MX2009008022A - Metodos y composiciones para tratar neuropatias. - Google Patents
Metodos y composiciones para tratar neuropatias.Info
- Publication number
- MX2009008022A MX2009008022A MX2009008022A MX2009008022A MX2009008022A MX 2009008022 A MX2009008022 A MX 2009008022A MX 2009008022 A MX2009008022 A MX 2009008022A MX 2009008022 A MX2009008022 A MX 2009008022A MX 2009008022 A MX2009008022 A MX 2009008022A
- Authority
- MX
- Mexico
- Prior art keywords
- methods
- activity
- treating
- neuropathies
- compositions
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
- A61K31/05—Phenols
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7084—Compounds having two nucleosides or nucleotides, e.g. nicotinamide-adenine dinucleotide, flavine-adenine dinucleotide
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0048—Eye, e.g. artificial tears
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
- G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
- G01N33/5044—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics involving specific cell types
- G01N33/5058—Neurological cells
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/90—Enzymes; Proenzymes
- G01N2333/91—Transferases (2.)
- G01N2333/912—Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
- G01N2333/91205—Phosphotransferases in general
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2800/00—Detection or diagnosis of diseases
- G01N2800/28—Neurological disorders
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- Biomedical Technology (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Immunology (AREA)
- Molecular Biology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Hematology (AREA)
- Cell Biology (AREA)
- Urology & Nephrology (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
- Toxicology (AREA)
- Biotechnology (AREA)
- Food Science & Technology (AREA)
- Physics & Mathematics (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- Tropical Medicine & Parasitology (AREA)
- Microbiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Ophthalmology & Optometry (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Se describen métodos para tratar o prevenir la degradación axonal en enfermedades neuropáticas y trastornos neurológicos en mamíferos; los métodos pueden comprender administrar al mamífero una cantidad efectiva de un agente que actúa, por lo menos en parte, aumentando la actividad sirtuinAMPK, la actividad LKB 1 y/o la actividad CaMKKß en neuronas enfermas y/o lesionadas; los métodos también pueden comprender administrar al mamífero una cantidad efectiva de un agente que actúa aumentando la cavidad de NAD en neuronas enfermas y/o lesionadas, solo o en combinación con agentes que actúan por otros mecanismos; también se describen métodos para analizar agentes para el tratamiento de neuropatías y vectores recombinantes para el tratamiento o la prevención de dichas neuropatías.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US88685407P | 2007-01-26 | 2007-01-26 | |
PCT/US2008/001085 WO2008091710A2 (en) | 2007-01-26 | 2008-01-28 | Methods and compositions for treating neuropathies |
Publications (1)
Publication Number | Publication Date |
---|---|
MX2009008022A true MX2009008022A (es) | 2009-12-11 |
Family
ID=39645095
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2009008022A MX2009008022A (es) | 2007-01-26 | 2008-01-28 | Metodos y composiciones para tratar neuropatias. |
Country Status (5)
Country | Link |
---|---|
US (3) | US20100047177A1 (es) |
