MX2011006432A - Metodo para controlar el peso molecular del polisacarido streptococcus pneumoniae serotipo 19a. - Google Patents
Metodo para controlar el peso molecular del polisacarido streptococcus pneumoniae serotipo 19a.Info
- Publication number
- MX2011006432A MX2011006432A MX2011006432A MX2011006432A MX2011006432A MX 2011006432 A MX2011006432 A MX 2011006432A MX 2011006432 A MX2011006432 A MX 2011006432A MX 2011006432 A MX2011006432 A MX 2011006432A MX 2011006432 A MX2011006432 A MX 2011006432A
- Authority
- MX
- Mexico
- Prior art keywords
- fermentation culture
- streptococcus pneumoniae
- molecular weight
- capsular polysaccharides
- pneumoniae serotype
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
- C12N1/20—Bacteria; Culture media therefor
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P19/00—Preparation of compounds containing saccharide radicals
- C12P19/04—Polysaccharides, i.e. compounds containing more than five saccharide radicals attached to each other by glycosidic bonds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Genetics & Genomics (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- General Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Medicinal Chemistry (AREA)
- Immunology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Tropical Medicine & Parasitology (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Virology (AREA)
- Biomedical Technology (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Polysaccharides And Polysaccharide Derivatives (AREA)
Abstract
La presente invención proporciona métodos mejorados para producir una solución que contiene polisacáridos capsulares Streptococcus pneumoniae 19A aislados de elevado peso molecular. En ciertos métodos, un cultivo de fermentación de células bacteriales Streptococcus pneumoniae que producen polisacáridos capsulares serotipo 19A es fermentado por menos de 6 horas antes de que las células bacteriales sean usadas y se recolecten los polisacáridos capsulares. En otros métodos, el CO2 es suministrado al cultivo de fermentación. El suministro de CO2 al cultivo de fermentación incluye agregar iones bicarbonato al cultivo de fermentación, agregar iones carbonato al cultivo de fermentación, agregar mezclas de iones bicarbonato y carbonato al cultivo de fermentación, y sobreponer el cultivo de fermentación con CO2.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US13856308P | 2008-12-18 | 2008-12-18 | |
| PCT/US2009/068429 WO2010080486A2 (en) | 2008-12-18 | 2009-12-17 | Method for controlling streptococcus pneumoniae serotype 19a polysaccharide molecular weight |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MX2011006432A true MX2011006432A (es) | 2011-09-29 |
Family
ID=42266457
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2011006432A MX2011006432A (es) | 2008-12-18 | 2009-12-17 | Metodo para controlar el peso molecular del polisacarido streptococcus pneumoniae serotipo 19a. |
Country Status (19)
| Country | Link |
|---|---|
| US (1) | US8795689B2 (es) |
| EP (1) | EP2379734B1 (es) |
| JP (1) | JP5843612B2 (es) |
| KR (2) | KR20110091546A (es) |
| CN (1) | CN102257155B (es) |
| AU (1) | AU2009335826B2 (es) |
| BR (1) | BRPI0922981A8 (es) |
| CA (1) | CA2743710C (es) |
| DK (1) | DK2379734T3 (es) |
| ES (1) | ES2666698T3 (es) |
| HK (1) | HK1163750A1 (es) |
| HU (1) | HUE037465T2 (es) |
| IL (1) | IL213169A (es) |
| MX (1) | MX2011006432A (es) |
| PL (1) | PL2379734T3 (es) |
| PT (1) | PT2379734T (es) |
| RU (1) | RU2511404C2 (es) |
| SI (1) | SI2379734T1 (es) |
| WO (1) | WO2010080486A2 (es) |
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2524436C2 (ru) * | 2008-12-18 | 2014-07-27 | УАЙТ ЭлЭлСи | Способ получения жидкой фракции, содержащей изолированные высокомолекулярные капсульные полисахариды streptococcus pneumoniae, и жидкая фракция, полученная таким способом |
| RU2536248C2 (ru) | 2009-04-30 | 2014-12-20 | Коули Фармасьютикал Груп, Инк. | Пневмококковая вакцина и ее применения |
| US9249439B2 (en) | 2011-12-15 | 2016-02-02 | Serum Institute Of India Ltd. | Process of cultivating bacteria for yield improvement of capsular polyoses |
