MX2010000813A - Proceso para preparar un intermediario para los antagonistas de los receptores opioides mu. - Google Patents

Proceso para preparar un intermediario para los antagonistas de los receptores opioides mu.

Info

Publication number
MX2010000813A
MX2010000813A MX2010000813A MX2010000813A MX2010000813A MX 2010000813 A MX2010000813 A MX 2010000813A MX 2010000813 A MX2010000813 A MX 2010000813A MX 2010000813 A MX2010000813 A MX 2010000813A MX 2010000813 A MX2010000813 A MX 2010000813A
Authority
MX
Mexico
Prior art keywords
preparing
receptor antagonists
opioid receptor
azabicyclo
oct
Prior art date
Application number
MX2010000813A
Other languages
English (en)
Inventor
Daniel D Long
Ioanna Stergiades
Pierre-Jean Colson
Ying Yu
Original Assignee
Theravance Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Theravance Inc filed Critical Theravance Inc
Publication of MX2010000813A publication Critical patent/MX2010000813A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
    • C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
    • C07D451/04—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof with hetero atoms directly attached in position 3 of the 8-azabicyclo [3.2.1] octane or in position 7 of the 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring system
    • C07D451/06—Oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
    • C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Indole Compounds (AREA)
  • Catalysts (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

Abstract

La invención provee un método eficiente para preparar 3-endo-(8-azabiciclo[3.2.1]oct-3-il)benzamida por hidrogenación, bajo condiciones controladas, de un intermediario 3-(8-azabiciclo[3.2.1]oct-2-en-3-il)benzamida protegido por amino en donde el grupo protector de amino es extraíble por hidrogenación catalítica.
MX2010000813A 2007-07-20 2008-07-15 Proceso para preparar un intermediario para los antagonistas de los receptores opioides mu. MX2010000813A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US96135307P 2007-07-20 2007-07-20
PCT/US2008/008607 WO2009014610A2 (en) 2007-07-20 2008-07-15 Process for preparing an intermediate to mu opioid receptor antagonists

Publications (1)

Publication Number Publication Date
MX2010000813A true MX2010000813A (es) 2010-03-01

Family

ID=40265383

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2010000813A MX2010000813A (es) 2007-07-20 2008-07-15 Proceso para preparar un intermediario para los antagonistas de los receptores opioides mu.

Country Status (13)

Country Link
US (3) US7932402B2 (es)
EP (2) EP2173746B1 (es)
JP (1) JP5351157B2 (es)
KR (1) KR101531617B1 (es)
CN (1) CN101743245B (es)
AU (1) AU2008279749B2 (es)
BR (1) BRPI0814288B8 (es)
CA (1) CA2690606C (es)
ES (2) ES2701251T3 (es)
MX (1) MX2010000813A (es)
RU (1) RU2469035C2 (es)
TW (1) TWI415850B (es)
WO (1) WO2009014610A2 (es)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MY145633A (en) 2006-03-01 2012-03-15 Theravance Inc 8-azabicyclo[3.2.1]octane compounds as mu opioid receptor antagonists
EP2195313B1 (en) * 2007-08-27 2014-04-02 Theravance, Inc. Heteroarylalkyl-8-azabicyclo[3.2.1]octane compounds as mu opioid receptor antagonists
EP2185553B1 (en) * 2007-08-27 2012-06-27 Theravance, Inc. Amidoalkyl-8-azabicyclo[3.2.1]octane compounds as mu opioid receptor antagonists
ATE502939T1 (de) * 2007-08-27 2011-04-15 Theravance Inc Disubstituierte alkyl-8-azabicycloä3.2.1üoktan- verbindungen als mu-opioid-rezeptorantagonisten
TWI423801B (zh) * 2007-08-27 2014-01-21 Theravance Inc 作為μ類鴉片受體拮抗劑之８－氮雜雙環〔３．２．１〕辛基－２－羥基苯甲醯胺化合物
SI3277278T1 (sl) 2015-04-02 2020-04-30 Theravance Biopharma R&D Ip, Llc Kombinacijska odmerna oblika mu-opioidnega receptorskega antagonista in opioidnega sredstva

