MX2012008411A - Hidrogel de microesferas. - Google Patents
Hidrogel de microesferas.Info
- Publication number
- MX2012008411A MX2012008411A MX2012008411A MX2012008411A MX2012008411A MX 2012008411 A MX2012008411 A MX 2012008411A MX 2012008411 A MX2012008411 A MX 2012008411A MX 2012008411 A MX2012008411 A MX 2012008411A MX 2012008411 A MX2012008411 A MX 2012008411A
- Authority
- MX
- Mexico
- Prior art keywords
- microspheres
- filling
- soft tissues
- animal
- gel
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
- A61K31/716—Glucans
- A61K31/717—Celluloses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
- A61K31/726—Glycosaminoglycans, i.e. mucopolysaccharides
- A61K31/728—Hyaluronic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
- A61K8/731—Cellulose; Quaternized cellulose derivatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
- A61K8/735—Mucopolysaccharides, e.g. hyaluronic acid; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/14—Macromolecular materials
- A61L27/20—Polysaccharides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/40—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material
- A61L27/44—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material having a macromolecular matrix
- A61L27/48—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material having a macromolecular matrix with macromolecular fillers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
- A61L27/52—Hydrogels or hydrocolloids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
- A61L27/58—Materials at least partially resorbable by the body
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/10—Drugs for disorders of the urinary system of the bladder
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/04—Drugs for skeletal disorders for non-specific disorders of the connective tissue
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P41/00—Drugs used in surgical methods, e.g. surgery adjuvants for preventing adhesion or for vitreum substitution
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/08—Anti-ageing preparations
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/41—Particular ingredients further characterized by their size
- A61K2800/412—Microsized, i.e. having sizes between 0.1 and 100 microns
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/80—Process related aspects concerning the preparation of the cosmetic composition or the storage or application thereof
- A61K2800/91—Injection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5005—Wall or coating material
- A61K9/5021—Organic macromolecular compounds
- A61K9/5036—Polysaccharides, e.g. gums, alginate; Cyclodextrin
- A61K9/5042—Cellulose; Cellulose derivatives, e.g. phthalate or acetate succinate esters of hydroxypropyl methylcellulose
- A61K9/5047—Cellulose ethers containing no ester groups, e.g. hydroxypropyl methylcellulose
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2400/00—Materials characterised by their function or physical properties
- A61L2400/06—Flowable or injectable implant compositions
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Epidemiology (AREA)
- Dermatology (AREA)
- Pharmacology & Pharmacy (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Transplantation (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Birds (AREA)
- Materials Engineering (AREA)
- Gerontology & Geriatric Medicine (AREA)
- Composite Materials (AREA)
- Dispersion Chemistry (AREA)
- Physical Education & Sports Medicine (AREA)
- Surgery (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Urology & Nephrology (AREA)
- Medicinal Preparation (AREA)
- Materials For Medical Uses (AREA)
- Compositions Of Macromolecular Compounds (AREA)
Abstract
