MX2008012490A - Aminotetrahidropiranos como inhibidores de dipeptidil peptidasa-iv para el tratamiento o prevencion de diabetes. - Google Patents

Aminotetrahidropiranos como inhibidores de dipeptidil peptidasa-iv para el tratamiento o prevencion de diabetes.

Info

Publication number
MX2008012490A
MX2008012490A MX2008012490A MX2008012490A MX2008012490A MX 2008012490 A MX2008012490 A MX 2008012490A MX 2008012490 A MX2008012490 A MX 2008012490A MX 2008012490 A MX2008012490 A MX 2008012490A MX 2008012490 A MX2008012490 A MX 2008012490A
Authority
MX
Mexico
Prior art keywords
dipeptidyl peptidase
diabetes
prevention
treatment
inhibitors
Prior art date
Application number
MX2008012490A
Other languages
English (en)
Inventor
Tesfaye Biftu
Ann E Weber
Original Assignee
Merck & Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck & Co Inc filed Critical Merck & Co Inc
Publication of MX2008012490A publication Critical patent/MX2008012490A/es

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
    • A61K31/351—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom not condensed with another ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04—Ortho-condensed systems

Abstract

La presente invención se refiere a aminotetrahidropiranos sustituidos novedosos de la fórmula estructural I que son inhibidores del enzima dipeptidil peptidasa-IV y que son útiles en el tratamiento o prevención de enfermedades en las que está implicada la enzima dipepetidil peptidasa-IV, tales como diabetes y en particular diabetes de tipo 2; la invención también se refiere a composiciones farmacéuticas que comprenden estos compuestos y al uso de estos compuestos y composiciones en la prevención o tratamiento de dichas enfermedades en las que está implicada la enzima dipeptidil peptidasa-IV. (ver fórmula (I)).
MX2008012490A 2006-03-28 2007-03-26 Aminotetrahidropiranos como inhibidores de dipeptidil peptidasa-iv para el tratamiento o prevencion de diabetes. MX2008012490A (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US78651806P 2006-03-28 2006-03-28
US83812206P 2006-08-16 2006-08-16
PCT/US2007/007434 WO2007126745A2 (en) 2006-03-28 2007-03-26 Aminotetrahydropyrans as dipeptidyl peptidase-iv inhibitors for the treatment or prevention of diabetes

Publications (1)

Publication Number Publication Date
MX2008012490A true MX2008012490A (es) 2008-10-10

Family

ID=38521359

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2008012490A MX2008012490A (es) 2006-03-28 2007-03-26 Aminotetrahidropiranos como inhibidores de dipeptidil peptidasa-iv para el tratamiento o prevencion de diabetes.

Country Status (22)

Country Link
US (1) US7678905B2 (es)
EP (1) EP2001883B1 (es)
JP (1) JP5229706B2 (es)
KR (1) KR20090005306A (es)
AR (1) AR059984A1 (es)
AT (1) ATE554091T1 (es)
AU (1) AU2007243631B2 (es)
BR (1) BRPI0709141A2 (es)
CA (1) CA2646962C (es)
CR (1) CR10343A (es)
DO (1) DOP2007000051A (es)
EA (1) EA200870380A1 (es)
EC (1) ECSP088765A (es)
GT (1) GT200800184A (es)
MA (1) MA30333B1 (es)
MX (1) MX2008012490A (es)
NO (1) NO20084508L (es)
PE (1) PE20071104A1 (es)
SV (1) SV2008003045A (es)
TN (1) TNSN08367A1 (es)
TW (1) TW200806669A (es)
WO (1) WO2007126745A2 (es)

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TW201221505A (en) 2010-07-05 2012-06-01 Sanofi Sa Aryloxyalkylene-substituted hydroxyphenylhexynoic acids, process for preparation thereof and use thereof as a medicament
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US8828995B2 (en) 2011-03-08 2014-09-09 Sanofi Branched oxathiazine derivatives, method for the production thereof, use thereof as medicine and drug containing said derivatives and use thereof
EP2766349B1 (de) 2011-03-08 2016-06-01 Sanofi Mit carbozyklen oder heterozyklen substituierte oxathiazinderivate, verfahren zu deren herstellung, diese verbindungen enthaltende arzneimittel und deren verwendung
US8871758B2 (en) 2011-03-08 2014-10-28 Sanofi Tetrasubstituted oxathiazine derivatives, method for producing them, their use as medicine and drug containing said derivatives and the use thereof
US8710050B2 (en) 2011-03-08 2014-04-29 Sanofi Di and tri- substituted oxathiazine derivatives, method for the production, method for the production thereof, use thereof as medicine and drug containing said derivatives and use thereof
RU2598072C2 (ru) 2011-06-29 2016-09-20 Мерк Шарп И Доум Корп. Новые кристаллические формы ингибиторов дипептидилпептидазы-iv
EP2729468A4 (en) 2011-07-05 2015-03-18 Merck Sharp & Dohme TRICYCLIC HETEROCYCLES AS DIPEPTIDYLPEPTIDASE IV INHIBITORS
WO2013037390A1 (en) 2011-09-12 2013-03-21 Sanofi 6-(4-hydroxy-phenyl)-3-styryl-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors
EP2760862B1 (en) 2011-09-27 2015-10-21 Sanofi 6-(4-hydroxy-phenyl)-3-alkyl-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors
EP2814485A4 (en) 2012-02-17 2015-08-26 Merck Sharp & Dohme DIPEPTIDYL PEPTIDASE-IV INHIBITORS FOR THE TREATMENT OR PREVENTION OF DIABETES
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CN105085528A (zh) * 2014-05-15 2015-11-25 成都贝斯凯瑞生物科技有限公司 作为二肽基肽酶-iv抑制剂的氨基四氢吡喃衍生物
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Also Published As

Publication number Publication date
PE20071104A1 (es) 2007-12-29
GT200800184A (es) 2011-09-05
ECSP088765A (es) 2008-10-31
TW200806669A (en) 2008-02-01
EA200870380A1 (ru) 2009-02-27
US20070232676A1 (en) 2007-10-04
AU2007243631A1 (en) 2007-11-08
SV2008003045A (es) 2009-11-09
US7678905B2 (en) 2010-03-16
EP2001883B1 (en) 2012-04-18
KR20090005306A (ko) 2009-01-13
CA2646962A1 (en) 2007-11-08
MA30333B1 (fr) 2009-04-01
ATE554091T1 (de) 2012-05-15
AR059984A1 (es) 2008-05-14
CA2646962C (en) 2011-06-21
TNSN08367A1 (en) 2009-12-29
AU2007243631B2 (en) 2011-11-24
BRPI0709141A2 (pt) 2011-06-28
CR10343A (es) 2008-10-29
JP2009531437A (ja) 2009-09-03
WO2007126745A2 (en) 2007-11-08
WO2007126745A3 (en) 2007-12-21
JP5229706B2 (ja) 2013-07-03
EP2001883A2 (en) 2008-12-17
NO20084508L (no) 2008-10-27
DOP2007000051A (es) 2007-12-15

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