MX2012003394A - O-benzyl nicotinamide analogs as mglur5 positive allosteric modulators. - Google Patents

O-benzyl nicotinamide analogs as mglur5 positive allosteric modulators.

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Publication number
MX2012003394A
MX2012003394A MX2012003394A MX2012003394A MX2012003394A MX 2012003394 A MX2012003394 A MX 2012003394A MX 2012003394 A MX2012003394 A MX 2012003394A MX 2012003394 A MX2012003394 A MX 2012003394A MX 2012003394 A MX2012003394 A MX 2012003394A
Authority
MX
Mexico
Prior art keywords
positive allosteric
allosteric modulators
compounds
nicotinamide analogs
benzyl
Prior art date
Application number
MX2012003394A
Other languages
Spanish (es)
Inventor
Richard Williams
P Jeffrey Conn
Craig W Lindsley
Charles David Weaver
Shaun R Stauffer
Gregor James Macdonald
Jose Manuel Bartolome-Nebreda
Ya Zhou
Original Assignee
Univ Vanderbilt
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Vanderbilt filed Critical Univ Vanderbilt
Publication of MX2012003394A publication Critical patent/MX2012003394A/en

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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
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    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
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    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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Abstract

In one aspect, the invention relates to 0-benzyl nicotinamide analogs, derivatives thereof, and related compounds, which are useful as positive allosteric modulators of the metabotropic glutamate receptor subtype 5 (mGluR5); synthetic methods for making the compounds; pharmaceutical compositions comprising the compounds; and methods of treating neurological and psychiatric disorders associated with glutamate dysfunction using the compounds and compositions.
MX2012003394A 2009-09-21 2010-09-21 O-benzyl nicotinamide analogs as mglur5 positive allosteric modulators. MX2012003394A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US24441709P 2009-09-21 2009-09-21
PCT/US2010/049697 WO2011035324A1 (en) 2009-09-21 2010-09-21 O-benzyl nicotinamide analogs as mglur5 positive allosteric modulators

Publications (1)

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MX2012003394A true MX2012003394A (en) 2012-08-15

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MX2012003394A MX2012003394A (en) 2009-09-21 2010-09-21 O-benzyl nicotinamide analogs as mglur5 positive allosteric modulators.

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US (1) US20110183980A1 (en)
EP (1) EP2482657A4 (en)
JP (1) JP2013505297A (en)
CN (1) CN102638979A (en)
AU (1) AU2010295288A1 (en)
BR (1) BR112012006330A2 (en)
CA (1) CA2774981A1 (en)
IL (1) IL218772A0 (en)
IN (1) IN2012DN03322A (en)
MX (1) MX2012003394A (en)
RU (1) RU2012116124A (en)
WO (1) WO2011035324A1 (en)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2011075699A2 (en) 2009-12-18 2011-06-23 Sunovion Pharmaceuticals Inc. Compounds for treating disorders mediated by metabotropic glutamate receptor 5, and methods of use thereof
JP2013526610A (en) * 2010-05-24 2013-06-24 ヴァンダービルト ユニバーシティー Substituted 6-methylnicotinamide as a positive allosteric modulator of MGLUR5
RU2542100C1 (en) * 2013-12-24 2015-02-20 Федеральное государственное бюджетное учреждение науки Институт химии растворов им. Г.А. Крестова Российской Академии Наук (ИХС РАН) Co-crystalline form of theophylline with diflunisal or diclofenac
TWI713497B (en) 2015-02-26 2020-12-21 南韓商愛思開生物製藥股份有限公司 Imidazopyrimidine and imidazotriazine derivative, and pharmaceutical composition comprising the same
CN114450274A (en) 2019-07-11 2022-05-06 伊斯凯普生物公司 Indazoles and azaindazoles as LRRK2 inhibitors