EP (1) | EP2124985A4 (es) |
CA (1) | CA2676609A1 (es) |
MX (1) | MX2009008022A (es) |
WO (1) | WO2008091710A2 (es) |
Families Citing this family (22)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU2009221634B2 (en) | 2008-03-03 | 2014-05-08 | Nad Life Pty Ltd | Pharmaceutical formulations of resveratrol and methods of use thereof for treating cell disorders |
WO2010011836A2 (en) * | 2008-07-25 | 2010-01-28 | Emory University | Treating various disorders with 7,8-dihydroxyflavone and derivatives thereof |
BRPI0917626A2 (pt) | 2008-12-08 | 2017-07-11 | Univ Northwestern | Método para modular atividade do fator 1 de transcrição do choque térmico (hsf1) em uma célula, método para aumentar ou diminuir a atividade de hsf1 em um indivíduo necessitando do mesmo método para tratar um paciente, método para identificar um agente que modula a atividade de hsf1 em uma célula, método para ativar a resposta ao choque térmico em uma célula ou em um paciente necessitando do mesmo e composição farmacêutica |
JP2010215563A (ja) * | 2009-03-17 | 2010-09-30 | Kao Corp | Lkb1活性化剤 |
WO2011156479A2 (en) | 2010-06-09 | 2011-12-15 | Emory University | Trkb agonists and methods of use |
CN102305863B (zh) * | 2011-07-18 | 2013-11-20 | 厦门大学 | 以Nur77-LKB1相互作用为靶点的抗糖尿病药物筛选方法 |
US9593125B2 (en) | 2012-07-27 | 2017-03-14 | Emory University | Heterocyclic flavone derivatives, compositions, and methods related thereto |
EP2968306B1 (en) | 2013-03-15 | 2023-06-07 | Washington University | Administration of nicotinamide mononucleotide in the treatment of dry eye |
CN103877076B (zh) * | 2014-03-21 | 2016-06-29 | 景临林 | 5,6,7,8-四羟基黄酮在制备抗缺氧药物中的应用 |
RU2016149767A (ru) | 2014-06-06 | 2018-07-16 | Глэксосмитклайн Интеллекчуал Проперти (Но.2) Лимитед | Аналоги никотинамидрибозида и фармацевтические композиции и их применение |
ES2908332T3 (es) | 2014-07-24 | 2022-04-28 | Grace W R & Co | Forma cristalina de cloruro de ribosilnicotinamida |
ES2963057T3 (es) | 2015-03-09 | 2024-03-25 | Grace W R & Co | Forma cristalina de ribósido de nicotinamida |
US20170068860A1 (en) * | 2015-09-09 | 2017-03-09 | Alex Adekola | System for measuring crowd density |
US20190203207A1 (en) * | 2016-05-20 | 2019-07-04 | The Trustees Of Columbia University In The City Of New York | Anabolic Enhancers for Ameliorating Neurodegeneration |
US11103465B2 (en) | 2017-11-22 | 2021-08-31 | Ted's Brain Science, Inc. | Trans-resveratrol topical medication for the treatment of pain and method of manufacture thereof |
US11414407B2 (en) | 2017-12-22 | 2022-08-16 | Elysium Health, Inc. | Crystalline forms of nicotinamide riboside chloride |
AU2020215510A1 (en) | 2019-01-28 | 2021-07-22 | Mitochondria Emotion, Inc. | Trans-4-hydroxycyclohexyl phenyl amide mitofusin activators and methods of use thereof |
EP3917508A4 (en) | 2019-01-28 | 2022-12-21 | Mitochondria Emotion, Inc. | EAAT2 ACTIVATORS AND METHODS OF USE THEREOF |
IT202000007726A1 (it) * | 2020-04-10 | 2021-10-10 | Solongevity Nutraceuticals S R L | Composizioni mimetiche della restrizione calorica |
CN114259486B (zh) * | 2020-09-16 | 2024-04-02 | 香港科技大学 | 木犀草素及其药物组合物的应用 |
AU2022226257A1 (en) * | 2021-02-26 | 2023-09-07 | Icahn School Of Medicine At Mount Sinai | Method for decreasing degeneration of retinal ganglion cells |
EP4338798A1 (en) | 2022-09-16 | 2024-03-20 | Wasilewicz, Robert Henryk | Pharmaceutical preparation containing genistein for use in the prevention or treatment of glaucoma and/or ocular hypertension |
