ME02423B - 1-(3,3-DIMETILBUTIL)-3-(2-FLUOR-4-METIL-5-(7-METIL-2-(METILAMINO)PIRIDO[2,3-d]PIRIMIDIN-6-IL)FENIL)UREA KAO INHIBITOR Raf KINAZE U LIJEČENJU RAKA - Google Patents

1-(3,3-DIMETILBUTIL)-3-(2-FLUOR-4-METIL-5-(7-METIL-2-(METILAMINO)PIRIDO[2,3-d]PIRIMIDIN-6-IL)FENIL)UREA KAO INHIBITOR Raf KINAZE U LIJEČENJU RAKA

Info

Publication number
ME02423B
ME02423B MEP-2016-124A MEP2016124A ME02423B ME 02423 B ME02423 B ME 02423B ME P2016124 A MEP2016124 A ME P2016124A ME 02423 B ME02423 B ME 02423B
Authority
ME
Montenegro
Prior art keywords
methyl
inhibltor
pyrido
dimethylbutyl
pyrimidin
Prior art date
Application number
MEP-2016-124A
Other languages
German (de)
English (en)
French (fr)
Inventor
Matthew Carl Allgeier
Daniel L Flynn
Michael D Kaufman
Phenil J Patel
Craig D Wolfangel
Original Assignee
Fourt Jesse Arnold
Deciphera Pharmaceuticals Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=47884613&utm_source=***_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ME02423(B) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Fourt Jesse Arnold, Deciphera Pharmaceuticals Llc filed Critical Fourt Jesse Arnold
Publication of ME02423B publication Critical patent/ME02423B/me

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4985—Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicinal Preparation (AREA)
MEP-2016-124A 2012-03-07 2013-03-05 1-(3,3-DIMETILBUTIL)-3-(2-FLUOR-4-METIL-5-(7-METIL-2-(METILAMINO)PIRIDO[2,3-d]PIRIMIDIN-6-IL)FENIL)UREA KAO INHIBITOR Raf KINAZE U LIJEČENJU RAKA ME02423B (me)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201261607702P 2012-03-07 2012-03-07
PCT/US2013/029084 WO2013134243A1 (en) 2012-03-07 2013-03-05 2-amino, 6-phenyl substituted pyrido [2, 3 - d] pyrimidine derivatives useful as raf kinase inhibitors
EP13712005.1A EP2850082B1 (en) 2012-03-07 2013-03-05 1-(3,3-dimethylbutyl)-3-(2-fluoro-4-methyl-5-(7-methyl-2-(methylamino)pyrido(2,3-d)pyrimidin-6-yl)phenyl)urea as Raf kinase inhibitor for the treatment of cancer

Publications (1)

Publication Number Publication Date
ME02423B true ME02423B (me) 2016-09-20

Family

ID=47884613

Family Applications (1)

Application Number Title Priority Date Filing Date
MEP-2016-124A ME02423B (me) 2012-03-07 2013-03-05 1-(3,3-DIMETILBUTIL)-3-(2-FLUOR-4-METIL-5-(7-METIL-2-(METILAMINO)PIRIDO[2,3-d]PIRIMIDIN-6-IL)FENIL)UREA KAO INHIBITOR Raf KINAZE U LIJEČENJU RAKA

Country Status (39)

Country Link
US (2) US8741911B2 (me)
EP (1) EP2850082B1 (me)
JP (1) JP2015509536A (me)
KR (1) KR20140129087A (me)
CN (1) CN104302646B (me)
AP (1) AP2014007899A0 (me)
AR (1) AR090151A1 (me)
AU (1) AU2013230146B2 (me)
BR (1) BR112014018528A8 (me)
CA (1) CA2863673A1 (me)
CL (1) CL2014002220A1 (me)
CO (1) CO7010837A2 (me)
CR (1) CR20140378A (me)
CY (1) CY1117846T1 (me)
DK (1) DK2850082T3 (me)
DO (1) DOP2014000200A (me)
EA (1) EA024824B1 (me)
EC (1) ECSP14017584A (me)
ES (1) ES2584387T3 (me)
HK (1) HK1202541A1 (me)
HR (1) HRP20160654T1 (me)
HU (1) HUE028095T2 (me)
IL (1) IL234052A (me)
IN (1) IN2014MN01575A (me)
LT (1) LT2850082T (me)
MA (1) MA37316B1 (me)
ME (1) ME02423B (me)
MX (1) MX2014010701A (me)
NZ (1) NZ627454A (me)
PE (1) PE20142338A1 (me)
PH (1) PH12014501986A1 (me)
PT (1) PT2850082T (me)
RS (1) RS54840B1 (me)
SG (1) SG11201404969YA (me)
SI (1) SI2850082T1 (me)
TN (1) TN2014000375A1 (me)
TW (1) TW201348233A (me)
UA (1) UA112340C2 (me)
WO (2) WO2013134243A1 (me)

