MX2010007404A - Procedimiento para la preparacion de asenapina y productos intermediarios utilizados en dicho procedimiento. - Google Patents

Procedimiento para la preparacion de asenapina y productos intermediarios utilizados en dicho procedimiento.

Info

Publication number
MX2010007404A
MX2010007404A MX2010007404A MX2010007404A MX2010007404A MX 2010007404 A MX2010007404 A MX 2010007404A MX 2010007404 A MX2010007404 A MX 2010007404A MX 2010007404 A MX2010007404 A MX 2010007404A MX 2010007404 A MX2010007404 A MX 2010007404A
Authority
MX
Mexico
Prior art keywords
asenapine
preparation
intermediate products
products used
novel
Prior art date
Application number
MX2010007404A
Other languages
English (en)
Inventor
Gerardis Johannes Kemperman
Original Assignee
Organon Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Organon Nv filed Critical Organon Nv
Publication of MX2010007404A publication Critical patent/MX2010007404A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
    • C07D491/044—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/08—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon radicals, substituted by hetero atoms, attached to ring carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pyrrole Compounds (AREA)

Abstract

La invención se refiere a un procedimiento novedoso para la preparación de asenapina, es decir, trans-5-cloro-2-metil-2,3,3a,1 2b-tetrahidro-1H-dibenz[2,3:6,7]oxepino[4,5-c]pirrol, asi como a productos intermediarios novedosos para usarse en dicho procedimiento.
MX2010007404A 2008-01-04 2008-12-22 Procedimiento para la preparacion de asenapina y productos intermediarios utilizados en dicho procedimiento. MX2010007404A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP08150058 2008-01-04
PCT/EP2008/068187 WO2009087058A1 (en) 2008-01-04 2008-12-22 Process for the preparation of asenapine and intermediate products used in said process

Publications (1)

Publication Number Publication Date
MX2010007404A true MX2010007404A (es) 2010-10-05

Family

ID=39186767

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2010007404A MX2010007404A (es) 2008-01-04 2008-12-22 Procedimiento para la preparacion de asenapina y productos intermediarios utilizados en dicho procedimiento.

Country Status (8)

Country Link
US (2) US7964739B2 (es)
EP (1) EP2240492B1 (es)
JP (1) JP2011508751A (es)
CN (1) CN101918411A (es)
AT (1) ATE527266T1 (es)
CA (1) CA2710800A1 (es)
MX (1) MX2010007404A (es)
WO (1) WO2009087058A1 (es)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP5245428B2 (ja) * 2007-07-06 2013-07-24 住友化学株式会社 トランス−ジベンゾオキセノピロール化合物の製造方法およびその中間体
JP2011508751A (ja) * 2008-01-04 2011-03-17 ナームローゼ・フエンノートチヤツプ・オルガノン アセナピンの調製方法および前記方法において使用される中間生成物
MX2012000061A (es) 2009-06-24 2012-06-01 Msd Oss Bv Formulaciones inyectables que contienen asenapina, y metodo de tratamiento usando las mismas.
US20130274466A1 (en) * 2010-09-27 2013-10-17 Alphora Research Inc. Process for the preparation of tetracyclic derivatives and intermediate products used in the process
ES2575544T3 (es) 2010-12-24 2016-06-29 Medichem, S.A. Procedimientos para la preparación de 5-cloro-2-metil-2,3,3a,12b-tetrahidro-1H-dibenzo[2,3:6,7]oxepino[4,5-c]pirrol
ITMI20110734A1 (it) 2011-05-02 2012-11-03 Olon Spa Sali cristallini di asenapina
KR20140075783A (ko) 2011-10-11 2014-06-19 유씨비 파마, 에스.에이. 2­옥소­피페리디닐 유도체
US20140336391A1 (en) 2011-11-28 2014-11-13 Ranbaxy Laboratories Limited Process for the preparation of asenapine intermediate
BR112015006825A2 (pt) 2012-09-27 2017-08-08 Bayer Cropscience Ag processo para a preparação de fenil e piridil pirrolidinas opcionalmente substituídas.
CN103113379A (zh) * 2013-03-12 2013-05-22 盛世泰科生物医药技术(苏州)有限公司 阿塞那平马来酸盐的合成工艺
CN107849456A (zh) * 2015-06-30 2018-03-27 默克专利股份有限公司 可聚合液晶材料和经聚合的液晶膜
CN105566336A (zh) * 2016-01-08 2016-05-11 万特制药(海南)有限公司 一种制备阿塞那平去甲基杂质的新方法
CA3047354A1 (en) 2016-12-20 2018-06-28 Lts Lohmann Therapie-Systeme Ag Transdermal therapeutic system containing asenapine and polysiloxane or polyisobutylene
EP3558275A1 (en) 2016-12-20 2019-10-30 LTS Lohmann Therapie-Systeme AG Transdermal therapeutic system containing asenapine
EP3644973B1 (en) 2017-06-26 2021-03-24 LTS LOHMANN Therapie-Systeme AG Transdermal therapeutic system containing asenapine and silicone acrylic hybrid polymer
CN112704672A (zh) 2018-06-20 2021-04-27 罗曼治疗***股份公司 含有阿塞那平的透皮治疗***

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL7605526A (nl) * 1976-05-24 1977-11-28 Akzo Nv Nieuwe tetracyclische derivaten.
DE602006010132D1 (de) 2005-04-07 2009-12-17 Organon Nv Zwischenprodukte für die Herstellung von Trans-5-Chlor-2-Methyl-2,3,3a,12b-Tetrahydro-1h-DibenzÄ2,3:6,7ÜOxepinoÄ4,5-cÜPyrrol
US7872147B2 (en) * 2005-04-07 2011-01-18 N. V. Organon Intermediate compounds for the preparation of trans-5-chloro-2-methyl-2,3,3a,12b-tetrahydro-1H-dibenz[2,3:6,7]oxepino[4,5-c]pyrrole
WO2007046554A1 (ja) 2005-10-21 2007-04-26 Sumitomo Chemical Company, Limited ジベンゾオキセピノピロール化合物の製造方法、その中間体及び該中間体の製造方法
TW200817414A (en) * 2006-07-05 2008-04-16 Organon Nv Process for the preparation of asenapine and intermediate products used in said process
US7750167B2 (en) * 2006-07-05 2010-07-06 N.V. Organon Process for the preparation of asenapine and intermediate products used in said process
US7875729B2 (en) * 2007-01-05 2011-01-25 Synthon Bv Process for making asenapine
JP2011508751A (ja) * 2008-01-04 2011-03-17 ナームローゼ・フエンノートチヤツプ・オルガノン アセナピンの調製方法および前記方法において使用される中間生成物

Also Published As

Publication number Publication date
US20090227803A1 (en) 2009-09-10
US20110166363A1 (en) 2011-07-07
CA2710800A1 (en) 2009-07-16
EP2240492A1 (en) 2010-10-20
ATE527266T1 (de) 2011-10-15
CN101918411A (zh) 2010-12-15
JP2011508751A (ja) 2011-03-17
EP2240492B1 (en) 2011-10-05
WO2009087058A1 (en) 2009-07-16
US7964739B2 (en) 2011-06-21

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Legal Events

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GB Transfer or rights

Owner name: MSD OSS B.V.

FA Abandonment or withdrawal