ME00349B - Novi kristalni anhidrat sa antiholinergij skim dejstvom - Google Patents
Novi kristalni anhidrat sa antiholinergij skim dejstvomInfo
- Publication number
- ME00349B ME00349B MEP-2008-517A MEP51708A ME00349B ME 00349 B ME00349 B ME 00349B ME P51708 A MEP51708 A ME P51708A ME 00349 B ME00349 B ME 00349B
- Authority
- ME
- Montenegro
- Prior art keywords
- novel crystalline
- anticholinergic effect
- crystalline anhydride
- preparation
- treatment
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
- C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
- C07D451/04—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof with hetero atoms directly attached in position 3 of the 8-azabicyclo [3.2.1] octane or in position 7 of the 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring system
- C07D451/06—Oxygen atoms
- C07D451/10—Oxygen atoms acylated by aliphatic or araliphatic carboxylic acids, e.g. atropine, scopolamine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/46—8-Azabicyclo [3.2.1] octane; Derivatives thereof, e.g. atropine, ***e
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pulmonology (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Emergency Medicine (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
Pronalazak se odnosi na novi, kristalni anhidrat tiotropijumbromida, na postupak za njegovo pripremanje, kao i na njegovu upotrebu za pripremanje leka za tretiranje oboljenja disajnih puteva, naročito za tretiranje COPD-a (chronic obstructive pulmonary disease= hronično opstruktivne oboljenje pluća) i astme.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP03025077 | 2003-11-03 | ||
PCT/EP2004/012269 WO2005042527A1 (de) | 2003-11-03 | 2004-10-29 | Neues kristallines anhydrat mit anticholinerger wirksamkeit |
Publications (2)
Publication Number | Publication Date |
---|---|
MEP51708A MEP51708A (en) | 2011-02-10 |
ME00349B true ME00349B (me) | 2011-05-10 |
Family
ID=34530662
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MEP-2008-517A ME00349B (me) | 2003-11-03 | 2004-10-29 | Novi kristalni anhidrat sa antiholinergij skim dejstvom |
Country Status (34)
Country | Link |
---|---|
EP (1) | EP1682542B1 (me) |
JP (1) | JP4553902B2 (me) |
KR (2) | KR101313904B1 (me) |
CN (1) | CN100509809C (me) |
AR (1) | AR046319A1 (me) |
AT (1) | ATE453641T1 (me) |
AU (1) | AU2004285684B2 (me) |
BR (1) | BRPI0415636A (me) |
CA (1) | CA2544352C (me) |
CO (1) | CO5690641A2 (me) |
CY (1) | CY1110339T1 (me) |
DE (1) | DE502004010602D1 (me) |
DK (1) | DK1682542T3 (me) |
EA (1) | EA008587B1 (me) |
EC (1) | ECSP066543A (me) |
ES (1) | ES2338563T3 (me) |
HK (1) | HK1099752A1 (me) |
HR (1) | HRP20100029T1 (me) |
IL (1) | IL175126A (me) |
ME (1) | ME00349B (me) |
MX (1) | MX272045B (me) |
MY (1) | MY146628A (me) |
NO (1) | NO20062569L (me) |
NZ (1) | NZ547581A (me) |
PE (1) | PE20050996A1 (me) |
PL (1) | PL1682542T3 (me) |
PT (1) | PT1682542E (me) |
RS (2) | RS20060291A (me) |
SI (1) | SI1682542T1 (me) |
TW (1) | TWI336330B (me) |
UA (1) | UA82909C2 (me) |
UY (1) | UY28596A1 (me) |
WO (1) | WO2005042527A1 (me) |
ZA (1) | ZA200602344B (me) |
Families Citing this family (21)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2008540367A (ja) * | 2005-05-02 | 2008-11-20 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | 新規結晶性臭化チオトロピウム |
RU2453547C2 (ru) * | 2005-12-19 | 2012-06-20 | Сикор Инк. | Новые формы тиотропия бромида и способы их получения |
MX2007009988A (es) * | 2005-12-19 | 2008-02-22 | Sicor Inc | Formas novedosas de bromuro de tiotropio y procesos para su preparacion. |
US9108962B2 (en) | 2005-12-19 | 2015-08-18 | Sicor, Inc. | Forms of tiotropium bromide and processes for preparation thereof |
AU2006334367B2 (en) * | 2006-01-04 | 2012-11-08 | Boehringer Ingelheim International Gmbh | Use of tiotropium salts in the treatment of moderate persistent asthma |
CN100999521B (zh) * | 2006-01-13 | 2010-12-08 | 江苏正大天晴药业股份有限公司 | 结晶性抗胆碱药噻托溴铵 |
US20080051582A1 (en) | 2006-07-10 | 2008-02-28 | Sicor Inc. | Process for the preparation of tiotropium bromide |
CN101032484B (zh) * | 2007-04-02 | 2010-05-26 | 南京卡文迪许生物工程技术有限公司 | 一种噻托溴铵胶囊型吸入粉雾剂 |
GB0716026D0 (en) | 2007-08-16 | 2007-09-26 | Norton Healthcare Ltd | An inhalable medicament |
NZ592861A (en) * | 2008-11-04 | 2013-01-25 | Cipla Ltd | Pharmaceutical aerosol composition |
KR101557633B1 (ko) * | 2008-11-04 | 2015-10-06 | 시플라 리미티드 | 낮은 결정화도를 갖는 티오트로피움 브로마이드 |
EP2462140A2 (en) * | 2009-08-07 | 2012-06-13 | Generics [UK] Limited | Anhydrate of triotropium bromide |