Family Cites Families (24)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20020106354A1 (en) * | 1998-04-28 | 2002-08-08 | Christen M. Anderson | Cellular and animal models for diseases associated with altered mitochondrial function |
US6001368A (en) * | 1998-09-03 | 1999-12-14 | Protein Technologies International, Inc. | Method for inhibiting or reducing the risk of macular degeneration |
IT1302365B1 (it) * | 1998-10-09 | 2000-09-05 | Sigma Tau Healthscience Spa | Uso di carnitine e resveratrolo per produrre una composizione per laprevenzione o il trattamento terapeutico di alterazioni cerebrali |
US6514719B1 (en) * | 1999-05-28 | 2003-02-04 | Immunex Corporation | Methods for identifying compounds that alter kinase activity |
US6573299B1 (en) * | 1999-09-20 | 2003-06-03 | Advanced Medical Instruments | Method and compositions for treatment of the aging eye |
US6821775B1 (en) * | 2000-02-11 | 2004-11-23 | Genvec, Inc. | Viral vector encoding pigment epithelium-derived factor |
US6964969B2 (en) * | 2001-04-19 | 2005-11-15 | Mccleary Edward Larry | Composition and method for treating impaired or deteriorating neurological function |
US20050080024A1 (en) * | 2002-08-15 | 2005-04-14 | Joseph Tucker | Nitric oxide donating derivatives for the treatment of cardiovascular disorders |
US7320806B2 (en) * | 2002-09-09 | 2008-01-22 | Vdf Futureceuticals, Inc. | Compositions and methods for treating NIDDM and other conditions and disorders associated with AMPK regulation |
GB2402938B (en) * | 2003-06-17 | 2005-11-09 | Medical Res Council | Kinase assay |
US20060025337A1 (en) * | 2003-07-01 | 2006-02-02 | President And Fellows Of Harvard College | Sirtuin related therapeutics and diagnostics for neurodegenerative diseases |
EP2236131A3 (en) * | 2003-07-01 | 2011-03-02 | President and Fellows of Harvard College | Sirt1 modulators for manipulating cell/organism lifespan/stress response |
WO2005004814A2 (en) * | 2003-07-02 | 2005-01-20 | Elixir Pharmaceuticals, Inc. | Sirt1 and genetic disorders |
US8017634B2 (en) * | 2003-12-29 | 2011-09-13 | President And Fellows Of Harvard College | Compositions for treating obesity and insulin resistance disorders |
EP1708689A2 (en) * | 2003-12-29 | 2006-10-11 | The President and Fellows of Harvard College | Compositions for treating or preventing obesity and insulin resistance disorders |
EP1723227A4 (en) * | 2004-02-10 | 2007-09-19 | Dartmouth College | NICOTINAMIDRIBOSIDE KINASE COMPOSITIONS AND METHOD FOR THEIR USE |
US20050227327A1 (en) * | 2004-02-10 | 2005-10-13 | Brenner Charles M | Nicotinamide riboside kinase compositions and methods for using the same |
ES2663226T3 (es) * | 2004-06-04 | 2018-04-11 | Washington University | Procedimientos y composiciones para tratar neuropatías |
US20060035302A1 (en) * | 2004-06-21 | 2006-02-16 | Applera Corporation | Kinase substrates with multiple phosphorylation sites |
US20070244202A1 (en) * | 2004-06-28 | 2007-10-18 | Kao Corporation | Ampk Activator |
US20070014833A1 (en) * | 2005-03-30 | 2007-01-18 | Sirtris Pharmaceuticals, Inc. | Treatment of eye disorders with sirtuin modulators |
CN103055313A (zh) * | 2005-07-07 | 2013-04-24 | 西特里斯药业公司 | 用于治疗或预防肥胖、胰岛素抵抗障碍和线粒体相关障碍的方法和相关组合物 |
WO2007019344A1 (en) * | 2005-08-04 | 2007-02-15 | Sirtris Pharmaceuticals, Inc. | Imidazo [2,1-b] thiayole derivatives as sirtuin modulating compounds |
CA2675638C (en) * | 2007-01-16 | 2015-11-24 | Ipintl, Llc | Composition comprising serotonin for treating metabolic syndrome |
-
2008
- 2008-01-28 MX MX2009008022A patent/MX2009008022A/es not_active Application Discontinuation