Family Cites Families (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AR208397A1 (en) * 1973-02-20 1976-12-27 Ciba Geigy Ag PROCEDURE FOR THE PREPARATION OF 1-PYRIDYLOXY-2-HYDROXY-3-AMINO-PROPANO1-PIRAZINYLOXY-2-HYDROXY-3-AMINO-PROPANE AND 1-PYRIMIDINYLOXY-2-HYDROXY-3-AMINO-PROPAN COMPOUNDS
JP2689093B2 (en) * 1986-01-30 1997-12-10 石原産業株式会社 Substituted pyridine sulfonamide compounds, herbicides containing them and method for producing these compounds
JP2000212076A (en) * 1998-11-20 2000-08-02 Takeda Chem Ind Ltd Beta-amyloid protein production/secretion inhibitor
US6586475B1 (en) * 1998-11-20 2003-07-01 Takeda Chemical Industries, Ltd. β-amyloid protein production/secretion inhibitors
AU2002214583A1 (en) * 2000-10-11 2002-04-22 Purdue Research Foundation Pharmaceutical applications of hydrotropic agents, polymers thereof, and hydrogels thereof
JP2002322163A (en) * 2001-04-20 2002-11-08 Sumitomo Pharmaceut Co Ltd Piperazine derivative
US6667327B2 (en) * 2002-02-04 2003-12-23 Hoffmann-La Roche Inc. Pyridine amido derivatives
US20040072802A1 (en) * 2002-10-09 2004-04-15 Jingwu Duan Beta-amino acid derivatives as inhibitors of matrix metalloproteases and TNF-alpha
WO2004078719A1 (en) * 2003-03-06 2004-09-16 Ono Pharmaceutical Co., Ltd. Indole derivative compounds and drugs containing the compounds as the active ingredient
GB0418267D0 (en) * 2004-08-16 2004-09-15 Glaxo Group Ltd Novel compounds
WO2006106054A1 (en) * 2005-04-06 2006-10-12 F. Hoffmann-La Roche Ag Pyridine-3-carboxamide derivatives as cb1 inverse agonists
US8138209B2 (en) * 2005-07-13 2012-03-20 Jenrin Discovery, Inc. Substituted picolinamides as MAO-B inhibitors useful for treating obesity
CN101321731A (en) * 2005-12-20 2008-12-10 诺瓦提斯公司 Nicotinic acid derivatives as modulators of metabotropic glutamate receptors
US20090005363A1 (en) * 2005-12-20 2009-01-01 Ralf Glatthar Organic Compounds
US20110172230A1 (en) * 2006-08-23 2011-07-14 Takahiro Ishii Urea compound or salt thereof
MX2009002684A (en) * 2006-09-11 2009-06-05 Novartis Ag New uses of metabotropic glutamate receptors.
WO2008038841A1 (en) * 2006-09-30 2008-04-03 Japan Tobacco Inc. Thiadiazolone derivative and use thereof
TW200821305A (en) * 2006-10-05 2008-05-16 Astrazeneca Ab MGluR5 modulators
US8853392B2 (en) * 2007-06-03 2014-10-07 Vanderbilt University Benzamide mGluR5 positive allosteric modulators and methods of making and using same
WO2009067401A1 (en) * 2007-11-20 2009-05-28 Janssen Pharmaceutica N.V. Cycloalkyloxy-and hetξrocycloalky- loxypyridine compounds as modulators of the histamine h3 receptor
ES2531023T3 (en) * 2007-12-04 2015-03-09 Hoffmann La Roche Isoxazole-Pyridine Derivatives
US7897621B2 (en) * 2008-03-31 2011-03-01 Hoffmann-La Roche Inc. 2-trifluoromethylnicotinamide derivatives as HDL-cholesterol raising agents
US8748623B2 (en) * 2009-02-17 2014-06-10 Syntrix Biosystems, Inc. Pyridinecarboxamides as CXCR2 modulators
US8222246B2 (en) * 2009-04-02 2012-07-17 Hoffmann-La Roche Inc. Substituted isoxazoles
CN102414203B (en) * 2009-05-07 2014-11-26 弗·哈夫曼-拉罗切有限公司 Isoxazole-pyridine derivatives as GABA modulators

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IL218772A0 (en) 2012-06-28
RU2012116124A (en) 2013-10-27
CN102638979A (en) 2012-08-15
AU2010295288A1 (en) 2012-05-03
JP2013505297A (en) 2013-02-14
EP2482657A1 (en) 2012-08-08
EP2482657A4 (en) 2013-05-15
BR112012006330A2 (en) 2017-07-04
CA2774981A1 (en) 2011-03-24
IN2012DN03322A (en) 2015-10-23
WO2011035324A1 (en) 2011-03-24
US20110183980A1 (en) 2011-07-28

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