MX2007007288A - Desacilacion de lps en bacterias gram negativas. - Google Patents
Desacilacion de lps en bacterias gram negativas.Info
- Publication number
- MX2007007288A MX2007007288A MX2007007288A MX2007007288A MX2007007288A MX 2007007288 A MX2007007288 A MX 2007007288A MX 2007007288 A MX2007007288 A MX 2007007288A MX 2007007288 A MX2007007288 A MX 2007007288A MX 2007007288 A MX2007007288 A MX 2007007288A
- Authority
- MX
- Mexico
- Prior art keywords
- gram negative
- lps
- negative bacteria
- deacylation
- bordetella
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/02—Bacterial antigens
- A61K39/099—Bordetella
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
- C07K14/235—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Bordetella (G)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/16—Hydrolases (3) acting on ester bonds (3.1)
- C12N9/18—Carboxylic ester hydrolases (3.1.1)
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Immunology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Microbiology (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Biochemistry (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Molecular Biology (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Gastroenterology & Hepatology (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Mycology (AREA)
- Epidemiology (AREA)
- Biomedical Technology (AREA)
- Biophysics (AREA)
- General Chemical & Material Sciences (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Peptides Or Proteins (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Enzymes And Modification Thereof (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
La presente invencion proporciona polipeptidos gram negativos novedosos que exhiben actividad 3-O-desacilasa del lipido A y son capaces de modificar y/o destoxificar LPS gram negativos. La presente invencion tambien proporciona bacterias gram negativas, lipopolisacaridos (LPS) de bacterias gram negativas y composiciones que comprenden los LPS, los cuales se proporcionan o se tratan con una actividad 3-O-desasilasa de acuerdo con la invencion, y los cuales se pueden utilizar para fines farmaceuticos y/o veterinarios, en particular para la preparacion de vacunas de celula total a acelulares, en contra de gram negativos patogenicos tales como por ejemplo, Bordetella pertusis, Bordetella parapertusis y Bordetella bronchiseptica.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP04078445 | 2004-12-17 | ||
PCT/NL2005/050081 WO2006065139A2 (en) | 2004-12-17 | 2005-12-16 | Deacylation of lps in gram negative bacteria |
Publications (1)
Publication Number | Publication Date |
---|---|
MX2007007288A true MX2007007288A (es) | 2008-02-25 |
Family
ID=34928754
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2007007288A MX2007007288A (es) | 2004-12-17 | 2005-12-16 | Desacilacion de lps en bacterias gram negativas. |
Country Status (15)
Country | Link |
---|---|
US (1) | US8048433B2 (es) |
EP (1) | EP1828378B1 (es) |
JP (1) | JP5378685B2 (es) |
CN (1) | CN101203605B (es) |
AU (1) | AU2005317304B2 (es) |
BR (1) | BRPI0519923A8 (es) |
CA (1) | CA2590906C (es) |
DK (1) | DK1828378T3 (es) |
ES (1) | ES2493440T3 (es) |
MX (1) | MX2007007288A (es) |
NO (1) | NO340331B1 (es) |
NZ (1) | NZ555889A (es) |
PL (1) | PL1828378T3 (es) |
PT (1) | PT1828378E (es) |
WO (1) | WO2006065139A2 (es) |
Families Citing this family (16)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
SI2134743T1 (sl) * | 2007-03-26 | 2013-01-31 | De Staat Der Nederlanden, Vert. Door De Minister Van Vws | Izboljšana cepiva proti Bordetelli perussis na osnovi LPS glikoziltransferaznih mutantov |
US20140037680A1 (en) | 2012-08-06 | 2014-02-06 | Glaxosmithkline Biologicals, S.A. | Novel method |
AU2013301312A1 (en) | 2012-08-06 | 2015-03-19 | Glaxosmithkline Biologicals S.A. | Method for eliciting in infants an immune response against RSV and B. pertussis |
US11052142B2 (en) | 2013-06-04 | 2021-07-06 | Petr G. Aparin | Modified endotoxic bacteria lipopolysaccharide (variants), combination of modified lipopolysaccharides (variants) and, containing same, a vaccine (variants) and a pharmaceutical composition (variants) |
EA031879B1 (ru) | 2013-06-04 | 2019-03-29 | Пётр Геннадиевич Апарин | Модифицированный липополисахарид эндотоксичных бактерий (варианты), комбинация модифицированных липополисахаридов (варианты) и включающие их вакцина (варианты) и фармацевтическая композиция (варианты) |
KR20160040290A (ko) | 2013-08-05 | 2016-04-12 | 글락소스미스클라인 바이오로지칼즈 에스.에이. | 조합 면역원성 조성물 |
US10420833B2 (en) | 2014-05-19 | 2019-09-24 | Board Of Regents, The University Of Texas System | Combinatorial platform for the display of surface adjuvants and antigens |
CN104388368B (zh) * | 2014-10-30 | 2017-02-15 | 四川农业大学 | 一株低内毒素大肠杆菌原核表达工程菌突变株及构建方法 |
