MX2009013393A - Expresion de fragmento de anticuerpo soluble mediante truncamiento de dominio de ch1. - Google Patents
Expresion de fragmento de anticuerpo soluble mediante truncamiento de dominio de ch1.Info
- Publication number
- MX2009013393A MX2009013393A MX2009013393A MX2009013393A MX2009013393A MX 2009013393 A MX2009013393 A MX 2009013393A MX 2009013393 A MX2009013393 A MX 2009013393A MX 2009013393 A MX2009013393 A MX 2009013393A MX 2009013393 A MX2009013393 A MX 2009013393A
- Authority
- MX
- Mexico
- Prior art keywords
- truncation
- expression
- fragment
- light chain
- chi
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/74—Vectors or expression systems specially adapted for prokaryotic hosts other than E. coli, e.g. Lactobacillus, Micromonospora
- C12N15/78—Vectors or expression systems specially adapted for prokaryotic hosts other than E. coli, e.g. Lactobacillus, Micromonospora for Pseudomonas
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/52—Constant or Fc region; Isotype
- C07K2317/53—Hinge
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/55—Fab or Fab'
Abstract
La expresión mejorada de fragmentos de anticuerpos activos (Fabs) es lograda al truncar una región constante de cadena pesada. El truncamiento del dominio CHI de un fragmento Fab puede aumentar el rendimiento de fragmento de anticuerpo activo soluble en Pseudomonas fluorescens. Otra modalidad de la invención incluye la secreción de la cadena ligera y un fragmento de la cadena pesada con varios extremos C (por ejemplo, VH-Cl truncado a diferentes longitudes). La región CHI truncada puede ser usada como un andamiaje para crear otros Fabs. También se incluye el truncamiento de los dominios de cadena ligera kappa y/o cadena ligera lambda de un fragmento Fab. La invención también incluye la expresión de fragmentos Fab fusionados a otros péptidos o moléculas (por ejemplo toxinas, proteínas, péptidos, enzimas, etc.).
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US94299707P | 2007-06-08 | 2007-06-08 | |
PCT/US2008/066187 WO2008151319A2 (en) | 2007-06-08 | 2008-06-06 | Expression of soluble antibody fragment by truncation of ch1 domain |
Publications (1)
Publication Number | Publication Date |
---|---|
MX2009013393A true MX2009013393A (es) | 2010-02-09 |
Family
ID=40076617
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2009013393A MX2009013393A (es) | 2007-06-08 | 2008-06-06 | Expresion de fragmento de anticuerpo soluble mediante truncamiento de dominio de ch1. |
Country Status (9)
Country | Link |
---|---|
US (1) | US20090042254A1 (es) |
EP (1) | EP2160405A2 (es) |
JP (1) | JP2010528664A (es) |
KR (1) | KR20100021627A (es) |
AU (1) | AU2008261042A1 (es) |
BR (1) | BRPI0812465A2 (es) |
CA (1) | CA2689556A1 (es) |
MX (1) | MX2009013393A (es) |
WO (1) | WO2008151319A2 (es) |
Families Citing this family (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP2450366A1 (en) | 2007-01-30 | 2012-05-09 | Epivax, Inc. | Regulatory t cell epitopes, compositions and uses thereof |
LT2954779T (lt) * | 2009-12-10 | 2019-05-27 | Regeneron Pharmaceuticals, Inc. | Pelės, gaminančios sunkiosios grandinės antikūnus |
BR112016004355A2 (pt) * | 2013-08-30 | 2017-10-17 | Aprilbio Co Ltd | constructo de fusão de parte efetora de fab anti-soroalbumina e método de preparação do mesmo |
KR20210088756A (ko) | 2014-03-21 | 2021-07-14 | 리제너론 파마슈티칼스 인코포레이티드 | 단일 도메인 결합 단백질을 생산하는 비-인간 동물 |
WO2018211529A1 (en) * | 2017-05-19 | 2018-11-22 | Council Of Scientific & Industrial Research | A method for producing refolded recombinant humanized ranibizumab |
KR20210095781A (ko) | 2020-01-24 | 2021-08-03 | 주식회사 에이프릴바이오 | 항원결합 단편 및 생리활성 이펙터 모이어티로 구성된 융합 컨스트럭트를 포함하는 다중결합항체 및 이를 포함하는 약학조성물 |
Family Cites Families (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB8720833D0 (en) * | 1987-09-04 | 1987-10-14 | Celltech Ltd | Recombinant dna product |
US5677425A (en) * | 1987-09-04 | 1997-10-14 | Celltech Therapeutics Limited | Recombinant antibody |
US9453251B2 (en) * | 2002-10-08 | 2016-09-27 | Pfenex Inc. | Expression of mammalian proteins in Pseudomonas fluorescens |
PL1644412T5 (pl) * | 2003-07-01 | 2019-01-31 | Ucb Biopharma Sprl | Modyfikowane fragmenty Fab przeciwciała |
GB0315457D0 (en) * | 2003-07-01 | 2003-08-06 | Celltech R&D Ltd | Biological products |
GB0315450D0 (en) * | 2003-07-01 | 2003-08-06 | Celltech R&D Ltd | Biological products |
GB0514779D0 (en) * | 2005-07-19 | 2005-08-24 | Celltech R&D Ltd | Biological products |
US20070274985A1 (en) * | 2006-05-26 | 2007-11-29 | Stefan Dubel | Antibody |
-
2008
- 2008-06-06 AU AU2008261042A patent/AU2008261042A1/en not_active Abandoned
- 2008-06-06 BR BRPI0812465-5A2A patent/BRPI0812465A2/pt not_active Application Discontinuation
- 2008-06-06 EP EP08770392A patent/EP2160405A2/en not_active Withdrawn
- 2008-06-06 MX MX2009013393A patent/MX2009013393A/es unknown
- 2008-06-06 JP JP2010511383A patent/JP2010528664A/ja active Pending
- 2008-06-06 KR KR1020097026858A patent/KR20100021627A/ko not_active Application Discontinuation
- 2008-06-06 US US12/135,071 patent/US20090042254A1/en not_active Abandoned
- 2008-06-06 CA CA002689556A patent/CA2689556A1/en not_active Abandoned
- 2008-06-06 WO PCT/US2008/066187 patent/WO2008151319A2/en active Application Filing
Also Published As
Publication number | Publication date |
---|---|
US20090042254A1 (en) | 2009-02-12 |
CA2689556A1 (en) | 2008-12-11 |
AU2008261042A1 (en) | 2008-12-11 |
WO2008151319A2 (en) | 2008-12-11 |
WO2008151319A3 (en) | 2009-03-26 |
KR20100021627A (ko) | 2010-02-25 |
BRPI0812465A2 (pt) | 2014-12-02 |
EP2160405A2 (en) | 2010-03-10 |
JP2010528664A (ja) | 2010-08-26 |
AU2008261042A2 (en) | 2010-01-28 |
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