-dihydro-2H-indole-2-ones as antiinflammatory agents |
| FR2708605A1 (fr) * | 1993-07-30 | 1995-02-10 | Sanofi Sa | Dérivés du N-sulfonylindol-2-one, leur préparation, les compositions pharmaceutiques en contenant. |
-
2011
- 2011-05-06 MX MX2012012959A patent/MX2012012959A/es active IP Right Grant
- 2011-05-06 KR KR1020127031887A patent/KR101783471B1/ko active IP Right Grant
- 2011-05-06 JP JP2013509511A patent/JP5815679B2/ja active Active
- 2011-05-06 TW TW100115968A patent/TWI499583B/zh active
- 2011-05-06 CN CN201180034200.3A patent/CN102985406B/zh active Active
- 2011-05-06 WO PCT/EP2011/057276 patent/WO2011141364A1/de active Application Filing
- 2011-05-06 EP EP11717663.6A patent/EP2569283B1/de active Active
- 2011-05-06 BR BR112012028767-2A patent/BR112012028767B1/pt active IP Right Grant
- 2011-05-06 ES ES11717663.6T patent/ES2523226T3/es active Active
- 2011-05-06 DK DK11717663.6T patent/DK2569283T3/en active
- 2011-05-09 US US13/103,673 patent/US8563749B2/en active Active
-
2012
- 2012-11-08 IL IL222929A patent/IL222929A/en active IP Right Grant
Also Published As
| Publication number | Publication date |
|---|---|
| JP5815679B2 (ja) | 2015-11-17 |
| US8563749B2 (en) | 2013-10-22 |
| ES2523226T3 (es) | 2014-11-24 |
| TWI499583B (zh) | 2015-09-11 |
| IL222929A0 (en) | 2012-12-31 |
| CN102985406B (zh) | 2015-04-29 |
| DK2569283T3 (en) | 2014-12-01 |
| IL222929A (en) | 2015-06-30 |
| BR112012028767A2 (pt) | 2015-09-15 |
| TW201206884A (en) | 2012-02-16 |
| WO2011141364A1 (de) | 2011-11-17 |
| CN102985406A (zh) | 2013-03-20 |
| JP2013526498A (ja) | 2013-06-24 |
| BR112012028767B1 (pt) | 2021-04-27 |
| KR20130100913A (ko) | 2013-09-12 |
| EP2569283A1 (de) | 2013-03-20 |
| US20110275832A1 (en) | 2011-11-10 |
| KR101783471B1 (ko) | 2017-09-29 |
| EP2569283B1 (de) | 2014-08-27 |
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Legal Events
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| FG | Grant or registration |