La invención se relaciona con una composición inyectable pretendida para inducción de tejido del tejido blando mediante un sistema de liberación progresiva prolongada e intermedia; en particular, la invención se relaciona con una composición comprendiendo un gel de al menos un primer polímero biodegradable formando un primer agente para rellenar tejido blando en un animal y una suspensión en este gel de microesferas con un diámetro promedio entre 5 y 50 micrómetros, las microesferas comprendiendo 50 a 90 % p de al menos un polisacárido biodegradable con relación al peso total de las microesferas, las microesferas induciendo un segundo relleno para inducción de tejido y conteniendo al menos un segundo polímero biodegradable formando al menos un tercer relleno de tejido blando en un animal.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR1050355A FR2955258A1 (fr) | 2010-01-20 | 2010-01-20 | Composition injectable |
US30309410P | 2010-02-10 | 2010-02-10 | |
PCT/EP2011/050727 WO2011089173A1 (en) | 2010-01-20 | 2011-01-20 | Hydrogel of microspheres |
Publications (2)
Publication Number | Publication Date |
---|---|
MX2012008411A true MX2012008411A (es) | 2012-08-15 |
MX336851B MX336851B (es) | 2016-02-03 |
Family
ID=42288575
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2012008411A MX336851B (es) | 2010-01-20 | 2011-01-20 | Hidrogel de microesferas. |
Country Status (10)
Country | Link |
---|---|
US (1) | US20130004546A1 (es) |
EP (1) | EP2525801A1 (es) |
AU (1) | AU2011208709B2 (es) |
BR (1) | BR112012018053A2 (es) |
CA (1) | CA2786866A1 (es) |
FR (1) | FR2955258A1 (es) |
IL (1) | IL221003A0 (es) |
MX (1) | MX336851B (es) |
RU (1) | RU2012134096A (es) |
WO (1) | WO2011089173A1 (es) |
Families Citing this family (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2013043828A1 (en) * | 2011-09-20 | 2013-03-28 | Grain Processing Corporation | Microspheres |
US9968708B2 (en) * | 2013-11-19 | 2018-05-15 | Cornell University | Tissue scaffold materials for tissue regeneration and methods of making |
EP3897763A1 (en) * | 2018-12-21 | 2021-10-27 | Galderma Holding SA | Hydrogel compositions encapsulating solid particles |
US20200376128A1 (en) * | 2019-06-01 | 2020-12-03 | Lupin Holdings B.V. | Monodisperse resorbable polyester polymer compositions, systems, and methods |
CN110327488B (zh) * | 2019-07-18 | 2021-10-22 | 王月玲 | 一种注射填充微球制剂及其制备方法 |
CN113058074B (zh) * | 2020-01-02 | 2022-04-29 | 华利源(上海)生物医药科技有限公司 | 温敏填充剂组合物 |
FR3116534B1 (fr) | 2020-11-23 | 2023-12-22 | Kiomed Pharma | Billes à base de chitosane, préparation, compositions et applications |
WO2024003790A1 (en) * | 2022-06-29 | 2024-01-04 | 11584022 Canada Inc. | Biopolymer formulations for drug delivery |
CN115414528B (zh) * | 2022-09-23 | 2023-05-26 | 杭州科腾生物制品有限公司 | 一种复合透明质酸钠微球凝胶及其制备方法和应用 |
CN117398518B (zh) * | 2023-12-15 | 2024-05-03 | 湘潭格莱威医疗科技有限公司 | 一种琼脂糖水凝胶材料及其用途 |
Family Cites Families (19)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5143724A (en) * | 1990-07-09 | 1992-09-01 | Biomatrix, Inc. | Biocompatible viscoelastic gel slurries, their preparation and use |
CA2060223C (en) | 1991-02-12 | 1999-07-20 | Clarence C. Lee | Injectable medical lubricating fluid composition and method of use |
TW209174B (es) * | 1991-04-19 | 1993-07-11 | Takeda Pharm Industry Co Ltd | |
GB2281861B (en) * | 1993-09-21 | 1997-08-20 | Johnson & Johnson Medical | Bioabsorbable wound implant materials containing microspheres |
JP4193917B2 (ja) * | 1995-12-18 | 2008-12-10 | アンジオデバイス インターナショナル ゲーエムベーハー | 架橋ポリマー組成物およびその使用方法 |
US6296873B1 (en) * | 1997-01-23 | 2001-10-02 | Yissum Research Development Company Of The Hebrew University Of Jerusalem | Zero-order sustained release delivery system for carbamazephine derivatives |
US6458375B1 (en) * | 1998-02-27 | 2002-10-01 | Musculoskeletal Transplant Foundation | Malleable paste with allograft bone reinforcement for filling bone defects |
FR2778336A1 (fr) * | 1998-05-11 | 1999-11-12 | Jean Pierre Perraud | Implant injectable en sous-cutane et en sous-gingival resorbable a base de maltodextrine micro-encapsulee et resorbable en un temps determine |
CA2380932A1 (en) | 1999-08-13 | 2001-02-22 | Bioform Inc. | Tissue augmentation material and methods |
FR2819722B1 (fr) * | 2001-01-19 | 2006-11-24 | Corneal Ind | Utilisation de l'acide hyaluronique ou d'au moins l'un de ses sels dans le cadre d'un traitemnet chirurgical de la presbytie |
GB0129489D0 (en) * | 2001-12-10 | 2002-01-30 | Quadrant Healthcare Uk Ltd | Sustained-release compositions |
US7842300B2 (en) * | 2002-07-31 | 2010-11-30 | Dentsply International, Inc. | Bone repair putty |