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AR090151A1 (es) * 2012-03-07 2014-10-22 Lilly Co Eli Compuestos inhibidores de raf
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TWI704151B (zh) 2014-12-22 2020-09-11 美商美國禮來大藥廠 Ｅｒｋ抑制劑
WO2017212442A1 (en) * 2016-06-10 2017-12-14 Novartis Ag Therapeutic uses of a c-raf inhibitor
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EA202091491A1 (ru) 2017-12-21 2020-11-13 Бёрингер Ингельхайм Интернациональ Гмбх Новые бензиламинозамещенные пиридопиримидиноны и производные в качестве ингибиторов sos1
JP7161849B2 (ja) * 2018-01-24 2022-10-27 株式会社クラレ 第一級アミンの製造方法
CA3089566A1 (en) 2018-01-31 2019-08-08 Deciphera Pharmaceuticals, Llc Combination therapy for the treatment of gastrointestinal stromal tumors
JP2022500385A (ja) 2018-09-10 2022-01-04 ミラティ セラピューティクス， インコーポレイテッド 組み合わせ療法
AU2019416117B2 (en) 2018-12-28 2024-05-02 Deciphera Pharmaceuticals, Llc CSF1R inhibitors for use in treating cancer
EP3921030B1 (en) 2019-02-06 2023-10-11 Eli Lilly and Company 1-((2-(2,2,2-trifluoroethoxy)pyridin-4-yl)methyl)urea derivatives as kcnq potentiators
EP3962484A4 (en) 2019-05-03 2023-01-18 Kinnate Biopharma Inc. RAF KINASE INHIBITORS
PE20220597A1 (es) 2019-05-10 2022-04-22 Deciphera Pharmaceuticals Llc Inhibidores de la autofagia de fenilaminopirimidina amida y metodos de uso de estos
TW202108574A (zh) 2019-05-10 2021-03-01 美商迪賽孚爾製藥有限公司 雜芳基胺基嘧啶醯胺自噬抑制劑及其使用方法
WO2020257180A1 (en) 2019-06-17 2020-12-24 Deciphera Pharmaceuticals, Llc Aminopyrimidine amide autophagy inhibitors and methods of use thereof
WO2021030405A1 (en) 2019-08-12 2021-02-18 Deciphera Pharmaceuticals, Llc Ripretinib for treating gastrointestinal stromal tumors
JP2022544234A (ja) 2019-08-12 2022-10-17 デシフェラ・ファーマシューティカルズ，エルエルシー 胃腸間質腫瘍を治療するためのリプレチニブ
KR20220123058A (ko) 2019-12-30 2022-09-05 데시페라 파마슈티칼스, 엘엘씨. 1-(4-브로모-5-(1-에틸-7-(메틸아미노)-2-옥소-1,2-디히드로-1,6-나프티리딘-3-일)-2-플루오로페닐)-3-페닐우레아의 조성물
EP4084778B1 (en) 2019-12-30 2023-11-01 Deciphera Pharmaceuticals, LLC Amorphous kinase inhibitor formulations and methods of use thereof
KR20230019462A (ko) 2020-06-02 2023-02-08 베링거 인겔하임 인터내셔날 게엠베하 암 치료용 고리형 2-아미노-3-시아노 티오펜 및 유도체
WO2022060996A1 (en) 2020-09-18 2022-03-24 Kinnate Biopharma Inc. Inhibitors of raf kinases
WO2022081469A1 (en) 2020-10-12 2022-04-21 Kinnate Biopharma Inc. Inhibitors of raf kinases
WO2022090481A1 (en) 2020-11-02 2022-05-05 Boehringer Ingelheim International Gmbh Substituted 1h-pyrazolo[4,3-c]pyridines and derivatives as egfr inhibitors
KR20230121758A (ko) 2020-11-18 2023-08-21 데시페라 파마슈티칼스, 엘엘씨. Gcn2 및 perk 키나제 억제제 및 그의 사용 방법
AR124449A1 (es) 2020-12-22 2023-03-29 Qilu Regor Therapeutics Inc Inhibidores de sos1 y usos de los mismos
AU2022261117A1 (en) 2021-04-23 2023-11-23 Kinnate Biopharma Inc. Treatment of cancer with a raf inhibitor
US20220388986A1 (en) 2021-04-29 2022-12-08 Boehringer Ingelheim International Gmbh Heterocyclic compounds capable of activating sting
WO2023099620A1 (en) 2021-12-01 2023-06-08 Boehringer Ingelheim International Gmbh Kras degrading compounds comprising annulated 2-amino-3-cyano thiophenes
TW202337431A (zh) 2021-12-01 2023-10-01 德商百靈佳殷格翰國際股份有限公司 用於治療癌症之環狀2-胺基-3-氰基噻吩及衍生物
WO2023099612A1 (en) 2021-12-01 2023-06-08 Boehringer Ingelheim International Gmbh Annulated 2-amino-3-cyano thiophenes and derivatives for the treatment of cancer
WO2023099592A1 (en) 2021-12-01 2023-06-08 Boehringer Ingelheim International Gmbh Annulated 2-amino-3-cyano thiophenes and derivatives for the treatment of cancer
WO2023099623A1 (en) 2021-12-01 2023-06-08 Boehringer Ingelheim International Gmbh Annulated 2-amino-3-cyano thiophenes and derivatives for the treatment of cancer
TW202337432A (zh) 2021-12-01 2023-10-01 德商百靈佳殷格翰國際股份有限公司 用於治療癌症之環狀2-胺基-3-氰基噻吩及衍生物
TW202342442A (zh) 2021-12-09 2023-11-01 美商迪賽孚爾製藥有限公司 Ｒａｆ激酶抑制劑及其使用方法
WO2023118250A1 (en) 2021-12-23 2023-06-29 Boehringer Ingelheim International Gmbh 8-aza quinazolines as brain-penetrant sos1-inhibitors
WO2023173017A1 (en) * 2022-03-09 2023-09-14 Blossomhill Therapeutics, Inc. Kras inhibitors for treating disease
US11779572B1 (en) 2022-09-02 2023-10-10 Deciphera Pharmaceuticals, Llc Methods of treating gastrointestinal stromal tumors
WO2024089008A1 (en) 2022-10-26 2024-05-02 Boehringer Ingelheim International Gmbh Heterocyclic compounds capable of activating sting
US20240166629A1 (en) 2022-10-26 2024-05-23 Boehringer Ingelheim International Gmbh Heterocyclic compounds capable of activating sting
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Also Published As

