MD4118C1 - 1,3,4-Oxadiazole compounds containing disubstituted thiourea, manifesting antituberculous properties - Google Patents
1,3,4-Oxadiazole compounds containing disubstituted thiourea, manifesting antituberculous propertiesInfo
- Publication number
- MD4118C1 MD4118C1 MDA20100102A MD20100102A MD4118C1 MD 4118 C1 MD4118 C1 MD 4118C1 MD A20100102 A MDA20100102 A MD A20100102A MD 20100102 A MD20100102 A MD 20100102A MD 4118 C1 MD4118 C1 MD 4118C1
- Authority
- MD
- Moldova
- Prior art keywords
- properties
- antituberculous
- manifesting
- oxadiazole compounds
- compounds containing
- Prior art date
Links
Landscapes
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Abstract
The invention relates to disubstituted 1,3,4-oxadiazole compounds obtained on the basis of disubstituted thiourea containing the residue of monoethanolamine, in particular to their derivatives manifesting antituberculous properties.The compounds, according to the invention, correspond to general formula:where:R=4-fluorphenacyl (1a);R=phenacyl (1b);R=allyl (1c);R=benzyl (1d);R=2,4-dichlorphenacyl (1e).The synthesis includes the following stages: hydrazinolysis of ethyl-p-aminobenzoate, cyclization-isothiocyanation-thiolation with tetramethylthiuram disulphide of the obtained hydrazide, thioalkylation and finally addition of monoethanolamine to the isothiocyanate group.The compounds manifest Mycobacterium tuberculosis culture growth inhibition properties.
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
MDA20100102A MD4118C1 (en) | 2010-09-02 | 2010-09-02 | 1,3,4-Oxadiazole compounds containing disubstituted thiourea, manifesting antituberculous properties |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
MDA20100102A MD4118C1 (en) | 2010-09-02 | 2010-09-02 | 1,3,4-Oxadiazole compounds containing disubstituted thiourea, manifesting antituberculous properties |
Publications (2)
Publication Number | Publication Date |
---|---|
MD4118B1 MD4118B1 (en) | 2011-07-31 |
MD4118C1 true MD4118C1 (en) | 2012-02-29 |
Family
ID=45815213
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MDA20100102A MD4118C1 (en) | 2010-09-02 | 2010-09-02 | 1,3,4-Oxadiazole compounds containing disubstituted thiourea, manifesting antituberculous properties |
Country Status (1)
Country | Link |
---|---|
MD (1) | MD4118C1 (en) |
Families Citing this family (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
MD4404C1 (en) * | 2015-03-18 | 2016-09-30 | Институт Химии Академии Наук Молдовы | 2-(Propylthio)-5H-[1,3,4]thiadiazole[2,3-b]quinazoline-5-one compound, exhibiting antituberculous activity and method for synthesis thereof |
Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB729891A (en) * | 1952-10-10 | 1955-05-11 | Bayer Ag | New 4,5-dihydro-1,3,4-oxadiazol-5-one derivatives |
GB925911A (en) * | 1960-07-28 | 1963-05-15 | Ed Geistlich Sohne A G | Antitubercular pharmaceutical compositions |
JPH07258234A (en) * | 1994-03-17 | 1995-10-09 | Shiratori Seiyaku Kk | Production of 1,3,4-oxadiazole-2(3h)-thione compound |
MD613G2 (en) * | 1994-02-24 | 1997-06-30 | Государственный Университет Молд0 | Process for 2 - mercapto - 1,3,4 - oxadiasols preparation |
-
2010
- 2010-09-02 MD MDA20100102A patent/MD4118C1/en not_active IP Right Cessation
Patent Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB729891A (en) * | 1952-10-10 | 1955-05-11 | Bayer Ag | New 4,5-dihydro-1,3,4-oxadiazol-5-one derivatives |
GB925911A (en) * | 1960-07-28 | 1963-05-15 | Ed Geistlich Sohne A G | Antitubercular pharmaceutical compositions |
MD613G2 (en) * | 1994-02-24 | 1997-06-30 | Государственный Университет Молд0 | Process for 2 - mercapto - 1,3,4 - oxadiasols preparation |
JPH07258234A (en) * | 1994-03-17 | 1995-10-09 | Shiratori Seiyaku Kk | Production of 1,3,4-oxadiazole-2(3h)-thione compound |
Non-Patent Citations (7)
Title |
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Chang Hoon Lee, Hyun In Cho, and Kee-Jung Lee. Bull. Korean Chem. Soc. 2001, Vol. 22, No. 10 1153 (regăsit în Internet la 2011.05.12, url: http://pdf.easechem.com/pdf/32/f0038874-65de-4d17-ad40-5ca8992fa8b7.pdf ) * |
Collins L., Franzblau S. G. Antimicrob. Agents chemother., 1997, vol. 41, pp. 1004-1009. * |
Fliur Macaev, Ghenadie Rusu, Serghei Pogrebnoi, Alexandru Gudima, Eugenia Stingaci, Ludmila Vlad, Nathaly Shvets, Fatma Kandemirli, Anatholy Dimoglo, and Robert Reynolds. Bioorganic & Medicinal Chemistry, Volume 13, (2005), Pages 4842-4850 * |
Gabriel Navarrete-Vázquez, Gloria Marı´a Molina-Salinas, Zetel Vahi Duarte-Fajardo, Javier Vargas-Villarreal, Samuel Estrada-Soto, Francisco González-Salazar, Emanuel Hernández-Núñez, Salvador Said-Fernández. Bioorganic & Medicinal Chemistry, Volume 15 (2007), Issue 16, pp. 5502-5508 * |
Gabriel Navarrete-Vázquez, Gloria Marı´a Molina-Salinas, Zetel Vahi Duarte-Fajardo, Javier Vargas-Villarreal, Samuel Estrada-Soto, Francisco González-Salazar, Emanuel Hernández-Núñez, Salvador Said-Fernández. Bioorganic & Medicinal Chemistry, Volume 15, Issue 16, 15 August 2007, pp. 5502-5508. * |
Harish Rajak, Murli Dhar Khary and Pradeep Mishra. International Journal of Pharmaceutical Sciences and Nanotechnology. 2009, vol. 2, issuie 1, p390. (Regăsit în Internet la 2011.05.12, url: http://ijpsnonline.com/Issues/310.pdf ) * |
Rusu G. G., Gutu E. E., Barba N. A. Russ. J. Org. Chem. 1995, vol. 31, p. 1721. * |
Also Published As
Publication number | Publication date |
---|---|
MD4118B1 (en) | 2011-07-31 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FG4A | Patent for invention issued | ||
KA4A | Patent for invention lapsed due to non-payment of fees (with right of restoration) | ||
KA4A | Patent for invention lapsed due to non-payment of fees (with right of restoration) | ||
MM4A | Patent for invention definitely lapsed due to non-payment of fees |