US20060099256A1 (en) * | 2002-11-27 | 2006-05-11 | Price James C | Microspheres and related processes and pharmaceutical compositions |
DE102004019241A1 (de) | 2004-04-16 | 2005-11-03 | Cellmed Ag | Injizierbare vernetzte und unvernetzte Alginate und ihre Verwendung in der Medizin und in der ästhetischen Chirurgie |
FR2897775B1 (fr) * | 2006-02-24 | 2013-05-03 | Elisabeth Laugier | Biomateriau, implant injectable le comprenant, son procede de preparation et ses utilisations |
KR101994513B1 (ko) * | 2006-06-05 | 2019-06-28 | 디에스엠 뉴트리셔널 프라덕츠 아게 | 개선된 쉘을 가지는 마이크로캡슐 |
WO2008147817A2 (en) | 2007-05-23 | 2008-12-04 | Allergan, Inc. | Coated hyaluronic acid particles |
FR2918377B1 (fr) * | 2007-07-05 | 2010-10-08 | Estelle Piron | Gel co-reticule de polysaccharides |
WO2009100422A2 (en) | 2008-02-08 | 2009-08-13 | Zimmer, Inc. | Drug delivery system comprising microparticles and gelation system |
-
2010
- 2010-01-20 FR FR1050355A patent/FR2955258A1/fr not_active Withdrawn
-
2011
- 2011-01-20 EP EP11700447A patent/EP2525801A1/en not_active Withdrawn
- 2011-01-20 MX MX2012008411A patent/MX336851B/es active IP Right Grant
- 2011-01-20 RU RU2012134096/15A patent/RU2012134096A/ru unknown
- 2011-01-20 WO PCT/EP2011/050727 patent/WO2011089173A1/en active Application Filing
- 2011-01-20 BR BR112012018053A patent/BR112012018053A2/pt not_active IP Right Cessation
- 2011-01-20 US US13/522,773 patent/US20130004546A1/en not_active Abandoned
- 2011-01-20 AU AU2011208709A patent/AU2011208709B2/en not_active Ceased
- 2011-01-20 CA CA2786866A patent/CA2786866A1/en not_active Abandoned
-
2012
- 2012-07-18 IL IL221003A patent/IL221003A0/en unknown
Also Published As
Publication number | Publication date |
---|---|
BR112012018053A2 (pt) | 2018-06-05 |
AU2011208709B2 (en) | 2016-06-09 |
FR2955258A1 (fr) | 2011-07-22 |
MX336851B (es) | 2016-02-03 |
CA2786866A1 (en) | 2011-07-28 |
RU2012134096A (ru) | 2014-02-27 |
US20130004546A1 (en) | 2013-01-03 |
EP2525801A1 (en) | 2012-11-28 |
IL221003A0 (en) | 2012-09-24 |
AU2011208709A1 (en) | 2012-08-02 |
WO2011089173A1 (en) | 2011-07-28 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
MX2012008411A (es) | Hidrogel de microesferas. | |
WO2011091205A3 (en) | Intracameral sustained release therapeutic agent implants | |
WO2012008722A3 (ko) | 조직 증강용 충전 조성물 | |
EP2309989A4 (en) | Polymerized Nanoparticles and Methods for Making and Using Them | |
WO2013142472A3 (en) | Superabsorbent polymers and silicone elastomer for use in skin care compositions | |
MX2017006232A (es) | Relleno dermico a base de acido hialuronico reticulado y lubricante de carboximetilcelulosa. | |
GB201101429D0 (en) | Drug delivery system | |
BRPI0909630B8 (pt) | composição em suspensão aquosa particularmente adequada para injeção dentro do olho | |
WO2011084521A3 (en) | Therapeutic polymeric nanoparticles comprising epothilone and methods of making and using same | |
WO2011084518A3 (en) | Therapeutic polymeric nanoparticles comprising corticosteroids and methods of making and using same | |
IN2012DN00570A (es) | ||
WO2010062523A3 (en) | Prostaglandin and prostamide drug delivery systems and intraocular therapeutic uses thereof | |
MX341475B (es) | Composiciones de copolimero hibrido para aplicaciones de cuidado personal. | |
WO2009140423A3 (en) | Targeted polymer bioconjugates | |
EP2395048A3 (en) | Polymers compositions including an antioxidant | |
MX2012014384A (es) | Composiciones solidas. | |
WO2014093489A3 (en) | Hydrogel membrane for adhesion prevention | |
GB201020193D0 (en) | Glucan compositions | |
MX2013011314A (es) | Tratamientos oftalmicos. | |
WO2010017215A3 (en) | Biodegradable microspheres and methods of use thereof | |
MX2009007774A (es) | Composiciones oftalmicas que contienen una combinacion sinergistica de tres polimeros. | |
WO2009149418A3 (en) | Compositions for the in vivo delivery of rnai agents | |
PH12015500610A1 (en) | Oral care composition | |
WO2015023773A3 (en) | Tooth remineralization compositions and methods | |
MX359713B (es) | Composiciones mejoradas para la cicatrizacion de heridas que comprenden microesferas. |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
FG | Grant or registration |