MX2007005199A - Indolizinas sustituidas y derivados como agentes del sistema nervioso central. - Google Patents
Indolizinas sustituidas y derivados como agentes del sistema nervioso central.Info
- Publication number
- MX2007005199A MX2007005199A MX2007005199A MX2007005199A MX2007005199A MX 2007005199 A MX2007005199 A MX 2007005199A MX 2007005199 A MX2007005199 A MX 2007005199A MX 2007005199 A MX2007005199 A MX 2007005199A MX 2007005199 A MX2007005199 A MX 2007005199A
- Authority
- MX
- Mexico
- Prior art keywords
- derivatives
- cns agents
- compounds
- indolizines
- substituted
- Prior art date
Links
- 150000002478 indolizines Chemical class 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 3
- 239000000556 agonist Substances 0.000 abstract 1
- 208000015114 central nervous system disease Diseases 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 239000004031 partial agonist Substances 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 201000000980 schizophrenia Diseases 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/32—Alcohol-abuse
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Abstract
Se proporcionan compuestos de la formula (I) de sales farmaceuticamente aceptables de los mismos: formula (I)., los cuales son agonistas o agonistas parciales del subtipo 2C de receptores de serotonina cerebral. Los compuestos, y composiciones que contienen los compuestos, pueden utilizarse para tratar una variedad de trastornos del sistema nervioso central, tal como esquizofrenia.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US62442304P | 2004-11-01 | 2004-11-01 | |
PCT/US2005/038702 WO2006050007A2 (en) | 2004-11-01 | 2005-10-27 | Substituted indolizines and derivatives as cns agents |
Publications (1)
Publication Number | Publication Date |
---|---|
MX2007005199A true MX2007005199A (es) | 2007-05-11 |
Family
ID=36177318
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2007005199A MX2007005199A (es) | 2004-11-01 | 2005-10-27 | Indolizinas sustituidas y derivados como agentes del sistema nervioso central. |
Country Status (9)
Country | Link |
---|---|
US (1) | US7608626B2 (es) |
EP (1) | EP1807427A2 (es) |
JP (1) | JP2008518917A (es) |
CN (1) | CN101094852A (es) |
AU (1) | AU2005302559A1 (es) |
BR (1) | BRPI0517955A (es) |
CA (1) | CA2585967A1 (es) |
MX (1) | MX2007005199A (es) |
WO (1) | WO2006050007A2 (es) |
Families Citing this family (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP2018863B9 (en) | 2006-05-16 | 2015-02-18 | Takeda Pharmaceutical Company Limited | Fused heterocyclic compound and use thereof |
WO2009063992A1 (ja) | 2007-11-15 | 2009-05-22 | Takeda Pharmaceutical Company Limited | 縮合ピリジン誘導体およびその用途 |
WO2011031086A2 (ko) * | 2009-09-10 | 2011-03-17 | 주식회사 엘지화학 | 신규한 헤테로고리 유도체 및 이를 이용한 유기 발광 소자 |
FR2953716B1 (fr) * | 2009-12-16 | 2015-03-27 | Oreal | Kit de formulation d'un produit cosmetique |
FR2961095B1 (fr) * | 2010-06-09 | 2012-06-15 | Oreal | Composition cosmetique et/ou dermatologique comprenant au moins un compose 6-alcoxy tryptamine |
FR2961097B1 (fr) * | 2010-06-09 | 2012-07-13 | Oreal | Procede cosmetique de traitement des odeurs corporelles humaines utilisant un compose 6-alkoxy tryptamine |
US20130267500A1 (en) | 2010-09-01 | 2013-10-10 | Arena Pharmaceuticals, Inc. | 5-ht2c receptor agonists in the treatment of disorders ameliorated by reduction of norepinephrine level |
CN102295644B (zh) * | 2011-05-25 | 2012-12-05 | 同济大学 | 一种合成1-卤-2-芳基中氮茚类化合物的方法 |
CN102603735B (zh) * | 2012-02-06 | 2014-07-16 | 浙江新和成股份有限公司 | 一种c-2芳基化吲哚嗪化合物的制备方法 |
WO2015066344A1 (en) | 2013-11-01 | 2015-05-07 | Arena Pharmaceuticals, Inc. | 5-ht2c receptor agonists and compositions and methods of use |
US20210052600A1 (en) | 2017-12-27 | 2021-02-25 | Takeda Pharmaceutical Company Limited | Therapeutic agents for stress urinary incontinence and incotinence of feces |
