MX2007002908A - Sondas inmovilizadas y metodos para detectar proteinas prionicas alteradas conformacionalmente. - Google Patents

Sondas inmovilizadas y metodos para detectar proteinas prionicas alteradas conformacionalmente.

Info

Publication number
MX2007002908A
MX2007002908A MX2007002908A MX2007002908A MX2007002908A MX 2007002908 A MX2007002908 A MX 2007002908A MX 2007002908 A MX2007002908 A MX 2007002908A MX 2007002908 A MX2007002908 A MX 2007002908A MX 2007002908 A MX2007002908 A MX 2007002908A
Authority
MX
Mexico
Prior art keywords
methods
prion proteins
immobilized probes
conformationally altered
probes
Prior art date
Application number
MX2007002908A
Other languages
English (en)
Inventor
Cindy S Orser
Tao Pan
Original Assignee
Adlyfe Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Adlyfe Inc filed Critical Adlyfe Inc
Publication of MX2007002908A publication Critical patent/MX2007002908A/es

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
    • G01N33/6896—Neurological disorders, e.g. Alzheimer's disease
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54393—Improving reaction conditions or stability, e.g. by coating or irradiation of surface, by reduction of non-specific binding, by promotion of specific binding
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/28—Neurological disorders
    • G01N2800/2814—Dementia; Cognitive disorders
    • G01N2800/2828—Prion diseases

Abstract

La presente invencion proporciona metodos para producir sondas inmovilizadas que son especificas para proteinas prionicas, metodos de uso de dichas sondas para unir, detectar y separar proteinas prionicas de muestras, y equipos para llevar a la practica la invencion. La invencion describe sondas inmovilizadas que se fijan en una configuracion predeterminada particular y que retienen su actividad y especificidad incluso cuando se exponen a condiciones que tipicamente alteran su actividad y especificidad.
MX2007002908A 2004-09-10 2005-09-09 Sondas inmovilizadas y metodos para detectar proteinas prionicas alteradas conformacionalmente. MX2007002908A (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US60854104P 2004-09-10 2004-09-10
US11/030,300 US20060057671A1 (en) 2004-09-10 2005-01-07 Immobilized probes and methods of detecting conformationally altered prion proteins
PCT/US2005/032135 WO2006031644A2 (en) 2004-09-10 2005-09-09 Immobilized probes and methods of detecting conformationally altered prion proteins

Publications (1)

Publication Number Publication Date
MX2007002908A true MX2007002908A (es) 2007-06-15

Family

ID=36034515

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2007002908A MX2007002908A (es) 2004-09-10 2005-09-09 Sondas inmovilizadas y metodos para detectar proteinas prionicas alteradas conformacionalmente.

Country Status (8)

Country Link
US (1) US20060057671A1 (es)
EP (2) EP2312313A3 (es)
JP (1) JP2008512483A (es)
AU (1) AU2005285143A1 (es)
BR (1) BRPI0515079A (es)
CA (1) CA2579848A1 (es)
MX (1) MX2007002908A (es)
WO (1) WO2006031644A2 (es)

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US7439041B2 (en) * 2003-08-13 2008-10-21 Novartis Vaccines And Diagnostics, Inc. Prion-specific peptide reagents
US20060035242A1 (en) * 2004-08-13 2006-02-16 Michelitsch Melissa D Prion-specific peptide reagents
WO2006076683A2 (en) * 2005-01-13 2006-07-20 Novartis Vaccines And Diagnostics Inc. Isolation and detection of pathogenic prions
EP1848830A4 (en) * 2005-01-13 2009-05-06 Novartis Vaccines & Diagnostic ISOLATION OF PATHOGENIC PRIONS
MX2007008497A (es) * 2005-01-13 2007-09-14 Novartis Vaccines & Diagnostic Ensayos inmunosorbentes enlazados a enzimas usando reactivos de peptidos especificos de prion.
JP5048522B2 (ja) * 2005-02-15 2012-10-17 エイディーライフ インコーポレイティッド 誤って折り畳まれたタンパク質およびプリオンを検出する方法
NZ594844A (en) * 2005-09-09 2013-04-26 Novartis Ag Prion-specific peptoid reagents
JP5164971B2 (ja) * 2006-04-21 2013-03-21 ピープルバイオ，アイ エヌ シー 三次元的相互作用を用いてマルチマー形成ポリペプチドのモノマーからマルチマーを分別検出する方法
EP2046822B1 (en) * 2006-07-12 2012-01-04 Agency for Science, Technology and Research Molecular probe for sphingolipids
US8673579B2 (en) * 2006-07-28 2014-03-18 Adlyfe, Inc. Peptide probes for diagnostics and therapeutics
WO2008029965A1 (en) * 2006-09-08 2008-03-13 Peoplebio, Inc. Simultaneous reaction assay for differentially detecting multimeric form
JP2011520108A (ja) * 2008-04-30 2011-07-14 ノバルティス アーゲー 病原性配座異性体についてのアッセイ
WO2010088411A2 (en) 2009-01-30 2010-08-05 Adlyfe, Inc. Conformationally dynamic peptides
CA2834056A1 (en) 2011-04-27 2012-11-01 Adlyfe, Inc. Ocular detection of amyloid proteins
CA3051839A1 (en) 2017-02-17 2018-08-23 Bristol-Myers Squibb Company Antibodies to alpha-synuclein and uses thereof

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US20060035242A1 (en) * 2004-08-13 2006-02-16 Michelitsch Melissa D Prion-specific peptide reagents
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Also Published As

Publication number Publication date
JP2008512483A (ja) 2008-04-24
EP1789788A4 (en) 2008-05-14
US20060057671A1 (en) 2006-03-16
AU2005285143A1 (en) 2006-03-23
EP2312313A2 (en) 2011-04-20
EP1789788A2 (en) 2007-05-30
WO2006031644A3 (en) 2006-08-31
EP2312313A3 (en) 2011-09-14
WO2006031644A2 (en) 2006-03-23
BRPI0515079A (pt) 2008-07-08
CA2579848A1 (en) 2006-03-23

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