- 2008-01-28 WO PCT/US2008/001085 patent/WO2008091710A2/en active Application Filing
- 2008-01-28 EP EP08724865A patent/EP2124985A4/en not_active Withdrawn
- 2008-01-28 US US12/524,718 patent/US20100047177A1/en not_active Abandoned
- 2008-01-28 CA CA002676609A patent/CA2676609A1/en not_active Abandoned
-
2013
- 2013-07-26 US US13/952,183 patent/US20140011890A1/en not_active Abandoned
-
2016
- 2016-09-06 US US15/257,599 patent/US20160367497A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
EP2124985A4 (en) | 2011-06-08 |
EP2124985A2 (en) | 2009-12-02 |
US20100047177A1 (en) | 2010-02-25 |
US20160367497A1 (en) | 2016-12-22 |
CA2676609A1 (en) | 2008-07-31 |
WO2008091710A3 (en) | 2008-10-09 |
US20140011890A1 (en) | 2014-01-09 |
WO2008091710A2 (en) | 2008-07-31 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
MX2009008022A (es) | Metodos y composiciones para tratar neuropatias. | |
WO2006001982A3 (en) | Methods and compositions for treating neuropathies | |
WO2007028085A3 (en) | Neuregulin for prevention and treatment of damage from acute assault on vascular and neuronal tissues | |
GB2463833A (en) | Methods and compositions for the treatment of neurological disorders | |
HRP20130707T1 (en) | Compositions and uses for treating multiple sclerosis | |
EP2331095A4 (en) | CYNURENINE-3-MONOOXYGENASE INHIBITORS, PHARMACEUTICAL COMPOSITIONS AND METHOD OF USE THEREOF | |
WO2009106991A3 (en) | Pyridazine derivatives and their use as therapeutic agents in the treatment of skin disorders | |
WO2005000331A3 (en) | Compositions for the treatment and prevention of degenerative joint disorders | |
UA85055C2 (ru) | Применение ингибиторов миостатика (gdf8) в сочетании с кортикостероидами для лечения нервно-мышечных заболеваний | |
WO2006128032A3 (en) | Compositions and methods for the prevention and treatment of conditions associated with inflammation | |
WO2007040565A3 (en) | Enhancing treatment of cancer and hif-1 mediated disoders with adenosine a3 receptor antagonists | |
MX2010003548A (es) | Metodos para el tratamiento de padecimientos neurologicos autoinmunes con ciclofosfamida. | |
WO2003068171A3 (en) | Method and composition for treatment of inflammation and aids-associated neurological disorders | |
AU2008232453A8 (en) | Methods and compositions for reduction of side effects of therapeutic treatments | |
EP3150635A3 (en) | Methods for treating disseminated intravascular coagulation by inhibiting masp-2 dependent complement activation | |
NZ597489A (en) | Methods for treating conditions associated with MASP-2 dependent complement activation | |
WO2007022470A3 (en) | Methods and compositions for treating neurological disease | |
AR049955A1 (es) | Composiciones y metodos para el tratamiento de trastornos metabolicos | |
NZ593343A (en) | Combination cancer treatment conprising Abraxane and an inflamatory inhibitor | |
WO2006055970A3 (en) | Enhancing treatment of hif-1 mediated disorders with adenosine a3 receptor agonists | |
MX2009002921A (es) | Derivados de azetidinona para el tratamiento de trastornos del metabolismo lipidico. | |
WO2005116088A3 (en) | Methods and compositions for treating diseases and disorders associated with siglec-8 expressing cells | |
WO2006085143A3 (en) | Improved bioactive agent compositions for repair of cell injuries | |
WO2006078574A3 (en) | Mitotic kinesin inhibitors | |
WO2007123848A3 (en) | Therapeutic compositions containing modified class i slrp proteins |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
FA | Abandonment or withdrawal |