MX2010009755A - Nuevos derivados de triarilo utiles como moduladores de receptores de acetilcolina nicotinicos. - Google Patents

Nuevos derivados de triarilo utiles como moduladores de receptores de acetilcolina nicotinicos.

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Publication number
MX2010009755A
MX2010009755A MX2010009755A MX2010009755A MX2010009755A MX 2010009755 A MX2010009755 A MX 2010009755A MX 2010009755 A MX2010009755 A MX 2010009755A MX 2010009755 A MX2010009755 A MX 2010009755A MX 2010009755 A MX2010009755 A MX 2010009755A
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Mexico
Prior art keywords
diseases
represent
disorders
modulators
nicotinic acetylcholine
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MX2010009755A
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English (en)
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Dan Peters
Jeppe Kejser Christensen
Antonio Nardi
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Publication of MX2010009755A publication Critical patent/MX2010009755A/es

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Abstract

La presente invención se refiere a nuevos derivados de triarilo, de fórmula (I), un estereoisómero del mismo o una mezcla de sus estereoisómeros, o una sal del mismo farmacéuticamente aceptable, en donde todos de X, Y y Z representan CH; o uno o dos de X, Y y Z representan N; y los otros de X, Y y Z representan CH, y R1, R2, R3, R4 y R5, independientemente entre sí, representan hidrógeno, halo, trifluorometilo, trifluorometoxi, ciano, hidroxilo, alcoxi, alquilo, amino o sulfamoilo; o R1 y R2, junto con el anillo fenilo al cual están unidos forman un anillo indolilo o un anillo benzo-dioxolilo; y R3, R4 y R5 son como se definen anteriormente; y R6 representa amino o nitro, los cuales se encuentran por ser moduladores de los receptores de acetilcolina nicotínicos. Debido a su perfil farmacológico, los compuestos de la invención pueden ser útiles para el tratamiento de enfermedades o trastornos tan diversos como aquellos relacionados al sistema colinérgico del sistema nervioso central (SNC), el sistema nervioso periférico (SNP), enfermedades o trastornos relacionados a contracción del músculo liso, enfermedades y trastornos endócrinos, enfermedades o trastornos relacionados a neuro-degeneración, enfermedades o trastornos relacionados a inflamación, dolor y síntomas de abstinencia causados por la terminación del abuso de sustancias químicas.
MX2010009755A 2008-03-11 2009-03-09 Nuevos derivados de triarilo utiles como moduladores de receptores de acetilcolina nicotinicos. MX2010009755A (es)

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DKPA200800371 2008-03-11
US3591508P 2008-03-12 2008-03-12
PCT/EP2009/052733 WO2009112461A1 (en) 2008-03-11 2009-03-09 Novel triaryl derivatives useful as modulators of nicotinic acetylcholine receptors

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EP (1) EP2262767A1 (es)
JP (1) JP2011513460A (es)
KR (1) KR20100125304A (es)
CN (1) CN101970406A (es)
AU (1) AU2009224738A1 (es)
BR (1) BRPI0908837A2 (es)
CA (1) CA2718241A1 (es)
IL (1) IL207488A0 (es)
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RU (1) RU2010135035A (es)
WO (1) WO2009112461A1 (es)
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EP2871179A4 (en) 2012-07-03 2016-03-16 Ono Pharmaceutical Co CONNECTION WITH AGONISTIC EFFECT ON THE SOMATOSTATIN RECEPTOR AND ITS USE FOR MEDICAL PURPOSES
CN105250316B (zh) * 2015-11-14 2018-01-19 西安力邦制药有限公司 一种含二联苯酚的抗癫痫药物组合
CA3068350A1 (en) 2017-06-30 2019-01-03 Bayer Animal Health Gmbh New azaquinoline derivatives
JP6965083B2 (ja) * 2017-10-04 2021-11-10 公益財団法人微生物化学研究会 化合物、及び発光化合物
JP7268049B2 (ja) 2018-03-08 2023-05-02 インサイト・コーポレイション ＰＩ３Ｋ－γ阻害剤としてのアミノピラジンジオール化合物
WO2020010003A1 (en) 2018-07-02 2020-01-09 Incyte Corporation AMINOPYRAZINE DERIVATIVES AS PI3K-γ INHIBITORS

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IL207488A0 (en) 2010-12-30
US20110105543A1 (en) 2011-05-05
AU2009224738A1 (en) 2009-09-17
RU2010135035A (ru) 2012-04-20
ZA201005691B (en) 2011-10-26
EP2262767A1 (en) 2010-12-22
JP2011513460A (ja) 2011-04-28
KR20100125304A (ko) 2010-11-30
WO2009112461A1 (en) 2009-09-17

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