MX2008002323A - Aggrecanase structure. - Google Patents

Aggrecanase structure.

Info

Publication number
MX2008002323A
MX2008002323A MX2008002323A MX2008002323A MX2008002323A MX 2008002323 A MX2008002323 A MX 2008002323A MX 2008002323 A MX2008002323 A MX 2008002323A MX 2008002323 A MX2008002323 A MX 2008002323A MX 2008002323 A MX2008002323 A MX 2008002323A
Authority
MX
Mexico
Prior art keywords
aggrecanase
ligand complexes
polypeptide
crystals
polypeptides
Prior art date
Application number
MX2008002323A
Other languages
Spanish (es)
Inventor
Edward R Lavallie
Ravindra Kumar
Lisa A Collins-Racie
Christopher John Corcoran
Thomas Saltmarsh Rush Iii
Lidia Mosyak
Xiaotian Zhong
Katy E Georgiadis
Phaik-Eng Sum
Thomas E Mcdonagh
Tracy Hebert
Stephane Hubert Olland
Stewart Andrews Mackie
Original Assignee
Wyeth Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wyeth Corp filed Critical Wyeth Corp
Publication of MX2008002323A publication Critical patent/MX2008002323A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C30—CRYSTAL GROWTH
    • C30B—SINGLE-CRYSTAL GROWTH; UNIDIRECTIONAL SOLIDIFICATION OF EUTECTIC MATERIAL OR UNIDIRECTIONAL DEMIXING OF EUTECTOID MATERIAL; REFINING BY ZONE-MELTING OF MATERIAL; PRODUCTION OF A HOMOGENEOUS POLYCRYSTALLINE MATERIAL WITH DEFINED STRUCTURE; SINGLE CRYSTALS OR HOMOGENEOUS POLYCRYSTALLINE MATERIAL WITH DEFINED STRUCTURE; AFTER-TREATMENT OF SINGLE CRYSTALS OR A HOMOGENEOUS POLYCRYSTALLINE MATERIAL WITH DEFINED STRUCTURE; APPARATUS THEREFOR
    • C30B7/00—Single-crystal growth from solutions using solvents which are liquid at normal temperature, e.g. aqueous solutions
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2299/00—Coordinates from 3D structures of peptides, e.g. proteins or enzymes

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Rheumatology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Biomedical Technology (AREA)
  • Wood Science & Technology (AREA)
  • Materials Engineering (AREA)
  • Immunology (AREA)
  • Microbiology (AREA)
  • Molecular Biology (AREA)
  • Metallurgy (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Pain & Pain Management (AREA)
  • Peptides Or Proteins (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

This invention relates to aggrecanase polypeptides and aggrecanase polypeptide/ligand complexes, crystals of aggrecanase and aggrecanase polypeptide/ligand complexes, and related methods and software systems.
MX2008002323A 2005-08-25 2006-08-24 Aggrecanase structure. MX2008002323A (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US71145705P 2005-08-25 2005-08-25
US71145805P 2005-08-25 2005-08-25
PCT/US2006/033498 WO2007025248A2 (en) 2005-08-25 2006-08-24 Aggrecanase structure

Publications (1)

Publication Number Publication Date
MX2008002323A true MX2008002323A (en) 2008-03-18

Family

ID=37695961

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2008002323A MX2008002323A (en) 2005-08-25 2006-08-24 Aggrecanase structure.

Country Status (7)

Country Link
EP (1) EP1917354A2 (en)
JP (1) JP2009508474A (en)
AU (1) AU2006282798A1 (en)
BR (1) BRPI0616729A2 (en)
CA (1) CA2619521A1 (en)
MX (1) MX2008002323A (en)
WO (1) WO2007025248A2 (en)

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20020160492A1 (en) * 2000-07-25 2002-10-31 Cook Michael N. Bovine aggrecanase-1
US7118902B2 (en) * 2002-07-29 2006-10-10 Wyeth Modified ADAMTS4 molecules and method of use thereof
WO2005103287A1 (en) * 2004-04-16 2005-11-03 Wyeth Truncated adamts molecules

Also Published As

Publication number Publication date
JP2009508474A (en) 2009-03-05
CA2619521A1 (en) 2007-03-01
WO2007025248A3 (en) 2007-08-09
WO2007025248A2 (en) 2007-03-01
AU2006282798A1 (en) 2007-03-01
WO2007025248B1 (en) 2007-10-11
BRPI0616729A2 (en) 2009-11-03
EP1917354A2 (en) 2008-05-07

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