MX2012005329A - Compuestos benzoimidazolicos y sus usos. - Google Patents

Compuestos benzoimidazolicos y sus usos.

Info

Publication number
MX2012005329A
MX2012005329A MX2012005329A MX2012005329A MX2012005329A MX 2012005329 A MX2012005329 A MX 2012005329A MX 2012005329 A MX2012005329 A MX 2012005329A MX 2012005329 A MX2012005329 A MX 2012005329A MX 2012005329 A MX2012005329 A MX 2012005329A
Authority
MX
Mexico
Prior art keywords
compound
methyl
benzoimidazole compounds
processes
relates
Prior art date
Application number
MX2012005329A
Other languages
English (en)
Inventor
Louis-David Cantin
Xuehong Luo
Miroslaw Jerzy Tomaszewski
Original Assignee
Astrazeneca Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Astrazeneca Ab filed Critical Astrazeneca Ab
Publication of MX2012005329A publication Critical patent/MX2012005329A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/10—Drugs for disorders of the urinary system of the bladder
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D265/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
    • C07D265/28—1,4-Oxazines; Hydrogenated 1,4-oxazines
    • C07D265/30—1,4-Oxazines; Hydrogenated 1,4-oxazines not condensed with other rings

Abstract

Esta invención se refiere en general a compuestos benzoimidazólicos sustituidos, particularmente 2- ((2- (2,6- difluoro-4- (metilcarbamoil) fenil)-5-metil-lH-benzo [djimidazol-l-il) metil) morfolin-4-carboxilato de metilo y sus sales. Esta invención también se refiere a composiciones farmacéuticas y a kits que comprenden un compuesto de este tipo, a los usos de un compuesto de este tipo (incluidos, por ejemplo, los métodos de tratamiento y los preparados farmacéuticos), a los procesos para fabricar un compuesto de este tipo y a los intermedios empleados en tales procesos.
MX2012005329A 2009-11-18 2010-11-17 Compuestos benzoimidazolicos y sus usos. MX2012005329A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US26226309P 2009-11-18 2009-11-18
PCT/SE2010/051269 WO2011062550A1 (en) 2009-11-18 2010-11-17 Benzoimidazole compounds and uses thereof

Publications (1)

Publication Number Publication Date
MX2012005329A true MX2012005329A (es) 2012-05-29

Family

ID=44059844

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2012005329A MX2012005329A (es) 2009-11-18 2010-11-17 Compuestos benzoimidazolicos y sus usos.

Country Status (16)

Country Link
US (1) US8530467B2 (es)
EP (1) EP2501697B1 (es)
JP (1) JP5657018B2 (es)
KR (1) KR20120113709A (es)
CN (1) CN102741245B (es)
AR (1) AR079050A1 (es)
AU (1) AU2010322478B2 (es)
BR (1) BR112012011518B8 (es)
CA (1) CA2777746C (es)
ES (1) ES2442797T3 (es)
IN (1) IN2012DN03391A (es)
MX (1) MX2012005329A (es)
RU (1) RU2542582C2 (es)
TW (1) TW201121957A (es)
UY (1) UY33037A (es)
WO (1) WO2011062550A1 (es)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2012158117A1 (en) * 2011-05-17 2012-11-22 Astrazeneca Ab Combination therapies for treating pain
CN105246888B (zh) * 2013-01-31 2017-09-05 尼奥迈德研究所 咪唑并吡啶化合物及其用途
CN105992761A (zh) * 2013-12-20 2016-10-05 盐野义制药株式会社 具有血小板生成素受体激动作用的光学活性的化合物及其中间体的制备方法
EP3981406A1 (en) 2014-07-03 2022-04-13 Afferent Pharmaceuticals Inc. Methods and compositions for treating diseases and conditions
US10111883B1 (en) * 2017-09-18 2018-10-30 Bellus Health Cough Inc. Selective P2X3 modulators
CN108904507A (zh) * 2018-02-11 2018-11-30 赖英杰 P2x3受体调节剂苯并咪唑化合物在制备抗呼吸疾病药物中的应用
US20240034729A9 (en) * 2018-12-29 2024-02-01 Wuhan Ll Science And Technology Development Co., Ltd. Heterocyclic compound, intermediate, preparation method therefor and application thereof
CA3187092A1 (en) * 2020-08-13 2022-02-17 Wenming Li Benzimidazole derivatives, preparation method therefor and medical use thereof
WO2022117062A1 (zh) * 2020-12-04 2022-06-09 上海拓界生物医药科技有限公司 含有稠合三环的化合物及其医药用途
CN114478508A (zh) * 2021-12-31 2022-05-13 淮北师范大学 一种苯并咪唑化合物的结晶形式
WO2023151660A1 (zh) * 2022-02-11 2023-08-17 江苏恒瑞医药股份有限公司 一种p2x3受体拮抗剂的结晶形式及其制备方法
WO2023151658A1 (zh) * 2022-02-11 2023-08-17 江苏恒瑞医药股份有限公司 一种p2x3受体拮抗剂的可药用盐及其制备方法

