MX2010001581A - Hidantoinas substituidas. - Google Patents
Hidantoinas substituidas.Info
- Publication number
- MX2010001581A MX2010001581A MX2010001581A MX2010001581A MX2010001581A MX 2010001581 A MX2010001581 A MX 2010001581A MX 2010001581 A MX2010001581 A MX 2010001581A MX 2010001581 A MX2010001581 A MX 2010001581A MX 2010001581 A MX2010001581 A MX 2010001581A
- Authority
- MX
- Mexico
- Prior art keywords
- compounds
- mek
- substituted hydantoins
- enzymes
- cancer
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/08—Drugs for disorders of the urinary system of the prostate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Abstract
Esta invención se refiere a los compuestos e la fórmula (1) o a las sales de los mismos farmacéuticamente aceptables, en donde R1, R2, R3, R4, R5 y R6 son descritos en esta solicitud. Estos compuestos inhiben las enzimas MEK 1 y MEK 2, que son proteínas cinasas que son componentes de la ruta de transducción de la señal de la MAP cinasa. Como tales, los compuestos tienen una actividad celular anti-hiperproliferativa y por consiguiente son útiles en el tratamiento de los trastornos proliferativos celulares, tales como el cáncer.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US95614507P | 2007-08-16 | 2007-08-16 | |
PCT/EP2008/060326 WO2009021887A1 (en) | 2007-08-16 | 2008-08-06 | Substituted hydantoins |
Publications (1)
Publication Number | Publication Date |
---|---|
MX2010001581A true MX2010001581A (es) | 2010-03-15 |
Family
ID=39830023
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2010001581A MX2010001581A (es) | 2007-08-16 | 2008-08-06 | Hidantoinas substituidas. |
Country Status (12)
Country | Link |
---|---|
US (1) | US7557221B2 (es) |
EP (1) | EP2188276B1 (es) |
JP (1) | JP2010536723A (es) |
KR (1) | KR101147583B1 (es) |
CN (1) | CN101778839A (es) |
AT (1) | ATE551336T1 (es) |
AU (1) | AU2008288556A1 (es) |
BR (1) | BRPI0815180A2 (es) |
CA (1) | CA2695956A1 (es) |
ES (1) | ES2383927T3 (es) |
MX (1) | MX2010001581A (es) |
WO (1) | WO2009021887A1 (es) |
Families Citing this family (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN102020651B (zh) | 2010-11-02 | 2012-07-18 | 北京赛林泰医药技术有限公司 | 6-芳基氨基吡啶酮甲酰胺mek抑制剂 |
MY193562A (en) * | 2011-08-01 | 2022-10-19 | Genentech Inc | Methods of treating cancer using pd-1 axis binding antagonists and mek inhibitors |
CA2890238A1 (en) | 2012-11-02 | 2014-05-08 | Merck Patent Gmbh | Method of reducing adverse effects in a cancer patient undergoing treatment with a mek inhibitor |
AR097279A1 (es) | 2013-08-09 | 2016-03-02 | Actelion Pharmaceuticals Ltd | Derivados de benzimidazolil-metil urea como agonistas del receptor de alx |
CA2926571C (en) * | 2013-10-08 | 2022-05-17 | Qing-bin LU | Non-platinum-based anti-cancer compounds for use in targeted chemotherapy |
PL3169361T3 (pl) | 2014-07-15 | 2019-11-29 | Hoffmann La Roche | Kompozycje do leczenia nowotworu z użyciem związków antagonistycznych wiązania osi pd-1 i inhibitorów mek |
Family Cites Families (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1999001426A1 (en) | 1997-07-01 | 1999-01-14 | Warner-Lambert Company | 4-bromo or 4-iodo phenylamino benzhydroxamic acid derivatives and their use as mek inhibitors |
KR19990012061A (ko) | 1997-07-26 | 1999-02-25 | 성재갑 | 파네실 전이효소 저해제로 유용한 하이덴토인 유도체 |
BR0110492A (pt) * | 2000-05-03 | 2003-04-08 | Hoffmann La Roche | Composto, composição farmacêutica que compreende esse composto, processo para a preparação de composição farmacêutica, utilização do composto e processo para a preparação do composto |
US7235537B2 (en) * | 2002-03-13 | 2007-06-26 | Array Biopharma, Inc. | N3 alkylated benzimidazole derivatives as MEK inhibitors |
WO2005009975A2 (en) | 2003-07-24 | 2005-02-03 | Warner-Lambert Company Llc | Benzimidazole derivatives as mek inhibitors |
JP2007523929A (ja) * | 2004-02-26 | 2007-08-23 | メルク パテント ゲゼルシャフト ミット ベシュレンクテル ハフトング | ベンズイミダゾリル誘導体 |
KR100889721B1 (ko) | 2004-08-17 | 2009-03-23 | 에프. 호프만-라 로슈 아게 | 치환 히단토인 |
TW200621766A (en) * | 2004-09-17 | 2006-07-01 | Hoffmann La Roche | Substituted hydantoins |
