MX2010004813A - Factor viii recombinante que tiene estabilidad incrementada. - Google Patents

Factor viii recombinante que tiene estabilidad incrementada.

Info

Publication number
MX2010004813A
MX2010004813A MX2010004813A MX2010004813A MX2010004813A MX 2010004813 A MX2010004813 A MX 2010004813A MX 2010004813 A MX2010004813 A MX 2010004813A MX 2010004813 A MX2010004813 A MX 2010004813A MX 2010004813 A MX2010004813 A MX 2010004813A
Authority
MX
Mexico
Prior art keywords
factor viii
recombinant factor
increased stability
nucleic acid
acid molecule
Prior art date
Application number
MX2010004813A
Other languages
English (en)
Inventor
Philip J Fay
Hironao Wakabayashi
Original Assignee
Univ Rochester
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Rochester filed Critical Univ Rochester
Publication of MX2010004813A publication Critical patent/MX2010004813A/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/36—Blood coagulation or fibrinolysis factors
    • A61K38/37—Factors VIII
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/745—Blood coagulation or fibrinolysis factors
    • C07K14/755—Factors VIII, e.g. factor VIII C (AHF), factor VIII Ag (VWF)

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Hematology (AREA)
  • Zoology (AREA)
  • Engineering & Computer Science (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Toxicology (AREA)
  • Diabetes (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • Virology (AREA)
  • General Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Cell Biology (AREA)
  • Developmental Biology & Embryology (AREA)
  • Physics & Mathematics (AREA)
  • Plant Pathology (AREA)
  • Microbiology (AREA)

Abstract

La presente invención se refiere a un factor VIII recombinante que incluye una o más mutaciones que resultan en estabilidad mejorada tanto del factor VIII como factor VIIIa. Los métodos para hacer y usar el factor VIII recombinante, y composiciones farmacéuticas que contienen el mismo también se describen. La presente invención adicionalmente se refiere a una molécula de ácido nucleico aislada que codifica el factor VIII recombinante, así como también sistemas de expresión de ADN y células huésped que contienen la molécula de ácido nucleico aislada.
MX2010004813A 2007-11-01 2008-07-25 Factor viii recombinante que tiene estabilidad incrementada. MX2010004813A (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US98451807P 2007-11-01 2007-11-01
US99130407P 2007-11-30 2007-11-30
PCT/US2008/071170 WO2009058446A1 (en) 2007-11-01 2008-07-25 Recombinant factor viii having increased stability

Publications (1)

Publication Number Publication Date
MX2010004813A true MX2010004813A (es) 2010-10-04

Family

ID=40588749

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2010004813A MX2010004813A (es) 2007-11-01 2008-07-25 Factor viii recombinante que tiene estabilidad incrementada.

Country Status (13)

Country Link
US (4) US8338571B2 (es)
EP (2) EP2711436A1 (es)
JP (2) JP2011502478A (es)
KR (1) KR20100113478A (es)
CN (2) CN101965409A (es)
AU (1) AU2008319183B2 (es)
BR (1) BRPI0818913A2 (es)
CA (1) CA2703948A1 (es)
IL (1) IL205422A0 (es)
MX (1) MX2010004813A (es)
RU (2) RU2531493C2 (es)
WO (1) WO2009058446A1 (es)
ZA (1) ZA201003049B (es)

