MX2009002462A - Siarn y metodos de manufactura del mismo. - Google Patents

Siarn y metodos de manufactura del mismo.

Info

Publication number
MX2009002462A
MX2009002462A MX2009002462A MX2009002462A MX2009002462A MX 2009002462 A MX2009002462 A MX 2009002462A MX 2009002462 A MX2009002462 A MX 2009002462A MX 2009002462 A MX2009002462 A MX 2009002462A MX 2009002462 A MX2009002462 A MX 2009002462A
Authority
MX
Mexico
Prior art keywords
methods
manufacture
double
sirna
stranded rna
Prior art date
Application number
MX2009002462A
Other languages
English (en)
Inventor
Samuel Jotham Reich
N Nicole Endejann
Original Assignee
Opko Opthalmics Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Opko Opthalmics Llc filed Critical Opko Opthalmics Llc
Publication of MX2009002462A publication Critical patent/MX2009002462A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/111—General methods applicable to biologically active non-coding nucleic acids
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C12N15/1136—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against growth factors, growth regulators, cytokines, lymphokines or hormones
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/10—Type of nucleic acid
    • C12N2310/14—Type of nucleic acid interfering N.A.
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2330/00—Production
    • C12N2330/30—Production chemically synthesised

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biomedical Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Chemical & Material Sciences (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Microbiology (AREA)
  • Plant Pathology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Endocrinology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Saccharide Compounds (AREA)

Abstract

Se proporcionan ARN de doble hebra de aproximadamente 19 a aproximadamente 25 nucleotidos de longitud aptos para regular la expresión genética mediante interferencia de ARN. Tales ARN de doble hebra son particularmente útiles para el tratamiento de enfermedad o condiciones asociadas con un mARN o gen objetivo. También se proporcionan métodos de manufactura y métodos de uso del ARN de doble hebra.
MX2009002462A 2006-09-08 2007-09-07 Siarn y metodos de manufactura del mismo. MX2009002462A (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US82495306P 2006-09-08 2006-09-08
US11/851,145 US7872118B2 (en) 2006-09-08 2007-09-06 siRNA and methods of manufacture
PCT/US2007/077810 WO2008030996A2 (en) 2006-09-08 2007-09-07 Sirna and methods of manufacture

Publications (1)

Publication Number Publication Date
MX2009002462A true MX2009002462A (es) 2009-07-31

Family

ID=38983407

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2009002462A MX2009002462A (es) 2006-09-08 2007-09-07 Siarn y metodos de manufactura del mismo.

Country Status (7)

Country Link
US (2) US7872118B2 (es)
EP (1) EP2076598B1 (es)
JP (1) JP2010502230A (es)
AU (1) AU2007292229A1 (es)
CA (1) CA2662959A1 (es)
MX (1) MX2009002462A (es)
WO (1) WO2008030996A2 (es)

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US7148342B2 (en) 2002-07-24 2006-12-12 The Trustees Of The University Of Pennyslvania Compositions and methods for sirna inhibition of angiogenesis
CA2745832A1 (en) 2008-12-04 2010-06-10 Opko Ophthalmics, Llc Compositions and methods for selective inhibition of pro-angiogenic vegf isoforms
KR20220056884A (ko) 2011-04-22 2022-05-06 더 리젠츠 오브 더 유니버시티 오브 캘리포니아 변이체 캡시드를 지니는 아데노-관련 바이러스 및 이의 사용 방법
GB201403684D0 (en) 2014-03-03 2014-04-16 King S College London Vector
EP3188799B1 (en) 2014-09-05 2022-07-06 Phio Pharmaceuticals Corp. Methods for treating aging and skin disorders using nucleic acids targeting tyr or mmp1
CA3022600A1 (en) 2016-04-29 2017-11-02 Adverum Biotechnologies, Inc. Evasion of neutralizing antibodies by a recombinant adeno-associated virus
CN109640949B (zh) 2016-07-29 2022-11-25 加利福尼亚大学董事会 具有变异衣壳的腺相关病毒病毒体和其使用方法
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CA3219898A1 (en) 2021-05-28 2023-11-21 Wentao Zhang Recombinant adeno-associated virus having variant capsid, and application thereof

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Also Published As

Publication number Publication date
WO2008030996A3 (en) 2008-05-02
US20090061487A1 (en) 2009-03-05
AU2007292229A1 (en) 2008-03-13
US7872118B2 (en) 2011-01-18
EP2076598B1 (en) 2012-05-23
CA2662959A1 (en) 2008-03-13
US20110143400A1 (en) 2011-06-16
JP2010502230A (ja) 2010-01-28
WO2008030996A2 (en) 2008-03-13
WO2008030996A8 (en) 2009-07-30
EP2076598A2 (en) 2009-07-08

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