WO2006124780A2 (en) * | 2005-05-12 | 2006-11-23 | Kalypsys, Inc. | Ih-benzo [d] imidazole compounds as inhibitors of b-raf kinase |
US7612212B2 (en) * | 2006-02-22 | 2009-11-03 | Hoffmann-La Roche Inc. | Substituted hydantoins |
-
2008
- 2008-08-06 EP EP08786933A patent/EP2188276B1/en not_active Not-in-force
- 2008-08-06 BR BRPI0815180A patent/BRPI0815180A2/pt not_active IP Right Cessation
- 2008-08-06 CN CN200880102760A patent/CN101778839A/zh active Pending
- 2008-08-06 US US12/186,648 patent/US7557221B2/en not_active Expired - Fee Related
- 2008-08-06 MX MX2010001581A patent/MX2010001581A/es active IP Right Grant
- 2008-08-06 AT AT08786933T patent/ATE551336T1/de active
- 2008-08-06 AU AU2008288556A patent/AU2008288556A1/en not_active Abandoned
- 2008-08-06 CA CA2695956A patent/CA2695956A1/en not_active Abandoned
- 2008-08-06 WO PCT/EP2008/060326 patent/WO2009021887A1/en active Application Filing
- 2008-08-06 ES ES08786933T patent/ES2383927T3/es active Active
- 2008-08-06 KR KR1020107003298A patent/KR101147583B1/ko not_active IP Right Cessation
- 2008-08-06 JP JP2010520534A patent/JP2010536723A/ja active Pending
Also Published As
Publication number | Publication date |
---|---|
EP2188276B1 (en) | 2012-03-28 |
ATE551336T1 (de) | 2012-04-15 |
US20090048452A1 (en) | 2009-02-19 |
WO2009021887A1 (en) | 2009-02-19 |
CA2695956A1 (en) | 2009-02-19 |
BRPI0815180A2 (pt) | 2019-09-24 |
US7557221B2 (en) | 2009-07-07 |
AU2008288556A1 (en) | 2009-02-19 |
EP2188276A1 (en) | 2010-05-26 |
JP2010536723A (ja) | 2010-12-02 |
KR101147583B1 (ko) | 2012-05-21 |
ES2383927T3 (es) | 2012-06-27 |
CN101778839A (zh) | 2010-07-14 |
KR20100031777A (ko) | 2010-03-24 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
WO2006120573A3 (en) | Heterocyclic n-oxides as hypoxic selective protein kinase inhibitors | |
MX2011012353A (es) | Derivados de n-(hetero)aril-pirrolidina de pirazol-4-il-pirrolo[2, 3-d]pirimidinas y pirrol-3-il-pirrolo[2,3-d]pirimidinas como inhibidores de la cinasa janus. | |
WO2009007390A3 (en) | 2-pyraz inylbenz imidazole derivatives as receptor tyrosine kinase inhibitors | |
GEP20135785B (en) | Pyrrolopyrimidine compounds as cdk inhibitors | |
IS6501A (is) | Pyrrólafleiður 2-indólínón prótín kínasa hindra | |
EA200970557A1 (ru) | Соединения и композиции в качестве ингибиторов протеинкиназы | |
MX2009012066A (es) | Imidazopirinas sustituidas como inhibidoras de cinasa de lipido p13k. | |
EA201100450A1 (ru) | Макроциклические пирамидины в качестве ингибиторов протеинкиназы | |
MX2008001538A (es) | Aril piridinas y metodos para su uso. | |
TW200801008A (en) | Protein kinase inhibitors | |
UA84954C2 (ru) | Конденсированные пиримидоны, пригодные для лечения и профилактики злокачественного новообразования | |
UA95244C2 (ru) | Соединения и способ модулирования активности киназ, и показания для их применения | |
WO2007123892A3 (en) | Raf inhibitors and their uses | |
ZA200702645B (en) | Diaminotriazole compounds useful as protein kinase inhibitors | |
MY153727A (en) | Pyridazinone derivatives | |
SG179430A1 (en) | Heteroaryl substituted pyrrolo[2,3-b]pyridines and pyrrolo[2,3-b]pyrimidines as janus kinase inhibitors | |
PH12014501355A1 (en) | Disubstituted benzothienyl-pyrrolotriazines and their use as fgfr kinase inhibitors | |
MY149957A (en) | Heterocyclic inhibitors of mek and methods of use thereof | |
TNSN06411A1 (en) | Pyrimidine urea derivatives as kinase inhibitors | |
NZ596571A (en) | Pyrazolopyrimidines and related heterocycles as kinase inhibitors | |
MX2009011950A (es) | Derivados de pirimidina y composiciones como inhibidores de cinasa c-kit y pdgfr. | |
MX2009004623A (es) | Imidazopiridazinas como inhibidores de la lipido cinasa pi3k. | |
EA200701930A1 (ru) | Производные пиримидина для лечения гиперпролиферативных нарушений | |
MX2010001581A (es) | Hidantoinas substituidas. | |
BRPI0512547A (pt) | pirimidinas |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
HH | Correction or change in general | ||
FG | Grant or registration |