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US20090203077A1 (en) * 2006-06-30 2009-08-13 The Regents Of The University Of Michigan Method of producing factor viii proteins by recombinant methods
AU2007269233B2 (en) * 2006-06-30 2011-06-09 Cnj Holdings, Inc. Method of producing Factor VIII proteins by recombinant methods
AU2010290077C1 (en) 2009-08-24 2015-12-03 Bioverativ Therapeutics Inc. Coagulation factor IX compositions and methods of making and using same
EP2536752B1 (en) * 2010-02-16 2015-04-08 Novo Nordisk A/S Modified recombinant Factor VIII
US8822663B2 (en) 2010-08-06 2014-09-02 Moderna Therapeutics, Inc. Engineered nucleic acids and methods of use thereof
US8637448B2 (en) 2010-09-14 2014-01-28 University Of Rochester Recombinant factor VIII having enhanced stability following mutation at the A1-C2 domain interface
HUE058896T2 (hu) 2010-10-01 2022-09-28 Modernatx Inc N1-metil-pszeudo-uracilt tartalmazó ribonukleinsavak és azok felhasználásai
DE102010042458A1 (de) * 2010-10-14 2012-04-19 Siemens Aktiengesellschaft Verfahren zum Betreiben einer kombinierten Gas- und Dampfturbinenanlage sowie zur Durchführung des Verfahrens hergerichtete Gas- und Dampfturbinenanlage und entsprechende Regelvorrichtung
US8710200B2 (en) 2011-03-31 2014-04-29 Moderna Therapeutics, Inc. Engineered nucleic acids encoding a modified erythropoietin and their expression
US9464124B2 (en) 2011-09-12 2016-10-11 Moderna Therapeutics, Inc. Engineered nucleic acids and methods of use thereof
RS62993B1 (sr) 2011-10-03 2022-03-31 Modernatx Inc Modifikovani nukleozidi, nukleotidi, i nukleinske kiseline, i njihove upotrebe
CN104114572A (zh) 2011-12-16 2014-10-22 现代治疗公司 经修饰的核苷、核苷酸和核酸组合物
BR112014017165B1 (pt) * 2012-01-12 2023-05-02 Bioverativ Therapeutics Inc Proteína quimérica compreendendo uma proteína de fator viii, composição farmacêutica, e seus usos
EP3549953A1 (en) 2012-02-15 2019-10-09 Bioverativ Therapeutics Inc. Recombinant factor viii proteins
ES2771208T3 (es) 2012-02-15 2020-07-06 Bioverativ Therapeutics Inc Composiciones de factor VIII y métodos de preparación y uso de las mismas
US9283287B2 (en) 2012-04-02 2016-03-15 Moderna Therapeutics, Inc. Modified polynucleotides for the production of nuclear proteins
US9572897B2 (en) 2012-04-02 2017-02-21 Modernatx, Inc. Modified polynucleotides for the production of cytoplasmic and cytoskeletal proteins
DE18200782T1 (de) 2012-04-02 2021-10-21 Modernatx, Inc. Modifizierte polynukleotide zur herstellung von proteinen im zusammenhang mit erkrankungen beim menschen
US9303079B2 (en) 2012-04-02 2016-04-05 Moderna Therapeutics, Inc. Modified polynucleotides for the production of cytoplasmic and cytoskeletal proteins
EP2666782A1 (en) 2012-05-22 2013-11-27 Imnate Sarl Coagulation factor VIII with reduced immunogenicity.
CN110054699A (zh) 2012-07-11 2019-07-26 比奥贝拉蒂治疗公司 具有xten和血管性血友病因子蛋白的因子viii复合物、及其用途
EP4074834A1 (en) 2012-11-26 2022-10-19 ModernaTX, Inc. Terminally modified rna
US8980864B2 (en) 2013-03-15 2015-03-17 Moderna Therapeutics, Inc. Compositions and methods of altering cholesterol levels
JP6523244B2 (ja) * 2013-03-15 2019-05-29 バイエル・ヘルスケア・エルエルシーＢａｙｅｒ ＨｅａｌｔｈＣａｒｅ ＬＬＣ 変異体第ｖｉｉｉ因子ポリペプチドならびにそれらの製造方法および使用方法
WO2015023894A1 (en) 2013-08-14 2015-02-19 Biogen Idec Ma Inc. Recombinant factor viii proteins
WO2015023891A2 (en) 2013-08-14 2015-02-19 Biogen Idec Ma Inc. Factor viii-xten fusions and uses thereof
MX2016004249A (es) 2013-10-03 2016-11-08 Moderna Therapeutics Inc Polinulcleotidos que codifican el receptor de lipoproteina de baja densidad.
EP3060242A1 (en) * 2013-10-22 2016-08-31 DBV Technologies Method of treating haemophilia by inducing tolerance to blood factors
CN103613658B (zh) * 2013-11-15 2015-04-01 同路生物制药股份有限公司 一种人第viii凝血因子的制备方法
GB201322091D0 (en) 2013-12-13 2014-01-29 Cambridge Entpr Ltd Modified serpins for the treatment of bleeding disorders
CN106456718A (zh) 2014-01-10 2017-02-22 比奥根Ma公司 因子viii嵌合蛋白及其用途
EP3114138B1 (en) 2014-03-05 2021-11-17 Pfizer Inc. Improved muteins of clotting factor viii
WO2017011275A1 (en) 2015-07-10 2017-01-19 Nersissian Aram M Factor viii protein compositions and methods of treating hemophilia a
EA201890423A1 (ru) 2015-08-03 2018-07-31 Биовератив Терапьютикс Инк. Слитые белки фактора ix, способы их получения и применения
MA42934A (fr) 2015-09-24 2018-08-01 Biomarin Pharm Inc Vecteurs de facteur viii à virus adéno-associé, particules virales associées et formulations thérapeutiques comprenant ceux-ci
AU2019366942A1 (en) * 2018-10-23 2021-06-10 The Children's Hospital Of Philadelphia Compositions and methods for modulating factor VIII function

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JP2004525608A (ja) 2000-09-19 2004-08-26 エモリー ユニバーシテイ 修飾された因子ｖｉｉｉ
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WO2005055930A2 (en) * 2003-12-03 2005-06-23 University Of Rochester Recombinant factor viii having increased specific activity
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Also Published As

Publication number Publication date
AU2008319183B2 (en) 2014-09-04
EP2209908A1 (en) 2010-07-28
US20130085110A1 (en) 2013-04-04
EP2209908B1 (en) 2014-09-03
RU2010122052A (ru) 2011-12-10
CN101965409A (zh) 2011-02-02
IL205422A0 (en) 2010-12-30
ZA201003049B (en) 2012-11-28
EP2209908A4 (en) 2011-06-01
US8338571B2 (en) 2012-12-25
CA2703948A1 (en) 2009-05-07
BRPI0818913A2 (pt) 2015-05-12
US20090118185A1 (en) 2009-05-07
AU2008319183A1 (en) 2009-05-07
CN104152489A (zh) 2014-11-19
JP2015110589A (ja) 2015-06-18
RU2014129759A (ru) 2016-02-10
RU2531493C2 (ru) 2014-10-20
US8183345B2 (en) 2012-05-22
US20140056861A1 (en) 2014-02-27
KR20100113478A (ko) 2010-10-21
US9072722B2 (en) 2015-07-07
WO2009058446A1 (en) 2009-05-07
US20090118184A1 (en) 2009-05-07
EP2711436A1 (en) 2014-03-26
JP2011502478A (ja) 2011-01-27

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