| CN104781413B (zh) * | 2012-09-07 | 2018-01-23 | Sk化学公司 | 用于具有肺炎球菌血清型的荚膜多糖的生产方法 |
| US11951165B2 (en) | 2016-12-30 | 2024-04-09 | Vaxcyte, Inc. | Conjugated vaccine carrier proteins |
| MA47223A (fr) | 2016-12-30 | 2019-11-06 | Sutrovax Inc | Conjugués polypeptide-antigène avec des acides aminés non naturels |
| CN110225764A (zh) | 2017-01-31 | 2019-09-10 | 默沙东公司 | 制备多糖-蛋白缀合物的方法 |
| CA3050120A1 (en) | 2017-02-24 | 2018-08-30 | Merck Sharp & Dohme Corp. | Enhancing immunogenicity of streptococcus pneumoniae polysaccharide-protein conjugates |
| KR20240018697A (ko) | 2017-06-10 | 2024-02-13 | 인벤트프라이즈 인크. | 면역원성과 항원항체 결합성이 개선된 2가 또는 다가 접합체 다당류를 가진 다가 접합체 백신 |
| US10729763B2 (en) | 2017-06-10 | 2020-08-04 | Inventprise, Llc | Mixtures of polysaccharide-protein pegylated compounds |
| MX2020002557A (es) | 2017-09-07 | 2020-07-13 | Merck Sharp & Dohme | Polisacaridos neumococicos y su uso en conjugados de polisacarido inmunogenico con proteina. |
| KR20200051005A (ko) | 2017-09-07 | 2020-05-12 | 머크 샤프 앤드 돔 코포레이션 | 폐렴구균 폴리사카라이드 및 면역원성 폴리사카라이드-담체 단백질 접합체에서의 그의 용도 |
| SG11202005255PA (en) | 2017-12-06 | 2020-07-29 | Merck Sharp & Dohme | Compositions comprising streptococcus pneumoniae polysaccharide-protein conjugates and methods of use thereof |
| US11951162B2 (en) * | 2018-04-18 | 2024-04-09 | Sk Bioscience Co., Ltd. | Streptococcus pneumoniae capsular polysaccharides and immunogenic conjugate thereof |
| EP3788143B1 (en) | 2018-04-30 | 2023-06-28 | Merck Sharp & Dohme LLC | Methods for providing a homogenous solution of lyophilized mutant diptheria toxin in dimethylsulfoxide |
| KR20210005158A (ko) | 2018-04-30 | 2021-01-13 | 머크 샤프 앤드 돔 코포레이션 | 스트렙토코쿠스 뉴모니아에 피막 폴리사카라이드 담체 단백질 접합체를 제조하는 방법 |
| TWI788610B (zh) | 2018-12-19 | 2023-01-01 | 美商默沙東有限責任公司 | 包含肺炎鏈球菌多醣-蛋白質結合物之組合物及其使用方法 |
Family Cites Families (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA1115210A (en) | 1977-11-28 | 1981-12-29 | Dennis J. Carlo | Pneumococcal vaccine |
| US4221906A (en) * | 1979-03-19 | 1980-09-09 | American Cyanamid Company | Stabilization of pneumococcal polysaccharides |
| US4242501A (en) | 1979-08-08 | 1980-12-30 | American Cyanamid Company | Purification of pneumococcal capsular polysaccharides |
| FR2495939B1 (fr) | 1980-12-11 | 1985-10-11 | Merieux Inst | Procede de purification de polyosides de streptococcus pneumoniae et vaccin a base de polyosides ainsi purifies |
| BE889979A (fr) | 1981-08-14 | 1982-02-15 | Smith Kline Rit | Procede de preparation de polysaccharides bacteriens capsulaires antigeniques purifies, produits obtenus et leur utilisation |
| US4686102A (en) * | 1984-04-12 | 1987-08-11 | American Cyanamid Company | Multivalent pneumococcal vaccine and preparation thereof |
| CA2059693C (en) * | 1991-01-28 | 2003-08-19 | Peter J. Kniskern | Polysaccharide antigens from streptococcus pneumoniae |
| CA2059692C (en) * | 1991-01-28 | 2004-11-16 | Peter J. Kniskern | Pneumoccoccal polysaccharide conjugate vaccine |
| US5314822A (en) * | 1992-10-15 | 1994-05-24 | Merck & Co., Inc. | Method of clonal growth of Streptococcus pneumoniae |
| US5714354A (en) * | 1995-06-06 | 1998-02-03 | American Home Products Corporation | Alcohol-free pneumococcal polysaccharide purification process |
| US6146902A (en) * | 1998-12-29 | 2000-11-14 | Aventis Pasteur, Inc. | Purification of polysaccharide-protein conjugate vaccines by ultrafiltration with ammonium sulfate solutions |
| EP1967591A3 (en) * | 2000-03-16 | 2008-12-03 | The Children's Hospital Of Philadelphia | Method of assessing the usefulness of a test compound for alleviating a pneumococcal infection in an animal |
| US6743610B2 (en) * | 2001-03-30 | 2004-06-01 | The University Of Chicago | Method to produce succinic acid from raw hydrolysates |
| ITTS20010013A1 (it) | 2001-06-04 | 2002-12-04 | Ct Ricerche Poly Tec H A R L S | Nuovi derivati di ialuronano. |
| DK1664319T3 (da) * | 2003-09-11 | 2010-05-10 | Staat Der Nederlanden Vert Doo | Fremgangsmåde til fremstilling af et kapsel-polysaccharid til anvendelse i konjugatvacciner |
