MX2009012525A - Pirazol-pirrolidinas como inhibidores de gamma secretasa. - Google Patents

Pirazol-pirrolidinas como inhibidores de gamma secretasa.

Info

Publication number
MX2009012525A
MX2009012525A MX2009012525A MX2009012525A MX2009012525A MX 2009012525 A MX2009012525 A MX 2009012525A MX 2009012525 A MX2009012525 A MX 2009012525A MX 2009012525 A MX2009012525 A MX 2009012525A MX 2009012525 A MX2009012525 A MX 2009012525A
Authority
MX
Mexico
Prior art keywords
formula
pyrazolopyrrolidines
inhibitors
compounds
gamma secretase
Prior art date
Application number
MX2009012525A
Other languages
English (en)
Inventor
Darren Dressen
Matthew N Mattson
Simeon Bowers
Albert W Garofalo
Roy K Hom
Original Assignee
Elan Pharm Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Elan Pharm Inc filed Critical Elan Pharm Inc
Publication of MX2009012525A publication Critical patent/MX2009012525A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

La presente invención se refiere a compuestos de Fórmula I, donde A, Y, R1, R1a, R2, y R2a se describen en la especificación. Los compuestos de la Fórmula I son útiles en el tratamiento y/o prevención de trastornos cognitivos, tales como la enfermedad de Alzheimer. La invención también abarca las composiciones farmacéuticas que comprenden compuestos de Fórmula I, métodos de preparación de compuestos de la Fórmula I, y métodos de tratamiento de trastornos cognitivos, tales como la enfermedad de Alzheimer.
MX2009012525A 2007-05-25 2008-05-21 Pirazol-pirrolidinas como inhibidores de gamma secretasa. MX2009012525A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US93184007P 2007-05-25 2007-05-25
PCT/US2008/064324 WO2008147800A1 (en) 2007-05-25 2008-05-21 Pyrazolopyrrolidines as inhibitors of gamma secretase

Publications (1)

Publication Number Publication Date
MX2009012525A true MX2009012525A (es) 2009-12-09

Family

ID=39679310

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2009012525A MX2009012525A (es) 2007-05-25 2008-05-21 Pirazol-pirrolidinas como inhibidores de gamma secretasa.

Country Status (17)

Country Link
US (1) US7977368B2 (es)
EP (1) EP2152713B1 (es)
JP (1) JP2010528036A (es)
AR (1) AR066712A1 (es)
AT (1) ATE523511T1 (es)
AU (1) AU2008256940A1 (es)
BR (1) BRPI0812014A2 (es)
CA (1) CA2687765A1 (es)
CL (1) CL2008001516A1 (es)
CO (1) CO6241122A2 (es)
ES (1) ES2373253T3 (es)
MX (1) MX2009012525A (es)
NZ (1) NZ582039A (es)
PE (1) PE20090280A1 (es)
TW (1) TW200904413A (es)
WO (1) WO2008147800A1 (es)
ZA (1) ZA200908919B (es)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AR073497A1 (es) * 2008-09-05 2010-11-10 Elan Pharm Inc Compuestos de pirazolilo policiclicos de n-sulfonamido
MX2012001520A (es) * 2009-08-03 2012-06-01 Acraf Proceso para la preparacion de 1-bencil-3-hidroximetil-1h-indazol y sus derivados e intermediarios de magnesio requeridos.
KR101755737B1 (ko) 2009-09-11 2017-07-07 프로비오드룩 아게 글루타미닐 사이클라제의 억제제로서 헤테로사이클릭 유도체
US8481541B2 (en) 2010-03-22 2013-07-09 Hoffmann-La Roche Inc. Pyrrolopyrazine kinase inhibitors
US8518945B2 (en) 2010-03-22 2013-08-27 Hoffmann-La Roche Inc. Pyrrolopyrazine kinase inhibitors
BR112012029437A2 (pt) 2010-05-20 2017-03-07 F Hoffmann - La Roche Ag derivados de pirrolo[2,3-b]pirazina-7-carboxamida e seu uso como inibidores de jak e syk
KR20130083387A (ko) 2010-05-20 2013-07-22 에프. 호프만-라 로슈 아게 Syk 및 jak 억제제로서 피롤로피라진 유도체
JP6644017B2 (ja) * 2017-03-30 2020-02-12 長弘生物科技股▲ふん▼有限公司 ブチリデンフタリドの用途、その使用方法及びそれを使用して医薬組成物を製造する方法
ES2812698T3 (es) 2017-09-29 2021-03-18 Probiodrug Ag Inhibidores de glutaminil ciclasa

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20010033648A (ko) * 1997-12-27 2001-04-25 후루타 타케시 β-할로게노-α-아미노카르복실산 및 페닐시스테인유도체와, 그의 중간체의 제조 방법
US6887898B1 (en) * 1999-10-22 2005-05-03 Darrick S. H. L. Kim Pharmaceutical compositions useful in prevention and treatment of beta-Amyloid protein-induced disease
US6559174B2 (en) 2001-03-20 2003-05-06 Merck & Co., Inc. N-arylsulfonyl aryl aza-bicyclic derivatives as potent cell adhesion inhibitors
US7256186B2 (en) 2002-02-06 2007-08-14 Schering Corporation Gamma secretase inhibitors
US20040171614A1 (en) * 2002-02-06 2004-09-02 Schering-Plough Corporation Novel gamma secretase inhibitors
TW200302717A (en) * 2002-02-06 2003-08-16 Schering Corp Novel gamma secretase inhibitors
AU2003244632A1 (en) * 2002-07-25 2004-02-25 Pharmacia Italia S.P.A. Bicyclo-pyrazoles active as kinase inhibitors, process for their preparation and pharmaceutical compositions comprising them
US20060264380A1 (en) 2003-07-21 2006-11-23 Mats Hellstrom Compounds and Methods for Promoting Angiogenesis
WO2005030776A1 (en) * 2003-09-23 2005-04-07 Vertex Pharmaceuticals Incorporated Pyrazolopyrrole derivatives as protein kinase inhibitors
JP2009504773A (ja) 2005-08-19 2009-02-05 エラン ファーマシューティカルズ，インコーポレイテッド ガンマセクレターゼの架橋ｎ−二環式スルホンアミド阻害剤
WO2007064914A2 (en) * 2005-12-01 2007-06-07 Elan Pharmaceuticals, Inc. 5-(arylsulfonyl)-pyrazolopiperidines
TW200813054A (en) 2006-06-02 2008-03-16 Elan Pharm Inc Fused, tricyclic sulfonamide inhibitors of gamma secretase

Also Published As

Publication number Publication date
ZA200908919B (en) 2010-08-25
PE20090280A1 (es) 2009-03-19
WO2008147800A1 (en) 2008-12-04
JP2010528036A (ja) 2010-08-19
US20090099235A1 (en) 2009-04-16
AR066712A1 (es) 2009-09-09
ES2373253T3 (es) 2012-02-01
US7977368B2 (en) 2011-07-12
CA2687765A1 (en) 2008-12-04
TW200904413A (en) 2009-02-01
CO6241122A2 (es) 2011-01-20
EP2152713B1 (en) 2011-09-07
BRPI0812014A2 (pt) 2014-11-18
CL2008001516A1 (es) 2008-10-10
ATE523511T1 (de) 2011-09-15
AU2008256940A1 (en) 2008-12-04
NZ582039A (en) 2012-02-24
EP2152713A1 (en) 2010-02-17

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