MEP47208A - 4-(n-phenylamino)-quinazolines / quinolines as tyrosine kinase inhibitors - Google Patents

4-(n-phenylamino)-quinazolines / quinolines as tyrosine kinase inhibitors

Info

Publication number
MEP47208A
MEP47208A MEP-472/08A MEP47208A MEP47208A ME P47208 A MEP47208 A ME P47208A ME P47208 A MEP47208 A ME P47208A ME P47208 A MEP47208 A ME P47208A
Authority
ME
Montenegro
Prior art keywords
quinazolines
quinolines
phenylamino
tyrosine kinase
kinase inhibitors
Prior art date
Application number
MEP-472/08A
Other languages
Bosnian (bs)
Croatian (hr)
Inventor
Frank Himmelsbach
Birgit Jung
Flavio Solca
Original Assignee
Boehringer Ingelheim Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from DE10214412A external-priority patent/DE10214412A1/en
Priority claimed from DE2002131711 external-priority patent/DE10231711A1/en
Application filed by Boehringer Ingelheim Pharma filed Critical Boehringer Ingelheim Pharma
Publication of MEP47208A publication Critical patent/MEP47208A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/08—Bronchodilators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/16—Otologicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
    • C07D239/72—Quinazolines; Hydrogenated quinazolines
    • C07D239/86—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in position 4
    • C07D239/94—Nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/08—Bridged systems

Abstract

Ovaj pronalazak se odnosi na biciklične heterociklične grupe opšte formule u kojoj su R³, Rb, Rc, Rd i X definisani kao u zahttjevu 1, njihovi tautomeri, stereoizomeri, smješe i soli, posebno njihovi fiziološki prihvatljive soli sa neorganskim ili organskim kisjelinama koje imaju dragocjene farmakološke osobine, posebno inhibitorni efekat na prenos signala posredovan tirozni kinazama, za njihovu primjenu u liječenju oboljenja, posebno tumora, kao i benigne hiperplazije prostate (BPH), oboljenja pluća i respiratornog trakta, i njihovi preparati.The present invention relates to bicyclic heterocyclic groups of general formula in which R³, Rb, Rc, Rd and X are as defined in claim 1, their tautomers, stereoisomers, mixtures and salts, in particular their physiologically acceptable salts with inorganic or organic acids having valuable pharmacological properties, in particular an inhibitory effect on signaling mediated by tyrosine kinases, for their use in the treatment of diseases, especially tumors, as well as benign prostatic hyperplasia (BPH), lung and respiratory tract diseases, and their preparations.

MEP-472/08A 2002-03-30 2003-03-25 4-(n-phenylamino)-quinazolines / quinolines as tyrosine kinase inhibitors MEP47208A (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DE10214412A DE10214412A1 (en) 2002-03-30 2002-03-30 Bicyclic heterocycles, pharmaceutical compositions containing these compounds, their use and process for their preparation
DE2002131711 DE10231711A1 (en) 2002-07-13 2002-07-13 New 4-amino-quinazoline or quinoline derivatives, are tyrosine kinase-mediated signal transduction inhibitors useful e.g. for treating tumors or respiratory or gastrointestinal diseases
PCT/EP2003/003062 WO2003082290A1 (en) 2002-03-30 2003-03-25 4-(n-phenylamino)-quinazolines / quinolines as tyrosine kinase inhibitors

Publications (1)

Publication Number Publication Date
MEP47208A true MEP47208A (en) 2011-02-10

Family

ID=28676040

Family Applications (1)

Application Number Title Priority Date Filing Date
MEP-472/08A MEP47208A (en) 2002-03-30 2003-03-25 4-(n-phenylamino)-quinazolines / quinolines as tyrosine kinase inhibitors

Country Status (24)

Country Link
EP (1) EP1492536B1 (en)
JP (1) JP4776882B2 (en)
KR (1) KR101064530B1 (en)
CN (1) CN1642552B (en)
AR (1) AR039187A1 (en)
AT (1) ATE557008T1 (en)
AU (1) AU2003226705B2 (en)
BR (1) BR0308902A (en)
CA (1) CA2476008C (en)
EA (2) EA009300B1 (en)
HK (1) HK1079095A1 (en)
HR (1) HRP20040898A2 (en)
IL (1) IL164167A0 (en)
ME (1) MEP47208A (en)
MX (1) MXPA04009536A (en)
MY (1) MY127771A (en)
NO (1) NO329271B1 (en)
NZ (1) NZ536114A (en)
PE (1) PE20040169A1 (en)
PL (1) PL371188A1 (en)
RS (1) RS85404A (en)
TW (2) TW201024269A (en)
UY (1) UY27737A1 (en)
WO (1) WO2003082290A1 (en)

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Also Published As

Publication number Publication date
PE20040169A1 (en) 2004-05-24
NO329271B1 (en) 2010-09-20
PL371188A1 (en) 2005-06-13
EP1492536A1 (en) 2005-01-05
KR101064530B1 (en) 2011-09-14
ATE557008T1 (en) 2012-05-15
CN1642552A (en) 2005-07-20
NO20043997L (en) 2004-10-27
TWI331604B (en) 2010-10-11
EA200401191A1 (en) 2005-04-28
EA200701302A1 (en) 2007-12-28
AU2003226705A1 (en) 2003-10-13
HK1079095A1 (en) 2006-03-31
HRP20040898A2 (en) 2005-10-31
IL164167A0 (en) 2005-12-18
EA009300B1 (en) 2007-12-28
WO2003082290A1 (en) 2003-10-09
CA2476008C (en) 2011-12-13
JP4776882B2 (en) 2011-09-21
NZ536114A (en) 2007-11-30
BR0308902A (en) 2005-01-04
AR039187A1 (en) 2005-02-09
KR20040094898A (en) 2004-11-10
MY127771A (en) 2006-12-29
CA2476008A1 (en) 2003-10-09
TW201024269A (en) 2010-07-01
TW200406211A (en) 2004-05-01
MXPA04009536A (en) 2005-01-25
RS85404A (en) 2007-02-05
CN1642552B (en) 2010-05-12
AU2003226705B2 (en) 2008-11-06
EP1492536B1 (en) 2012-05-09
JP2005529090A (en) 2005-09-29
UY27737A1 (en) 2003-10-31

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