TR201111589A2 (tr) * | 2011-03-03 | 2012-09-21 | Bi̇lgi̇ç Mahmut | Tiotropyum bromür susuz kristal formu. |
CZ304368B6 (cs) | 2011-11-28 | 2014-04-02 | Zentiva, K.S. | Směsný solvát tiotropium bromidu a způsob jeho přípravy |
GB201200525D0 (en) | 2011-12-19 | 2012-02-29 | Teva Branded Pharmaceutical Prod R & D Inc | An inhalable medicament |
EP2897955B1 (en) * | 2012-09-11 | 2019-11-06 | Bilgic, Mahmut | New tiotropium bromide crystalline form |
WO2014067499A1 (en) | 2012-11-05 | 2014-05-08 | Zentiva, K.S. | Stabilization of tiotropium solvates |
EP2913332A1 (en) | 2014-02-27 | 2015-09-02 | Euticals S.P.A. | Crystalline form of tiotropium bromide with lactose |
US10034866B2 (en) | 2014-06-19 | 2018-07-31 | Teva Branded Pharmaceutical Products R&D, Inc. | Inhalable medicament comprising tiotropium |
WO2017138896A1 (en) | 2016-02-11 | 2017-08-17 | Sima Patent Ve Lisanslama Hizmetleri Ltd. Şti | Crystalline form of tiotropium bromide anhydrate |
EP4108230A1 (en) | 2021-06-24 | 2022-12-28 | Laboratoires SMB | New dry powder composition of tiotropium for inhalation |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE3931041C2 (de) * | 1989-09-16 | 2000-04-06 | Boehringer Ingelheim Kg | Ester von Thienylcarbonsäuren mit Aminoalkoholen, ihre Quaternierungsprodukte, Verfahren zu ihrer Herstellung und diese enthaltende Arzneimittel |
TR200402579T4 (tr) * | 2000-10-12 | 2004-12-21 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Kristalin monohidrat, bunun imalat yöntemi ve bir ilaç maddesinin imalatında kullanımı |
DE10111843A1 (de) * | 2001-03-13 | 2002-09-19 | Boehringer Ingelheim Pharma | Verbindungen zur Behandlung von inflammatorischen Erkrankungen |
SK287262B6 (sk) * | 2001-06-22 | 2010-04-07 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Kryštalický bezvodný tiotropiumbromid, spôsob jeho výroby, farmaceutický prostriedok s jeho obsahom a jeho použitie |
-
2004
- 2004-10-29 BR BRPI0415636-6A patent/BRPI0415636A/pt not_active IP Right Cessation
- 2004-10-29 WO PCT/EP2004/012269 patent/WO2005042527A1/de active Application Filing
- 2004-10-29 DK DK04791029.4T patent/DK1682542T3/da active
- 2004-10-29 PT PT04791029T patent/PT1682542E/pt unknown
- 2004-10-29 UA UAA200605766A patent/UA82909C2/uk unknown
- 2004-10-29 RS YUP-2006/0291A patent/RS20060291A/sr unknown
- 2004-10-29 JP JP2006537208A patent/JP4553902B2/ja active Active
- 2004-10-29 RS RS20060291A patent/RS51599B/en unknown
- 2004-10-29 AU AU2004285684A patent/AU2004285684B2/en not_active Ceased
- 2004-10-29 EP EP04791029A patent/EP1682542B1/de active Active
- 2004-10-29 EA EA200600853A patent/EA008587B1/ru unknown
- 2004-10-29 KR KR1020127007695A patent/KR101313904B1/ko active IP Right Grant
- 2004-10-29 CA CA2544352A patent/CA2544352C/en not_active Expired - Fee Related
- 2004-10-29 ES ES04791029T patent/ES2338563T3/es active Active
- 2004-10-29 NZ NZ547581A patent/NZ547581A/en not_active IP Right Cessation
- 2004-10-29 CN CNB200480032521XA patent/CN100509809C/zh active Active
- 2004-10-29 SI SI200431356T patent/SI1682542T1/sl unknown
- 2004-10-29 PE PE2004001047A patent/PE20050996A1/es active IP Right Grant
- 2004-10-29 DE DE502004010602T patent/DE502004010602D1/de active Active
- 2004-10-29 AT AT04791029T patent/ATE453641T1/de active
- 2004-10-29 PL PL04791029T patent/PL1682542T3/pl unknown
- 2004-10-29 ME MEP-2008-517A patent/ME00349B/me unknown
- 2004-10-29 KR KR1020067010918A patent/KR101285571B1/ko active IP Right Grant
- 2004-11-01 MY MYPI20044518A patent/MY146628A/en unknown
- 2004-11-02 TW TW093133282A patent/TWI336330B/zh not_active IP Right Cessation
- 2004-11-03 UY UY28596A patent/UY28596A1/es not_active Application Discontinuation
- 2004-11-03 AR ARP040104040A patent/AR046319A1/es unknown
-
2006
- 2006-03-22 ZA ZA200602344A patent/ZA200602344B/en unknown
- 2006-04-24 IL IL175126A patent/IL175126A/en active IP Right Grant
- 2006-05-02 CO CO06041173A patent/CO5690641A2/es not_active Application Discontinuation
- 2006-05-03 EC EC2006006543A patent/ECSP066543A/es unknown
- 2006-05-03 MX MXPA06004940 patent/MX272045B/es active IP Right Grant
- 2006-06-02 NO NO20062569A patent/NO20062569L/no not_active Application Discontinuation
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2007
- 2007-05-29 HK HK07105629.1A patent/HK1099752A1/xx not_active IP Right Cessation
-
2010
- 2010-01-15 HR HR20100029T patent/HRP20100029T1/hr unknown
- 2010-02-09 CY CY20101100120T patent/CY1110339T1/el unknown
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