CN112010777B (zh) * | 2020-08-20 | 2022-10-11 | 浙江大学衢州研究院 | 于管道化反应器内进行的酰胺连续化制备腈的方法 |
CA3236339A1 (en) * | 2021-11-03 | 2023-05-11 | Matthew BAGGOTT | Indolizine compounds for the treatment of mental disorders or mental enhancement |
Family Cites Families (18)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB8416724D0 (en) | 1984-06-30 | 1984-08-01 | Sorbio Sa Lab | Active compounds |
EP0213696B1 (en) | 1985-06-28 | 1991-01-23 | Beecham Wuelfing GmbH & Co KG | Tetrahydropyrido [1,2-a] indole derivatives, process and intermediates for their preparation and pharmaceutical compositions containing them |
EP0252643A1 (en) | 1986-07-01 | 1988-01-13 | BEECHAM - WUELFING GmbH & Co. KG | Pyrido[1,2-a]indole derivatives, process for their preparation and pharmaceutical compounds containing them |
CA1329597C (en) | 1986-12-22 | 1994-05-17 | Dagmar Hoeltje | Derivatives of tetrahydropyrido[1,2-a]indole |
PT100570A (pt) | 1991-06-07 | 1993-08-31 | Smithkline Beecham Corp | Compostos de pirrolo(1,2-a)indolo-hidroxiureia/hidroxamato, seu uso e preparacao e composicoes farmaceuticas que os contem |
GB9316195D0 (en) | 1993-08-05 | 1993-09-22 | Smithkline Beecham Plc | Pharmaceuticals |
GB9318790D0 (en) | 1993-09-10 | 1993-10-27 | Fujisawa Pharmaceutical Co | Heterocyclic derivatives |
US6013653A (en) | 1995-09-22 | 2000-01-11 | Fujisawa Pharmaceuticals Co., Ltd. | Processes for producing pyridoindole derivatives |
IL129484A0 (en) | 1998-04-17 | 2000-02-29 | Lilly Co Eli | Substituted tricyclics |
AU4929999A (en) | 1998-07-30 | 2000-02-21 | Japan Tobacco Inc. | Disubstituted maleimide compounds and medicinal utilization thereof |
GB9819035D0 (en) | 1998-09-01 | 1998-10-28 | Cerebrus Res Ltd | Chemical compounds VII |
WO2000034242A1 (en) | 1998-12-11 | 2000-06-15 | Virginia Commonwealth University | Selective 5-ht6 receptor ligands |
DE19907701A1 (de) | 1999-02-23 | 2000-08-24 | Bayer Ag | Mit tricyclischen Indolen substituierte Oxazolidinone |
JP4636521B2 (ja) | 1999-07-19 | 2011-02-23 | 塩野義製薬株式会社 | sPLA2阻害作用を有する三環系化合物 |
ES2290115T3 (es) * | 2000-02-01 | 2008-02-16 | ABBOTT GMBH & CO. KG | Compuestos heterociclicos y su aplicacion como inhibidores de parp. |
FR2805539B1 (fr) * | 2000-02-25 | 2005-06-10 | Oreal | Compositions de teinture des fibres keratiniques contenant des derives d'indolizine et procede de teinture |
ATE258553T1 (de) | 2000-03-31 | 2004-02-15 | Ortho Mcneil Pharm Inc | Phenyl-substituierte indolizinderivate und deren verwendung als histamin h3 liganden |
MXPA03005915A (es) | 2000-12-27 | 2003-09-10 | Hoffmann La Roche | Derivados de indol y su uso como ligandos receptores de 5-ht2b y 5-ht2c. |
-
2005
- 2005-10-27 WO PCT/US2005/038702 patent/WO2006050007A2/en active Application Filing
- 2005-10-27 JP JP2007539092A patent/JP2008518917A/ja active Pending
- 2005-10-27 CN CNA2005800454342A patent/CN101094852A/zh active Pending
- 2005-10-27 BR BRPI0517955-6A patent/BRPI0517955A/pt not_active Application Discontinuation
- 2005-10-27 US US11/260,716 patent/US7608626B2/en not_active Expired - Fee Related
- 2005-10-27 CA CA002585967A patent/CA2585967A1/en not_active Abandoned
- 2005-10-27 AU AU2005302559A patent/AU2005302559A1/en not_active Abandoned
- 2005-10-27 MX MX2007005199A patent/MX2007005199A/es unknown
- 2005-10-27 EP EP05822693A patent/EP1807427A2/en not_active Withdrawn
Also Published As
Publication number | Publication date |
---|---|
EP1807427A2 (en) | 2007-07-18 |
US20060094752A1 (en) | 2006-05-04 |
WO2006050007A3 (en) | 2006-08-03 |
CN101094852A (zh) | 2007-12-26 |
BRPI0517955A (pt) | 2008-10-21 |
JP2008518917A (ja) | 2008-06-05 |
AU2005302559A1 (en) | 2006-05-11 |
CA2585967A1 (en) | 2006-05-11 |
WO2006050007A2 (en) | 2006-05-11 |
US7608626B2 (en) | 2009-10-27 |
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