| US7709001B2 (en) * | 2005-04-08 | 2010-05-04 | Wyeth Llc | Multivalent pneumococcal polysaccharide-protein conjugate composition |
| US7955605B2 (en) * | 2005-04-08 | 2011-06-07 | Wyeth Llc | Multivalent pneumococcal polysaccharide-protein conjugate composition |
| US20070184072A1 (en) | 2005-04-08 | 2007-08-09 | Wyeth | Multivalent pneumococcal polysaccharide-protein conjugate composition |
| ME01334B (me) | 2005-04-08 | 2013-12-20 | Wyeth Llc | Polivalentni pripravak konjugata pneumokoknog polisaharida s proteinom |
| MX2007012337A (es) * | 2005-04-08 | 2007-11-21 | Wyeth Corp | Separacion de contaminantes de polisacarido de streptococcus pneumoniae por manipulacion de ph. |
| GB0522303D0 (en) * | 2005-11-01 | 2005-12-07 | Chiron Srl | Culture method |
| MX2009003730A (es) | 2006-10-10 | 2009-04-22 | Wyeth Corp | Purificacion de polisacaridos de streptococcus pneumoniae tipo 3. |
| US7860500B2 (en) * | 2006-10-27 | 2010-12-28 | Motorola, Inc. | Method and apparatus for determining appropriate channels for communication |
| MX2009010221A (es) * | 2007-03-23 | 2009-10-19 | Wyeth Corp | Proceso abreviado de purificacion para la produccion de polisacaridos capsulares de streptococcus pneumoniae. |
| RU2524436C2 (ru) * | 2008-12-18 | 2014-07-27 | УАЙТ ЭлЭлСи | Способ получения жидкой фракции, содержащей изолированные высокомолекулярные капсульные полисахариды streptococcus pneumoniae, и жидкая фракция, полученная таким способом |
-
2009
- 2009-12-17 CN CN200980150879.5A patent/CN102257155B/zh active Active
- 2009-12-17 MX MX2011006432A patent/MX2011006432A/es active IP Right Grant
- 2009-12-17 ES ES09795862.3T patent/ES2666698T3/es active Active
- 2009-12-17 US US12/640,769 patent/US8795689B2/en active Active
- 2009-12-17 SI SI200931830T patent/SI2379734T1/en unknown
- 2009-12-17 DK DK09795862.3T patent/DK2379734T3/en active
- 2009-12-17 RU RU2011128564/10A patent/RU2511404C2/ru active
- 2009-12-17 HU HUE09795862A patent/HUE037465T2/hu unknown
- 2009-12-17 EP EP09795862.3A patent/EP2379734B1/en active Active
- 2009-12-17 BR BRPI0922981-7 patent/BRPI0922981A8/pt not_active Application Discontinuation
- 2009-12-17 CA CA2743710A patent/CA2743710C/en active Active
- 2009-12-17 JP JP2011542425A patent/JP5843612B2/ja active Active
- 2009-12-17 PL PL09795862T patent/PL2379734T3/pl unknown
- 2009-12-17 AU AU2009335826A patent/AU2009335826B2/en active Active
- 2009-12-17 PT PT97958623T patent/PT2379734T/pt unknown
- 2009-12-17 WO PCT/US2009/068429 patent/WO2010080486A2/en active Application Filing
- 2009-12-17 KR KR1020117013836A patent/KR20110091546A/ko not_active Application Discontinuation
- 2009-12-17 KR KR1020137031507A patent/KR101593770B1/ko active IP Right Grant
-
2011
- 2011-05-26 IL IL213169A patent/IL213169A/en active IP Right Grant
-
2012
- 2012-04-24 HK HK12104021.1A patent/HK1163750A1/zh unknown
Also Published As
| Publication number | Publication date |
|---|---|
| US8795689B2 (en) | 2014-08-05 |
| JP2012512660A (ja) | 2012-06-07 |
| PT2379734T (pt) | 2018-04-27 |
| BRPI0922981A8 (pt) | 2019-11-26 |
| RU2011128564A (ru) | 2013-01-27 |
| CA2743710A1 (en) | 2010-07-15 |
| KR20130136011A (ko) | 2013-12-11 |
| HUE037465T2 (hu) | 2018-09-28 |
| EP2379734B1 (en) | 2018-03-21 |
| RU2511404C2 (ru) | 2014-04-10 |
| IL213169A (en) | 2015-02-26 |
| CN102257155A (zh) | 2011-11-23 |
| AU2009335826B2 (en) | 2013-10-31 |
| CN102257155B (zh) | 2016-03-02 |
| KR20110091546A (ko) | 2011-08-11 |
| DK2379734T3 (en) | 2018-04-23 |
| IL213169A0 (en) | 2011-07-31 |
| KR101593770B1 (ko) | 2016-02-15 |
| WO2010080486A2 (en) | 2010-07-15 |
| HK1163750A1 (zh) | 2012-09-14 |
| PL2379734T3 (pl) | 2018-08-31 |
| BRPI0922981A2 (pt) | 2015-08-25 |
| JP5843612B2 (ja) | 2016-01-13 |
| AU2009335826A1 (en) | 2010-07-15 |
| ES2666698T3 (es) | 2018-05-07 |
| EP2379734A2 (en) | 2011-10-26 |
| WO2010080486A3 (en) | 2010-11-04 |
| CA2743710C (en) | 2017-01-24 |
| US20100158953A1 (en) | 2010-06-24 |
| SI2379734T1 (en) | 2018-05-31 |
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| FG | Grant or registration |