ME00349B - Novi kristalni anhidrat sa antiholinergij skim dejstvom - Google Patents

Novi kristalni anhidrat sa antiholinergij skim dejstvom

Info

Publication number
ME00349B
ME00349B MEP-2008-517A MEP51708A ME00349B ME 00349 B ME00349 B ME 00349B ME P51708 A MEP51708 A ME P51708A ME 00349 B ME00349 B ME 00349B
Authority
ME
Montenegro
Prior art keywords
novel crystalline
anticholinergic effect
crystalline anhydride
preparation
treatment
Prior art date
Application number
MEP-2008-517A
Other languages
German (de)
English (en)
French (fr)
Inventor
Waldemar Pfrengle
Peter Sieger
Original Assignee
Boehringer Ingelheim Int
Boehringer Ingelheim Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=34530662&utm_source=***_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ME00349(B) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Boehringer Ingelheim Int, Boehringer Ingelheim Pharma filed Critical Boehringer Ingelheim Int
Publication of MEP51708A publication Critical patent/MEP51708A/xx
Publication of ME00349B publication Critical patent/ME00349B/me

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
    • C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
    • C07D451/04—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof with hetero atoms directly attached in position 3 of the 8-azabicyclo [3.2.1] octane or in position 7 of the 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring system
    • C07D451/06—Oxygen atoms
    • C07D451/10—Oxygen atoms acylated by aliphatic or araliphatic carboxylic acids, e.g. atropine, scopolamine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/46—8-Azabicyclo [3.2.1] octane; Derivatives thereof, e.g. atropine, ***e
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pulmonology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Emergency Medicine (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Pronalazak se odnosi na novi, kristalni anhidrat tiotropijumbromida, na postupak za njegovo pripremanje, kao i na njegovu upotrebu za pripremanje leka za tretiranje oboljenja disajnih puteva, naročito za tretiranje COPD-a (chronic obstructive pulmonary disease= hronično opstruktivne oboljenje pluća) i astme.
MEP-2008-517A 2003-11-03 2004-10-29 Novi kristalni anhidrat sa antiholinergij skim dejstvom ME00349B (me)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP03025077 2003-11-03
PCT/EP2004/012269 WO2005042527A1 (de) 2003-11-03 2004-10-29 Neues kristallines anhydrat mit anticholinerger wirksamkeit

Publications (2)

Publication Number Publication Date
MEP51708A MEP51708A (en) 2011-02-10
ME00349B true ME00349B (me) 2011-05-10

Family

ID=34530662

Family Applications (1)

Application Number Title Priority Date Filing Date
MEP-2008-517A ME00349B (me) 2003-11-03 2004-10-29 Novi kristalni anhidrat sa antiholinergij skim dejstvom

Country Status (34)

Country Link
EP (1) EP1682542B1 (me)
JP (1) JP4553902B2 (me)
KR (2) KR101313904B1 (me)
CN (1) CN100509809C (me)
AR (1) AR046319A1 (me)
AT (1) ATE453641T1 (me)
AU (1) AU2004285684B2 (me)
BR (1) BRPI0415636A (me)
CA (1) CA2544352C (me)
CO (1) CO5690641A2 (me)
CY (1) CY1110339T1 (me)
DE (1) DE502004010602D1 (me)
DK (1) DK1682542T3 (me)
EA (1) EA008587B1 (me)
EC (1) ECSP066543A (me)
ES (1) ES2338563T3 (me)
HK (1) HK1099752A1 (me)
HR (1) HRP20100029T1 (me)
IL (1) IL175126A (me)
ME (1) ME00349B (me)
MX (1) MX272045B (me)
MY (1) MY146628A (me)
NO (1) NO20062569L (me)
NZ (1) NZ547581A (me)
PE (1) PE20050996A1 (me)
PL (1) PL1682542T3 (me)
PT (1) PT1682542E (me)
RS (2) RS20060291A (me)
SI (1) SI1682542T1 (me)
TW (1) TWI336330B (me)
UA (1) UA82909C2 (me)
UY (1) UY28596A1 (me)
WO (1) WO2005042527A1 (me)
ZA (1) ZA200602344B (me)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2008540367A (ja) * 2005-05-02 2008-11-20 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング 新規結晶性臭化チオトロピウム
RU2453547C2 (ru) * 2005-12-19 2012-06-20 Сикор Инк. Новые формы тиотропия бромида и способы их получения
MX2007009988A (es) * 2005-12-19 2008-02-22 Sicor Inc Formas novedosas de bromuro de tiotropio y procesos para su preparacion.
US9108962B2 (en) 2005-12-19 2015-08-18 Sicor, Inc. Forms of tiotropium bromide and processes for preparation thereof
AU2006334367B2 (en) * 2006-01-04 2012-11-08 Boehringer Ingelheim International Gmbh Use of tiotropium salts in the treatment of moderate persistent asthma
CN100999521B (zh) * 2006-01-13 2010-12-08 江苏正大天晴药业股份有限公司 结晶性抗胆碱药噻托溴铵
US20080051582A1 (en) 2006-07-10 2008-02-28 Sicor Inc. Process for the preparation of tiotropium bromide
CN101032484B (zh) * 2007-04-02 2010-05-26 南京卡文迪许生物工程技术有限公司 一种噻托溴铵胶囊型吸入粉雾剂
GB0716026D0 (en) 2007-08-16 2007-09-26 Norton Healthcare Ltd An inhalable medicament
NZ592861A (en) * 2008-11-04 2013-01-25 Cipla Ltd Pharmaceutical aerosol composition
KR101557633B1 (ko) * 2008-11-04 2015-10-06 시플라 리미티드 낮은 결정화도를 갖는 티오트로피움 브로마이드
EP2462140A2 (en) * 2009-08-07 2012-06-13 Generics [UK] Limited Anhydrate of triotropium bromide
TR201111589A2 (tr) * 2011-03-03 2012-09-21 Bi̇lgi̇ç Mahmut Tiotropyum bromür susuz kristal formu.
CZ304368B6 (cs) 2011-11-28 2014-04-02 Zentiva, K.S. Směsný solvát tiotropium bromidu a způsob jeho přípravy
GB201200525D0 (en) 2011-12-19 2012-02-29 Teva Branded Pharmaceutical Prod R & D Inc An inhalable medicament
EP2897955B1 (en) * 2012-09-11 2019-11-06 Bilgic, Mahmut New tiotropium bromide crystalline form
WO2014067499A1 (en) 2012-11-05 2014-05-08 Zentiva, K.S. Stabilization of tiotropium solvates
EP2913332A1 (en) 2014-02-27 2015-09-02 Euticals S.P.A. Crystalline form of tiotropium bromide with lactose
US10034866B2 (en) 2014-06-19 2018-07-31 Teva Branded Pharmaceutical Products R&D, Inc. Inhalable medicament comprising tiotropium
WO2017138896A1 (en) 2016-02-11 2017-08-17 Sima Patent Ve Lisanslama Hizmetleri Ltd. Şti Crystalline form of tiotropium bromide anhydrate
EP4108230A1 (en) 2021-06-24 2022-12-28 Laboratoires SMB New dry powder composition of tiotropium for inhalation