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6026A (en) * 1849-01-09 Cast-iron car-wheel
GB9624482D0 (en) 1995-12-18 1997-01-15 Zeneca Phaema S A Chemical compounds
US6184225B1 (en) 1996-02-13 2001-02-06 Zeneca Limited Quinazoline derivatives as VEGF inhibitors
DE69709319T2 (de) 1996-03-05 2002-08-14 Astrazeneca Ab 4-anilinochinazolin derivate
GB9718972D0 (en) 1996-09-25 1997-11-12 Zeneca Ltd Chemical compounds
GB9714249D0 (en) 1997-07-08 1997-09-10 Angiogene Pharm Ltd Vascular damaging agents
GB9900334D0 (en) 1999-01-07 1999-02-24 Angiogene Pharm Ltd Tricylic vascular damaging agents
GB9900752D0 (en) 1999-01-15 1999-03-03 Angiogene Pharm Ltd Benzimidazole vascular damaging agents
ES2351699T3 (es) 1999-02-10 2011-02-09 Astrazeneca Ab Derivados de quinazolina como inhibidores de la angiogénesis e intermedios de los mismos.
CN1198819C (zh) * 2000-01-17 2005-04-27 帝人株式会社 苯并咪唑衍生物
JP2003535078A (ja) 2000-05-31 2003-11-25 アストラゼネカ アクチボラグ 血管損傷活性のあるインドール誘導体
UA73993C2 (uk) 2000-06-06 2005-10-17 Астразенека Аб Хіназолінові похідні для лікування пухлин та фармацевтична композиція
EP1301498A1 (en) 2000-07-07 2003-04-16 Angiogene Pharmaceuticals Limited Colchinol derivatives as angiogenesis inhibitors
BR0112224A (pt) 2000-07-07 2003-06-10 Angiogene Pharm Ltd Composto, composição farmacêutica, uso de um composto ou de um sal, solvato ou pró-droga farmaceuticamente aceitável do mesmo, e, processo para preparar um composto
RU2374234C2 (ru) * 2004-09-24 2009-11-27 Астразенека Аб Бензимидазольные производные, содержащие их композиции, их получение и применение
KR20090127902A (ko) * 2007-03-02 2009-12-14 쉐링 코포레이션 벤즈이미다졸 유도체 및 이의 사용방법
US20090099195A1 (en) 2007-05-08 2009-04-16 Astrazeneca Ab Therapeutic Compounds 570
CA2703909A1 (en) * 2007-10-31 2009-05-07 Merck Sharp & Dohme Corp. P2x3, receptor antagonists for treatment of pain

Also Published As

Publication number Publication date
CA2777746C (en) 2019-05-14
US20120289504A1 (en) 2012-11-15
RU2542582C2 (ru) 2015-02-20
EP2501697A1 (en) 2012-09-26
AR079050A1 (es) 2011-12-21
UY33037A (es) 2011-06-30
BR112012011518B1 (pt) 2020-03-10
IN2012DN03391A (es) 2015-10-23
AU2010322478B2 (en) 2013-11-14
JP5657018B2 (ja) 2015-01-21
CN102741245B (zh) 2014-11-05
JP2013511517A (ja) 2013-04-04
CN102741245A (zh) 2012-10-17
ES2442797T3 (es) 2014-02-13
AU2010322478A1 (en) 2012-05-31
KR20120113709A (ko) 2012-10-15
BR112012011518A2 (pt) 2016-06-28
EP2501697A4 (en) 2013-04-24
CA2777746A1 (en) 2011-05-26
RU2012124268A (ru) 2013-12-27
TW201121957A (en) 2011-07-01
WO2011062550A1 (en) 2011-05-26
US8530467B2 (en) 2013-09-10
BR112012011518B8 (pt) 2023-01-10
EP2501697B1 (en) 2013-10-23

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