MX2009011495A - V cholerae que sobreexpresa la subunidad b de la toxina del colera recombinante y que presenta doble inmunogenicidad. - Google Patents
V cholerae que sobreexpresa la subunidad b de la toxina del colera recombinante y que presenta doble inmunogenicidad.Info
- Publication number
- MX2009011495A MX2009011495A MX2009011495A MX2009011495A MX2009011495A MX 2009011495 A MX2009011495 A MX 2009011495A MX 2009011495 A MX2009011495 A MX 2009011495A MX 2009011495 A MX2009011495 A MX 2009011495A MX 2009011495 A MX2009011495 A MX 2009011495A
- Authority
- MX
- Mexico
- Prior art keywords
- cholerae
- cholera toxin
- hyperexpressing
- recombinant cholera
- immunogenicity
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/02—Bacterial antigens
- A61K39/025—Enterobacteriales, e.g. Enterobacter
- A61K39/0258—Escherichia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/02—Bacterial antigens
- A61K39/107—Vibrio
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/52—Bacterial cells; Fungal cells; Protozoal cells
- A61K2039/522—Bacterial cells; Fungal cells; Protozoal cells avirulent or attenuated
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/52—Bacterial cells; Fungal cells; Protozoal cells
- A61K2039/523—Bacterial cells; Fungal cells; Protozoal cells expressing foreign proteins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/54—Medicinal preparations containing antigens or antibodies characterised by the route of administration
- A61K2039/541—Mucosal route
- A61K2039/543—Mucosal route intranasal
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/70—Multivalent vaccine
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Immunology (AREA)
- General Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Microbiology (AREA)
- Epidemiology (AREA)
- Mycology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Abstract
Se presentan composiciones inmunogénicas orales que imparten doble protección, contra Escherichia ccli que expresa la toxina lábil (LT) enterotoxigénica y contra Vibrio cholerae, con base en el suministro de antígeno toxina B de cólera recombinante por medio de vectores bacterianos vivos atenuados, derivados de Vibrio cholerae. Las composiciones tienen doble inmunogenicidad y retienen la capacidad para colonizar tejidos linfoides asociados a la mucosa gastrointestinal.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US92612307P | 2007-04-24 | 2007-04-24 | |
PCT/US2008/005261 WO2008133926A1 (en) | 2007-04-24 | 2008-04-24 | V. cholerae hyperexpressing recombinant cholera toxin b subunit showing dual immunogenicity |
Publications (1)
Publication Number | Publication Date |
---|---|
MX2009011495A true MX2009011495A (es) | 2010-02-15 |
Family
ID=39925978
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2009011495A MX2009011495A (es) | 2007-04-24 | 2008-04-24 | V cholerae que sobreexpresa la subunidad b de la toxina del colera recombinante y que presenta doble inmunogenicidad. |
Country Status (5)
Country | Link |
---|---|
US (2) | US8287855B2 (es) |
CN (1) | CN101730737B (es) |
CA (1) | CA2684742C (es) |
MX (1) | MX2009011495A (es) |
WO (1) | WO2008133926A1 (es) |
Families Citing this family (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA2684742C (en) * | 2007-04-24 | 2014-07-08 | Celldex Therapeutics, Inc. | V. cholerae hyperexpressing recombinant cholera toxin b subunit showing dual immunogenicity |
WO2021005623A1 (en) * | 2019-07-08 | 2021-01-14 | Msd Wellcome Trust Hilleman Laboratories Pvt. Ltd. | A vaccine formulation for protection against enterotoxigenic e. coli (etec) and cholera |
Family Cites Families (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0381706B1 (en) | 1987-10-07 | 1995-04-26 | Washington University | A method of maintaining a desired recombinant gene in a genetic population of cells |
ATE242319T1 (de) * | 1992-07-06 | 2003-06-15 | Harvard College | Deletionsmutanten als impfstoffe gegen cholera |
US6203799B1 (en) | 1993-07-01 | 2001-03-20 | Presidents And Fellows Of Harvard College | Vibrio cholerae mutants which are soft-agar penetration defective and lack a functional CtxA subunit |
EP0832255B1 (en) * | 1995-06-07 | 2005-12-14 | Washington University | Recombinant bacterial system with environmentally limited viability |
JP4086945B2 (ja) * | 1996-12-10 | 2008-05-14 | カウンシル・オブ・サイエンティフィック・アンド・インダストリアル・リサーチ | 非毒性V.Cholerae株の単離法およびその株由来のコレラワクチンの製造法 |
SE515285C2 (sv) * | 1998-12-18 | 2001-07-09 | Sbl Vaccin Ab | Oralt vaccin mot diarré |
GB0325494D0 (en) * | 2003-10-31 | 2003-12-03 | Sbl Vaccin Ab | Expression system |
EP1543836A1 (en) * | 2003-12-17 | 2005-06-22 | Berna Biotech AG | Recombinant Vibrio cholerae strain and vaccine comprising said strain |
CA2684742C (en) * | 2007-04-24 | 2014-07-08 | Celldex Therapeutics, Inc. | V. cholerae hyperexpressing recombinant cholera toxin b subunit showing dual immunogenicity |
-
2008
- 2008-04-24 CA CA2684742A patent/CA2684742C/en not_active Expired - Fee Related
- 2008-04-24 CN CN200880021528.XA patent/CN101730737B/zh not_active Expired - Fee Related
- 2008-04-24 WO PCT/US2008/005261 patent/WO2008133926A1/en active Application Filing
- 2008-04-24 MX MX2009011495A patent/MX2009011495A/es active IP Right Grant
- 2008-04-24 US US12/451,101 patent/US8287855B2/en not_active Expired - Fee Related
-
2012
- 2012-10-16 US US13/573,963 patent/US20130122039A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
US8287855B2 (en) | 2012-10-16 |
CA2684742C (en) | 2014-07-08 |
US20100129396A1 (en) | 2010-05-27 |
US20130122039A1 (en) | 2013-05-16 |
CN101730737B (zh) | 2016-06-01 |
WO2008133926A1 (en) | 2008-11-06 |
CN101730737A (zh) | 2010-06-09 |
CA2684742A1 (en) | 2008-11-06 |
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Legal Events
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FG | Grant or registration |