MX2010000370A - Metodos para inhibir la formacion de ligandos difusibles beta-amiloides usando compuestos de acilhidrazida. - Google Patents

Metodos para inhibir la formacion de ligandos difusibles beta-amiloides usando compuestos de acilhidrazida.

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Publication number
MX2010000370A
MX2010000370A MX2010000370A MX2010000370A MX2010000370A MX 2010000370 A MX2010000370 A MX 2010000370A MX 2010000370 A MX2010000370 A MX 2010000370A MX 2010000370 A MX2010000370 A MX 2010000370A MX 2010000370 A MX2010000370 A MX 2010000370A
Authority
MX
Mexico
Prior art keywords
amyloid
formation
methods
inhibiting
acylhydrazide
Prior art date
Application number
MX2010000370A
Other languages
English (en)
Inventor
Grant A Krafft
Todd Pray
William F Goure
Gary Charles Look
Lauri Schultz
Alexandre Mikhaylovich Polozov
Nikhil Bhagat
Jian Wang
David E Zembower
Original Assignee
Acumen Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US11/777,266 external-priority patent/US8962677B2/en
Priority claimed from US11/777,264 external-priority patent/US9006283B2/en
Application filed by Acumen Pharmaceuticals Inc filed Critical Acumen Pharmaceuticals Inc
Publication of MX2010000370A publication Critical patent/MX2010000370A/es

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    • A61K31/166—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the carbon of a carboxamide group directly attached to the aromatic ring, e.g. procainamide, procarbazine, metoclopramide, labetalol
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Abstract

La presente invención se refiere a métodos para inhibir, regular y/o modular la formación de oligómeros amiloides ß1-42 neurotóxicos, no fibrilares, globulares, solubles, a partir de monómeros amiloides ß1-42, usando compuestos de azilhidrazida. También se describen métodos para tratar un paciente que sufre de enfermedades asociadas con la formación de oligómeros amiloides ß1-42 neurotóxicos, no fibrilares, globulares, solubles, usando compuestos de acilhidrazida.
MX2010000370A 2007-07-12 2008-07-11 Metodos para inhibir la formacion de ligandos difusibles beta-amiloides usando compuestos de acilhidrazida. MX2010000370A (es)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US11/777,266 US8962677B2 (en) 2007-07-12 2007-07-12 Methods of restoring cognitive ability using non-peptidic compounds
US11/777,264 US9006283B2 (en) 2007-07-12 2007-07-12 Methods of modifying amyloid β oligomers using non-peptidic compounds
US95081007P 2007-07-19 2007-07-19
US95072407P 2007-07-19 2007-07-19
PCT/US2008/069878 WO2009009768A2 (en) 2007-07-12 2008-07-11 METHODS OF INHIBITING THE FORMATION OF AMYLOID-β DIFFUSABLE LIGANDS USING A ACYLHYDRAZIDE COMPOUDS

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DE10303974A1 (de) 2003-01-31 2004-08-05 Abbott Gmbh & Co. Kg Amyloid-β(1-42)-Oligomere, Verfahren zu deren Herstellung und deren Verwendung
SG2014013437A (en) 2005-11-30 2014-07-30 Abbott Lab Monoclonal antibodies and uses thereof
RU2442793C2 (ru) 2005-11-30 2012-02-20 Эбботт Лэборетриз АНТИТЕЛА ПРОТИВ ГЛОБУЛОМЕРА Аβ, ИХ АНТИГЕНСВЯЗЫВАЮЩИЕ ЧАСТИ, СООТВЕТСТВУЮЩИЕ ГИБРИДОМЫ, НУКЛЕИНОВЫЕ КИСЛОТЫ, ВЕКТОРЫ, КЛЕТКИ-ХОЗЯЕВА, СПОСОБЫ ПОЛУЧЕНИЯ УКАЗАННЫХ АНТИТЕЛ, КОМПОЗИЦИИ, СОДЕРЖАЩИЕ УКАЗАННЫЕ АНТИТЕЛА, ПРИМЕНЕНИЯ УКАЗАННЫХ АНТИТЕЛ И СПОСОБЫ ИСПОЛЬЗОВАНИЯ УКАЗАННЫХ АНТИТЕЛ
US8455626B2 (en) 2006-11-30 2013-06-04 Abbott Laboratories Aβ conformer selective anti-aβ globulomer monoclonal antibodies
US20100311767A1 (en) 2007-02-27 2010-12-09 Abbott Gmbh & Co. Kg Method for the treatment of amyloidoses
US9217024B2 (en) 2007-12-18 2015-12-22 Acumen Pharmaceuticals, Inc. ADDL receptor polypeptides, polynucleotides and host cells for recombinant production
MX360403B (es) 2010-04-15 2018-10-31 Abbvie Inc Proteinas de union a amiloide beta.
JP6147665B2 (ja) 2010-08-14 2017-06-14 アッヴィ・インコーポレイテッド アミロイドベータ結合タンパク質
JP2017518312A (ja) * 2014-06-05 2017-07-06 ユニバーシティ・オブ・カンザス マルメリン類似体および癌治療における使用方法

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AU2002210385A1 (en) * 2000-10-16 2002-04-29 Novo-Nordisk A/S Furazanyl-triazole derivates for the treatment of diseases
DE10348044A1 (de) * 2003-10-15 2005-05-19 Imtm Gmbh Duale Alanyl-Aminopeptidase- und Dipeptidylpeptidase IV-Inhibitoren zur funktionellen Beeinflussung unterschiedlicher Zellen und zur Behandlung immunologischer, entzündlicher, neuronaler und anderer Erkrankungen
DE10348023A1 (de) * 2003-10-15 2005-05-19 Imtm Gmbh Neue Alanyl-Aminopeptidasen-Inhibitoren zur funktionellen Beeinflussung unterschiedlicher Zellen und zur Behandlung immunologischer, entzündlicher, neuronaler und anderer Erkrankungen
ATE410696T1 (de) * 2004-05-24 2008-10-15 Univ Muenchen L Maximilians Identizifierung von antiprionwirkstoffen mittels screening mit hohem durchsatz auf sift-basis

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