Publication number Publication date
CN104302646B (zh) 2016-05-04
CO7010837A2 (es) 2014-07-31
CN104302646A (zh) 2015-01-21
TW201348233A (zh) 2013-12-01
US8741911B2 (en) 2014-06-03
BR112014018528A2 (me) 2017-06-20
TN2014000375A1 (en) 2015-12-21
NZ627454A (en) 2016-09-30
KR20140129087A (ko) 2014-11-06
EA201491456A1 (ru) 2014-12-30
EP2850082A1 (en) 2015-03-25
WO2013134252A1 (en) 2013-09-12
SI2850082T1 (sl) 2016-07-29
MA37316B1 (fr) 2017-03-31
AP2014007899A0 (en) 2014-08-31
ECSP14017584A (es) 2016-01-29
ES2584387T3 (es) 2016-09-27
US20150119392A1 (en) 2015-04-30
WO2013134243A1 (en) 2013-09-12
MA37316A1 (fr) 2016-06-30
MX2014010701A (es) 2015-03-10
AU2013230146B2 (en) 2015-09-10
DK2850082T3 (en) 2016-08-15
SG11201404969YA (en) 2014-10-30
AU2013230146A1 (en) 2014-08-14
EP2850082B1 (en) 2016-05-18
PE20142338A1 (es) 2015-01-10
BR112014018528A8 (pt) 2017-07-11
US9334267B2 (en) 2016-05-10
UA112340C2 (uk) 2016-08-25
PH12014501986B1 (en) 2014-11-24
HUE028095T2 (en) 2016-11-28
IN2014MN01575A (me) 2015-05-08
CL2014002220A1 (es) 2015-06-05
US20130252977A1 (en) 2013-09-26
JP2015509536A (ja) 2015-03-30
LT2850082T (lt) 2016-09-12
AR090151A1 (es) 2014-10-22
EA024824B1 (ru) 2016-10-31
IL234052A (en) 2016-05-31
PT2850082T (pt) 2016-07-15
CA2863673A1 (en) 2013-09-12
CR20140378A (es) 2014-11-27
HK1202541A1 (en) 2015-10-02
CY1117846T1 (el) 2017-05-17
RS54840B1 (sr) 2016-10-31
PH12014501986A1 (en) 2014-11-24
DOP2014000200A (es) 2014-10-15
HRP20160654T1 (hr) 2016-07-01

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