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP3829879B2 (ja) 1994-05-18 2006-10-04 大正製薬株式会社 キノリンカルボン酸誘導体
US5731317A (en) * 1995-03-10 1998-03-24 Merck & Co., Inc. Bridged piperidines promote release of growth hormone
EP0859777B1 (en) * 1995-10-13 2007-05-23 Neurosearch A/S 8-azabicyclo(3.2.1)oct-2-ene derivatives, their preparation and use
KR100589872B1 (ko) * 1997-05-30 2006-06-15 뉴로서치 에이/에스 8-아자비사이클로(3,2,1)옥트-2-엔 유도체 및 이의 제조방법
AU4819099A (en) * 1998-06-19 2000-01-05 Eli Lilly And Company Inhibition of serotonin reuptake
EP1382605A3 (en) * 1998-11-27 2004-09-15 Neurosearch A/S 8-azabicyclo(3.2.1)oct-2-ene derivatives and their use as nAChR ligands
BRPI0409307A (pt) * 2003-04-14 2006-04-25 Pfizer Prod Inc derivados de 3-azabiciclo[3.2.1]octano
TWI351282B (en) 2004-04-07 2011-11-01 Theravance Inc Quinolinone-carboxamide compounds as 5-ht4 recepto
US20090137625A1 (en) * 2005-04-08 2009-05-28 Dan Peters Novel Enantiomers and Their Use as Monoamine Neurotransmitter Re-Uptake Inhibitors
AU2006233884A1 (en) * 2005-04-08 2006-10-19 Neurosearch A/S (+) - and (-) -8-alkyl-3-(trifluoralkylsulfonyloxy)-8-azabicycl (3.2.1.)oct-2-ene
MY145633A (en) * 2006-03-01 2012-03-15 Theravance Inc 8-azabicyclo[3.2.1]octane compounds as mu opioid receptor antagonists
TWI409067B (zh) * 2007-02-28 2013-09-21 Theravance Inc ８-氮雜雙環〔３．２．１〕辛烷化合物之結晶型
TWI423801B (zh) * 2007-08-27 2014-01-21 Theravance Inc 作為μ類鴉片受體拮抗劑之８－氮雜雙環〔３．２．１〕辛基－２－羥基苯甲醯胺化合物

Also Published As

Publication number Publication date
AU2008279749B2 (en) 2013-05-23
CA2690606A1 (en) 2009-01-29
ES2608412T3 (es) 2017-04-10
TWI415850B (zh) 2013-11-21
CA2690606C (en) 2015-05-26
US7932402B2 (en) 2011-04-26
AU2008279749A1 (en) 2009-01-29
RU2469035C2 (ru) 2012-12-10
WO2009014610A3 (en) 2009-06-04
EP2173746B1 (en) 2016-09-28
EP3037420B1 (en) 2018-09-12
US20090023934A1 (en) 2009-01-22
US20110166355A1 (en) 2011-07-07
CN101743245A (zh) 2010-06-16
EP3037420A1 (en) 2016-06-29
US8476440B2 (en) 2013-07-02
RU2010106082A (ru) 2011-08-27
JP5351157B2 (ja) 2013-11-27
CN101743245B (zh) 2015-06-10
ES2701251T3 (es) 2019-02-21
US20130079523A1 (en) 2013-03-28
EP2173746A2 (en) 2010-04-14
KR20100034748A (ko) 2010-04-01
BRPI0814288B1 (pt) 2021-04-20
US8247559B2 (en) 2012-08-21
BRPI0814288A2 (pt) 2015-02-03
JP2010534205A (ja) 2010-11-04
TW200911801A (en) 2009-03-16
BRPI0814288B8 (pt) 2021-05-25
WO2009014610A2 (en) 2009-01-29
KR101531617B1 (ko) 2015-06-25

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