US11389520B2 (en) * | 2016-01-28 | 2022-07-19 | Intravacc B.V. | Modified tetra-acylated neisserial LPS |
CN105567620B (zh) * | 2016-01-29 | 2019-03-19 | 江南大学 | 一株产减毒类脂A的Cronobacter sakazakii突变株及其应用 |
CN105695540A (zh) * | 2016-03-18 | 2016-06-22 | 辽宁成大生物股份有限公司 | 一种革兰氏阴性菌胞壁抗原的制备方法 |
JP7311227B2 (ja) * | 2017-03-13 | 2023-07-19 | イントラヴァック ビー.ブイ. | 低下した反応源性を有するlpsを含むボルデテラワクチン |
WO2018213242A1 (en) * | 2017-05-15 | 2018-11-22 | University Of Maryland, Baltimore | Live salmonella typhi vectors engineered to express heterologous outer membrane protein antigens and methods of use thereof |
CN111433348B (zh) * | 2017-12-04 | 2024-07-02 | Intravacc有限责任公司 | 一种改良的生产外膜囊泡的方法 |
EP4208472A1 (en) | 2020-09-04 | 2023-07-12 | Intravacc B.V. | Ompa mutations enhance omv production in bordetella pertussis |
EP4169513A1 (en) | 2021-10-19 | 2023-04-26 | GlaxoSmithKline Biologicals S.A. | Adjuvant composition comprising sting agonists |
Family Cites Families (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CH650681A5 (en) | 1981-08-14 | 1985-08-15 | Dso Pharmachim | Whooping cough vaccine |
WO1989001976A1 (en) * | 1987-09-04 | 1989-03-09 | Amgen Inc. | Recombinant dna-derived bordetella toxin subunit analogs |
EP0484621A3 (en) * | 1990-07-11 | 1992-08-26 | American Cyanamid Company | Efficacious vaccines against bordetella pertussis comprising a combination of individually purified pertussis antigens |
HU219819B (hu) * | 1992-08-18 | 2001-08-28 | Dimminaco Ag/Sa/Ltd. | Izolált polinukleotidok, ezeket tartalmazó Bordetella bronchiseptica törzs, és Bordetella bronchiseptica elleni vakcina |
AU715417B2 (en) * | 1995-05-04 | 2000-02-03 | Connaught Laboratories Limited | Acellular pertussis vaccines and methods of preparation thereof |
US6887483B2 (en) * | 1995-12-01 | 2005-05-03 | University Of Iowa Research Foundation | Non-toxic mutants of pathogenic gram-negative bacteria |
ES2227825T3 (es) * | 1997-04-01 | 2005-04-01 | Corixa Corporation | Composiciones inmunologicas aduvantes acuosas de monofosforil lipido a. |
CA2264970A1 (en) | 1998-03-10 | 1999-09-10 | American Cyanamid Company | Antigenic conjugates of conserved lipolysaccharides of gram negative bacteria |
JP3595264B2 (ja) * | 1998-11-03 | 2004-12-02 | デ・スタート・デル・ネーデルランデン・ベルテゲンボールディクト・ドール・デ・ミニステル・バン・ベルジーン・ボルクスゲツォントヘイト・エン・クルトゥール | 遺伝的に修飾されたグラム陰性細菌由来の低毒性lps |
US6531131B1 (en) * | 1999-08-10 | 2003-03-11 | The United States Of America As Represented By The Department Of Health And Human Services | Conjugate vaccine for Neisseria meningitidis |
AU2002307448A1 (en) * | 2001-04-20 | 2002-11-05 | President And Fellows Of Harvard College | Methods and compositions for the modulation of biofilm formation |
-
2005
- 2005-12-16 BR BRPI0519923A patent/BRPI0519923A8/pt not_active Application Discontinuation
- 2005-12-16 CA CA2590906A patent/CA2590906C/en not_active Expired - Fee Related
- 2005-12-16 PT PT58154675T patent/PT1828378E/pt unknown
- 2005-12-16 MX MX2007007288A patent/MX2007007288A/es active IP Right Grant
- 2005-12-16 DK DK05815467.5T patent/DK1828378T3/da active
- 2005-12-16 NZ NZ555889A patent/NZ555889A/en not_active IP Right Cessation
- 2005-12-16 US US11/722,034 patent/US8048433B2/en not_active Expired - Fee Related
- 2005-12-16 AU AU2005317304A patent/AU2005317304B2/en not_active Ceased
- 2005-12-16 EP EP05815467.5A patent/EP1828378B1/en not_active Not-in-force
- 2005-12-16 CN CN200580048420.6A patent/CN101203605B/zh not_active Expired - Fee Related
- 2005-12-16 ES ES05815467.5T patent/ES2493440T3/es active Active
- 2005-12-16 WO PCT/NL2005/050081 patent/WO2006065139A2/en active Application Filing
- 2005-12-16 PL PL05815467T patent/PL1828378T3/pl unknown
- 2005-12-16 JP JP2007546589A patent/JP5378685B2/ja not_active Expired - Fee Related
-
2007
- 2007-06-18 NO NO20073088A patent/NO340331B1/no not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
JP2008523805A (ja) | 2008-07-10 |
NO340331B1 (no) | 2017-04-03 |
PL1828378T3 (pl) | 2014-10-31 |
EP1828378A2 (en) | 2007-09-05 |
US8048433B2 (en) | 2011-11-01 |
NZ555889A (en) | 2009-07-31 |
PT1828378E (pt) | 2014-10-10 |
JP5378685B2 (ja) | 2013-12-25 |
AU2005317304A1 (en) | 2006-06-22 |
CN101203605A (zh) | 2008-06-18 |
US20080274145A1 (en) | 2008-11-06 |
NO20073088L (no) | 2007-09-17 |
DK1828378T3 (da) | 2014-09-01 |
CA2590906A1 (en) | 2006-06-22 |
BRPI0519923A2 (pt) | 2009-08-11 |
WO2006065139A2 (en) | 2006-06-22 |
CA2590906C (en) | 2017-01-03 |
ES2493440T3 (es) | 2014-09-11 |
CN101203605B (zh) | 2016-01-27 |
EP1828378B1 (en) | 2014-06-11 |
BRPI0519923A8 (pt) | 2018-01-23 |
AU2005317304B2 (en) | 2011-06-23 |
WO2006065139A3 (en) | 2006-10-19 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FG | Grant or registration | ||
GB | Transfer or rights |