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3931041C2 (de) * 1989-09-16 2000-04-06 Boehringer Ingelheim Kg Ester von Thienylcarbonsäuren mit Aminoalkoholen, ihre Quaternierungsprodukte, Verfahren zu ihrer Herstellung und diese enthaltende Arzneimittel
TR200402579T4 (tr) * 2000-10-12 2004-12-21 Boehringer Ingelheim Pharma Gmbh & Co. Kg Kristalin monohidrat, bunun imalat yöntemi ve bir ilaç maddesinin imalatında kullanımı
DE10111843A1 (de) * 2001-03-13 2002-09-19 Boehringer Ingelheim Pharma Verbindungen zur Behandlung von inflammatorischen Erkrankungen
SK287262B6 (sk) * 2001-06-22 2010-04-07 Boehringer Ingelheim Pharma Gmbh & Co. Kg Kryštalický bezvodný tiotropiumbromid, spôsob jeho výroby, farmaceutický prostriedok s jeho obsahom a jeho použitie

Also Published As

Publication number Publication date
ES2338563T3 (es) 2010-05-10
EA200600853A1 (ru) 2006-10-27
CN1875019A (zh) 2006-12-06
IL175126A0 (en) 2006-09-05
AU2004285684B2 (en) 2011-07-14
EA008587B1 (ru) 2007-06-29
IL175126A (en) 2010-11-30
NO20062569L (no) 2006-07-12
JP4553902B2 (ja) 2010-09-29
HRP20100029T1 (hr) 2010-02-28
TWI336330B (en) 2011-01-21
KR101285571B1 (ko) 2013-07-15
EP1682542A1 (de) 2006-07-26
WO2005042527A1 (de) 2005-05-12
ECSP066543A (es) 2006-10-17
MX272045B (en) 2009-11-23
ZA200602344B (en) 2007-07-25
CA2544352A1 (en) 2005-05-12
CO5690641A2 (es) 2006-10-31
NZ547581A (en) 2009-03-31
HK1099752A1 (en) 2007-08-24
KR101313904B1 (ko) 2013-09-30
MY146628A (en) 2012-09-14
MEP51708A (en) 2011-02-10
KR20120036381A (ko) 2012-04-17
RS20060291A (en) 2008-06-05
CY1110339T1 (el) 2015-01-14
AR046319A1 (es) 2005-11-30
PT1682542E (pt) 2010-01-27
RS51599B (en) 2011-08-31
ATE453641T1 (de) 2010-01-15
CN100509809C (zh) 2009-07-08
DE502004010602D1 (de) 2010-02-11
PE20050996A1 (es) 2005-12-20
DK1682542T3 (da) 2010-05-10
PL1682542T3 (pl) 2010-06-30
KR20060121131A (ko) 2006-11-28
UY28596A1 (es) 2005-06-30
UA82909C2 (en) 2008-05-26
TW200526652A (en) 2005-08-16
BRPI0415636A (pt) 2006-12-12
CA2544352C (en) 2013-07-16
JP2007509894A (ja) 2007-04-19
SI1682542T1 (sl) 2010-04-30
MXPA06004940A (es) 2006-07-20
EP1682542B1 (de) 2009-12-30
AU2004285684A1 (en) 2005-05-12

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